The Dlg signal transduction pathway
Project/Area Number |
19390082
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
AKIYAMA Tetsu The University of Tokyo, 分子細胞生物学研究所, 教授 (70150745)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | Dlg / Runx / Wnt シグナル / sFRP2 / シグナル伝達 / 細胞膜裏打ち蛋白質 / beta-catenin / sFRP / 癌抑制遺伝子 |
Research Abstract |
Dlg-Runx-sFRP2-Wntシグナル伝達経路の実体と生理的意義を明らかにすることを目的として研究を行い、以下の成果を得た。1)RunxがA-MybおよびRhoA特異的guanine nucleotide exchange factor Net1と複合体を形成することを見出した。3)Dlg-/-細胞ではProBからPreBへの分化に異常があることが確認された。4)Dlg-/-マウスでは、心室中核欠損、口蓋裂、腎泌尿器系の発生異常を起こすことを見出した。5)ヒト乳癌培養細胞株35種類についてDlgの変異が存在しないことを明らかにした。
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Report
(3 results)
Research Products
(46 results)
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[Journal Article] Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer2008
Author(s)
Togo N., Ohwada S., Sakurai S., Toya H., Sakamoto I., Yamada T., Nakano T., Muroya K., Takeyoshi I., Nakajima T., Sekiya T., Yamazumi Y., Nakamura T., Akiyama T.
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Journal Title
World J. Gastroenterol 14
Pages: 4880-4888
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[Journal Article] Phosphorylation and activation of a Rac1/Cdc42 guanine nucleotide exchange factor Asef in A431 cells stimulated by epidermal growth factor2008
Author(s)
Itoh, R. E., Kiyokawa, E., Aoki, K., Nishioka, T., Akiyama, T., Matsuda, M.
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Journal Title
J Cell Sci 121
Pages: 2635-2642
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[Journal Article] A human homolog of Notum, over-expressed in hepatocellular carcinoma, is transcriptionally regulated by β-catenin/TCF2008
Author(s)
Torisu, Y., Watanabe, A., Nonaka, A., Midorikawa, Y., Makuuchi, M., Shimamura, T., Sugimura, H., Niida, A., Akiyama, T., Iwanari, H., Kodama, T., Zeniya, M., Aburatani, H.
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Journal Title
Cancer Sci 99
Pages: 1139-1146
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[Journal Article] α-catenin is essential in intestinal adenoma formation2007
Author(s)
Shibata, H., Takano, H., Ito, M., Shioya, H., Hirota, M., Matsumoto, H., Kakudo, Y., Ishioka, C., Akiyama, T., Kanegae, Y., Saito, I., Noda T.
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Journal Title
Proc. Natl. Acad. Sci. USA. 104
Pages: 18199-18204
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[Journal Article] Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis2007
Author(s)
Hasegawa, Y., Satoh, K., Iizuka-Kogo, A., Shimomura, A., Nomura, R., Akiyama, T., Senda, T.
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Journal Title
Biochem. Biophys. Res. Commun 362
Pages: 988-994
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[Journal Article] Novel clusters of highly expressed genes accompany genomic amplification in breast cancers2007
Author(s)
Ito E., Honma R., Yanagisawa Y., Imai JI., Azuma S., Oyama T., Ohwada S., Akiyama T., Nomura N., Inoue JI., Watanabe S, Semba K.
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Journal Title
FEBS Letters 581
Pages: 3909-3914
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[Journal Article] Helicobacter pylori CagA interacts with E-cadherin and deregulates the β-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells2007
Author(s)
Murata-Kamiya, N., Kurashima, Y., Teishikata, Y., Yamahashi, Y., Saito, Y., Higashi, H., Aburatani, H., Akiyama, T., Peek Jr., R. M., Azuma, T., Hatakeyama, M.
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Journal Title
Oncogene 26
Pages: 4617-4626
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[Journal Article] Up-regulation of a BCL9-related beta-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma2007
Author(s)
Sakamoto I., Ohwada S., Toya H., Togo N., Kashiwabara K., Oyama T., Nakajima T., Ito H., Adachi S., Jigami T., Akiyama T.
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Journal Title
Cancer Sci 98
Pages: 83-87
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[Journal Article] Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers2007
Author(s)
Toya H., Oyama T., Ohwada S., Togo N., Sakamoto I., Horiguchi J., Koibuchi Y., Adachi S., Jigami T., Nakajima T., Akiyama T.
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Journal Title
Cancer Sci 98
Pages: 484-490
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[Journal Article] Crystal structure of the rac activator, asef, reveals its autoinhibitory mechanism2007
Author(s)
Murayama K., Shirouzu M., Kawasaki Y., Kato-Murayama M., Hanawa-Suetsugu K., Sakamoto A., Katsura Y., Suenaga A., Toyama M., Terada T., Taiji M., Akiyama T., Yokoyama S.
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Journal Title
J Biol Chem. 282
Pages: 4238-4242
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