Analysis of the molecular mechanism for the determination of cell fate and the tissue organization with Notch signaling
| Project/Area Number |
19390115
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Tokai University |
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Principal Investigator |
HOZUMI Katsuto Tokai University, 医学部, 准教授 (30246079)
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| Co-Investigator(Kenkyū-buntansha) |
ANDO Kiyoshi 東海大学, 医学部, 教授 (70176014)
IMAI Kenji 東海大学, 医学部, 教授 (70193646)
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| Co-Investigator(Renkei-kenkyūsha) |
ANDO Kiyoshi
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | Notch / Notchリガンド / 細胞系譜 / 胸腺 / 骨髄 / Jaggedl / 骨芽細胞 / 膵臓 |
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| Research Abstract |
生体防御反応にて中心的な役割を果たすT細胞は、胸腺にて分化成熟し、末梢リンパ組織に供給される。T細胞は胸腺に依存して分化するが、その分子基盤については明らかでなかった。本研究では、T細胞分化に必須のNotchシグナルが、胸腺分化環境を担う胸腺上皮細胞上に発現するNotchリガンド:Dll4を介して、胸腺に移動してきた造血未分化細胞に付与され、T細胞への系列決定が成されることを明らかにした。
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Delta-like 4 is indispensable in thymic environment specific for T cell development.2008
Author(s)
Hozumi, K., Mailhos, C., Negishi, N., Hirano, K., Yahata, T., Ando, K., Zuklys, S., Hollander, G. A., Shima, D. T. and Habu, S.
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Journal Title
J. Exp. Med. 205
Pages: 2507-2513
NAID
Related Report
Peer Reviewed
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[Journal Article] Notch signaling is necessary for GATA3 function in the initiation of T cell development.2008
Author(s)
Hozumi, K., Negishi, N., Tsuchiya, I., Abe, N., Hirano, K., Suzuki, D., Yamamoto, M., Engel, J. D. and Habu, S.
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Journal Title
Eur. J. Immunol. 38
Pages: 977-985
Related Report
Peer Reviewed
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[Journal Article] Expression of Delta-like 1 in the splenic non-hematopoietic cells is essential for marginal zone B cell development.2008
Author(s)
Sheng, Y., Yahata, T., Negishi, N., Nakano, Y., Habu, S., Hozumi, K. and Ando, K.
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Journal Title
Immunol. Lett. 121
Pages: 33-37
Related Report
Peer Reviewed
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[Journal Article] Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.2007
Author(s)
Oyama, T., Harigaya, K., Muradil, A., Hozumi, K., Habu, S., Iwama, A., Oguro, H., Matsuno, K., Sakamoto, R., Sato, M., Yoshida, N. and Kitagawa, M.
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Journal Title
Proc. Natl. Acad. Sci. USA. 104
Pages: 9764-9769
Related Report
Peer Reviewed
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