| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Research Abstract |
The critical amino acid sequences of sf-Stk in which Friend virus gp55 transforms NIH3T3 cells in cooperation with sf-Stk were identified. Several signal molecules were constitutively activated in the transformed cells. PI3-kinase, one of these molecules, was identified to interact with sf-Stk. Splenomegaly induced by Friend virus was depend on Fv-2 and p85 expression status. Futthermore, p85 was shown to involved in stress- induced erythropoiesis. HTLV-1 expression was associated with IL-2 withdrawal in cells and its regulation was due to via p38 stress pathway. Apoptosis-related molecules were elevated in cats with MDS induced by FeLV. These studies identified molecular mechanisms in retroviruses-induced diseases.
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