The critical role of inflammation in angiogenesis and malignant progression by cancer cells through altered tumor microenvironment
Project/Area Number |
19390089
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathological medical chemistry
|
Research Institution | Kyushu University |
Principal Investigator |
ONO Mayumi Kyushu University, 薬学研究院, 客員教授 (80128347)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2009: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | 炎症 / がん / 血管新生 / がん微小環境 / リンパ管新生 / 腫瘍関連マクロファージ / マクロファージ標的薬 / がん間質 |
Research Abstract |
Increasing evidence confirms that chronic inflammation is the strongest link to cancer. In 1850, Rudolf Virchow from Wurzburg, Germany, was the first to link chronic inflammation with arthritis, obesity, asthma and cancer. We observed that inflammatory cytokines, IL-1β, could induce angiogenesis and lymphangiogenesis through activation of transcription factor, NF-κB and proinflammatory gene products. Enhanced angiogenesis resulted in tumor progression with macrophage infilteration and this was inhibited by macrophage targeting drugs.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells.2010
Author(s)
Murakami, Y., Hosoi, F., Izumi, H., Maruyama, Y., Ureshino, H., Watari, K., Kohno, K., Kuwano, M., Ono, M.
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Journal Title
Biochem. and Biophys. Res Commun. (In press)
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[Journal Article] Y-box binding protein-1(YB-1)promotes cell cycle progression through CDC6-dependent pathway in human cancer cells.2010
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Basaki, Y., Taguchi, K., Izumi, H., Murakami, Y., Kubo, T., Hosoi, F., Watari, K., Nakano, K., Kawaguchi, H., Ohno, S., Kohno, K., Ono, M., Kuwano, M
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[Journal Article] M. The close correlation between 8-hydroxy-2'-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancer.2010
Author(s)
Kawahara, A., Azuma, K., Hattori, S., Nakashima, K., Basaki, Y., Akiba, J., Takamori, S, Aizawa, H., Yanagawa, T., Izumi, H., Kohno, K., Kono, S., Kage, M., Kuwano, M., Mayumi Ono
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[Journal Article] Suppressioni of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis.2009
Author(s)
Taniguchi, K., Sasaki, K., Watari, K., Yasukawa, H., Imaizumi, T., Ayada, T., Okamoto, F., Ishizaki, T., Kato, R., Kohno, R., Kimura, H., Sato, Y., Ono, M., Yonemitsu, Y., Yoshimura, A.
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[Journal Article] N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of IKKbeta expression.2009
Author(s)
Hosoi, F., Izumi, H., Kawahara, A., Yuichi, M., Kinoshita, H., Kage, M., Nishio, K., Kohno, K., Kuwano, M., Ono, M.
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Journal Title
Cancer Res. 69
Pages: 4983-4991
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[Journal Article] M. Higher expression of deoxyuridinetriphosphatase(dUTPase)may predict the metastasis potential of colorectal cancer.2009
Author(s)
Kawahara, A., Akagi, Y., Hattori, S., Mizobe, T., Shirouzu, K., Ono, M., Yanagawa, T., Kuwano, M., Kage
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Journal Title
J.Clinic. Pathology 62
Pages: 364-369
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[Journal Article] N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of IKKβ expression.2009
Author(s)
Hosoi, F., Izumi, H., Kawahara, A., Yuichi, M., Kinoshita, H., Kage, M., Nishio, K., Kohno, K., Kuwano, M., Ono, M
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Journal Title
Cancer Res. 69
Pages: 4983-4991
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[Journal Article] Suppressioni of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis.2009
Author(s)
Taniguchi, K., Sasaki, K., Watari, K., Yasukawa, H., Imaizumi, T., Ayada, T., Okamoto, F., Ishizaki, T., Kato, R., Kohno, R., Kimura, H., Sato, Y., Ono, M., Yonemitsu, Y., Yoshimura A
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[Journal Article] Nuclear Y -box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer.2009
Author(s)
Kashihara, M., Azuma, k., Kawahara, A., Basaki, Y., Hattori, S., Yanagawa, T., Terazaki, Y., Takamori, S., Shirouzu, K., Aizawa, H., Nakao, K., Kage, M., Kuwano, M., Ono, M
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Journal Title
Jornal of Thoracic Oncology 4
Pages: 1066-74
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[Journal Article] Overexpression of Cap43 is associated with malignant status of esophageal cancer.2009
Author(s)
Sohda, M., Mochida, Y., Kato, H., Miyazaki, T., Nakajima, M., Fukuchi, M., Manda, R., Fukai, Y., Masuda, N., Ono, M., Kuwano, M., Kuwano, H
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Anticancer Res. 29
Pages: 965-970
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[Journal Article] N-myc downstream regulated genel(NDRG1)/Cap43 may play a important role in malignant progression of prostate cancer, in its close association with E-cadherin.2009
Author(s)
Song Y., Oda, Y., Hori, M., Kuroiwa, K., Ono, M., Hosoi, F., Basaki, Y., Kuwano, M., Naito, S., Tsuneyoshi, M
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Journal Title
J.Pathol. 41
Pages: 214-222
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[Journal Article] NDRG1/Cap43 play an essential role in tumor growth and angiogenesis suppression though the blockade of NF-κB signaling pathw ay by pancreatic cancer.2009
Author(s)
Hosoi, H., Izumi, H., Kawahara, A., Nakashima K., Murakami, Y., Tanaka, Y., Kinoshita, H., Koga, M., Nishio, K., Kohno, K., Kuwano, M., Ono, M.
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[Journal Article] Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-κB activation.2008
Author(s)
Watari, K., Nakao, S., Fotovati, A., Basaki, Y., Hosoi, F., Bereczky, B., Higuchi, R., Miyamoto, T., Kuwano, M., Ono, M.
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Journal Title
Biochem. and Biophys. Res Commun. 377
Pages: 826-31
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[Journal Article] Role of macrophages in inflammatory lymphangiogenesis : Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation.2008
Author(s)
Watari, K. Nakao, S., Fotovati, A., Basaki, Y., Hosoi, F., Bereczky, B., Higuchi, R., Miyamoto. T., Kuwano., Mayumi, Ono M. Role of macrophagesa
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Journal Title
Biochem. and Biophys. Res Commun. 377
Pages: 826-831
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[Journal Article] Ets Transchption factors Regulate Peroxiredoxinl and Peroxiredoxin5 Expression through their Interaction with the High Mobility Group Prote in HMGB12008
Author(s)
Shiota M., Izumi H., Miyamoto N., Onitsuka T., Kashiwagi E., Kidani A., Hirano G., Ono M., Kuwano M., Naito S., Sasaguri Y., Kohno K
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[Journal Article] Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.2007
Author(s)
Kimura, Y., Watari, K., Fotovati, A., Hosoi, F., Yasumoto, K., Izumi, H., Kohno, K., Umezawa, K., Iguchi, H., Shirouzu, K., Takamori, S., Kuwano, M., Ono, M.
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Journal Title
Cancer Sci. 98
Pages: 2009-2018
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[Journal Article] Dexamethasone inhibits IL-1・-induced corneal neovascularization: role of NF-κB-activated stromal cells in inflammatory angiogenesis.2007
Author(s)
Nakao, S., Hata, Y., Miura, M., Noda, K., Kinura, Y., Kawahara, S., Kita, T., Hisatomi, T., Nakazawa, T., Jin, Y., Dana, R., Kuwano, M., Ono, M., Ishibashi, T., Hafezi-Moghadam, A.
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Journal Title
Am. J. Path. 171
Pages: 1058-1065
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[Journal Article] Dexamethasone inhibits IL-1□-induced corneal neovascularization:role of NF-□B-activated stromal cells in inflammatory angiogenesis2007
Author(s)
Nakao S., Hata Y., Miura M., Noda K., Kinura Y., Kawahara, S., Kita T., Hisatomi T., Nakazawa T., Jin Y., Dana R., Kuwano M., Ono. M., Ishibashi T., Hafezi-Moghadam A.
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Am. J. Path 171
Pages: 1058-1065
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[Journal Article] Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis2007
Author(s)
Kimura Y., Watari K., Fotovati A., Hosoi F., Yasumoto K., Izumi H., Kohno K., Umezawa K., Iguchi H., Shirouzu K., Takamori S., Kuwano M., Ono M0
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Journal Title
Cancer science 98
Pages: 2009-2018
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