Analysis of pathological significance of a cell adhesion molecule TSLC1 in male infertility and in ulcerative colitis

• Project/Area Number: 19390091
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: MURAKAMI Yoshinori The University of Tokyo, 医科学研究所, 教授 (30182108)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Takumi 東京大学, 大学院・医学部附属病院, 准教授 (90167487)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000); Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 分子病態学 / 男性不妊 / 潰瘍性大腸炎 / 細胞接着分子 / 病理学 / 遺伝子 / 発現制御

Research Abstract

細胞接着分子TSLC1 の男性不妊症、潰瘍性大腸炎における病理学的意義を検討した。Tslc1遺伝子欠損マウスが精子形成障害を示す知見に基づき、130 例のヒト男性不妊症例を解析し、TSLC1 タンパク質発現欠如を示す6 例を見出したが遺伝子変異は認めなかった。一方、TSLC1遺伝子の転写制御機構を解明し、精巣での新規結合タンパク質を同定した。さらにTSLC1 タンパク質の発現が潰瘍性大腸炎の病勢に相関することを見出した。

Research Products

• [Journal Article] Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth (2009)
  • Author(s): Hagiyama, M., Ichiyanagi, N., Kimura, B. K., Murakami, Y. Ito, A.
  • Journal Title: American Journal of Pathology (in press)
  • Peer Reviewed
• [Journal Article] TSLC1 mapped top 11q23 is a candidate tumor suppressor in neuroblastoma (2008)
  • Author(s): Ando K, Ohira M, Ozaki T, Akazawa K, Suenaga Y, Nakamura Y, Koda T, Kamijo T, Murakami Y, Nakagawara A
  • Journal Title: Int J Cancer 123 Pages: 2087-2094
  • Peer Reviewed
• [Journal Article] Male gamete empowerment (2008)
  • Author(s): Takeuchi T, Neri QV, Palermo GD
  • Journal Title: Ann N Y Acad Sci 1127 Pages: 64-66
  • Peer Reviewed
• [Journal Article] Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells (2008)
  • Author(s): Wakayama T, Sai Y, Ito A, Kato Y, Kurobo M, Murakami Y, Nakashima E, Tsuji A, Kitamura Y, Iseki S
  • Journal Title: Biology Reprod 76 Pages: 1081-1090
  • NAID: 120006380690
  • Peer Reviewed
• [Journal Article] TSLC1 mapped top 11q23 is a candidate tumor suppressor in neuroblastoma. (2008)
  • Author(s): Ando K, Ohira M, Ozaki T, Akazawa K, Suenaga Y, Nakamura Y, Koda T, Kamijo T, Murakami Y, Nakagawara A.
  • Journal Title: Int J Cancer 123 Pages: 2087-2094
  • Peer Reviewed
• [Journal Article] Male gamete empowerment (2008)
  • Author(s): Takeuchi T, Neri QV, Palermo GD
  • Journal Title: Ann Y N Acad Sci 1127 Pages: 64-66
  • Peer Reviewed
• [Journal Article] Involvement of the SgIGSF/Necl-2 adhesion molecule in degradation of mesenteric mast cells (2007)
  • Author(s): Ito A, Hagiyama M, Oonuma J, Murakami Y, Yokozaki H, Takaki M
  • Journal Title: J Neuro Immunol 184 Pages: 209-213
  • Peer Reviewed
• [Journal Article] The prognostic value of E-cadherin, alpha-, beta-and gamma-catenin in bladder cancer patients who underwent radical cystectomy (2007)
  • Author(s): Kashibuchi K, Tomita K, Schalken JA, Kume H, Takeuchi T, Kitamura T
  • Journal Title: Int J Urol 14 Pages: 789-794
  • Peer Reviewed
• [Journal Article] Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells (2007)
  • Author(s): Wakayama T, Sai Y, Ito A, Kato Y, Kurobo M, Murakami Y, Nakashima E, Tsuji A, Kitamura Y, Iseki S.
  • Journal Title: Biology Reprod 76 Pages: 1081-190
  • NAID: 120006380690
  • Peer Reviewed
• [Journal Article] Involvement of the SgIGSF/Necl-2 adhesion molecule in degradation of mesenteric mast cells (2007)
  • Author(s): Ito, A, Hagiyama, M, Oonuma, J, Murakami, Y, Yokozaki, H, Takaki, M
  • Journal Title: J Neuro Immunol 184 Pages: 209-213
  • Peer Reviewed
• [Journal Article] The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy (2007)
  • Author(s): Kashibuchi K, Tomita K, Schalken JA, Kume H, Takeuchi T, Kitamura T.
  • Journal Title: Int J Urol. 14 Pages: 789-794
  • Peer Reviewed
• [Journal Article] Expression of a soluble isoform of cell adhesion molecule 1 in the brain and its involvement in directional neurite outgrowth
  • Author(s): Hagiyama M, Ichiyanagi N, Kimura BK, Murakami Y, Ito A
  • Journal Title: Am J Pathol (in press)
  • Peer Reviewed
• [Presentation] Involvement of a tumor suppressor CADM1/TSLC1 in lung tumorigenesis (2008)
  • Author(s): Yoshinori Murakami
  • Organizer: The 13th Japan-Korea Cancer Research Workshop. Symposium.
  • Place of Presentation: Daejon, Korea
• [Presentation] Involvement of a tumor suppressor CADM1/TSLC1 in lung tumorigenesis. (2008)
  • Author(s): Yoshinori Murakami
  • Organizer: The 13th Japan-Korea Cancer Research Workshop. Symposium.
  • Place of Presentation: Daejon, Korea
• [Presentation] ヒト家族性腫瘍のモデルとしてのTslc1/Cadm1 遺伝子欠損マウスの解析 (2007)
  • Author(s): 山田大介、永田政義、尾鼻孝滋、増田万里、市原博美、増田智子、吉田緑、堤雅弘、北村唯一、村上善則
  • Organizer: 第12回家族性腫瘍学会
  • Place of Presentation: 高知市
  • Year and Date: 2007-06-16
• [Presentation] ヒト家族性腫瘍のモデルとしてのTslc1/Cadm1遺伝子欠損マウスの解析 (2007)
  • Author(s): 山田大介, 永田政義, 尾鼻孝滋, 増田万里, 市原博美, 増田智子, 吉田緑, 堤雅弘, 北村唯一, 村上善則
  • Organizer: 第12回家族性腫瘍学会
  • Place of Presentation: 高知県高知市
  • Year and Date: 2007-06-16
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/hitogan/index.html
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/hitogan/index.html