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The critical role of inflammation in angiogenesis and malignant progression by cancer cells through altered tumor microenvironment

Research Project

Project/Area Number 19390089
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionKyushu University

Principal Investigator

ONO Mayumi  Kyushu University, 薬学研究院, 客員教授 (80128347)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords炎症 / がん / 血管新生 / がん微小環境 / リンパ管新生 / 腫瘍関連マクロファージ / マクロファージ標的薬 / がん間質
Research Abstract

Increasing evidence confirms that chronic inflammation is the strongest link to cancer. In 1850, Rudolf Virchow from Wurzburg, Germany, was the first to link chronic inflammation with arthritis, obesity, asthma and cancer. We observed that inflammatory cytokines, IL-1β, could induce angiogenesis and lymphangiogenesis through activation of transcription factor, NF-κB and proinflammatory gene products. Enhanced angiogenesis resulted in tumor progression with macrophage infilteration and this was inhibited by macrophage targeting drugs.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (53 results)

All 2010 2009 2008 2007 Other

All Journal Article (21 results) (of which Peer Reviewed: 14 results) Presentation (26 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.2010

    • Author(s)
      Murakami, Y., Hosoi, F., Izumi, H., Maruyama, Y., Ureshino, H., Watari, K., Kohno, K., Kuwano, M., Ono, M.
    • Journal Title

      Biochem. and Biophys. Res Commun. (In press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Y-box binding protein-1(YB-1)promotes cell cycle progression through CDC6-dependent pathway in human cancer cells.2010

    • Author(s)
      Basaki, Y., Taguchi, K., Izumi, H., Murakami, Y., Kubo, T., Hosoi, F., Watari, K., Nakano, K., Kawaguchi, H., Ohno, S., Kohno, K., Ono, M., Kuwano, M
    • Journal Title

      Eur. J.Cancer (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] M. The close correlation between 8-hydroxy-2'-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancer.2010

    • Author(s)
      Kawahara, A., Azuma, K., Hattori, S., Nakashima, K., Basaki, Y., Akiba, J., Takamori, S, Aizawa, H., Yanagawa, T., Izumi, H., Kohno, K., Kono, S., Kage, M., Kuwano, M., Mayumi Ono
    • Journal Title

      Human Pathol. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressioni of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis.2009

    • Author(s)
      Taniguchi, K., Sasaki, K., Watari, K., Yasukawa, H., Imaizumi, T., Ayada, T., Okamoto, F., Ishizaki, T., Kato, R., Kohno, R., Kimura, H., Sato, Y., Ono, M., Yonemitsu, Y., Yoshimura, A.
    • Journal Title

      PLoS ONE. 4

    • Related Report
      2009 Final Research Report
  • [Journal Article] N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of IKKbeta expression.2009

    • Author(s)
      Hosoi, F., Izumi, H., Kawahara, A., Yuichi, M., Kinoshita, H., Kage, M., Nishio, K., Kohno, K., Kuwano, M., Ono, M.
    • Journal Title

      Cancer Res. 69

      Pages: 4983-4991

    • Related Report
      2009 Final Research Report
  • [Journal Article] M. Higher expression of deoxyuridinetriphosphatase(dUTPase)may predict the metastasis potential of colorectal cancer.2009

    • Author(s)
      Kawahara, A., Akagi, Y., Hattori, S., Mizobe, T., Shirouzu, K., Ono, M., Yanagawa, T., Kuwano, M., Kage
    • Journal Title

      J.Clinic. Pathology 62

      Pages: 364-369

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of IKKβ expression.2009

    • Author(s)
      Hosoi, F., Izumi, H., Kawahara, A., Yuichi, M., Kinoshita, H., Kage, M., Nishio, K., Kohno, K., Kuwano, M., Ono, M
    • Journal Title

      Cancer Res. 69

      Pages: 4983-4991

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressioni of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.2009

    • Author(s)
      Taniguchi, K., Sasaki, K., Watari, K., Yasukawa, H., Imaizumi, T., Ayada, T., Okamoto, F., Ishizaki, T., Kato, R., Kohno, R., Kimura, H., Sato, Y., Ono, M., Yonemitsu, Y., Yoshimura A
    • Journal Title

      PLoS ONE 4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear Y -box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer.2009

    • Author(s)
      Kashihara, M., Azuma, k., Kawahara, A., Basaki, Y., Hattori, S., Yanagawa, T., Terazaki, Y., Takamori, S., Shirouzu, K., Aizawa, H., Nakao, K., Kage, M., Kuwano, M., Ono, M
    • Journal Title

      Jornal of Thoracic Oncology 4

      Pages: 1066-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Cap43 is associated with malignant status of esophageal cancer.2009

    • Author(s)
      Sohda, M., Mochida, Y., Kato, H., Miyazaki, T., Nakajima, M., Fukuchi, M., Manda, R., Fukai, Y., Masuda, N., Ono, M., Kuwano, M., Kuwano, H
    • Journal Title

      Anticancer Res. 29

      Pages: 965-970

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-myc downstream regulated genel(NDRG1)/Cap43 may play a important role in malignant progression of prostate cancer, in its close association with E-cadherin.2009

    • Author(s)
      Song Y., Oda, Y., Hori, M., Kuroiwa, K., Ono, M., Hosoi, F., Basaki, Y., Kuwano, M., Naito, S., Tsuneyoshi, M
    • Journal Title

      J.Pathol. 41

      Pages: 214-222

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NDRG1/Cap43 play an essential role in tumor growth and angiogenesis suppression though the blockade of NF-κB signaling pathw ay by pancreatic cancer.2009

    • Author(s)
      Hosoi, H., Izumi, H., Kawahara, A., Nakashima K., Murakami, Y., Tanaka, Y., Kinoshita, H., Koga, M., Nishio, K., Kohno, K., Kuwano, M., Ono, M.
    • Journal Title

      Cancer Res. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-κB activation.2008

    • Author(s)
      Watari, K., Nakao, S., Fotovati, A., Basaki, Y., Hosoi, F., Bereczky, B., Higuchi, R., Miyamoto, T., Kuwano, M., Ono, M.
    • Journal Title

      Biochem. and Biophys. Res Commun. 377

      Pages: 826-31

    • Related Report
      2009 Final Research Report
  • [Journal Article] Review)Molecular links between tumor angiogenesis and inflammation :inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy.2008

    • Author(s)
      Ono, M.
    • Journal Title

      Cancer Sci. 99

      Pages: 1501-1506

    • Related Report
      2009 Final Research Report
  • [Journal Article] Molecular links between tumor angiogenesis and inflammation : inflam matory stimuli of macrophages and cancer cells as targets for therapeut ic strategy2008

    • Author(s)
      Ono, Mayumi
    • Journal Title

      Cancer Sci. 99

      Pages: 1501-1506

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of macrophages in inflammatory lymphangiogenesis : Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation.2008

    • Author(s)
      Watari, K. Nakao, S., Fotovati, A., Basaki, Y., Hosoi, F., Bereczky, B., Higuchi, R., Miyamoto. T., Kuwano., Mayumi, Ono M. Role of macrophagesa
    • Journal Title

      Biochem. and Biophys. Res Commun. 377

      Pages: 826-831

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ets Transchption factors Regulate Peroxiredoxinl and Peroxiredoxin5 Expression through their Interaction with the High Mobility Group Prote in HMGB12008

    • Author(s)
      Shiota M., Izumi H., Miyamoto N., Onitsuka T., Kashiwagi E., Kidani A., Hirano G., Ono M., Kuwano M., Naito S., Sasaguri Y., Kohno K
    • Journal Title

      J. Biol. Chem (in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.2007

    • Author(s)
      Kimura, Y., Watari, K., Fotovati, A., Hosoi, F., Yasumoto, K., Izumi, H., Kohno, K., Umezawa, K., Iguchi, H., Shirouzu, K., Takamori, S., Kuwano, M., Ono, M.
    • Journal Title

      Cancer Sci. 98

      Pages: 2009-2018

    • Related Report
      2009 Final Research Report
  • [Journal Article] Dexamethasone inhibits IL-1・-induced corneal neovascularization: role of NF-κB-activated stromal cells in inflammatory angiogenesis.2007

    • Author(s)
      Nakao, S., Hata, Y., Miura, M., Noda, K., Kinura, Y., Kawahara, S., Kita, T., Hisatomi, T., Nakazawa, T., Jin, Y., Dana, R., Kuwano, M., Ono, M., Ishibashi, T., Hafezi-Moghadam, A.
    • Journal Title

      Am. J. Path. 171

      Pages: 1058-1065

    • Related Report
      2009 Final Research Report
  • [Journal Article] Dexamethasone inhibits IL-1□-induced corneal neovascularization:role of NF-□B-activated stromal cells in inflammatory angiogenesis2007

    • Author(s)
      Nakao S., Hata Y., Miura M., Noda K., Kinura Y., Kawahara, S., Kita T., Hisatomi T., Nakazawa T., Jin Y., Dana R., Kuwano M., Ono. M., Ishibashi T., Hafezi-Moghadam A.
    • Journal Title

      Am. J. Path 171

      Pages: 1058-1065

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis2007

    • Author(s)
      Kimura Y., Watari K., Fotovati A., Hosoi F., Yasumoto K., Izumi H., Kohno K., Umezawa K., Iguchi H., Shirouzu K., Takamori S., Kuwano M., Ono M0
    • Journal Title

      Cancer science 98

      Pages: 2009-2018

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 天然由来新規リンパ管新生阻害剤の探索 第1報.2010

    • Author(s)
      鄭ダミ、渡公佑、白水隆喜、小野眞弓、小泉桂一、済木育夫、金ユンチュル、樋口隆一、宮本智文
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山大学島津キャンパス
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炎症性サイトカイン誘導のリンパ管新生にはマクロファージ由来のVEGF-Cと-Dが関与する.2009

    • Author(s)
      渡公佑、樋口隆一、小野眞弓、宮本智文
    • Organizer
      (講演)(九大)第26回(平成21年度)日本薬学会九州支部総会・大会
    • Place of Presentation
      九大
    • Related Report
      2009 Final Research Report
  • [Presentation] 腫瘍内に浸潤してくるマクロファージはがんの血管新生や悪性進展に重要な役割を担っている.2009

    • Author(s)
      渡公佑、細井文仁、馬崎雄二、宮本智文、樋口隆一、小野眞弓
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム(口演)
    • Related Report
      2009 Final Research Report
  • [Presentation] ichihiko Kuwano N-myc downstream regulated gene 1 (NDRG1)/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of NF-κB signaling.2009

    • Author(s)
      Mayumi Ono, Fumihito Hosoi, Hiroto Izumi, Kazuto Nishio, Kimitoshi Kohno
    • Organizer
      AACR 100th Annual Meeting 2009(ポスター)
    • Place of Presentation
      Denver, Colorado, USA.
    • Related Report
      2009 Final Research Report
  • [Presentation] N-myc downstream regulated gene 1(NDRG1)/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of NF-kB signaling.2009

    • Author(s)
      Mayumi Ono, Fumihito Hosoi, Hiroto Izumi, Kazuto Nishio, Kimitoshi Kohno, Michihiko Kuwano
    • Organizer
      AACR 100^<th> Annual Meeting 2009(ポスター)
    • Place of Presentation
      Denver, Colorado, USA.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis and evaluation of 6-[(2-iminopyrrolidinyl)methyl]-5-[125I]iodouracil for mapping thymidine phosphorylase in tumors.2009

    • Author(s)
      Takahiro Mukai, Masaaki Tashiro, Masato Taketomi, Mayumi Ono, Fumihiko Yamamoto, Minoru Maeda
    • Organizer
      Society of Nuclear Medicine Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2009 Annual Research Report
  • [Presentation] がん血管新生機構と阻害剤開発.2009

    • Author(s)
      小野眞弓
    • Organizer
      第13回日本がん分子標的治療学会学術集会(招待口演)
    • Place of Presentation
      ホテルクレメント 徳島
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト胃癌におけるN-myc Downstream-Regulated Gene-1(NDRG1)/Cap43の発現と血管新生の制御.2009

    • Author(s)
      姥真奈美、細井文仁、村上雄一、嬉野浩樹、河原明彦、小野眞弓
    • Organizer
      第13回日本がん分子標的治療学会学術集会(口演)
    • Place of Presentation
      ホテルクレメント 徳島
    • Related Report
      2009 Annual Research Report
  • [Presentation] N-myc downstream regulated gene 1(NDRG1)/Cap43による膵癌の血管新生抑制におけるNF-κBシグナルの関与.2009

    • Author(s)
      細井文仁、和泉弘人、河原明彦、西尾和人、河野公俊、小野眞弓
    • Organizer
      第13回日本がん分子標的治療学会学術集会(口演)
    • Place of Presentation
      ホテルクレメント 徳島
    • Related Report
      2009 Annual Research Report
  • [Presentation] 転移抑制遺伝子NDRG1/Cap43による膵癌の血管新生抑制におけるNF-κBシグナルの関与.2009

    • Author(s)
      細井文仁、渡公佑、西尾和人、木下壽文、桑野信彦、小野眞弓
    • Organizer
      第18回日本がん転移学会学術集会・総会
    • Place of Presentation
      旭川グランドホテル
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腫瘍の内用放射線療法および悪性度診断を目的とする、チミジンボスホリラーゼを標的とした放射性ヨウ素標識薬剤の開発.2009

    • Author(s)
      佐野鉱平、向高弘、田代賢哲、竹富聖人、小野眞弓、前田稔
    • Organizer
      2009年度がん特定若手研究者ワークショップ
    • Place of Presentation
      蓼科(長野県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] SGK1によるNDRG1-Cap43リン酸化の血管新生制御における役割.2009

    • Author(s)
      村上雄一、細井文仁、和泉弘人、河野公俊、小野眞弓
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] N-myc downstream regulated gene 1(NDRG1)/Cap43による膵癌の血管新生抑制におけるNF-κBシグナルの関与.2009

    • Author(s)
      細井文仁、和泉弘人、河原明彦、村上雄一、渡公佑、鹿毛政義、西尾和人、河野公俊、小野眞弓
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] YB-1によるCDC6発現を介した細胞周期の制御2009

    • Author(s)
      馬崎雄二、和泉弘人、田口健一、樫原正樹、渡公佑、中野賢二、河野公俊、小野眞弓、桑野信彦
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺癌における核内YB-1局在はgefitinib治療効果を予測するバイオマーカー.2009

    • Author(s)
      樫原正樹、馬崎雄二、東公一、河原明彦、細井文仁、寺崎泰宏、高森信三、白水和雄、鹿毛政義、桑野信彦、小野眞弓
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] N-myc downstream regulated gene 1(NDRG1)小Cap43のヒト胃癌における腫瘍増殖と血管新生の制御2009

    • Author(s)
      姥真奈美、細井文仁、村上雄一、嬉野浩樹、河原明彦、鹿毛政義、小野眞弓
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      九州大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト膵癌におけるN-myc downstream regulated gene 1(NDRG1/Cap43)の機能へのSGK1によるリン酸化の関与.2009

    • Author(s)
      村上雄一、細井文仁、姥真奈美、嬉野浩樹、和泉弘人、河野公俊、小野眞弓
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      九州大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腫瘍内に浸潤してくるマクロファージはがんの血管新生や悪性進展に重要な役割を担っている.2009

    • Author(s)
      渡公佑、細井文仁、馬崎雄二、宮本智文、樋口隆一、小野眞弓
    • Organizer
      第3回次世代を担う若手医療薬科学シンポジウム
    • Place of Presentation
      九州大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト膵癌におけるN-myc downstream regulated gene 1(NDRG1)/Cap43のリン酸化の役割.2009

    • Author(s)
      村上雄一、細井文仁、姥真奈美、嬉野浩樹、和泉弘人、河野公俊、小野眞弓
    • Organizer
      第26回(平成21年度)日本薬学会九州支部総会・大会
    • Place of Presentation
      九州大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 炎症性サイトカイン誘導のリンパ管新生にはマクロファージ由来のVEGF-Cと-Dが関与する.2009

    • Author(s)
      渡公佑、樋口隆一、小野眞弓、宮本智文
    • Organizer
      第26回(平成21年度)日本薬学会九州支部総会・大会
    • Place of Presentation
      九州大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒト胃癌におけるN-myc downstream regulated gene 1(NDRG1)/Cap43の機能の解析.2009

    • Author(s)
      姥真奈美、細井文仁、村上雄一、嬉野浩樹、河原明彦、鹿毛政義、小野眞弓
    • Organizer
      第26回(平成21年度)日本薬学会九州支部総会・大会
    • Place of Presentation
      九州大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] がん治療創薬の新しい標的としての血管新生と炎症2008

    • Author(s)
      小野眞弓
    • Organizer
      薬学研究フォーラムin東京2008
    • Place of Presentation
      東京(口頭発表)
    • Year and Date
      2008-03-14
    • Related Report
      2009 Final Research Report
  • [Presentation] がんの血管新生とリンパ管新生におけるNF-_KBシグナルの役割.2008

    • Author(s)
      渡公祐, 細井文仁, 村上雄一, 馬崎雄二, 宮本智文, 桑野信彦, 小野眞弓
    • Organizer
      第6 7回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel therapeutic strategy of tumor angiogenesis and bone metastasis by targeting tumor-associated macrophages.2007

    • Author(s)
      Ono, M.
    • Organizer
      The Sixth Japan-China Joint Conference for Cancer Research Cancer-Host Interaction
    • Place of Presentation
      Hokkaido, Japan.(Invited speaker)
    • Related Report
      2009 Final Research Report
  • [Presentation] 66th Annual Meeting of the Japanese Cancer Association2007

    • Author(s)
      Ono, M.
    • Organizer
      Tumor Microenvironment ; The role of tumor-associated macrophages in malignant cancer progression
    • Place of Presentation
      Yokohama, Japan.
    • Related Report
      2009 Final Research Report
  • [Presentation] The role of tumor-associated macrophages in malignant cancer progression2007

    • Author(s)
      小野 真弓
    • Organizer
      日本癌学会シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Book] 血管新生の分子メカニズムと標的分子.呼吸器内科2010

    • Publisher
      科学評論社(印刷中)
    • Related Report
      2009 Final Research Report
  • [Book] 腫瘍血管新生における炎症細胞の役割.細胞2008

    • Publisher
      ニューサイエンス社
    • Related Report
      2009 Final Research Report
  • [Book] 血管新生の分子機構と標的分子(特集:肺がんの分子標的治療-最新の基礎と臨床-).呼吸器科2008

    • Publisher
      科学評論社
    • Related Report
      2009 Final Research Report
  • [Book] 血管発生・新生の分子機序マクロファージ浸潤による血管新生.医学のあゆみ2007

    • Publisher
      医歯薬出版
    • Related Report
      2009 Final Research Report
  • [Book] 消化器癌浸潤・転移における間質血管新生を探る.分子消化器病42007

    • Publisher
      先端医学社
    • Related Report
      2009 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://shuyo.phar.kyushu-u.ac.jp/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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