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Differentiation and function of M cells, a specialized intestinal epithelial cell type, in the mucosal immune system

Research Project

Project/Area Number 19390143
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

大野 博司  The Institute of Physical and Chemical Research, 免疫系構築研究チーム, チームリーダー (50233226)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords免疫学 / 細胞・組織 / M細胞 / 分化 / 抗原取り込み / 腸管免疫 / パイエル板 / FAE / ケモカイン / CCL20 / M-sec / TNT
Research Abstract

パイエル板にはD11c^+CCR6^+のユニークなB細胞が存在し、パイエル板を覆う腸管上皮細胞が分泌するCCR6のリガンドCCL20の作用によりこの細胞が上皮直下へと郵送して上皮と相互作用することによりM細胞が誘導されることが示唆された。
また、M細胞同士はtunneling nanotube (TNT)と呼ばれる細い細胞膜のチューブで連結されているが、われわれはTNT形成因子M-Secを発見し、M-Secがアクチン・リモデリングに働く低分子量GTPaseのRalA/Bや膜輸送の制御因子であるexocyst複合体と相互作用することによりTNT形成を制御していることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (76 results)

All 2009 2008 2007 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (57 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Mechanism of NKT cell activation by intranasal coadministration of a-galactosylceramide, which can induce cross-protection against influenza2008

    • Author(s)
      Kamijuku, H., Nagata, Y., Jiang, X., Ichinohe, T., Tashiro, T., Mori, K., Taniguchi, M., Hase, K., Ohno, H., Shimaoka, T., Yonehara, S., Odagiri, T., Tahiro, M., Sata, T., Hasegawa, H., Seino, K-i.
    • Journal Title

      Mucosal Immunol 1

      Pages: 208-218

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells2008

    • Author(s)
      Terahara, K., Yoshida, M., Igarashi, O., Nochi, T., Pontes, G. S., Hase, K., Ohno, H., Kurokawa, S., Mejima, M., Takayama, N., Yuki, Y., Lowe, A. W., Kiyono, H.
    • Journal Title

      J. Immunol 180

      Pages: 7840-7846

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production2008

    • Author(s)
      Morita, H., Toh, H., Fukuda, S., Horikawa, H., Oshima, K., Suzuki, T., Murakami, M., Hisamatsu, S., Kato, Y., Takizawa, T., Fukuoka, H., Yoshimura, T., Itoh, K., O'Sullivan, D. J., McKay, L. L., Ohno, H., Kikuchi, J., Masaoka, T., Hattori, M.
    • Journal Title

      DNA Res 15

      Pages: 151-161

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant trafficking of the high-affinity choline transporter in AP-3-deficient mice2008

    • Author(s)
      Misawa, H., Fujigaya, H., Nishimura, T., Moriwaki, Y., Okuda, T., Kawashima, K., Nakata, K., Ruggiero, A. M., Blakely, R. D., Nakatsu, F., Ohno, H.
    • Journal Title

      Eur. J. Neurosci 27

      Pages: 3109-3117

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease2008

    • Author(s)
      Hase, K., Takahashi, D., Ebisawa, M., Kawano, S., Itoh, K., Ohno, H.
    • Journal Title

      PLoS ONE 3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells2008

    • Author(s)
      Terahara, K., Yoshida, M., Igarashi, O., Nochi, T., Pontes, G. S., Hase, K., Ohno, H., Kurokawa, S., Mejima, M., Takayama, N., Yuki, Y., Lowe, A. W., Kiyono, H.
    • Journal Title

      J. Immunol. 180

      Pages: 7840-7846

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanism of NKT cell activation by intranasal coadministration of a-galactosylceramide, which can induce cross-protection against influenza2008

    • Author(s)
      Kamijuku, H., Nagata, Y., Jiang, X., Ichinohe, T., Tashiro, T., Mori, K., Taniguchi, M., Hase, K., Ohno, H., Shimaoka, T., Yonehara, S., Odagiri, T., Tahiro, M., Sata, T., Hasegawa, H., Seino, K-i
    • Journal Title

      Mucosal Immunol. 1

      Pages: 208-218

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Splenic CD19-CD35+B220+ cells function as an inducer of the follicular dendritic cell-network formation2007

    • Author(s)
      Murakami, T., Chen, X., Hase, K., Sakamoto, A., Nishigaki, C., Ohno, H.
    • Journal Title

      Blood 110

      Pages: 1215-1224

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an open-access database that integrates cross-reference information from the transcriptome anda proteome of immune cells2007

    • Author(s)
      Hijikata, A., Kitamura, H., Kimura, Y., Yokoyama, R., Aiba, Y., Bao, Y., Fujita, S., Hase, K., Hori, S., Ishii, Y., Kanagawa, O., Kawamoto, H., Kawano, K., Koseki, H., Kibo, M., Kurita-Miki, A., Kurosaki, T., Masuda, K., Nakata, M., Oboki, K., Ohno, H., Okamoto, M., Okayama, Y., O-Wang, J., Saito, H., Saito, T., Sakuma, M., Sato, K., Seino, K., Setoguchi, R., Tamura, Y., Tanaka, M., Taniguchi, M., Taniuchi, I., Teng, A., Watanabe, T., Watarai, H., Yamasaki, S., Ohara, O.
    • Journal Title

      Bioinformatics 23

      Pages: 2934-2941

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Psg18 is specifically expressed in follicle-associated epithelium2007

    • Author(s)
      Kawano, K., Ebisawa, M., Hase, K., Fukuda, S., Hijikata, H., Kawano, S., Date, Y., Tsuneda, S., Itoh, K., Ohno, H.
    • Journal Title

      Cell Struct. Funct 32

      Pages: 115-126

    • NAID

      130004137523

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Psg18 is specifically expressed in follicle-associated epithelium.2007

    • Author(s)
      Kawano, K, 他
    • Journal Title

      Cell Struct.Funct. 32

      Pages: 115-126

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of an open-access database that integrates cross-reference information from the transcriptome anda proteome of immune cells.2007

    • Author(s)
      Hijikata, A, 他
    • Journal Title

      Bioinformatics 23

      Pages: 2934-2941

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD19-CD35+B220+cells function as an inducer of the follicular dendritic cell-network formation.2007

    • Author(s)
      Murakami, T, 他
    • Journal Title

      Blood 110

      Pages: 1215-1224

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation screening of AP3M2 in Japanese epilepsy patients.2007

    • Author(s)
      Huang, M.C. 他
    • Journal Title

      Brain Dev. 29

      Pages: 462-467

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Glycoprotein 2, a transcytotic receptor expressed by intestinal M cells, plays a critical role in immunosurveillance against enterobacteria2009

    • Author(s)
      Kawano, K., Hase, K., Nochi, T., Pontes, G. S., Fukuda, S., Nakato, G., Ebisawa, M., Iimura, M., Fukuoka, S., Waguri, S., Itoh, K., Kiyono, H., Ohno, H.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology "Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota"
    • Year and Date
      2009-01-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Multi-omic analysis identifies microbial metabolites to protect host from enterohaemorrhagic Escherichia coli O157:H7 lethal infection2009

    • Author(s)
      Fukuda, S., Nakanishi, Y., Toh, H., Yoshimura, K., Oshima, K., Morita, H., Tobe, T., Itoh, K., Kikuchi, J., Hattori, M., Ohno, H.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology "Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota"
    • Year and Date
      2009-01-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 通常培養状態におけるc-Jun N-terminal kinase (JNK)による翻訳制御2008

    • Author(s)
      伊藤誠.、北村浩、菊口千智、湯浅朋子、大野博司、小原収
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] バクテリア発現遺伝子情報を付与したDGGE-NMR相関解析法による腸内環境評価系の構築2008

    • Author(s)
      加藤完、伊達康博、福田真嗣、中西由美子、近山英輔、坪井裕理、常田聡、守屋繁春、菊地淳、大野博司
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 腸内細菌の代謝変動に着目した植物性プレバイオティクス候補の探索2008

    • Author(s)
      中西由美子、縫島裕美、福田真嗣、加藤完、梅原三貴久、大野博司、菊地淳
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Year and Date
      2008-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] リンパ濾胞上皮層における宿主-微生物相互作用の解析2008

    • Author(s)
      福田真嗣、大野博司
    • Organizer
      Hindgut Club Japan 2008
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 小腸パイエル板M細胞におけるCCL9の機能解析2008

    • Author(s)
      山崎龍、木村俊介、長谷耕二、伊達康博、海老澤昌史、大野博司
    • Organizer
      Hindgut Club Japan 2008
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 腸内環境を評価するためのバクテリア発現遺伝子解析法の構築2008

    • Author(s)
      加藤完、伊達康博、福田真嗣、中西由美子、近山英輔、坪井裕理、常田聡、守屋繁春、菊地淳、大野博司
    • Organizer
      Hindgut Club Japan 2008
    • Year and Date
      2008-12-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Deficiency of epithelium-specific basolateral sorting factor AP-1B heads to spontaneous development of colitis2008

    • Author(s)
      Takahashi, D., Hase, K., Ohno, H.
    • Organizer
      第38回日本免疫学会学術集会
    • Year and Date
      2008-12-03
    • Related Report
      2008 Final Research Report
  • [Presentation] CXCR6 is upregulated in effector CD4+ T cells infiltrating into chronically inflamed colonic tissue2008

    • Author(s)
      Mandai, Y., Takahashi, D., Hase, K., Sato, T., Ebisawa, M., Katsuno, Y., Ohno, H.
    • Organizer
      第38回日本免疫学会学術集会
    • Year and Date
      2008-12-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Comprehensive gene expression profiling of antigen-sampling M cells: Specific expression of GP2 and MLP genes by Peyer's patch M cells2008

    • Author(s)
      吉田理人、寺原和孝、野地智法、Pontes, G. S., 長谷耕二、大野博司、幸義和、清野宏
    • Organizer
      第38回日本免疫学会学術集会
    • Year and Date
      2008-12-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Glycopotein 2 is specifically expressed on the apical membrane of Peyre's patch M cells but not Villous M cells2008

    • Author(s)
      Pontes, G. S., Toshida, M., Nochi, T., Hase, K., Ohno, H., Terahara, K., Yuki, Y., Koyono, H.
    • Organizer
      第38回日本免疫学会学術集会
    • Year and Date
      2008-12-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Comprehensive analysis of the expression of M-cell-associated proteins among mucosa-associated lymphoid tissue2008

    • Author(s)
      Date, Y., Fukuda, S., Hase, K., Tsuneda, S., Ohno, H.
    • Organizer
      第38回日本免疫学会学術集会
    • Year and Date
      2008-12-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Tunneling nanotubules formed by Peyer's patch M cells: Potential function as the antigen-transporting web2008

    • Author(s)
      Hase, K., Takatsu, H., Kimura, S., Ohno, H.
    • Organizer
      第38回日本免疫学会学術集会
    • Year and Date
      2008-12-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Tunneling nanotubules formed by Peyer's patch M cells : Potential function as the antigen-transporting web2008

    • Author(s)
      Hase, K., Takatsu, H., Kimura, S., Ohno, H.
    • Organizer
      第38回日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Spatial and temporal specific expression patterns of RANLK/RANK in developing peripheral lymphoid organs2008

    • Author(s)
      Sugiyama, M., Ohno, H., Yoshida, H.
    • Organizer
      第38回日本免疫学会学術集会
    • Year and Date
      2008-12-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Brucella abortus is taken up via intestinal M cells by interacting with cellular prion protein2008

    • Author(s)
      Nakato, G., Hase, K., Fukuda, S., Kawano, K., Ohno, H.
    • Organizer
      第38回日本免疫学会学術集会
    • Year and Date
      2008-12-02
    • Related Report
      2008 Final Research Report
  • [Presentation] (2008) CXCR6 is upregulated in effector memory CD4+ T cells infiltrating into chronically inflamed colonic tissue2008

    • Author(s)
      Mandai, Y., Hase, K., Sato, T., Takahashi, D., Ebisawa, M., Katsuno, Y., Saito, Y., Ohno, H.
    • Organizer
      Digestive Disease Week-
    • Year and Date
      2008-05-19
    • Related Report
      2008 Final Research Report
  • [Presentation] 栄養源に伴う腸内環境変動の微生物群集構造解析法に基づく評価2008

    • Author(s)
      中西由美子、福田真嗣、伊達康博、加藤完、坪井裕理、常田聡、大野博司、菊地淳
    • Organizer
      日本農芸化学会2008年度大会
    • Year and Date
      2008-03-27
    • Related Report
      2008 Final Research Report
  • [Presentation] ニュートリメタボノミクスにおける安定同位体標識技術の適用2007

    • Author(s)
      Date, Y., Nakanishi, Y., Fukuda, S., Tsuneda, S., Ohno, H., Kikuchi, J.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] (2007 )腸内細菌群のニュートリメタボノミクス基盤技術の構築2007

    • Author(s)
      Nakanishi, Y., Fukuda, S., Chikayama, E,. Kimura, Y., Ohno, H., Kikuchi, J.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 非ストレス状態におけるJNKによる翻訳調節2007

    • Author(s)
      Ito, M., Kitamura, H., Kikuguchi, C., Yuasa, T., Ohara, O., Ohno, H.
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Year and Date
      2007-12-13
    • Related Report
      2008 Final Research Report
  • [Presentation] ニュートリメタボノミクスにおける安定同位体標識技術の適用2007

    • Author(s)
      伊達 康博, 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腸内細菌群のニュートリメタボノミクス基盤技術の構築2007

    • Author(s)
      中西 裕美子, 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] 非ストレス状態におけるJNKによる翻訳調節2007

    • Author(s)
      伊藤 誠〓, 他
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of molecules expressed in FAE and M cells to be involved in mucosal immunity2007

    • Author(s)
      Kawano, K., Hase, K., Ohno, H.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of a CD11c^+CD19^+ unique cell population in the mucosa-associated lymphoid tissues: A potential role in M cell development2007

    • Author(s)
      Ebisawa, M., Hase, K., Ohno, H.
    • Organizer
      第37回日本免疫学会学術集会
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Epithelial-specific adaptor complex, AP-1B is essential for maintenance of immunological tolerance in the colon2007

    • Author(s)
      Takahashi, D., Hase, K., Ohno, H.
    • Organizer
      第37回日本免疫学会学術集会
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Bacterial adhesin is a ligand for endocytic receptor glycoprotein 2 expressed on M cells2007

    • Author(s)
      Kawano, K., Hase, K., Fukuda, S., Nakato, G., Murakami, T., Ebisawa, M., Itoh, K., Ohno, H.
    • Organizer
      第37回日本免疫学会学術集会
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Psg18 is specifically expressed in follicle-associated epithelium2007

    • Author(s)
      Date, Y., Ebisawa, M., Kawano, K., Fukuda, S Hase, K., Tsuneda, S., Itoh, K., Ohno, H.
    • Organizer
      第37回日本免疫学会学術集会
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene expression profiles of follicle-associated epithelium covering murine intestinal Peyer's patches in response to host-bacterial cross-talk2007

    • Author(s)
      Fukuda, S., Nakato, G., Miura, K., Date, Y., Yokosawa, K., Kawano, K., Hase, K., Tsuneda, S., Itoh, K., Ohno, H.
    • Organizer
      第37回日本免疫学会学術集会
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Endogenous prion protein expressed on M cells: A potential antigen uptake receptor2007

    • Author(s)
      Nakato, G., Fukuda, S., Takatsu, H., Murakami, T., Kawano, K., Hase, K., Ohno, H.
    • Organizer
      第37回日本免疫学会学術集会
    • Year and Date
      2007-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of molecules expressed in FAE and M cells to be involved inmucosal immunity2007

    • Author(s)
      Ohno, H, 他
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of a CD11c^+CD19^+ unique cell population in the mucosa-associated lymphoid tissues:A potential role in M cell development2007

    • Author(s)
      海老澤 昌史, 他
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Epithelial-specific adaptor complex,AP-1B is essential for maintenance of immunological tolerance in the colon2007

    • Author(s)
      高橋 大輔, 他
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bacterial adhesin is a ligand for endocytic receptor glycoproein 2 expressed on M cells2007

    • Author(s)
      河野 和也, 他
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Psg18 is specifically expressed in follicle-associated epithelium2007

    • Author(s)
      伊達 康博, 他
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gene expression profiles of follicle-associated epithelium covering murine intestinal Peyer's patches in response to host-bacterial cross-talk2007

    • Author(s)
      福田 真嗣, 他
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] Endogenous prion protein expressed on M cells:A potential antigen uptake receptor2007

    • Author(s)
      中藤 学, 他
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Related Report
      2007 Annual Research Report
  • [Presentation] M-Sec: the M cell-specific Sec family molecule that regulates tunneling nanotubule (TNT) formation2007

    • Author(s)
      Hase, K., Takatsu, H., Kawano, S., Ohno, H.
    • Organizer
      第37回日本免疫学会総会・学術集会
    • Year and Date
      2007-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] M-Sec: the M cell-specific Sec family molecule that regulates tunneling nanotubule(TNT)formation2007

    • Author(s)
      Hase, K, 他
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Activation-induced cytidine deaminase deficiency causes severe gastritis with mucosal hyperplasia2007

    • Author(s)
      Hase, K, 他
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Place of Presentation
      東京
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of CD11c+CD19+ cells in the mucosa-associated lymphoid tissues:A potential role in M cell development2007

    • Author(s)
      Ebisawa, M, 他
    • Organizer
      13^<th> lnternational Congress of mucosal Immunology
    • Place of Presentation
      東京
    • Year and Date
      2007-07-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] Differential gene expression profiles of follicle-associated epithelium covering murine intestinal Peyer's patches in response to host-bacterial cross-talks2007

    • Author(s)
      Fukuda, S., Nakato, G., Miura, K., Kawano, K., Hase, K., Itoh, K., Ohno, H.
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of a new endocytic receptor expressed in the apical plasma membrane of M cells2007

    • Author(s)
      Kawano, K., Hase, K., Fukuda, S., Murakami, T., Waguri, S., Itoh, K., Ohno, H.
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Endogenous prion protein expressed on the apical plasma membrane in M cells could function as a potential antigen uptake receptor2007

    • Author(s)
      Nakato, G., Fukuda, S., Takatsu, H., Murakami, T., Kawano, K., Hase, K., Ohno, H.
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Activation-induced cytidine deaminase deficiency causes severe gastritis with mucosal hyperplasia2007

    • Author(s)
      Hase, K., Itoh, K., Ebisawa, M., Ohshima, S., Fagarasan, S., Ohno, H.
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Identification of CD11c^+CD19^+ cells in the mucosa-associated lymphoid tissues: A potential role in M cell development2007

    • Author(s)
      Ebisawa, M., Hase, K., Ohno, H.
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Year and Date
      2007-07-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Differential gene expression profiles of follicle-associated epithelium covering murine intestinal Peyer's patches in resonse to host-bacterial cross-talks.2007

    • Author(s)
      Fukuda, S, 他
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Place of Presentation
      東京
    • Year and Date
      2007-07-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Identification of a new endocytic receptor expressed in the apical plasma membrane of M cells.2007

    • Author(s)
      Kawano, K, 他
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Place of Presentation
      東京
    • Year and Date
      2007-07-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Endogenous prion protein expressed on the apical plasma membrane in M cells could function as a potential antigen uptake receptor2007

    • Author(s)
      Nakato, G, 他
    • Organizer
      13^<th> International Congress of mucosal Immunology
    • Place of Presentation
      東京
    • Year and Date
      2007-07-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] 宿主-腸内フローラ間相互作用の解析とその評価系の構築2007

    • Author(s)
      福田 真嗣, 他
    • Organizer
      第11回腸内細菌学会
    • Place of Presentation
      東京
    • Year and Date
      2007-06-14
    • Related Report
      2007 Annual Research Report
  • [Presentation] 宿主.腸内フローラ間相互作用の解析とその評価系の構築2007

    • Author(s)
      福田真嗣、中藤学、中西裕美子、三浦克吉、伊藤喜久治、菊地淳、大野博司
    • Organizer
      第11回腸内細菌学会
    • Year and Date
      2007-06-12
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of epithelial-specific AP-1B-deficient mice2007

    • Author(s)
      Nakato, G., Yamashita, T., Yonemura, S., Sugihara, K., Nakatsu, F., Hase, K., Murakami, T., Asano, M., Ohno, H.
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Year and Date
      2007-05-30
    • Related Report
      2008 Final Research Report
  • [Presentation] T CD300 antigen like family member G: A novel Ig receptor like protein exclusively expressed on capillary endothelium2007

    • Author(s)
      akatsu, H., Hase, K., Ohmae, M., Ohshima, S., Yamamoto, A., Ohno, H.
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Year and Date
      2007-05-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Analysis of epithelial-specific AP-1B-deficient mice2007

    • Author(s)
      中藤 学,他
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] CD300 antigen like family member G:A novel Ig receptor like proteinexclusively expressed on capillary endothelium2007

    • Author(s)
      高津 宏之, 他
    • Organizer
      第40回日本発生生物学会・第59回日本細胞生物学会合同大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-30
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://leib.rcai.riken.jp/riken/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://leib.rcai.riken.jp/riken/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://leib.rcai.riken.jp/riken/index.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] IgA腎症の予測方法およびIgA腎症患者の選択方2009

    • Inventor(s)
      長澤康行、飯尾健一郎、猪阪善隆、福田真嗣、大野博司
    • Industrial Property Rights Holder
      国立大学法人大阪大学、独立行政法人理化学研究所
    • Industrial Property Number
      2009-029227
    • Filing Date
      2009-02-01
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 原核生物、特に、真性細菌のcDNAの簡易な調整方法2008

    • Inventor(s)
      守屋繁春、加藤完、福田真嗣、大野博司、菊地淳
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      2008-052503
    • Filing Date
      2008-03-03
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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