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Platelet function and dynamics in various phases of inflammation

Research Project

Project/Area Number 19390108
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionTohoku University

Principal Investigator

ONO Masao  Tohoku University, 大学院・医学系研究科, 教授 (20302218)

Co-Investigator(Kenkyū-buntansha) ENDO Yasuo  東北大学, 大学院・歯学系研究科, 非常勤講師 (50005039)
古川 宏  東北大学, 大学院・医学系研究科, 助教 (00372293)
能勢 眞人  愛媛大学, 医学部, 教授 (70030913)
Co-Investigator(Renkei-kenkyūsha) NOSE Masato  愛媛大学, 医学部, 教授 (70030913)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2008: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2007: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywords血小板 / 炎症 / 自己免疫病 / 動物実験 / アレルギー
Research Abstract

血小板機能不全マウスを実験に利用して、様々なショック誘導や病態維持における血小板の機能を調べた。その結果、IgE依存性アレルギーショックからの回復機能、エンドトキシンショックに対する促進効果、アドレナリンショックに対する促進効果が初めて明らかとなった。今後は各ショック関連の血小板由来因子、作用を明らかにし、血小板を標的とした新たなショック治療に繋げていく

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (47 results)

All 2008 2007

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (24 results)

  • [Journal Article] Biotin deficiency up- regulates TNF-alpha production in murine macrophages2008

    • Author(s)
      Kuroishi T, Endo Y, Muramoto K, Sugawara S
    • Journal Title

      J Leukoc Biol 83

      Pages: 912-920

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin F(2alpha) regulates cytokine responses of mast cells through the receptors for prostaglandin E2008

    • Author(s)
      Kaneko I, Hishinuma T, Suzuki K, Owada Y, Kitanaka N, Kondo H, Goto J, Furukawa H, Ono M
    • Journal Title

      Biochem Biophys Res Commun 367

      Pages: 590-596

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel recombinant congenic mouse strain developing arthritis with enthesopathy2008

    • Author(s)
      Mori S, Tanda N, Ito MR, Oishi H, Tsubaki T, Komori H, Zhang MC, Ono M, Nishimura M, Nose M
    • Journal Title

      Pathol Int58

      Pages: 407-414

    • NAID

      10027377068

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Co-inhibitory roles for glucocorticoid- induced TNF receptor in CD1d- dependent natural killer T cells2008

    • Author(s)
      Chen S, Ndhlovu LC, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, Murata K, Pandolfi PP, Riccardi C, Ono M, Sugamura K, Ishii N
    • Journal Title

      Eur J Immunol 38

      Pages: 2229-2240

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice2008

    • Author(s)
      Zhang MC, Furukawa H, Tokunaka K, Saiga K, Date F, Owada Y, Nose M, Ono M
    • Journal Title

      Immunogenetics 60

      Pages: 599-607

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fatty acid-binding protein regulates LPS-induced TNF-alpha production in mast cells2008

    • Author(s)
      Yamamoto N, Kaneko I, Motohashi K, Sakagami H, Adachi Y, Tokuda N, Sawada T, Furukawa H, Ueyama Y, Fukunaga K, Ono M, Kondo H, Owada Y
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids 79

      Pages: 21-26

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration2008

    • Author(s)
      Tamai K, Toyoshima M, Tanaka N, Yamamoto N, Owada Y, Kiyonari H, Murata K, Ueno Y, Ono M, Shimosegawa T, Yaegashi N, Watanabe M, Sugamura K
    • Journal Title

      Am J Pathol 173

      Pages: 1806-1817

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of 2B4-mediated signals in the pathogenesis of a murine hepatitis model independent of Fas and Valpha 14 NKT cells2008

    • Author(s)
      Furukawa H, Kitazawa H, Kaneko I, Matsubara M, Nose M, Ono M
    • Journal Title

      Immunology 17

      Pages: 1-18

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biotin deficiency up-regulates TNF-alpha production in murine macrophages2008

    • Author(s)
      Kuroishi T, Endo Y, Muramoto K, Sugawara S
    • Journal Title

      J Leukoc Biol 83

      Pages: 912-920

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biotin deficiency up-regulates TNF-alpha production in murine macrophages2008

    • Author(s)
      Kuroishi T, Endo Y, Muramoto K, Sugawara S.
    • Journal Title

      J Leukoc Biol. 83

      Pages: 912-920

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin F (2alpha) regulates cytokine responses of mast cells through the receptors for prostaglandin E2008

    • Author(s)
      Kaneko I, Hishinuma T, Suzuki K, Owada Y, Kitanaka N, Kondo H, Goto J, Furukawa H, Ono M.
    • Journal Title

      Biochem Biophys Res Commun 367

      Pages: 590-596

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel recombinant congenic mouse strain developing arthritis with enthesopathy2008

    • Author(s)
      Mori S, Tanda N, Ito MR, Oishi H, Tsubaki T, Komori H, Zhang MC, Ono M. Nishimura M, Nose M.
    • Journal Title

      Pathol Int 58

      Pages: 407-414

    • NAID

      10027377068

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-inhibitory roles for glucocorticoid-induced TNF receptor in CDld-dependent natural killer T cells2008

    • Author(s)
      Chen S, Ndhlovu LC, Takahashi T, Takeda K, Ikarashi Y, Kikuchi T, Murata K, Pandolfi PP, Riccardi C, Ono M, Sugamura K, Ishii N.
    • Journal Title

      Eur J Immunol, 38

      Pages: 2229-2240

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mast cell hyperplasia in the skin of Dsg4-deficient hypotrichosis mice, which are long-living mutants of lupus-prone mice.2008

    • Author(s)
      Zhang MC, Furukawa H, Tokunaka K, Saiga K, Date F, Owada Y, Nose M, Ono M.
    • Journal Title

      Immunogenetics 60

      Pages: 599-607

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatty acid-binding protein regulates LPS-induced TNF-alpha production in mast cells2008

    • Author(s)
      Yamamoto N, Kaneko I, Motohashi K, Sakagami H, Adachi Y, Tokuda N, Sawada T, Furukawa H, Ueyama Y, Fukunaga K, Ono M, Kondo H, Owada Y.
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids 79

      Pages: 27-26

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration.2008

    • Author(s)
      Tamai K, Toyoshima M, Tanaka N, Yamamoto N, Owada Y, Kiyonari H, Murata K, Ueno Y, Ono M, Shimosegawa T, Yaegashi N. Watanabe M. Sugamura K.
    • Journal Title

      Am J Pathol 173

      Pages: 1806-1817

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of 2B4-mediated signals in the pathogenesis of a murine hepatitis model independent of Fas and Valpha14 NKT cells2008

    • Author(s)
      Furukawa H, Kitazawa H, Kaneko I, Matsubara M. Nose M. Ono M.
    • Journal Title

      Immunology Sep17

      Pages: 1-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase2007

    • Author(s)
      Sato N, Kinbara M, Kuroishi T, Kimura K, Iwakura Y, Ohtsu H, Sugawara S, Endo Y
    • Journal Title

      Clin Exp Allergy 37

      Pages: 743-751

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inductions of histidine decarboxylase in mouse tissues following systemic antigen challenge: contributions made by mast cells, non-mast cells and IL-1., Int Arch2007

    • Author(s)
      Deng X, Wu X, Yu Z, Arai I, Sasano T, Sugawara S, Endo Y
    • Journal Title

      Allergy Immunol 144

      Pages: 69-78

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral bacterial lipopolysaccharide acts in mice to promote sensitisation to ovalbumin and to augment anaphylaxis via platelets2007

    • Author(s)
      Yoshida A, Deng X, Sasano T, Takada H, Sugawara S, Endo Y
    • Journal Title

      Arch Oral Biol 52(10)

      Pages: 990-994

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A non-MFHC locus determines tissue-specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model.2007

    • Author(s)
      Zhang MC, Mori S, Date F, Furukawa H, Ono M,
    • Journal Title

      Ann Rheum Dis 66

      Pages: 242-245

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autosomal loci associated with sex-related difference in the development of autoimmune phenotypes in a lupus model.2007

    • Author(s)
      Misu N, Zhang MC, Mori S, Miyazaki T, Furukawa H, Sasaki T, Nose M, Ono M.
    • Journal Title

      Eur J Immunol 37

      Pages: 2787-2796

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genetic locus controlling aging-sensitive regression of B lymphopoiesis in an autoimmune-prone MRL/lpr strain of mice.2007

    • Author(s)
      Nakatani K, Qu WM, Zhang MC, Fujii H, Furukawa H, Miyazaki T, Iwano M, Saito Y, Nose M, Ono M.
    • Journal Title

      Scand J Immunol 66

      Pages: 654-661

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 即時型アレルギーの諸相を制御するメカニズム2008

    • Author(s)
      小野栄夫
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川
    • Related Report
      2008 Final Research Report
  • [Presentation] Collagen代謝による特発性肺線維症病期分類の検討2008

    • Author(s)
      山下雅大, 小野栄夫
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川
    • Related Report
      2008 Final Research Report
  • [Presentation] 褥初期に出現するCD34強陽性細胞に関する免疫組織化学的検討2008

    • Author(s)
      伊達文子, 小野栄夫
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川
    • Related Report
      2008 Final Research Report
  • [Presentation] 肺非小細胞における女性ステロイドホルモンの受容体の発現2008

    • Author(s)
      神 幸希, 小野栄夫, 笹野公伸
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      石川
    • Related Report
      2008 Final Research Report
  • [Presentation] 全身性受動的アナフィラキシー反応の感受性を規定する遺伝的要因の解析2007

    • Author(s)
      北沢 博、古川 宏、小野 栄夫
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] A spontaneous model for pulmonary arterial hypertension associated with OX40 ligand overexpression and genetic background in mice.2007

    • Author(s)
      M. RABIEYOUSEFI, S. PEJMAN, H. FURUKAWA, N. ISHII, K. SUGAMURA, M. ONO
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] マウスConcanavalin A誘導肝炎の重症化を規定する遺伝的要因の全ゲノム解析2007

    • Author(s)
      北沢 博、古川 宏、小野 栄夫
    • Organizer
      第51回日本リウマチ学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] ConA肝炎の発症におけるSAP分子の役割2007

    • Author(s)
      古川 宏、北沢 博、小野栄夫
    • Organizer
      第51回日本リウマチ学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-04-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Possible Involvement of Eosinophils in the Tumor Rejection from Mice by Specific Elimination of Tumor-associated Macro -phages2007

    • Author(s)
      T. Takahashi, M. Ono, R.Yoshida, et.al.
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスにおけるニッケルアレルギー : 交差反応およびLPSのニッケル濃度におよぼす効果2007

    • Author(s)
      金原正敬, 遠藤康男
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスにおけるニッケルアレルギー : 感作過程における各種微生物成分および炎症性物質の効果2007

    • Author(s)
      高橋春江, 遠藤康男
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 全身性受動的アナフェラシキー反応の感受性を規定する遺伝的要因の解析2007

    • Author(s)
      北沢博, 小野栄夫
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Modula-tion of IL-1βproduction2007

    • Author(s)
      T.Kuroishi, Y.Endo, S.Sugawara
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Muramyl-dipeptideによるマウス組織におけるIL-1βの産生 : エンドトキシンショック増強ショックとの関連性2007

    • Author(s)
      四釜洋介, 遠藤康男
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Alendronate augments the production of IL-1βbut not TNF α by macrophages stimulated by Porphyromonas gingivalis and Tannerella forsythia2007

    • Author(s)
      X.Deng,Y.Endo, Y.Kiyoura
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨吸収抑制薬bisphosphonates(BP)の壊死作用 : 窒素含有BP(NBP) と窒素非含有BP(non-NBP)の作用の違い2007

    • Author(s)
      大泉丈史, 遠藤康男
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Concanavalin A肝炎のLPS前投与による抑制 : 血小板とマクロファージの関与2007

    • Author(s)
      愈志前, 遠藤康男
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] ヒスタミン刺激によるヒト単球様細胞表面NKG2Dリガンド発現の抑制2007

    • Author(s)
      佐藤隆太郎, 遠藤康男他, 菅原俊二
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Fas-FasL axis- dependant syngeneic tumor rejection in MRL mice2007

    • Author(s)
      H. Furukawa, M. Ono
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Genetic characterization of Concanavalin A-induced hepatitis in mice2007

    • Author(s)
      M. Ono, H. Furukawa
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] A spontaneous model for pulmonary arterial hypertension associated with OX40 ligand overexpression and genetic background in mece2007

    • Author(s)
      R. Moloud, M. Ono
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] マウスConcanavalin A 誘導肝炎の重症化を規定する遺伝要因の全ゲノム解析2007

    • Author(s)
      北沢博, 小野栄夫
    • Organizer
      第51回日本リウマチ学会総会、第16回国際リウマチシンポジウム(以下、リウマチ学会2007)
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 抗原の繰り返し投与による自己抗体産生と腎炎発症におけるT細胞の関与2007

    • Author(s)
      古川宏, 小野栄夫
    • Organizer
      リウマチ学会2007
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 耳下腺炎を自然発症するリコンビナントコンジェニックマウスの検討2007

    • Author(s)
      丹田奈緒子, 小野栄夫他, 能勢眞人
    • Organizer
      リウマチ学会2007
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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