Study on host factors associated with retroviruses-induced diseases
| Project/Area Number |
19390131
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
NISHIGAKI Kazuo Yamaguchi University, 農学部, 准教授 (20401333)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 病原性 / 発癌 / レトロウイルス / 白血病 / 抵抗性因子 / ウイルス発がん / 抵抗性遺伝子 / 病原生 / ウイルス発ガン / シグナル伝達 / マウス白血病ウ / 猫白血病ウイルス / ウイルス発現 / マウス白血病ウイルス / HTLV-1 / 癌化 |
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| Research Abstract |
The critical amino acid sequences of sf-Stk in which Friend virus gp55 transforms NIH3T3 cells in cooperation with sf-Stk were identified. Several signal molecules were constitutively activated in the transformed cells. PI3-kinase, one of these molecules, was identified to interact with sf-Stk. Splenomegaly induced by Friend virus was depend on Fv-2 and p85 expression status. Futthermore, p85 was shown to involved in stress- induced erythropoiesis. HTLV-1 expression was associated with IL-2 withdrawal in cells and its regulation was due to via p38 stress pathway. Apoptosis-related molecules were elevated in cats with MDS induced by FeLV. These studies identified molecular mechanisms in retroviruses-induced diseases.
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Report
(4 results)
Research Products
(22 results)
