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Genetic, medical and anthropological study of human earwax gene, ABCC11

Research Project

Project/Area Number 19390095
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

NIIKAWA Norio  Health Sciences University of Hokkaido, 個体差健康科学研究所, 教授 (00111170)

Co-Investigator(Kenkyū-buntansha) 太田 亨  北海道医療大学, 個体差健康科学研究所, 准教授 (10223835)
吉浦 孝一郎  長崎大学, 医歯薬学総合研究科, 教授 (00304931)
Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2007: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords分子遺伝学 / ABCC11遺伝子 / 耳垢型 / 遺伝子多型 / 乳がん / 初乳量 / 腋窩臭症 / ABCC11アレルの全国地図 / 関連解析
Research Abstract

ヒト耳垢型決定遺伝子ABCC11多型に関する分子遺伝学的・医学的・人類学的研究を行った。乳癌との関係は証明されないが、産婦の初乳量と湿型耳垢型との間、および腋窩臭症と湿型多型間に相関を認めた。全国SSHコンソーシアムとの共同研究で、乾型耳垢型のアレル頻度に関する日本地図を完成した。さらに、ABCC11遺伝子多型が湿型。乾型耳垢型表現型を形成する分子機構を明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2009 2008 2007 2006 2005 Other

All Journal Article (12 results) (of which Peer Reviewed: 4 results) Presentation (12 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Earwax, osmidrosis, and breast cancer : Why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?2009

    • Author(s)
      Toyoda Y, Sakurai A, Mitani Y, Nakashima M, Yoshiura K, Nakagawa H, Sakai Y, Ota I, Lezhava A, Hayashizaki Y, Niikawa N, Ishikawa T
    • Journal Title

      FASEB J 23(6)

      Pages: 2001-2013

    • Related Report
      2008 Final Research Report
  • [Journal Article] A strong association of body odor and axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene2009

    • Author(s)
      Miwa N, Nakano M, Nakashima M, Miura S, Miura K. Masuzaki H, Hirano A, Yoshiura K, Niikawa N
    • Journal Title

      BMC Genetics (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Why does one SNP in human ABC transporter ABCC11 gene determine earwax type? Critical role of N-glycosyation and proteasomal degradation2009

    • Author(s)
      Toyoda Y, Sakurai A, Mitani Y, Nakashima M, Yoshiura K, Nakagawa H, Sakai Y, Lezhava A, Hayashizaki Y, Niikawa N, Ishikawa T
    • Journal Title

      FASEB J (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative SAR analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB12007

    • Author(s)
      Sakurai A, Onishi Y, Hirano H, Seigneuret M, Obanayama K, Kim GW. Liew EL, Sakaeda T, Yoshiura K, Niikawa N, Sakurai M, Ishikawa T
    • Journal Title

      J Biochem 46(26)

      Pages: 7678-7693

    • Related Report
      2008 Final Research Report
  • [Journal Article] A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland2007

    • Author(s)
      Miura K, Yoshiura K, Miura S, Shimada T, Yamasaki K, Yoshida A, Nakayama D, Shibata Y, Niikawa N, Masuzaki H
    • Journal Title

      Hum Genet 121

      Pages: 631-633

    • Related Report
      2008 Final Research Report
  • [Journal Article] Quantitative SAR analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB12007

    • Author(s)
      Sakurai A, Onishi Y, Hirano H, Seigneuret M, ObanayamaK, Kim GW.Liew EL, Sakaeda T, Yoshiura K, Niikawa N, Sakurai M, Ishikawa T
    • Journal Title

      Journal of Biochemistry 46

      Pages: 7678-7693

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland2007

    • Author(s)
      Miura K, Yoshiura K, Miura S, Shimada T, Yamasaki K, Yoshida A, Nakayama D, Shibata Y, Niikawa N, Masuzaki H
    • Journal Title

      Human Genetics 121

      Pages: 631-633

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 耳垢型はABCC11遺伝子の一塩基多型によって決定されている2006

    • Author(s)
      吉浦孝一郎、新川詔夫
    • Journal Title

      医学のあゆみ 217(13)

      Pages: 1197-1198

    • Related Report
      2008 Final Research Report
  • [Journal Article] 耳垢型は一塩基の違いで決定される2006

    • Author(s)
      吉浦孝一郎、新川詔夫
    • Journal Title

      バイオニクス 6

      Pages: 68-69

    • Related Report
      2008 Final Research Report
  • [Journal Article] 耳垢のタイプ2006

    • Author(s)
      新川詔夫
    • Journal Title

      Medical Technology 10

      Pages: 1013-1014

    • Related Report
      2008 Final Research Report
  • [Journal Article] Japan map of the earwax gene frequency : A nation-wide collaborative study by Super Science High School(SSH)

    • Author(s)
      Satoshi Sakai, Kazumi Imai, Takashi Ogawa, Hiroshi Iwaoka, Mikiko Ishii, Shinichiro Komori, Toyohiko Yoshida, Hideyuki Jumonji, Keiji Iizumi, Hiroshi Ohshima, Toshiaki Maeda, Akira Kanno, Kenji Takahashi, Hiroto Kubota, Yoko Inoue, Yoshiyuki Takahashi, Hiroshi Onoda, Rie Uchiyama, Michihiko Matsuda, Takashi Akazawa, Naohiro Kawamura, Toru Odagiri, Yasuharu Watanabe, Yukihiro Matsumoto, Seiji Shinoda, * Masato Terada, Manabu Matsuoka, Chikara Ueno, Etsuo Ozaki, Sadafusa Takaya, Tetsuharu Takeyama, Toshiaki Hujita, Kazuya Kawakatsu, Junichi Takemura, Hitonori Maekawa, Tomoko Doei, Shigeru Ihara, Yuji Sakaguchi, Yasuyuki Hirota, Akihiko Shindo, Hiroko Araki, Junko Miura, Tatsumi Morita, Takayuki Fujiwara, Haruhiko Akiyama, Shinya Itome, Yoshihisa Tanaka, Kazunori Nakagawa, Sumito Okamoto, Shushi Yamamoto, Takaaki Aoyagi, Toru Noda, Shinichi Inoue, Isao Hirota, Kiyoshi Tanaka, Tetsuya Nagashima, Iwao Koga, Kayo Watanabe, Hideto Kusadome, Hirosi Otsuka, Tosifumi Takayama, Hiroshi Miwa, Atsushi Hamakawa, Katsunori China, Norio Niikawa, Tohru Ohta, Dmytro Starenki, Ken Umehara, Kensuke Yamada, Yoichi Shimada, Hiroyuki Nagasawa, Takashi Minato, Toshihiko Ogino, Koh-ichiro Yoshiura, Nobutomo Miwa, Masayo Nomura, Hideo Kuniba, Yasuko Noguchi, Shinji Ono, Masayoshi Tsuda, Mitsuko Nakashima, Taeko Kikuchi, Daisuke Satoh, Tatsuya Kishino, Shinji Kondo, Akira Kinoshita
    • Journal Title

      Consortium(J Hum Genet) (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] A strong association of body odor and axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene

    • Author(s)
      Miwa N, Nakano M, Nakashima M, Miura S, Miura K, Masuzaki H, Hirano A, Yoshiura K, Niikawa N
    • Journal Title

      BMC Genetics (in press)

    • Related Report
      2008 Final Research Report
  • [Presentation] A strong association of axillary osmidrosis with genotype of the ABCC11 gene defining the earwax type.2008

    • Author(s)
      Tsuda M, Mivva N, Nakano M, Nakashima M, Yoshiura K, Ohta T, Niikawa N
    • Organizer
      The 2008 EAUHGS Symposium & the 8^<th> EAUHGS Annual Meeting
    • Place of Presentation
      Sapporo
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 全国スーパーサイエンスハイスクール(SSH)の共同による耳垢型対立遺伝子の全国地図作成の研究2008

    • Author(s)
      本多隆利, 村松紋佳, 田中清, 長嶋哲也, 小川隆, 吉浦孝一郎, 新川詔夫
    • Organizer
      第53回日本人類遺伝学会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 全国スーパーサイエンスハイスクール(SSH)の共同による耳垢型対立遺伝子の全国地図作成の研究2008

    • Author(s)
      本多隆利, 村松紋佳, 田中清, 長嶋哲也, 小川隆, 吉浦孝一郎, 新川詔夫
    • Organizer
      第53回日本人類遺伝学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] 古人骨における耳垢遺伝解析の試み(続報)2008

    • Author(s)
      佐伯和信, 吉浦孝一郎, 新川詔夫, 岡本啓圭史, 分部哲秋
    • Organizer
      第53回日本人類遺伝学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2008 Annual Research Report
  • [Presentation] Biomedical characterization of a genetic polymorphism of human ABCC11 as a determinant of earwax type2008

    • Author(s)
      豊田優, 櫻井亜季, 中島正洋, 中川 大, 吉浦孝一郎, 新川詔夫, 石川智久
    • Organizer
      第31回日本分子生物会年会・第81回日本生化学学大学 合同大学
    • Place of Presentation
      神戸ボートアイフンド
    • Related Report
      2008 Annual Research Report
  • [Presentation] 耳垢型決定因子としてのABCトランスポーター遺伝子(ABCC11)2007

    • Author(s)
      新川 詔夫、吉浦 孝一郎
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜市みなとみらい国際会議場
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 古人骨における耳垢遺伝子解析の試み2007

    • Author(s)
      佐伯 和信、吉浦 孝一郎、新川 詔夫、岡本 圭史、分部 哲秋
    • Organizer
      第52回日本人類遺伝学会
    • Place of Presentation
      東京京王プラザホテル
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 全国スーパーサイエンスハイスクール(SSH)の共同による耳垢型対立遺伝子の全国地図作製の研究2007

    • Author(s)
      山田 賢輔、北島 玲那、田中 清、長嶋 哲也、古賀 巌、吉浦 孝一郎、新川 詔夫
    • Organizer
      第52回日本人類遺伝学会
    • Place of Presentation
      東京京王プラザホテル
    • Year and Date
      2007-09-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 耳垢型決定遺伝子ABCC11が細胞の薬剤感受性に与える影響の検討2006

    • Author(s)
      三輪晋智、吉浦孝一郎
    • Organizer
      第51回日本人類遺伝学会
    • Place of Presentation
      米子
    • Related Report
      2008 Final Research Report
  • [Presentation] 耳垢型決定遺伝子の同定2005

    • Author(s)
      吉浦孝一郎、木下晃、齋藤成也、徳永勝士、石川智久、中村祐輔、新川詔夫
    • Organizer
      第28回日本分子生物学会年会
    • Place of Presentation
      福岡市
    • Related Report
      2008 Final Research Report
  • [Presentation] 耳垢型決定遺伝子の同定

    • Author(s)
      新川詔夫、駒木亮一、園田俊郎、平山謙二、石田貴文、斉藤成也、吉浦孝一郎
    • Organizer
      第50回人類遺伝学会
    • Place of Presentation
      倉敷
    • Related Report
      2008 Final Research Report
  • [Presentation] 世界民族集団における乾型アリルの頻度とモンゴロイドの移住・拡散

    • Author(s)
      吉浦孝一郎、木下晃、斉藤成也、徳永勝士、中村祐輔、新川詔夫
    • Organizer
      第50回人類遺伝学会(山崎庸子)
    • Place of Presentation
      倉敷
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 耳垢型又は腋下臭症の評価方法2007

    • Inventor(s)
      新川詔夫、吉浦孝一郎
    • Acquisition Date
      2007-12-14
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 耳垢型又は腋下臭症の評価方法2007

    • Inventor(s)
      新川 詔夫、吉浦 孝一郎
    • Industrial Property Rights Holder
      長崎大学長
    • Filing Date
      2007-12-14
    • Related Report
      2007 Annual Research Report
    • Overseas

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Published: 2007-04-01   Modified: 2016-04-21  

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