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Genesis and physiologic significance of secretory RAGE-a new vasoprotective factor

Research Project

Project/Area Number 19390085
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKanazawa University

Principal Investigator

YAMAMOTO Hiroshi  Kanazawa University, 医学系, 教授 (00115198)

Co-Investigator(Kenkyū-buntansha) WATANABE Takuo  金沢大学, 医学系, 准教授 (40303268)
浅野 雅秀  金沢大学, 学際科学実験センター, 教授 (50251450)
Co-Investigator(Renkei-kenkyūsha) YAMAMOTO Yasuhiko  金沢大学, 医学系, 講師 (20313637)
MUNESUE Seiichi  金沢大学, 医学系, 助教 (10399040)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2010: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
KeywordsRAGE / 分泌型バリアント / RNAスプライシング / 遺伝子改変動物 / アルツハイマー病 / LPS誘発ショック / アポトーシス / esRAGE / alternative splicing / 糖尿病合併症 / デコイ受容体 / ノックインマウス
Research Abstract

First, we identified cis-acting regulatory elements and a putative trans-acting factor that may participate in the production of secretory RAGE. Second, we created a secretory RAGE-overexpressing transgenic mouse model, and demonstrated with it that RAGE accounts for the transition of amyloid・into the brain. Further, we also found that RAGE is involved in lipopolysaccharide-induced inflammation and in phosphatidyl serine-mediated apoptosis.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (135 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (75 results) (of which Peer Reviewed: 66 results) Presentation (43 results) Book (9 results) Remarks (1 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 1 results)

  • [Journal Article] Endogenous Secretory Receptor for AGE Inhibits Amyloid-β_<1-42> Uptake into Mouse Brain2011

    • Author(s)
      Sugihara T, Munesue S, Yamamoto Y, Sakaurai S, Akhter N, Kitamura Y, Shiba k, Watanabe T, Yonekura H, Hayashi Y, Hamada J, Yamamoto H
    • Journal Title

      (投稿中)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells.2011

    • Author(s)
      Takagi T, Taguchi O, Toda M, Ruiz DB, Bernabe PG, D'Alessandro-Gabazza CN, Miyake Y, Kobayashi T, Aoki S, Chiba F, Yano Y, Conway EM, Munesue S, Yamamoto Y, Yamamoto H, Suzuki K, Takei Y, Morser Y, ?Gabazza EC
    • Journal Title

      Am.J.Respir.Crit.Care Med. 183

      Pages: 31-42

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] RAGE provides a link between genetic susceptibility and env ironmental factors in type 1 diabetes2011

    • Author(s)
      J.M.Forbes
    • Journal Title

      Diabetologia

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor for advallced glycation end products binds to phos hatidylserine and assists in the clearance of apoptotic cells.2011

    • Author(s)
      He M
    • Journal Title

      EMBOR Rep

      Volume: 12(4) Pages: 358-364

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of receptor for advanced glycation end products (RAGE) on bone metabolism under physiological and diabetic condition.2010

    • Author(s)
      Hamada Y, Kitazawa S, Kitazawa R, Kono K, Goto S, Komaba H, Fujii H, Yamamoto Y, Yamamoto H, Usami M, Fukagawa M
    • Journal Title

      Endocrine in press

    • NAID

      120003338593

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity : Role of macrophage scavenger receptor class A type I and II.2010

    • Author(s)
      IIchmann A, Burgdorf S, Scheurer S, Waibler Z, Nagai R, Wellner A, Yamamoto Y, Yamamoto H, Henle T, Kurts C, Kalinke U, Vieths S, Toda M
    • Journal Title

      J.Allergy Clin.Immunol. 125

      Pages: 175-183

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice.2010

    • Author(s)
      Matsuoka N, Itch T, Watarai H, Sekine-Kondo E, Nagata N, Okamoto K, Mera T, Yamamoto H, Yamada S, Maruyama I, Taniguchi M, Yasunami Y
    • Journal Title

      J.Clin.Invest. 120

      Pages: 735-743

    • NAID

      120002142757

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in ape E-deficient mouse.2010

    • Author(s)
      Ueno H, Koyama H, Shoji T, Kurato M, Fukumoto S, Tanaka S, Otsuka Y, Mima Y, Morioka T, Mori K, Shioi A, Yamamoto H, Inaba M, Nishizawa Y
    • Journal Title

      Atherosclerosis 211

      Pages: 431-436

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooper ME, Forbes JM : Recepter for AGEs(RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin type 2 (AT2) receptor.2010

    • Author(s)
      Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Tomas MC, Bierhaus A, Nawroth PP, Yamamoto H, Allen TJ, Walther T, Hussain T
    • Journal Title

      Diabetologia 53

      Pages: 2442-2451

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of endothelial-mesenchymal-transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy.2010

    • Author(s)
      Li J, Qu X, Yao J, Caruana G, Ricardo SD, Yamamoto Y, Yamamoto H, Bertram JF
    • Journal Title

      Diabetes 59

      Pages: 2612-2624

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of alternative splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein (hnRNP)2010

    • Author(s)
      Ohe K, Watanabe T, Harada S, Munesue S, Yamamoto Y, Yonekura H, Yamamoto H
    • Journal Title

      H.J.Biochem. 147

      Pages: 651-659

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of the receptor for advanced glycation end produc ts(RAGE)on bone metabolism under physiological and diabe tic conditions.2010

    • Author(s)
      Hamada Y.
    • Journal Title

      J.Endocrine

      Volume: 38 Pages: 369-376

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recepter for AGEs (RAGE) blockade may eXert its renoprotecti ve effects in patients with diabetic nephropathy via induction of the angiotensin II type2 (AT2) receptor.2010

    • Author(s)
      K.C.Sourris
    • Journal Title

      Diabetologia

      Volume: 53 Pages: 2442-2451

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of endothelial-mesenchymal-transition by a Smad3 inhibitor delays the early development of streptozotocin-induce d diabetic nephropathy2010

    • Author(s)
      Li J
    • Journal Title

      Diabetes

      Volume: 59 Pages: 2612-2624

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Septic shock is associated with receptor for advanced glycatio n endproducts(RAGE) ligation of LPS2010

    • Author(s)
      Yamamoto Y
    • Journal Title

      J.Immulogy

      Volume: 186(5) Pages: 3248-3257

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells.2010

    • Author(s)
      Takagi T
    • Journal Title

      Am.J.Respir.Crit.Care Med.

      Volume: 183 Pages: 31-42

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice2010

    • Author(s)
      Matsuoka, N., Itoh, T., Watarai, H., Sekine-Kondo, E., Nagata, N., Okamoto, K., Mera, T., Yamamoto, H., Yamada, S., Maruyama, I., Taniguchi, M., Yasunami, Y.
    • Journal Title

      J.Clin.Invest.

    • NAID

      120002142757

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Regulation of alternative splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein (hnRNP) H2010

    • Author(s)
      Ohe, K., Watanabe, T., Harada, S., Munesue, S., Yamamoto, Y., Yonekura, H., Yamamoto, H.
    • Journal Title

      J.Biochem. (in press)

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity : Role of macrophage scavenger receptor class Atype I and II2010

    • Author(s)
      Ilchmann A, et al.
    • Journal Title

      J Allergy Clin Immunol 125

      Pages: 175-83

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intronic G-stretch switches the membrane-bound type versus secretory type splicing of human receptor for advanced glycation endproducts (RAGE) transcript via interaction with heterogenous nuclear ribonucleoprotein (hnRNP) H.2010

    • Author(s)
      Ohe K, et al.
    • Journal Title

      Biochemical J (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice2010

    • Author(s)
      Matsuoka, N., et al.
    • Journal Title

      J.Clini.Invest. 120

      Pages: 735-743

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apo E-deficient mouse2010

    • Author(s)
      Ueno, H., et al.
    • Journal Title

      Atherosclerosis (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice.2009

    • Author(s)
      Sakatani S, Yamada K, Homma C, Munesue S, Yamamoto Y, Yamamoto H, Hirase H
    • Journal Title

      PLoS ONE 4(12:e8309)

      Pages: 1-7

    • NAID

      120006386953

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice.2009

    • Author(s)
      Sun L, Ishida T, Yasuda T, Kojima Y, Honjo T, Yamamoto Y, Yamamoto H, Ishibashi S, Hirata K, Hayashi Y
    • Journal Title

      Cardiovascular Research 82

      Pages: 371-381

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] RAGE mediates oxidized LDL-induced proinflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice2009

    • Author(s)
      Sun, L., Ishida, T., Yasuda, T., Kojima, Y., Honjo, T., Yamamoto, Y., Yamamoto, H., Ishibashi, S., Hirata, K., Hayashi, Y.
    • Journal Title

      Cardiovas.Res. 82

      Pages: 371-381

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerrosis in non-diabetic LDL receptor-deficient mice2009

    • Author(s)
      L.Sun, et al.
    • Journal Title

      Cardiovascular Research 82

      Pages: 371-381

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delection of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice2009

    • Author(s)
      Sakatani, S., et al.
    • Journal Title

      PLoS ONE 4(12)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous bone loss in RIP-INOS transgenic mouse : a mouse model for diabetes-mediated osteopenia/osteoporosis2009

    • Author(s)
      Mi QS, et al.
    • Journal Title

      Cell Cycle 8(24)

      Pages: 4179-81

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration.2009

    • Author(s)
      Ueno, M., et al.
    • Journal Title

      Blood 113

      Pages: 555-562

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mice lacking asparaginyl endopeptidase (AEP) develop disorders resembling hemophagocytic syndrome.2009

    • Author(s)
      Chan, C. -B., et al.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 468-473

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in b4-galactosvltransferase-II-deficient mice.2009

    • Author(s)
      Yoshihara, T., et al.
    • Journal Title

      J. Biol. Chem. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Important role of heparan sulfate in postnatal islet growth and insulin secretion.2009

    • Author(s)
      Takahashi, I., et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis2009

    • Author(s)
      Irie, N., et al.
    • Journal Title

      J. Biol. Chem. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural activity dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo.2008

    • Author(s)
      Sakatani S, Seto-Ohshima A, Shinohara Y, Yamamoto Y, Yamamoto H, Ttohara S, Hirase H
    • Journal Title

      J.Neuroscience 28(43)

      Pages: 10928-10936

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin upregulates RAGE expression on podocytes : Role of AT2 receptors.2008

    • Author(s)
      Ruster C, Bondeva T, Franke S, Tanaka N, Yamamoto H, WolfG
    • Journal Title

      Am.J.Nephrol. 29

      Pages: 538-550

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Solution structure of the variable-type domain of the receptor for advanced glycation end products : New insight into AGE-RAGE interaction.2008

    • Author(s)
      Matsumoto S, Yoshida T, Murata H, Harada S, Fujita N, Nakamura S, Yamamoto Y, Watanabe T, Yonekura H, Yamamoto H, Ohkubo T, Kobayashi Y
    • Journal Title

      Biochemistry 47(47)

      Pages: 12299-12311

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Solution structure of the variable-type domain of the receptor for advanced glycation end products2008

    • Author(s)
      Matsumoto, S., Yoshida, T., Murata, H., Harada, S., Fujita, N., Nakamura, S., Yamamoto, Y., Watanabe, T., Yonekura, H., Yamamoto, H., Ohkubo, T., Kobayashi, Y.
    • Journal Title

      Biochemistry 47(47)

      Pages: 12299-12311

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Neural activity dependent release of S 100B from astrocytes enhances kainate-induced gamma oscillations in vivo.2008

    • Author(s)
      Sakatani, S., et al.
    • Journal Title

      J. Neuroscience 28

      Pages: 10928-10936

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II Upregulates RAGE Expression on Podocytes : Role of AT2 Receptors.2008

    • Author(s)
      Ruster, C., et al.
    • Journal Title

      Am. J. Nephrol. 29

      Pages: 538-550

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] esRAGE, multipotential guardian of cells2008

    • Author(s)
      Watanabe, T., et al.
    • Journal Title

      IMARS Highlights 3, No. 4

      Pages: 10-12

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase.2008

    • Author(s)
      Liu, Z., et al.
    • Journal Title

      Mol. Cell 29

      Pages: 665-678

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation of the scaffold protein JLP causes reduced fertility in malemice.2008

    • Author(s)
      Iwanaga, A., et al.
    • Journal Title

      Transgenic Research 17

      Pages: 1045-1058

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling.2008

    • Author(s)
      Sato, T., et al.
    • Journal Title

      Mol. Cell. Neurosci. 39

      Pages: 569-578

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AGE (糖化最終産物)2008

    • Author(s)
      山本博
    • Journal Title

      Medical View Point (MVP) 29, No. 3

      Pages: 5-5

    • Related Report
      2008 Annual Research Report
  • [Journal Article] がんと糖尿病におけるAGE-RAGEの意義2008

    • Author(s)
      山本博
    • Journal Title

      胆膵の生理機能 24, No. 1

      Pages: 1-5

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Anovel b-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular noncompaction in humans, resulted in left ventri cular hypertrophy that progressed to dilation in a mouse model.2008

    • Author(s)
      Kaneda, T., et. al.
    • Journal Title

      Clinic Sci. 114

      Pages: 431-440

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressive Role of Leukocyte Cell-Derived, Chemotaxin 2 in Mouse Anti-Type II Collagen Antibody-Induced Arthritis.2008

    • Author(s)
      Okumura, Y., et. al.
    • Journal Title

      Arthritis & Rheumatism 58

      Pages: 413-421

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo.2008

    • Author(s)
      Fukusumi, Y., et. al.
    • Journal Title

      Dev. Dyn. 237

      Pages: 618-629

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EphA2 is an essential mediator of ultraviolet radiation-induced apoptosis.2008

    • Author(s)
      Zhang, G., et. al.
    • Journal Title

      Cancer Research 68

      Pages: 1691-1696

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase (AEP).2008

    • Author(s)
      Liu, Z., et. al.
    • Journal Title

      Mol. Cell (印刷中掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains.2007

    • Author(s)
      Nozaki I, Watanabe T, Kawaguchi M, Akatsu H, Tsuneyama K, Yamamoto Y, Ohe K, Yonekura H, Yamada M, Yamamoto H
    • Journal Title

      Arch.Histol.Cytol. 70

      Pages: 279-290

    • NAID

      10021186902

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] RAGE in diabetic nephropathy.2007

    • Author(s)
      Yamamoto H, Watanabe T, Yamamoto Y, Yonekura H, Munesue S, Harashima A, Ohe K, Hossain S, Saito H, Murakami N
    • Journal Title

      Curr.Mol.Med. 7

      Pages: 752-757

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] RAGE and soluble RAGE : potential therapeutic targets for cardiovascular diseases.2007

    • Author(s)
      Koyama H, Yamamoto H Nishizawa Y
    • Journal Title

      Mel.Med. 13(11-12)

      Pages: 625-635

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of the receptor for advanced glycation end-products in lung fibrosis.2007

    • Author(s)
      He M, Kobe H, Tshizawa K, Hegab AE, Yamamoto Y, Yamamoto H, Yamaya M
    • Journal Title

      Am.J.Physiol.Lung Cull.Met.Physiol. 293(6)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation endproducts.2007

    • Author(s)
      Osawa M, Yamamoto Y, Munesue S, Murakami N, Sakurai S, Watanabe T, Yonekura H, Uchigata Y, Iwamoto Y, Yamamoto H
    • Journal Title

      Biochim.Biophys.Acta 1770(10)

      Pages: 1468-1474

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assaying soluble forms of receptor for advanced glycation endproducts.2007

    • Author(s)
      Yamamoto Y, Miura J, Matsuki H., Tamei H., Obata K., Sakurai S, Watanabe T, Uchigata Y, Iwamoto Y, Koyama H, Yamamoto H.
    • Journal Title

      Arterioscler.Thromb.Vase.Biol.s 27

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells.2007

    • Author(s)
      Yamamoto Y, Yonekura H, Watanabe T, Sakurai S, Li H, Harashima A, Myint KM, Osawa M, Takeuchi A, Takeuchi M, Yamamoto H
    • Journal Title

      Diabetes Res.Clin.Pract. 77S

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous secretory receptor for advanced glycation end-producs as a novel prognostic marker in chondrosarcoma.2007

    • Author(s)
      Takeuchi A, Yamamoto Y, Tsuneyama K, Cheng C, Yonekura H, Watanabe T, Shimizu K, Tomita K, Yamamoto H, Tsuchiya H.
    • Journal Title

      Cancer 109

      Pages: 2532-2540

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products.2007

    • Author(s)
      Kaji Y, Usui T, Ishida S, Yamashiro K, Moore CB Tara, Moore J, Yamamoto Y, Yamamoto H, Adamis AP
    • Journal Title

      Investigative Ophthalmology and Visual Science 48

      Pages: 858-856

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous secretory receptor for advanced glycation end products in non-small cell lung carcinoma.2007

    • Author(s)
      Kobayashi S, Kubo H, Suzuki R, Ishizawa K, Yamada M, He M, Yamamoto Y, Yamamoto H, Sasano H, Sasaki H, Suzuki S
    • Journal Title

      Am.J.Respir.Crit.Care Med. 175

      Pages: 184-189

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low circulating endogenous secretory receptor for AGEs (esRAGE) predicts cardiovascular mortality in patients with end-stage renal disease.2007

    • Author(s)
      Koyama H, Shoji T, Fukumoto S, Shinohara K, Shoji T, Emote M, Mori K, Tahara H, Ishimura E, Kakiya R, Tabata T, Yamamoto H, Nishizawa Y
    • Journal Title

      Arterioseler.Thromb.Vase.Biol. 27

      Pages: 147-153

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endogenous secretory receptor for advanced glycation endproducts levels are correlated with serum pentosidine and CML in patients with type 1 diabetes.2007

    • Author(s)
      Miura J, Yamamoto Y, Osawa M, Watanabe T, Yonekura H, Uchigata Y, Yamamoto H, Iwamoto Y
    • Journal Title

      Arterioscler.Thromb.Vasc.Biol. 27

      Pages: 253-254

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation endproducts2007

    • Author(s)
      Osawa, M., Yamamoto, Y., Munesue, S., Murakami, N., Sakurai, S., Watanabe, T., Yonekura, H., Uchigata, Y., Iwamoto, Y., Yamamoto, H.
    • Journal Title

      Biochim.Biophys.Acta 1770(10)

      Pages: 1468-1474

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Short-chain aldehyde-derived ligands for RAGE and their actions onendothelial cells.2007

    • Author(s)
      Yamamoto, Y, et. al.
    • Journal Title

      Diabetes Res. Clin. Prac. 77Suppl.1

      Pages: 30-40

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Endogenous Secretory Receptor for Advanced Glycation Endproducts-a Novel Prognostic Marker of Chondrosarcomas2007

    • Author(s)
      Takeuchi, A., et. al.
    • Journal Title

      Cancer 109(12)

      Pages: 2532-2540

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assaying soluble forms of receptor for advanced glycation endproducts.2007

    • Author(s)
      Yamamoto, Y., et. al.
    • Journal Title

      Arterioscler. Thromb. Vasc. Biol. 27

      Pages: 33-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of the receptor for advanced glycation end-products in lungfibrosis.2007

    • Author(s)
      He, M, et. al.
    • Journal Title

      Am. J. Physiol. Lung Cull. Mol. Physiol. 293

      Pages: 1427-1436

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases.2007

    • Author(s)
      Koyama, H., et. al.
    • Journal Title

      Mol. Med. 13

      Pages: 625-635

    • Related Report
      2007 Annual Research Report
  • [Journal Article] RAGE in diabetic nephropathy.2007

    • Author(s)
      Yamamoto, H., et. al.
    • Journal Title

      Curr. Mol. Med. 7

      Pages: 752-757

    • Related Report
      2007 Annual Research Report
  • [Journal Article] De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation end products.2007

    • Author(s)
      Osawa, M., et. al.
    • Journal Title

      Biochem. Biophys. Acta. 1770(10)

      Pages: 1468-1474

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Reduced expression endogenous secretory receptor for advanced glycation endproducts in hippocampal neurons of Alzheimer's disease brains.2007

    • Author(s)
      Nozaki, I., et. al.
    • Journal Title

      Arch. Histol. Cytol. 70

      Pages: 1691-1696

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Legumain/asparaginyl endopetidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.2007

    • Author(s)
      Morita, Y., et. al.
    • Journal Title

      FEBS. Lett. 581

      Pages: 1417-1424

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of IgA nephropathy-like disease with high serum IgA levelsand hlcreased proponion of polymeric IgA in Beta-1, 4-galactoSy Itransferase-deficient mice.2007

    • Author(s)
      Nishie, T., et. al.
    • Journal Title

      Contrib. Nephrol. 157

      Pages: 125-128

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.2007

    • Author(s)
      Iwanaga, A., et. al.
    • Journal Title

      Neurosci. Lettr. 429

      Pages: 43-48

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミニレビュー「IgAの糖鎖不全とIgA腎症」2007

    • Author(s)
      浅野 雅秀., 外.
    • Journal Title

      生化学. 79(7)

      Pages: 673-678

    • Related Report
      2007 Annual Research Report
  • [Presentation] A Multifunctional Receptor RAGE in Health and Disease.2010

    • Author(s)
      Yamamoto, H
    • Organizer
      2010 Kanazawa-Chonbuk Symposium
    • Place of Presentation
      Chonbuk Univ., KORE A 招待講演
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食品AGE受容体シグナル伝達系阻害成分の探索2010

    • Author(s)
      棟居聖一
    • Organizer
      第20回日本メイラード学会
    • Place of Presentation
      お茶の水女子大学(東京)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] cAMP Exerts Anti-Inflammatory Effects by Controling RAGE Isoform Biogenesis.2010

    • Author(s)
      Sob Motoyoshi, Yasuhiko Yamamoto, Seiichi Munesue, Takuo Watanabe, Hiroshi Yamamoto
    • Organizer
      70^<th> American Diabetes Association Scientific Sessions
    • Place of Presentation
      Orland USA(会場:オーランドコンベンションセンター)
    • Related Report
      2010 Final Research Report
  • [Presentation] Enemies and friends within in the pathogenesis and prevention of diabetic vascular complications.2010

    • Author(s)
      Yamamoto H, Watanabe T, Yamamoto Y, Yonekura H, Munesue S Ohe K, Sugihara T^1 Saito H, Motoyoshi S, Han D, Win MTT, Abou-Zed TK, Ohara T
    • Organizer
      4^<th> international HMGBI Symposium - Signals of Tissue Damage.
    • Place of Presentation
      Helsinki, Finland(会場:ヘルシンキ大学)
    • Related Report
      2010 Final Research Report
  • [Presentation] The Role of AGE in Atherosclerosis-Focused on Diabetic Angiopathy2010

    • Author(s)
      Yamamoto, H
    • Organizer
      20^<th> World Congress of International Society for Heart Research
    • Place of Presentation
      京都国際会議場(京都) 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enemies and fhends within in the pathogenesis and preventi on of diabetic vascular complications.2010

    • Author(s)
      Yamamoto, H
    • Organizer
      4^<th>International HMGBl Symposium-Signals of Tissue Damage.
    • Place of Presentation
      Helsinki Univ., FINL AND 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] cAMP ExertsAnti-Inflammatory Effects by Controhng RAGE Isoform Biogenesis2010

    • Author(s)
      Motoyoshi, S
    • Organizer
      70^<th> American Diabetes Association Scient ific Sessions
    • Place of Presentation
      Orland Convention Center USA 招待講演
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病腎症とAGE-RAGE系の新展開2010

    • Author(s)
      山本靖彦
    • Organizer
      第25回日本糖尿病合併症学会
    • Place of Presentation
      びわ湖ホール(滋賀)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Senscent Macromolecule AGE and Vascular Derangement in Diabetes2010

    • Author(s)
      山本博
    • Organizer
      第18回・日本血管生物医学会学術集会・8^<th>Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      梅田スカイビル(大阪)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Receptor for advanced glycation endproducts(RAGE) can bind flagena and host defense against Listeria monocytegenes infection2010

    • Author(s)
      Yamamoto, Y
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食品AGEの生物学的評価2010

    • Author(s)
      棟居聖一
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Receptor for advanced glycation endproducts (RAGE) ameliorat es LPS-induced septic shock in mice2010

    • Author(s)
      H Saito
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] RAGE-AGER相互作用におけるRAGECドメインの関与2010

    • Author(s)
      渡邉琢夫
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Endogenous secretory receptor for advanced glycation endprod ucts blocks A β uptake into the brain.2010

    • Author(s)
      T Sugihara
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(兵庫)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechansims for the development of diabetic angiopathy and its prevention : Enemies and friends within.2009

    • Author(s)
      Yamamoto H, Watanabe T, Yamamoto Y, Yonekura H, Munesue S, Ooe K, Sugihara T, Saito H, Motoyoshi S, Han D
    • Organizer
      2^<nd> International Symposium on Adipobiology and Adipopharmacolgy
    • Place of Presentation
      Varna, Bulgaria(会場:The Festival and Congress Center)
    • Related Report
      2010 Final Research Report
  • [Presentation] Enemies and Friends Within in the Pathogenesis and Prevention of Diabetic Vasculopathy (Invited Lecture)2009

    • Author(s)
      Yamamoto, H.
    • Organizer
      2009 International Conference on Vascular Biology
    • Place of Presentation
      Zhunan, Taiwan
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Mechansims for the Development of Diabetic Angiopathy and Its Prevention (Invited Lecture)2009

    • Author(s)
      Yamamoto, H.
    • Organizer
      2^<nd> International Symposium on Adipobiology and Adipopharmacolgy
    • Place of Presentation
      Varna, Bulgaria
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 血管内皮細胞における細胞保護性RAGEスプラスバリアント (esRAGE) の産生調節機構2009

    • Author(s)
      大江和代
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場 (大阪)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 終末糖化産物受容体 (RAGE) は肥満の進展に影響する2009

    • Author(s)
      庄司拓仁
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば国際会議場 (茨城)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 終末糖化産物受容体(RAGE)は脳梗塞発症に関与する2009

    • Author(s)
      大塚淑子
    • Organizer
      第40回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      つくば国際会議場 (茨城)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管内皮細胞における細胞保護性RAGEスプラスバリアント (esRAGE) の産生調節機構2009

    • Author(s)
      大江和代
    • Organizer
      第24回日本糖尿病合併症学会
    • Place of Presentation
      岡山コンベンションセンター (岡山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] RAGEを介した単球/マクロファージにおける炎症惹起とその抑制機構2009

    • Author(s)
      本吉創
    • Organizer
      第24回日本糖尿病合併症学会
    • Place of Presentation
      岡山コンベンションセンター (岡山)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Mechansims for the Development of Diabetic Angiopathy and Its Prevention : Enemies and Friends Within2009

    • Author(s)
      山本靖彦
    • Organizer
      2^<nd> International Symposium on Adipobiology and Adipopharmacolgy (ISAA)
    • Place of Presentation
      Varna 医科大学 (Bulgaria)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Enemies and Friends Within in the Pathogenesis and Prevention of Diabetic Vasculopathy2009

    • Author(s)
      山本靖彦
    • Organizer
      2009 International Conference on Vascular Biology
    • Place of Presentation
      国家衛生研究院国際会議場, (TAIWAN)
    • Related Report
      2009 Annual Research Report
  • [Presentation] RAGEを介した炎症惹起に対するcAMPによる新たな抗炎症作用メカニズム2009

    • Author(s)
      本吉創
    • Organizer
      第19回日本メイラード学会
    • Place of Presentation
      金沢エクセルホテル東急 (石川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] アルツハイマー病におけるesRAGEの役割2009

    • Author(s)
      杉原崇大
    • Organizer
      第19回日本メイラード学会
    • Place of Presentation
      金沢エクセルホテル東急 (石川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] RNA結合タンパクhnRNP H によるRAGE mRNA選択的スプライシングの制御2009

    • Author(s)
      大江和代
    • Organizer
      第19回日本メイラード学会
    • Place of Presentation
      金沢エクセルホテル東急 (石川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] LPS誘発septic shock の病態形成に関わるRAGEの役割2009

    • Author(s)
      山本靖彦
    • Organizer
      第19回日本メイラード学会
    • Place of Presentation
      金沢エクセルホテル東急 (石川)
    • Related Report
      2009 Annual Research Report
  • [Presentation] G-triplets in intron 9 activate the membrane-type RAGE splicing via interaction with hnRNP-H2009

    • Author(s)
      大江和代
    • Organizer
      第32回日本分子生物学会年会・第82回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場 (兵庫)
    • Related Report
      2009 Annual Research Report
  • [Presentation] cAMP signal attenuates S100b-induced proinflammatory effect through the regulation of RAGE expression2009

    • Author(s)
      本吉創
    • Organizer
      第32回日本分子生物学会年会・第82回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場 (兵庫)
    • Related Report
      2009 Annual Research Report
  • [Presentation] AβとRAGE (receptor for advanced glycation endproducts) の相互作用におけるesRAGE (endogenous secretor RAGE) の役割2009

    • Author(s)
      杉原崇大
    • Organizer
      第32回日本分子生物学会年会・第82回日本生化学会大会合同大会
    • Place of Presentation
      神戸国際会議場 (兵庫)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低分子化合物を用いたRAGE-AGE相互作用の解析2008

    • Author(s)
      渡邉琢夫
    • Organizer
      第81回日本生化学大会・第31日本分子生物学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] AβとRAGEの相互作用におけるesRAGEの役割2008

    • Author(s)
      杉原崇大
    • Organizer
      第81回日本生化学大会・第31日本分子生物学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管内皮細胞におけるRAGEmRNA選択的スプライシングの制御機構2008

    • Author(s)
      大江和代
    • Organizer
      第81回日本生化学大会・第31日本分子生物学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] RAGEmRNA選択的スプライシングの制御機構2008

    • Author(s)
      大江和代
    • Organizer
      第51日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖尿病細小血管症克服にむけて2008

    • Author(s)
      山本 博
    • Organizer
      日本糖尿病がん学会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] An approach toward identification of cis-RNA elements and trans-factors involved in alternative splicing of RAGE gene transcript2008

    • Author(s)
      大江和代
    • Organizer
      The 6th Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] Analysis of AGE-RAGE interaction of using sybthetic small molecules2008

    • Author(s)
      渡邉琢夫
    • Organizer
      The 6th Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      金沢
    • Related Report
      2008 Annual Research Report
  • [Presentation] RAGEmRNA選択的スプライシングの制御機構2007

    • Author(s)
      大江 和代
    • Organizer
      日本生化学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] FRETを用いた細胞表面受容体RAGEの挙動の解析2007

    • Author(s)
      齋藤 英仁
    • Organizer
      日本生化学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] RAGEのリガンド応答におけるアスパラギン酸結合糖の役割2007

    • Author(s)
      村上 奈穂
    • Organizer
      日本生化学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] 糖尿病血管症の発症と防止におけるAGE-RAGEの意義2007

    • Author(s)
      山本 博
    • Organizer
      日本糖尿病合併症学会
    • Place of Presentation
      つくば
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] RAGE糖鎖付加部位変異導入によるAGE反応性の増強2007

    • Author(s)
      棟居 聖一
    • Organizer
      日本糖尿病合併症学会
    • Place of Presentation
      つくば
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Book] 糖化による疾患と抗糖化食品・素材序編-2、1編-5、1編-122010

    • Author(s)
      山本博、久保田浩之、杉原崇大、山本靖彦
    • Publisher
      (株)シーエムシー出版
    • Related Report
      2010 Final Research Report
  • [Book] 生命への鍵「ステロイド」-その研究に貢献した生化学者と臨床家たち-2009

    • Author(s)
      竹田亮祐、宮森勇、山本博
    • Publisher
      (株)前田書店
    • Related Report
      2010 Final Research Report
  • [Book] 生命への鍵「ステロイド」その研究に貢献した生化学者と臨床家たち2009

    • Author(s)
      山本博
    • Total Pages
      132
    • Publisher
      前田書店
    • Related Report
      2009 Self-evaluation Report
  • [Book] 生命への鍵「ステロイド」その研究に貢献した生化学者と臨床家たち2009

    • Author(s)
      山本博, ほか
    • Total Pages
      132
    • Publisher
      (株)前田書店
    • Related Report
      2009 Annual Research Report
  • [Book] The mosaic evolution of the pancreatic polypeptide gene 107-124 Molecular biology of the islets Langerhans2008

    • Author(s)
      Yamamoto H, Yonekura H, Nata K
    • Publisher
      digitally printed ver.
    • Related Report
      2010 Final Research Report
  • [Book] RAGEと糖尿病合併症(岡芳知、谷澤幸生 編)2008

    • Author(s)
      村上奈穂, 他
    • Total Pages
      7
    • Publisher
      診断と治療社
    • Related Report
      2008 Annual Research Report
  • [Book] 最新透析医学2008(西沢良記 編)2008

    • Author(s)
      山本博
    • Total Pages
      6
    • Publisher
      医薬ジャーナル社
    • Related Report
      2008 Annual Research Report
  • [Book] 新時代の糖尿病学42008

    • Author(s)
      齋藤英仁, 他
    • Total Pages
      6
    • Publisher
      日本臨休社
    • Related Report
      2008 Annual Research Report
  • [Book] 生活習慣病キーワード32008

    • Author(s)
      山本博
    • Total Pages
      2
    • Publisher
      医事出版社
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://maeda-shoten.com/yamamoto/index

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] esRAGE過剰発現マウ2009

    • Inventor(s)
      渡邉琢夫、山本博、山本靖彦、棟居聖一、杉原崇大、米倉秀人
    • Industrial Property Rights Holder
      国立大学法人金沢大学
    • Filing Date
      2009-05-19
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] RAGE遺伝子の2種類のスプライシングバリアントを区別して増幅可能なプライマリーセット及びプローブ2009

    • Inventor(s)
      山本博、米倉秀人、渡邉琢夫、山本董彦、棟居聖一、大江和代
    • Industrial Property Rights Holder
      国立大学法人金沢大学
    • Filing Date
      2009-03-31
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] esRAGE過剰発現マウス2009

    • Inventor(s)
      山本博, ほか
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2009-120572
    • Filing Date
      2009-05-19
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] RAGE遺伝子の2種類のスプライシングバリアントを区別して増幅可能なプライマーセット及びプローブ2009

    • Inventor(s)
      山本博, ほか5名
    • Industrial Property Rights Holder
      金沢大学および金沢医科大学
    • Industrial Property Number
      2009-087418
    • Filing Date
      2009-03-31
    • Related Report
      2009 Self-evaluation Report
  • [Patent(Industrial Property Rights)] esRAGE過剰発現マウス2009

    • Inventor(s)
      山本博, 他
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2009-120572
    • Filing Date
      2009-05-19
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] RAGE遺伝子の2種類のスプライシングバジアントを区別して増幅可能なプライマーセット及びプローブ2009

    • Inventor(s)
      山本博, 他5名
    • Industrial Property Rights Holder
      金沢大学および金沢医科大学
    • Industrial Property Number
      2009-087418
    • Filing Date
      2009-03-31
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] Soluble RAGE Protein

    • Inventor(s)
      山本博, 渡邉琢夫, 山本靖彦, ほか2名
    • Industrial Property Rights Holder
      金沢大学
    • Related Report
      2009 Self-evaluation Report
    • Overseas

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Published: 2007-04-01   Modified: 2016-04-21  

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