Roles of low-molecular weight bioactive factors in the protective mechanisms of brain function

• Project/Area Number: 19390152
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Kyoto University
• Principal Investigator: AKAIKE Akinori Kyoto University, 薬学研究科, 教授 (80135558)
• Co-Investigator(Kenkyū-buntansha): KUME Toshiaki 京都大学, 薬学研究科, 准教授 (10303843)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2007: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
• Keywords: 脳神経疾患 / 生体分子 / 薬理学

Research Abstract

様々な脳疾患の防御に重要な生体内機能分子の役割を解明するため、研究を遂行し下記の成果を得た。胎仔由来神経保護物質であるセロフェンド酸が作用を発現する際に重要な直接のターゲット分子の候補タンパクが見出された。また、セロフェンド酸は末梢投与においてもin vivoにおける虚血障害に対して保護的に働くことが明らかとなった。ニコチン受容体関連では、アストロサイトにおけるα7受容体発現にはニューロンとの接触によるシグナルが重要な役割を果たしていることを見出した。

Research Products

• [Journal Article] Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil (2008)
  • Author(s): Takada-Takatori, Y., Kume, T., Ohgi, Y., Izumi, Y., Niidome, T., Fujii, T., Sugimoto, H. and Akaike, A.
  • Journal Title: J. Neurosci. Res. 86 Pages: 3575-3583
  • Peer Reviewed
• [Journal Article] Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells (2008)
  • Author(s): Osakada, F., Ikeda, H., Mandai, M., Wataya, T., Watanabe, K., Yoshimura, N., Akaike, A., Sasai, Y. and Takahashi,M,
  • Journal Title: Nature Biotechnol. 26 Pages: 215-352
  • Peer Reviewed
• [Journal Article] Bromocriptine, a dopamineD_2 receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells (2008)
  • Author(s): Oda, T., Kume, T., Izumi, Y., Takada-Takatori, Y., Niidome, T. and Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 598 Pages: 27-31
  • Peer Reviewed
• [Journal Article] Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats (2008)
  • Author(s): Nakamura, T., Kume, T., Katsuki, H., Niidome, T., Sugimoto, H. and Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 586 Pages: 151-155
  • Peer Reviewed
• [Journal Article] Regulation of intracellular dopamine levels by dopaminergic drugs: involvement of vesicular monoamine transporter (2008)
  • Author(s): Izumi, Y., Yamamoto, N., Kume, T., Katsuki, H., Sawada, H. and Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 582 Pages: 52-61
  • Peer Reviewed
• [Journal Article] Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells (2008)
  • Author(s): Hama, Y., Katsuki, H., Suminaka, C., Kume, T. and Akaike, A.
  • Journal Title: Neuropharm. 55 Pages: 677-686
  • Peer Reviewed
• [Journal Article] Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats (2008)
  • Author(s): Fujimoto, S., Katsuki, H., Ohnishi, M., Takagi, M., Kume, T. and Akaike, A.
  • Journal Title: J. Cereb. Blood Flow Metab. 28 Pages: 506-515
  • NAID: 120002468476
  • Peer Reviewed
• [Journal Article] Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine (2008)
  • Author(s): Akasofu, S., Sawada, K., Kosasa, T., Hihara, H., Ogura, H. and Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 588 Pages: 189-197
  • Peer Reviewed
• [Journal Article] DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. (2008)
  • Author(s): Yanagisawa, D., Kitamura. Y., Inden, M., Takata, K., Taniguohi, T., Morikawa. S., Morita. M., Inubushi, T., Tooyama, I., Taira, T., Iguchi-Ariga, M. S., Akaike, A., Ariga, H.
  • Journal Title: J. Cereb. Blood Flow Metab. 28 Pages: 563-578
  • Peer Reviewed
• [Journal Article] Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by α-and ε-secretase. (2008)
  • Author(s): Takahashi, K., Niidome, T., Akaike, A., Kihara, T., Sugimoto, H.
  • Journal Title: Biochem. Biophys. Res. Commun. 377 Pages: 544-549
  • Peer Reviewed
• [Journal Article] Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil. (2008)
  • Author(s): Takada-Takatori, Y., Kume, T., Ohgi, Y., Izumi, Y., Niidome, T., Fujii, T., Sugimoto, H., Akaike, A.
  • Journal Title: J. Neurosci. Res. 86 Pages: 3575-3583
  • Peer Reviewed
• [Journal Article] Three destinct neuroprotective functions of myrioetin against glutamate-induced neuronal cell death : involvement of direct inhibition of caspase-3. (2008)
  • Author(s): Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., Sugimoto, H.
  • Journal Title: J. Neurosci. Res. 86 Pages: 1836-1845
  • Peer Reviewed
• [Journal Article] Multifunction of myricetln on Ab : neuroprotection via a conformational change of Ab and reduction of Ab via the interference of secretases. (2008)
  • Author(s): Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., Sugimoto, H.
  • Journal Title: J. Neurosci. Res. 86 Pages: 368-377
  • Peer Reviewed
• [Journal Article] Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. (2008)
  • Author(s): Osakada, F., Ikeda, H., Mandai, M., Wataya, T., Watanabe, K., Yoshimura, N., Akaike, A., Sasai, Y., Takahashi, M.
  • Journal Title: Nature Biotechnol. 26 Pages: 215-352
  • Peer Reviewed
• [Journal Article] Bromocriptine, a dopamineD2 receptor agonist with the structure of the amino acid ergot alkaloids, induces neurite outgrowth in PC12 cells. (2008)
  • Author(s): Oda, T., Kume, T. Izumi, Y., Takada-Takatori, Y., Nlidome, T., Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 598 Pages: 27-31
  • Peer Reviewed
• [Journal Article] α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3β. (2008)
  • Author(s): Nishimoto, T., Kihara, T., Akaifce, A., Niidome, T., Sugimoto, H.
  • Journal Title: J. Neurosci. Res. 86 Pages: 1096-1105
  • Peer Reviewed
• [Journal Article] Differential regulation of neurogenesis in two neurogenic regions of APPswe/PSldE9 transgenic mice. (2008)
  • Author(s): Niidome, T., Taniuchi, N., Akaike, A., Kihara, T., Sugimoto, H.
  • Journal Title: Neuroreport 19 Pages: 1361-1364
  • Peer Reviewed
• [Journal Article] A molecular pathway involved in the generation of microtubule associated protein 2-positive cells from microglia. (2008)
  • Author(s): Niidome, T., Matsuda, S., Nonaka, H., Akaike, A., Kihara, T., Sugimoto, H.
  • Journal Title: Biochemical and Biophysical Research Communications 370 Pages: 184-188
  • Peer Reviewed
• [Journal Article] Protective effect of serofendic acid on ischemic injury induced by occlusion of the middle cerebral artery in rats. (2008)
  • Author(s): Nakamura, T., Kume, T., Katsuki, H., Niidome, T., Sugimoto, H., Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 586 Pages: 151-155
  • Peer Reviewed
• [Journal Article] Microtubule-associated protein 2-positive cells derived from microglia possess properties of functional neurons. (2008)
  • Author(s): Matsuda, S., Niidome, T., Nonaka, H., Goto, Y., Fujiraura, K., Kato, M., Nakanishi, M., Akaike, A., Kihara, T., Sugimoto, H.
  • Journal Title: Biochem. Biophys. Res, Gommun. 368 Pages: 971-976
  • Peer Reviewed
• [Journal Article] Regulation of intracellular dopamine levels by dopaminergic drugs : involvement of vesicular monoamine transporter. (2008)
  • Author(s): Izumi, Y., Yamamoto, N., Kume, T., Katsuki, H., Sawada, H., Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 582 Pages: 52-61
  • Peer Reviewed
• [Journal Article] Chloride-dependent acute excitotoxicity in adult rat retinal ganglion cells. (2008)
  • Author(s): Hama, Y., Katsuki, H., Suminaka, C., Kume, T., Akaike, A.
  • Journal Title: Neuropharm. 55 Pages: 677-686
  • Peer Reviewed
• [Journal Article] Impaired muscarlnic regulation of excitatpry synaptic transmission in the APPswe/PSldE9 mouse model of Alzheimer's disease. (2008)
  • Author(s): Goto, Y., Niidome, T., Hongo, H., Akaike, A., Kihara, T., Sugiaoto, H.
  • Journal Title: Eur. J. Pharmacol. 583 Pages: 84-91
  • Peer Reviewed
• [Journal Article] Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats. (2008)
  • Author(s): Fujimoto, S., Katsuki, H., Ohnishi, M., Takagi, M., Kume T, Akaike, A.
  • Journal Title: J Cereb. Blood Flow Metab. 28 Pages: 506-515
  • NAID: 120002468476
  • Peer Reviewed
• [Journal Article] Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to vratridine. (2008)
  • Author(s): Akasofu, S., Sawada, K., Kosasa, T., Hihara, H., Ogura, H., Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 588 Pages: 189-197
  • Peer Reviewed
• [Journal Article] 薬学OSCEでの患者応対課題における評価方法に関する検討 (2008)
  • Author(s): 窪田愛恵, 矢野義孝, 森本剛, 高田香織, 蔵本伸生, 関進, 前田祐子, 赤池昭紀, 平出敦
  • Journal Title: 医療薬学 34 Pages: 1004-1010
  • NAID: 110006987284
• [Journal Article] Multifunction of myricetin on Abeta: neuroprotection via a conformational change of Abeta and reduction of Abeta via the interference of secretases (2008)
  • Author(s): Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T. and Sugimoto, H.
  • Journal Title: J. Neurosci. Res. 86 Pages: 368-377
  • Peer Reviewed
• [Journal Article] Plasminogen potentiates thrombin cytotoxicity and contributes to pathology of intracerebral hemorrhage in rats (2008)
  • Author(s): Fujimoto, S., Katsuki, H., Ohnishi, M., Takagi, M., Kume, T. and Akaike, A.
  • Journal Title: J. Cereb. Blood Flow Metab 28 Pages: 506-515
  • NAID: 120002468476
  • Peer Reviewed
• [Journal Article] alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate attenuates glutamate-induced caspase-3 cleavage via regulation of glycogen synthase kinase 3beta (2008)
  • Author(s): Nishimoto, T., Kihara, T., Akaike, A., Niidome, T. and Sugimoto, H.
  • Journal Title: J. Neurosci. Res. 86 Pages: 1096-1105
  • Peer Reviewed
• [Journal Article] Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress (2007)
  • Author(s): Yamamoto, N., Sawada, H., Izumi, Y., Kume, T., Katsuki, H., Shimohama, S. and Akaike, A.
  • Journal Title: J. Biol. Chem. 282 Pages: 4364-4372
  • Peer Reviewed
• [Journal Article] Wnt signaling promotes regeneration in the retina of adult mammals (2007)
  • Author(s): Osakada, F., Ooto, S., Akagi, T., Mandai, M., Akaike, A. and Takahashi, M.
  • Journal Title: J. Neurosci. 27 Pages: 4210-4219
  • Peer Reviewed
• [Journal Article] Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults (2007)
  • Author(s): Okawara, M., Katsuki, H., Kurimoto, E., Shibata, H., Kume, T. and Akaike, A.
  • Journal Title: Biochem. Pharmacol. 73 Pages: 550-560
  • NAID: 120002468473
  • Peer Reviewed
• [Journal Article] Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury (2007)
  • Author(s): Ohnishi, M., Katsuki, H., Fujimoto, S., Takagi, M., Kume, T. and Akaike, A.
  • Journal Title: Experimental Neurology 206 Pages: 43-52
  • NAID: 120002468474
  • Peer Reviewed
• [Journal Article] Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells (2007)
  • Author(s): Oda, T., Kume, T., Katsuki, H., Niidome, T., Sugimoto, H. and Akaike, A.
  • Journal Title: J. Pharmacol. Sci. 104 Pages: 349-354
  • NAID: 10024315249
  • Peer Reviewed
• [Journal Article] Contribution of endogenous glycine and D-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures (2007)
  • Author(s): Katsuki, H., Watanabe, Y., Fujimoto, S., Kume, T. and Akaike, A.
  • Journal Title: Life Sci. 81 Pages: 740-749
  • Peer Reviewed
• [Journal Article] Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity (2007)
  • Author(s): Izumi, Y., Sawada, H., Yamamoto, N., Kume, T., Katsuki, H., Shimohama, S. and Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 557 Pages: 132-140
  • Peer Reviewed
• [Journal Article] Thrombin induces striatal Neurotoxicity depending on mitogen-activated protein kinase pathways in vivo (2007)
  • Author(s): Fujimoto, S., Katsuki, H., Ohnishi, M., Takagi, M., Kume, T. and Akaike, A.
  • Journal Title: Neurosci. 144 Pages: 694-701
  • NAID: 120002468472
  • Peer Reviewed
• [Journal Article] Serofendic Acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection (2007)
  • Author(s): Akao, M., Takeda, T., Kita, T., Kume, T. and Akaike, A.
  • Journal Title: Cardiovasc Drug Rev. 25 Pages: 333-341
  • Peer Reviewed
• [Journal Article] Serofendic Acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection (2007)
  • Author(s): Akao, M., Takeda, T., Kita, T., Kume, T. and Akaike,
  • Journal Title: Cardiovasc Drug Rev. 25 Pages: 333-341
  • Peer Reviewed
• [Journal Article] Synthesis and pharmacological profile of serofendic acids A and B. (2007)
  • Author(s): Terauchi, T., Asai, N., Doko, T., Taguchi, R., Takenaka, O., Sakurai, H., Yonaga, M., Kimura, T., Kajiwara, A., Niidome, T., Kume, T., Akaike, A. and Sugimoto, H.
  • Journal Title: Bioorg. Med. Chem. 15 Pages: 7098-7107
  • Peer Reviewed
• [Journal Article] Decreased proliferation of hippocampal progenitor cells in APPswe/PSldE9 transgenic mice. (2007)
  • Author(s): Taniuchi, N., Niidome, T., Goto, Y., Akaike, A., Kihara, T. and Sugimoto, H.
  • Journal Title: Neuroreport 18 Pages: 1801-1805
  • Peer Reviewed
• [Journal Article] Contribution of endogenous glycine and D-serine to excitotoxic and ischemic cell death in rat cerebrocortical slice cultures. (2007)
  • Author(s): Katsuki, H., Watanabe, Y., Fujimoto, S., Kume, T. and Akaike, A.
  • Journal Title: Life Sci. 81 Pages: 740-749
  • Peer Reviewed
• [Journal Article] Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury. (2007)
  • Author(s): Ohnishi, M., Katsuki, H., Fujimoto, S., Takagi, M., Kume, T. and Akaike, A.:
  • Journal Title: Experimental Neurology 206 Pages: 43-52
  • NAID: 120002468474
  • Peer Reviewed
• [Journal Article] DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. (2007)
  • Author(s): Yanagisawa, D., Kitamura, Y., Inden, M., Takata, K., Taniguchi, T., Morikawa, S., Morita, M., Inubushi, T., Tooyama, I, , Taira, T., Iguchi-Ariga, M. S., Akaike, A. and Ariga, H.
  • Journal Title: J. Cereb. Blood Flow Metab. 28 Pages: 563-578
  • Peer Reviewed
• [Journal Article] Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells. (2007)
  • Author(s): Oda, T., Kume, T., Katsuki, H., Niidome, T., Sugimoto, H. and Akaike, A.
  • Journal Title: J. Pharmacol. Sci. 104 Pages: 349-354
  • NAID: 10024315249
  • Peer Reviewed
• [Journal Article] Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity. (2007)
  • Author(s): Niidome, T., Takabashi, K., Goto, Y., Goh, S., Tanaka, N., Kamei, K., Ichida, M., Hara, S., Akaike, A., Kihaza, T. and Sugimoto, H.
  • Journal Title: Neuroreport 18 Pages: 813-816
  • Peer Reviewed
• [Journal Article] Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. (2007)
  • Author(s): Nakanishi, M., Niidome, T., Matsuda, S., Akaike, A., Kihara, T. and Sugimoto, H.
  • Journal Title: Eur. J. Neurosci. 25 Pages: 649-658
  • Peer Reviewed
• [Journal Article] Wnt signaling promotes regeneration in the retina of adult mammals. (2007)
  • Author(s): Osakada, F., Ooto, S., Akagi, T., Mandai, M., Akaike, A. and Takahashi, M.
  • Journal Title: J. Neurosci. 27 Pages: 4210-4219
  • Peer Reviewed
• [Journal Article] Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. (2007)
  • Author(s): Okawara, M., Katsuki, H., Kurimoto, E., Shibata, H., Kume, T. and Akaike, A.
  • Journal Title: Biochem. Pharmacol. 73 Pages: 550-560
  • NAID: 120002468473
  • Peer Reviewed
• [Journal Article] Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress. (2007)
  • Author(s): Yamamoto, N., Sawada, H., Izumi, Y., Kume, T., Katsuki, H., Shimohama, S., Akaike, A.
  • Journal Title: J. Biol. Chem. 282 Pages: 4364-4372
  • Peer Reviewed
• [Journal Article] Thrombin induces striatal Neurotoxicity depending on mitogen-activated protein kinase pathways in vivo. (2007)
  • Author(s): Fujimoto, S., Katsuki, H., Ohnishi, M., Takagi, M., Kume, T. and Akaike, A.
  • Journal Title: Neuroscience 144 Pages: 694-701
  • NAID: 120002468472
  • Peer Reviewed
• [Journal Article] Novel neuroprotective mechanisms of pramipexole, an anti-Parkinsondrug, against endogenous dopamine-mediated excitotoxicity. (2007)
  • Author(s): Izumi, Y., Sawada, H., Yamamoto, N., Kume, T., Katsuki, H., Shimohama, S., Akaike, A.
  • Journal Title: Eur. J. Pharmacol. 557 Pages: 132-140
  • Peer Reviewed
• [Presentation] ドネペジル慢性処置による神経保護作用の感受性上昇機序 (2008)
  • Author(s): 高鳥悠記, 久米利明, 大木雄太, 泉安彦, 新留徹広, 藤井健志, 岡部進, 杉本八郎, 赤池昭紀
  • Organizer: 第2回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2008-12-20
• [Presentation] 培養大脳皮質細胞におけるグルタミン酸神経毒性に対する pitavastatin の保護作用 (2008)
  • Author(s): 大木雄太, 泉安彦, 久米利明, 赤池昭紀
  • Organizer: 第2回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2008-12-20
• [Presentation] 培養大脳皮質細胞におけるグルタミン酸神経毒性に対するpitavastatinの保護作用 (2008)
  • Author(s): 大木雄太, 泉安彦, 久米利明, 赤池昭紀
  • Organizer: 第2回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2008-12-20
• [Presentation] 培養神経細胞における果汁・野菜エーテル抽出物の酸化ストレスに対する作用の検討 (2008)
  • Author(s): 武藤千恵, 水野景太, 久米利明, 泉安彦, 赤池昭紀
  • Organizer: 第114回日本薬理学会近畿部会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] Serofendic acid protects ischemic injury by occlusion of the middle cerebral artery in rats (2008)
  • Author(s): Kume, T., Nakamura, T., Izumi, Y. and Akaike, A
  • Organizer: The 19^<th> Korea-Japan Joint Seminar on Pharmacology
  • Place of Presentation: Busan, Korea
  • Year and Date: 2008-11-07
• [Presentation] Serofendic acid protects ischemic injury by occlusion of the middle cerebral artery in rats. (2008)
  • Author(s): Kume, T., Nakamura, T., Izumi, Y., Akaike, A.
  • Organizer: The 19th Korea-Japan Joint Seminar on Pharmacology
  • Place of Presentation: Busan, Korea
  • Year and Date: 2008-11-07
• [Presentation] Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection (2008)
  • Author(s): Akaike, A., Kume, T., Izumi, Y. and Takada-Takatori, Y
  • Organizer: XIII International Symposium on Cholinergic Mechanisms
  • Place of Presentation: Foz do Iguasu, Brazil
  • Year and Date: 2008-08-20
• [Presentation] Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors : role of alpha4 and alpha7 receptors in neuroprotection. (2008)
  • Author(s): Akaike, A., Kurae, T., Izumi, Y., Takada-Takatori, Y.
  • Organizer: XIII International Symposium on Cholinergic Mechanisms
  • Place of Presentation: Foz do Iguasu, Brazil
  • Year and Date: 2008-08-20
• [Presentation] 薬学教育モデル・コアカリキュラムと国家試験 (2008)
  • Author(s): 赤池昭紀
  • Organizer: 医療薬学フォーラム2008-第16回クリニカルファーマシーシンポジウム-
  • Place of Presentation: 東京都
  • Year and Date: 2008-07-13
• [Presentation] 培養アストロサイトのα7ニコチン受容体のニューロンとの相互作用による発現制御 (2008)
  • Author(s): 久米利明, 森本典子, 泉安彦, 赤池昭紀
  • Organizer: Neuroscience 2008 第31回日本神経科学大会(The 31st Annual Meeting of tha Japan Neuroscience Society)
  • Place of Presentation: 東京都
  • Year and Date: 2008-07-09
• [Presentation] 培養アストロサイトのa7ニコチン受容体のニューロンとの相互作用による発現制御 (2008)
  • Author(s): 久米利明, 森本典子, 泉安彦, 赤池昭紀
  • Organizer: Neuroscience 2008 第31回日本神経科学大会The 31st Annual Meeting of tha Japan Neuroscience
  • Place of Presentation: 東京都
  • Year and Date: 2008-07-09
• [Presentation] Na^+/Ca<2+> exchanger 阻害薬による PC12 細胞における NGF 誘発性神経突起伸長の抑制 (2008)
  • Author(s): 小田徹, 久米利明, 泉安彦, 赤池昭紀
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Presentation] Na +/Ca^<2+> exchanger阻害薬によるPC12細胞におけるNGF誘発性神経突起伸長の抑制 (2008)
  • Author(s): 小田徹, 久米利明, 泉安彦, 赤池昭紀
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: 岡山
  • Year and Date: 2008-06-20
• [Presentation] Heme oxygenase-1 is degraded by ubiquitin-proteasome system and related to neuroprotective role (2008)
  • Author(s): Yamamoto, N., Izumi, Y., Kato, F., Kume, T., Sawada, H. and Akaike, A
  • Organizer: The 4th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-04-24
• [Presentation] Heme oxygenase-1 is degraded by ubiquitin-proteasome system and related to neuroprotective role. (2008)
  • Author(s): Yamamoto, N., Izumi, Y., Kato, F., Kume, T., Sawada, H.
  • Organizer: The 4th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-04-24
• [Presentation] 出血性脳障害におけるポリアミン類の関与 (2008)
  • Author(s): 高木美佳子, 香月博志, 藤本真二, 大西正俊, 久米利明, 赤池昭紀
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-28
• [Presentation] 酸化ストレスに対するイソチオシアネート類の神経保護作用機序 (2008)
  • Author(s): 水野景太, 久米利明, 武藤千恵.泉安彦, 赤池昭紀
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-27
• [Presentation] ユビキチン-プロテアソーム系の heme oxygenase-1 の分解への寄与:神経保護作用との関係 (2008)
  • Author(s): 山本憲幸, 泉安彦, 加藤文彦, 久米利明, 澤田秀幸, 赤池昭紀
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] ユビキチン-プロテアソーム系のheme oxygenase-1の分解への寄与:神経保護作用との関係 (2008)
  • Author(s): 山本憲幸, 泉安彦, 加藤文彦, 久米利明, 澤田秀幸, 赤池昭紀
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] FlavonoidのAbeta産生酵素BACE-1(beta-secretase)に対する阻害メカニズム (2008)
  • Author(s): 新名芳有, 木原武士, 赤池昭紀, 新留徹広, 杉本八郎
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-18
• [Presentation] ドネペジル慢性処置した大脳皮質ニューロンにおける低濃度ドネペジル前処置の神経保護作用機序 (2008)
  • Author(s): 高鳥悠記, 久米利明, 大木雄太, 新留徹広, 藤井健志, 岡部進, 杉本八郎, 赤池昭紀
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] 酸化ストレスに対するイソチオシアネート類の神経保護作用機序 (2008)
  • Author(s): 水野景太, 久米利明, 武藤千恵, 泉安彦, 赤池昭紀
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] グルタミン酸誘発ニューロン死に対する sulforaphane の神経保護作用機序 (2008)
  • Author(s): 久米利明, 高田宜則, 水野景太, 赤池昭紀
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] グルタミン酸誘発ニューロン死に対するsulforaphaneの神経保護作用機序 (2008)
  • Author(s): 久米利明, 高田宜則, 水野景太, 赤池昭紀
  • Organizer: 第81回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-17
• [Presentation] 神経細胞死を制御する内在性保護因子と低分子化合物 (2008)
  • Author(s): 赤池昭紀
  • Organizer: 第7回福岡大学高機能物質研究所研究成果報告会
  • Place of Presentation: 福岡
  • Year and Date: 2008-01-23
• [Presentation] イソチオシアネート類の中枢ニューロンにおける酸化的障害への有効性 (2007)
  • Author(s): 水野景太, 久米利明, 武藤千恵, 泉安彦, 赤池昭紀
  • Organizer: 第1回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-12-16
• [Presentation] Heme oxygenase-1のユビキチン-プロテアソーム系による分解制御と神経保護効果 (2007)
  • Author(s): 山本憲幸, 泉安彦, 加藤文彦, 久米利明, 澤田秀幸, 赤池昭紀
  • Organizer: 第1回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-12-15
• [Presentation] PC12細胞におけるブロモクリプチンの神経突起伸長作用 (2007)
  • Author(s): 小田徹, 久米利明, 泉安彦, 赤池昭紀
  • Organizer: 第112回日本薬理学会近畿部会
  • Place of Presentation: 大阪
  • Year and Date: 2007-11-16
• [Presentation] グルタミン酸誘発ドパミンニューロン死における内在性ドパミンの関与 (2007)
  • Author(s): 泉安彦, 澤田秀幸, 山本憲幸, 久米利明, 香月博志, 赤池昭紀
  • Organizer: Neuro2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-09-10
• [Presentation] 脱分極性刺激あるいは発火抑制による視床下部オレキシンニューロンの選択的消失 (2007)
  • Author(s): 黒須真介, 香月博志, 久米利明, 赤池昭紀
  • Organizer: 第111回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
• [Presentation] Cl-流入に依存した興奮毒性による網膜神経節細胞死 (2007)
  • Author(s): 浜康博, 香月博志, 角中ちひろ, 久米利明, 赤池昭紀
  • Organizer: 第111回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
• [Presentation] C1-流入に依存した興奮毒性による網膜神経節細胞死 (2007)
  • Author(s): 浜康博, 香月博志, 角中ちひろ, 久米利明, 赤池昭紀
  • Organizer: 第111回日本薬理学会近畿部会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-15
• [Presentation] 中脳ドパミンニューロンの炎症性変性における NO の役割 (2007)
  • Author(s): 香月博志, 赤池昭紀
  • Organizer: 第7回日本NO学会学術集会
  • Place of Presentation: 大津市
  • Year and Date: 2007-05-17
• [Presentation] 培養大脳皮質ニューロンにおける sulforaphane の神経保護作用 (2007)
  • Author(s): 久米利明, 高田宜則, 水野景太, 香月博志, 赤池昭紀
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-09
• [Presentation] 培養大脳皮質ニューロンにおけるsulforaphaneの神経保護作用 (2007)
  • Author(s): 久米利明, 高田宜則, 水野景太, 香月博志, 赤池昭紀
  • Organizer: 日本ケミカルバイオロジー研究会 第2回年会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-09
• [Book] 最新薬物治療学 第8章 血液および造血器疾患第10章感覚器疾患 (2008)
  • Author(s): 赤池昭紀, 石井邦雄, 越前宏俊, 金子周司, 他16名
  • Publisher: 廣川書店
• [Book] 内在性グリシン結合部位リガンドによるNMDA誘発網膜障害の制御 (2007)
  • Author(s): 香月博志, 赤池昭紀, 浜康博, 渡辺佳典
  • Publisher: 眼薬理
• [Book] 科学英語論文作成・投稿の基礎知識 (2007)
  • Author(s): 赤池昭紀, 木村喜代史, FOONG, A. F.
  • Total Pages: 221
  • Publisher: イメックスジャパン株式会社
• [Book] 薬科学大辞典第4版 (2007)
  • Author(s): 木村邦彦, 赤池昭紀, 他46名
  • Total Pages: 2364
  • Publisher: 廣川書店