Analysis of mechanisms of the host defense against parasite infection by new cytokines (IL-27, IL-33)
| Project/Area Number |
19390121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
YOSHIMOTO Tomohiro Hyogo College of Medicine, 医学部, 准教授 (60241171)
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| Co-Investigator(Kenkyū-buntansha) |
NAKANISHI Kenji 兵庫医科大学, 医学部, 教授 (60172350)
善本 隆之 兵庫医科大学, 医学部, 准教授 (80202406)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2008: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 原虫感染 / 蠕虫感染 / 生体防御 / IL-27 / IL-33 |
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| Research Abstract |
IL-27の生体内投与は、宿主のTh1 反応を増強しTh2反応を抑制する結果、細胞内寄生原虫Leishmania. majorに対する生体防御機能を誘導する。一方IL-33の生体内投与は、獲得系免疫細胞の関与なしにIL-13産生を誘導し、腸管杯細胞の活性化とムチン産生を誘導する結果、腸管寄生線虫(Nippostrongylus brasiliensis)の排虫を促進する。今回の研究結果から、新規サイトカイン(IL-27, IL-33)はそれぞれ、住血鞭毛原虫や腸管寄生線虫に対する、新規抗寄生虫薬の開発に結びつくものと考えられた。
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Report
(3 results)
Research Products
(101 results)
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[Journal Article] Association of IL-33 level and IL-33 genetic variant with Japanese cedar pollinosis.2008
Author(s)
Sakishita M, Yoshimoto T, Hirota T, Harada M, Ohkubo K, Osawa Y, Fujieda S, Nakamura Y, Yasuda K, Nakanishi K, and Tamari M.
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Journal Title
Clinical & Exp Allergy 38
Pages: 1875-1881
Related Report
Peer Reviewed
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