| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2007: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Research Abstract |
To develop technology of nuclear reprogramming of somatic cells into pluripotent stem cells, human somatic cells were cell-fused with human embryonic stem (ES) cells. We got the following results ; 1) human ES cells had potential ofreprogramming of human somatic cells into pluripotent stem cells, 2) selected chromosome (s) were eliminated from ES-somatic hybrid cells, and 3) karyotypically normal ES cells were generated by duplication of an eliminated chromosome. These developed techniques could be applied to induced pluripotent stem (iPS) cells.
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