| Project/Area Number |
19390103
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SAWADA Norimasa Sapporo Medical University, 医学部, 教授 (30154149)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Takashi 札幌医科大学, 医学部, 准教授 (30260764)
CHIBA Hideki 札幌医科大学, 医学部, 准教授 (00295346)
TANAKA Satoshi 札幌医科大学, 医学部, 講師 (30374250)
MURATA Masaki 札幌医科大学, 医学部, 助教 (10404592)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 糖尿病網膜症 / Ca吸収 / 鼻アレルギー / 膵管上皮 / 肝(黄疸) / タイト結合 / バリア機能 / サイトカイン / 病理学 / 細胞・組織 / 生体機能利用 / ヒト鼻粘膜 / 樹状細胞 / TSLP / claudin / Toll-like receptor / Ca吸収機構 / ビタミンD受容体欠損マウス |
|---|
| Research Abstract |
Tight junctions are intercellular junctions sealing intercellular spaces at the apical end of the lateral cell membranes. Tight junctions regulate the passage of various substances, and also maintain the cell polarity. In this study, we examined regulation of tight junctions by vitamin D, and patho-physiological changes of a barrier function of tight junctions in hepatic cells and human nasal epithelial cells by various cytokines, and in endothelial cells forming blood retinal barrier under a diabetic condition.
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