| Project/Area Number |
19390090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
|
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| Research Institution | Keio University |
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Principal Investigator |
ADACHI Takeshi Keio University, 医学部, 講師 (50231931)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Michiko 慶應義塾大学, 医学部, 助教 (60445450)
IZUMI Yotaroy 慶應義塾大学, 医学部, 助教 (90245506)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 分子病態学 / メタボリック・シンドローム / プロテオミクス / インスリン / 血管内皮細胞 / メタボリックシンドローム |
|---|
| Research Abstract |
Metabolic syndrome is a complex diseases, which is closely associated with insulin resistance. In this study, we characterized aorta from Zucker rat, a typical animal model of MS. In aorta from MS, we found following results, 1) Hypo-vasoconstriction induced by iNOS, 2) A decrease in thiol-antioxidants, Changes in arginine, methionine metabolisms (including a decrease in SAM level, a methyl donor) 3) Decreases in the methyl-arginine modifications on vascular proteins. Moreover, we found the involvement of reactive oxygen/nitrogen species and gas molecules with insulin signal in cultured endothelial cells.
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