Study on in vivo roles of basophils
| Project/Area Number |
19390110
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KARASUYAMA Hajime Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (60195013)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2007: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | 炎症 / 好塩基球 / アレルギー / アナフィラキシー / マクロファージ / 好中球 / GFP / 可視化 / マスト細胞 / IgE / IgG / ヒスタミン / 血小板活性化因子 |
|---|
| Research Abstract |
好塩基球は末梢血白血球のわずか0.5%を占めるに過ぎない最少血球細胞であり、またマスト細胞と類似性があるために、その存在意義が疑問視されていた。私たちは本研究において、好塩基球がIgE依存性慢性アレルギー炎症ならびにIgG依存性全身性アナフィラキシーの責任細胞であることを世界に先駆けて明らかにした。本研究により、生体内において好塩基球とマスト細胞が明らかに異なる役割を果たしていることが証明された。
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Report
(3 results)
Research Products
(151 results)
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[Journal Article] Fc receptor γ-chain, a constitutive component of the interleukin 3 receptor is required for interleukin 3-induced interleukin 42009
Author(s)
Hida, S., Yamasaki, S., Sakamoto, Y., Takamoto, M., Obata, K., Takai, T., Karasuyama, H., Sugane, K., Saito, T.and Taki, S.
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Journal Title
Nat.Immunol 10
Pages: 214-222
Related Report
Peer Reviewed
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[Journal Article] Peanuts can contribute to anaphylactic shock by activating complement2009
Author(s)
Khodoun, M., Strait, R., Orekov, T., Hogan,S., Karasuyama, H., Herbert, D. R., Kohl, J.and Finkelman, F.D.
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Journal Title
J.Allergy Clin.Immunol 58
Pages: 11-19
Related Report
Peer Reviewed
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[Journal Article] Basophils play a pivotal role inimmunoglobulin G-but not immunoglobulinE-mediated systemic anaphylaxis2008
Author(s)
Tsujimura, Y., Obata, K., Mukai, K., Shindou,H., Yoshida, M., Nishikado, H., Kawano, Y.,Minegishi, Y., Shimizu, T.and Karasuyama, H.
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Journal Title
Immunity 28
Pages: 581-589
Related Report
Peer Reviewed
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[Journal Article] Erk kinases link pre-B cellreceptor signaling to transcriptional events required for early B cell expansion2008
Author(s)
Yasuda, T., Sanjo, H., Pages, G., Kawano, Y.,Karasuyama, H., Pouyssegur, J., Ogata, M.and Kurosaki, T.
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Journal Title
Immunity 28
Pages: 499-508
Related Report
Peer Reviewed
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[Journal Article] Overproduction of IgE induces macrophage-derived chemokine(CCL22)secretion from basophils2008
Author(s)
Watanabe, M., Satoh, T., Yamamoto, Y.,Kanai, Y., Karasuyama, H.and Yokozeki, H.
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Journal Title
J.Immunol 181
Pages: 5653-5659
Related Report
Peer Reviewed
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[Journal Article] A novel hairless mouse model on anatopic dermatitis-prone genetic backgroundgenerated by receptor-mediated transgenesis2008
Author(s)
Takada, T., Shitara, H., Matsuoka, K.,Kojima, E., Ishii, R., Kikkawa, Y.,Karasuyama, H., Kohno, K.and Yonekawa, H.
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Journal Title
Transgenic Res. 17(6)
Pages: 1155-1162
Related Report
Peer Reviewed
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[Journal Article] Basophils play a pivotal role in immunoglobulin G-but not immunoglobulin E-mediated systemic anaphylaxis.2008
Author(s)
Tsujimura, Y., Obata, K., Mukai, K., Shindou, H., Yoshida, M., Nishikado, H., Kawano, Y., Minegishi, Y., Shimizu, T. and Karasuyazna, H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.2008
Author(s)
Yasuda, T., Sanjo, H., Pages, G., Kawano, Y., Karasuyama, H. Pouyssegur, J., Ogata, M. and Kurosaki, T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Basophils are essentialinitiators of a novel type of chronic allergic inflammation2007
Author(s)
Obata, K., Mukai, K., Tsujimura, Y., Ishiwata,K., Kawano, Y., Minegishi, Y., Watanabe, N.and Karasuyama, H
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome2007
Author(s)
Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge,I., Takada, H., Hara T., Kawamura, N., Ariga,T., Pasic, S., Stojkovic, O., Metin, A., and Karasuyama, H.
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Journal Title
Nature 448
Pages: 1058-1062
Related Report
Peer Reviewed
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[Journal Article] Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner2007
Author(s)
Kojima, T., Obata, K., Mukai, K., Sato, S.,Takai, T., Minegishi, Y.,and Karasuyama, H.
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Journal Title
J.Immunol. 179
Pages: 7093-7100
Related Report
Peer Reviewed
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[Journal Article] Basophils are essential initiators of a novel type of chronic allergic inflammation.2007
Author(s)
Obata, K., Mukai, K., Tsujimura, Y., Ishiwata, K., Kawano, Y., Minegishi, Y., Watanabe, N., and Karasuyama, H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.2007
Author(s)
Minegishi, Y., Saito, M., Tsuchiya, S., Tsuge, I., Takada, H., Hara T., Kawamura, N., Ariga, T., Pasic, S., Stojkovic, O., Metin, A., and Karasuyama, H.
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Journal Title
Nature 448
Pages: 1058-1062
Related Report
Peer Reviewed
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[Journal Article] Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner.2007
Author(s)
Kojima, T., Obata, K., Mukai, K., Sato, S., Takai, T., Minegishi, Y., and Karasuyama, H.
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Journal Title
J. Immunol 179
Pages: 7093-7100
Related Report
Peer Reviewed
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