| Project/Area Number |
19390106
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
FURUKAWA Toru Tokyo Women's Medical University, 国際統合医科学インスティテュート, 教授 (30282122)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGAKI Yohtaro 東京女子医科大学, 国際統合医科学インスティテュート, 教授 (50281324)
MASAKI Tomoo 東京女子医科大学, 国際統合医科学インスティテュート, 教授 (60009991)
YAMAMOTO Masakazu 東京女子医科大学, 医学部, 教授 (60220498)
HATORI Takashi 東京女子医科大学, 医学部, 講師 (50208550)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 分子病理 / がん / 膵臓 / 膵臓がん / MAPK / RNA干渉 / 分子診療 / アポトーシス / 増殖抑制 / 細胞回転 / 網羅的解析 / 膵臓癌 |
|---|
| Research Abstract |
To identify novel diagnostic and therapeutic molecular targets for pancreatic cancer, we carried out RNA interference-mediated systemic knockdown screening of downstream targets of MAPK, which led us to identify novel therapeutic molecular targets repressing survival, proliferation, and tumorigenesity of pancreatic cancer cells. We constructed a detection system in serum for overexpressed molecules in pancreatic cancer and found a candidate serum diagnostic marker that was elevated in patients' serum. Short RNA intereference sequences specific for the therapeutic target molecules were filed for a patent application.
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