Dual Modulation of Airway Smooth Muscle Contraction by Th2 Cytokines via Matrix Metalloproteinase-1 Production
Project/Area Number |
19390065
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Kumamoto Health Science University |
Principal Investigator |
ITO Yusii Kumamoto Health Science University, 大学院, 教授 (80037506)
|
Co-Investigator(Kenkyū-buntansha) |
OIKE Masahiro 九州大学, 大学院 医学研究院, 准教授 (70271103)
木村 千稚 九州大学, 医学(系)研究科(研究院), 研究員 (90359935)
|
Co-Investigator(Renkei-kenkyūsha) |
KIMURA Chiwaka
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
|
Keywords | 気道 / 平滑筋 / 気道過敏性 / サイトカイン / IL-13 / IL-4 / Ca^<2+> / ミオシン軽鎖 |
Research Abstract |
研究成果の概要:Th2 サイトカインであるIL-4 及びIL-13 は気道平滑筋の収縮増強効果を有し、この増強効果には細胞内Ca 濃度や収縮蛋白のCa 感受性、MLCK のリン酸化は全く関与しないことを明らかにした。結論としてTh2 サイトカインによる収縮増強効果にはMMP-1 が関与し気道平滑筋細胞と細胞外コラーゲンの網状組織の再構築が関与することを世界に先駆け明らかにした。
|
Report
(3 results)
Research Products
(36 results)
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[Journal Article] Gastric relaxation induced by electrical and chemical stimulation of the area postrema2009
Author(s)
Kawachi, M., Hori, N., Takei, M., Kurimoto, T., Akaike, N., Ito,Y
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Journal Title
General Physiology & Biophysics 27
Pages: 243-252
Related Report
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[Journal Article] Histamine responses of large neostriatal interneurons in histamine H1 and H2 receptor knock-out mice2009
Author(s)
Ogawa, S., Yanai, K., Watanabe, T., Wang, ZM., Akaike, H., Ito, Y., Akaike, N
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Journal Title
Brain Research Bulletin 78
Pages: 189-194
Related Report
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[Journal Article] Differential effects of divalent cations on spontaneous ans evoked glycine release from spinal interneurns2009
Author(s)
Maeda, M., Tanaka, E., Shoudai, K., Nonaka, K., Murayama, N., Ito, Y., Akaike, N
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Journal Title
Journal of Neurophysiology 101
Pages: 1103-1113
Related Report
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[Journal Article] Gastric relaxation induced by electrical and chemical stimulation of the area postrema2009
Author(s)
Kawachi, M., Hori, N., Takei, M., Kurimoto, T., Akaike, N., Ito, Y
-
Journal Title
General Physiology & Biophysics 27
Pages: 243-252
Related Report
Peer Reviewed
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[Journal Article] Differential effects of divalent cations on spontaneous and evoked glycine release from spinal interneurons.2009
Author(s)
Maeda, M., Tanaka, E., Shoudai, K., Nonaka, K., Ito, Y., Akaike, N.
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Journal Title
Journal of Neurophysiology 101
Pages: 1103-1113
Related Report
Peer Reviewed
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[Journal Article] responses of large neostriatal interneurons in histamine H1 and H2receptor knock-out mice2009
Author(s)
Ogawa, S., Yanai, K., Watanabe, T., Wang, ZM., Akaike, H., Ito, Y., Akaike, N
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Journal Title
Brain Research Bulletin 78
Pages: 189-194
Related Report
Peer Reviewed
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[Journal Article] Synergistic Activation of Vascular TRPC6 Channel by Receptor and Mechanical Stimulation via Phospholipase C/Diacylglycerol and Phospholipase A2/{omega}-Hydroxylase/ 20-HETE Pathways.2009
Author(s)
Inoue, R, Jensen, LJ, Jian Z, Shi J, Hai L, Lurie AI, Henriksen FH, Salmonsson M, Morita H, Kawarabayashi Y, Mori M, Mori Y, Ito Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Quantitative analysis of toxin extracts from various tissues of wild and cultured puffer fish by an electrophysiological merhod2008
Author(s)
Sasaki, K., Takayama, Y., Tahara, T., Anraku, K., Ito, Y., Akaike, N
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Journal Title
Toxicon 51
Pages: 606-614
Related Report
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[Journal Article] Dual modulation of airway smooth muscle contraction by TH2 cytokines via matrix metalloproteinase-1 production2008
Author(s)
Ohta, Y., Hayashi, M., Kanenura, T., Abe, K., Ito, Y., Oike, M
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Journal Title
The Journal of Immunology 180
Pages: 4191-4199
Related Report
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[Journal Article] Holstein-Rathlou, NH., Jensen, Lj The role of L-and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles2008
Author(s)
Braunstein, TH., Inoue, R., Crebbs, L., Oke, M., Ito, Y
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Journal Title
Vascular Research 46(2)
Pages: 138-151
Related Report
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[Journal Article] The role of L-and T-type calcium channels in local and remote calcium responses in rat mesenteric terminal arterioles2008
Author(s)
Braunstein, TH., Inoue, R., Crebbs, L., Oke, M., Ito, Y., Holstein-Eathlou, NH., Jensen, Lj
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Journal Title
Vascular Research 46 (2)
Pages: 138-151
Related Report
Peer Reviewed
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[Journal Article] Membrane stretch-induced activationb of a TRPM4-like nonselective cation channel in cerebral artery myocytes2007
Author(s)
Morita,H., Honda, A., Inoue, R., Ito, Y., Abe, K., Nelson, MT., Brayden, JE
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Journal Title
Journal of Pharmacological Sciences 103
Pages: 417-426
Related Report
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