Pathological roles of ion transporter/channel as therapeutic targets in muscle degenerative disease
| Project/Area Number |
19390080
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
WAKABAYASHI Shigeo National Cardiovascular Center Research Institute, 循環分子生理部, 部長 (70158583)
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| Co-Investigator(Kenkyū-buntansha) |
IWATA Yuko 国立循環器病センター研究所, 循環分子生理部, 室長 (80171908)
NISHITANI Tomoe 国立循環器病センター研究所, 循環分子生理部, 室長 (50393244)
HISAMITSU Takashi 国立循環器病センター研究所, 循環分子生理部, 室員 (50327946)
KOBAYASHI Soushi 国立循環器病センター研究所, 循環分子生理部, 流動研究員 (50511531)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 循環器・高血圧 / 生体分子 / 蛋白質 / トランスレーショナルリサーチ / バイオテクノロジー |
|---|
| Research Abstract |
We conclude that Ca^<2+>-permeable channel TRPV2 and Na^+/H^+ exchanger NHE1 play important pathological roles in abnormal Ca^<2+>-handling commonly occurring in dilated cardiomyopathy, heart failure and muscular dystrophy.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Dominant-negative inhibition of Ca2+ influx via TRPV2 ameliorates muscular dystrophy in animal models2009
Author(s)
Iwata, Y., Katanosaka, Y., Arai, Y., Shigekawa, M., Wakabayashi, S
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Journal Title
Hum. Mol. Gen Vol.18,No.5
Pages: 824-834
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
中村(西谷)友重, 他
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Journal Title
創薬研究者必見!-最新トランスポーター研究2009“遺伝子医学MOOK 12"(株式会社メディカル ドゥ)
Pages: 255-261
Related Report
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