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Development of serum tumor markers by using antibodies generated by Top-Down screening strategy

Research Project

Project/Area Number 19390158
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionKitasato University

Principal Investigator

MAEDA Tadakazu  Kitasato University, 理学部, 教授 (90265728)

Co-Investigator(Kenkyū-buntansha) SATO Yuichi  北里大学, 医療衛生学部, 准教授 (30178793)
BABA Shiro  北里大学, 医学部, 教授 (00051889)
MATSUMOTO Kazumasa  北里大学, 医学部, 講師 (70306603)
KODERA Yoshio  北里大学, 理学部, 准教授 (60265733)
野崎 直仁  神奈川歯科大学, 歯学部, 講師 (70222198)
Co-Investigator(Renkei-kenkyūsha) NOZAKI Naohito  神奈川歯科大学, 歯学部, 講師 (70222198)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2008: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2007: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords臨床検査医学 / ランダム免疫 / 抗体 / 診断法 / 膀胱癌 / 血清
Research Abstract

ヒト腫瘍部位の組織もしくは樹立癌細胞株から取得したタンパク質混合物をそのままマウスに免疫し、取り出した脾細胞に対して常法に従い細胞融合し、限界希釈法を経てモノクローナル抗体を獲得する(ランダム免疫法)。我々の最終目的は低侵襲性で患者への負担の少ない体液(血液、尿)を対象とした癌診断法の確立である。本研究ではランダム免疫法で獲得した抗体について、免疫ブロットならびに組織染色によって、有用抗体を評価した

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (81 results)

All 2009 2008 2007 Other

All Journal Article (38 results) (of which Peer Reviewed: 38 results) Presentation (34 results) Patent(Industrial Property Rights) (9 results) (of which Overseas: 2 results)

  • [Journal Article] A simple and highly reproducible method for discovering potential disease markers in low abundance serum proteins2009

    • Author(s)
      Kawashima, Y., Fukuno T., Satoh M., Takahashi H., Matsui T., Maeda T., and Kodera Y.
    • Journal Title

      J. Electrophoresis 57

      Pages: 13-18

    • NAID

      10025191974

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hoffman RM. Human and mouse hair follicles contain both multipotent and monopotent stem cells2009

    • Author(s)
      Amoh Y, Sato Y, Katsuoka K(他3名)
    • Journal Title

      Cell Cycle 8

      Pages: 1-2

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human and mouse hair follicles contain both multipotent and monopotent stem cells.2009

    • Author(s)
      Amoh Y, Kanoh M, Niiyama S, Kawahara K, Sato Y, Katsuoka K, Hoffman RM
    • Journal Title

      Cell Cycle 8

      Pages: 1-2

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the hair stem cell-specific Marker nestin in epithelial and follicular tumors2008

    • Author(s)
      Kanoh M,Amoh Y, Sato Y, Katsuoka K.
    • Journal Title

      Eur J Dermatol 18(5)

      Pages: 518-523

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of tumor-specific autoantibodies in sera of patients with lung cancer2008

    • Author(s)
      Nagashio R, Sato Y, Jiang Shi-Xu Ryuge S, Kodera Y, Maeda T, Nakajima T.
    • Journal Title

      Lung Cancer 62

      Pages: 364-373

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MAGE-A protein and MAGE-A10 gene expression in liver metastasis in patients with stomach cancer2008

    • Author(s)
      Suzuki S, Sato Y, Tsukui T(他5名)
    • Journal Title

      Br J Cancer 99

      Pages: 350-356

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A lymphatic vessel network in normal urothelium of the urinary bladder2008

    • Author(s)
      Matsumoto K, Soh S, Satoh T, Iwamura M, Ishikawa Y, Ishii T, Baba S.
    • Journal Title

      Urology 12

      Pages: 706-710

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in molecular markers for bladder cancer2008

    • Author(s)
      Matsumoto K, Matsushita K, Baba S (他5名)
    • Journal Title

      Res Adv in Urol 1

      Pages: 1-17

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Loss expression of uroplakin III is associated with clinicopathological features of aggressive bladder cancer2008

    • Author(s)
      Matsumoto K, Baba S (他5名)
    • Journal Title

      Urology 72

      Pages: 444-449

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein Carbonyl Detection by Two-Dimensional Fluorescence Difference Gel Electrophoresis2008

    • Author(s)
      Sawada A., Kodera Y. and Maeda T.(他4名)
    • Journal Title

      J. Electrophoresis 52

      Pages: 1-17

    • NAID

      10024175202

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Searching for new biomarkers of bladder cancer based on proteomic analysis2008

    • Author(s)
      Okusa H., Kodera Y., Oh-ishi M., Minamida M., Tsuchida M., Kavoussi N., Matsumoto K., Sato T., Iwamura M., Maeda T. and Baba S.
    • Journal Title

      J. Electrophoresis 52

      Pages: 19-24

    • NAID

      10024175227

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel immunohistochemical tumor markers for primary hepatocellular carcinoma ; clathrin heavy chain and formiminotransferase cyclodeaminase2008

    • Author(s)
      Seimiya M., Kodera Y., Maeda T., Nomura F.(他11名)
    • Journal Title

      Hepatology 48

      Pages: 519-530

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of tumor-specific autoantibodies in sera of patients with lung cancer2008

    • Author(s)
      Nagashio R, Sato Y, Jiang SX, Ryuge S, Kodera Y, Maeda T, Nakajima T.
    • Journal Title

      Lung Cancer 62

      Pages: 364-73

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disease proteomics of endocrine disorders revealed by two-dimensional gel electrophoresis and mass spectrometry2008

    • Author(s)
      Oh-Ishi M, Kodera Y, Furudate S, Maeda T.
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 327-337

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MAGE-A protein and MAGE-A10 gene expression in liver metastasis in patients with stomach cancer.2008

    • Author(s)
      Suzuki s, Sasajima K, Sato Y, Watanabe H, Matsutani T, Iida S, Hosone M, Tsukui T, Maeda S, Shimizu K, Tajiri T
    • Journal Title

      Br J Cancer 99

      Pages: 350-356

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the hair stem cell specific marker 'nestin' in epidermal and follicular tumors2008

    • Author(s)
      Kanoh M, Amoh Y, Sato Y, Katsuoka K
    • Journal Title

      Eur J Dermatol 18

      Pages: 518-523

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in molecular markers for bladder cancer.2008

    • Author(s)
      Matsumoto K, Okusa Y, Ishikawa W, Matsushita K, Tabata K, Satoh T, Iwamura M, Baba S.
    • Journal Title

      Res Adv in Urol 1

      Pages: 1-17

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss expression of uroplakin III is associated with clinicopathological features of aggressive bladder cancer.2008

    • Author(s)
      Matsumoto K, Satoh, T, Me A, Ishii J, Kuwao S, Iwamura M, Baba S.
    • Journal Title

      Urology : 72

      Pages: 444-449

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A lymphatic vessel network in normal urothelium of the urinary bladder2008

    • Author(s)
      Matsumoto K, Soh S, Satoh T, Iwamura M, Ishikawa Y, Ishii T, Baba S.
    • Journal Title

      Urology 72

      Pages: 706-710

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Searching for new biomarkers of bladder cancer based on proteomic analysis.2008

    • Author(s)
      Okusa H., Kodera Y., Oh-ishi M., Minamida M., Tsuchida M., Kavoussi N., Matsumoto K, Sato T., Iwamura M., Maeda T., Baba S.
    • Journal Title

      J. Electropboresis 52

      Pages: 19-24

    • NAID

      10024175227

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease proteomics of endocrine disorders revealed by two-dimensional gelelectrophoresis and mass spectrometry2008

    • Author(s)
      Oh-Ishi M., Kodera Y., Furudate S., Maeda T.
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 327-337

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel immunohistochemical tumor markers for primary hepatocellular carcinoma ; clathrin heavy chain and formiminotransferase cyclodeaminase.2008

    • Author(s)
      Seimiya M., Tomonaga T., Matsushita K, Sunaga M., Oh-ishi M., Kodera Y., Maeda T., Takano S, Togawa A., Yoshitomi H., Otsuka M., Yamamoto M., NakanoM, Miyazaki M., Nomura F
    • Journal Title

      Hepatology 48

      Pages: 519-530

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Carbonyl Detection by Two-Dimensional Fluorescence Difference Gel Electrophoresis2008

    • Author(s)
      Sawada A., Ueno T., Kawashima Y., Haruta-Satoh E., Oh-Ishi M., Kodera Y., Maeda M.
    • Journal Title

      J. Electrophoresis 52

      Pages: 9-17

    • NAID

      10024175202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of tumor-specific autoantibodies in sera of patients with lung cancer.2008

    • Author(s)
      Nagashio R, Sato Y, Jiang SX, Ryuge S, Kodera Y, Maeda T, Nakaiima T.
    • Journal Title

      Lung Cancer. Dec 62

      Pages: 346-373

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Searching for new biomarkers of bladder cancer based on proteomic analysis.2008

    • Author(s)
      Okusa H., Kodera Y., Oh-ishi M., Minamida M., Tsuchida M., Kavoussi N., Matsumoto K., Sato T., Iwamura M., Maeda T.and Baba S.
    • Journal Title

      J.Electrophoresis 52

      Pages: 19-24

    • NAID

      10024175227

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein Carbonyl Detection by Two-Dimensional Fluorescence Difference Gel Electrophoresis2008

    • Author(s)
      Sawada A., Ueno T., Kawashima Y., Haruta-Satoh E., Oh-Ishi M., Kodera Y. and Maeda M.
    • Journal Title

      J.Electrophoresis 52

      Pages: 9-17

    • NAID

      10024175202

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disease proteomics of endocrine disorders revealed by two-dimensional gel electrophoresis and mass spectrometry2008

    • Author(s)
      Oh-Ishi M., Kodera Y., Furudate S., Maeda T.
    • Journal Title

      Proteomics Clin Appl 2

      Pages: 327-337

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of S100A2 and S100A4 predicts disease progression and patient survival in bladder cancer2007

    • Author(s)
      Matsumoto K, Baba S.(他6名)
    • Journal Title

      Urology 70

      Pages: 602-607

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gemcitabine and paclitaxel chemotherapy as a second-line treatement for advanced transitionalcell carcinoma2007

    • Author(s)
      Matsumoto K, Irie A, Satoh T, Okazaki M, Iwamura M, Baba S.
    • Journal Title

      Int J Urol 14

      Pages: 1000-1004

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural role of the secondary active domain of HIV-2 NCp8 in multi-functionality. Biochem2007

    • Author(s)
      Matsui T., Kodera Y., Maeda T. (他6名)
    • Journal Title

      Biophys. Res. Commun 678

      Pages: 373-678

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] RNA Recognition Mechanism of the Minimal Active Domain of the Human Immunodeficiency Virus Type-2 Nucleocapsid Protein2007

    • Author(s)
      Matsui T., Kodera Y., and Maeda T.(他6名)
    • Journal Title

      J Biochem 141

      Pages: 269-277

    • NAID

      10020101562

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of biomarkers for alcoholism by two-dimensional differential gel electrophoresis2007

    • Author(s)
      Wu D, Kodera Y, Maeda T, Nomura F.(他7名)
    • Journal Title

      Alcohol Clin Exp Res. 31

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural role of the secondary active domain of HIV-2 NCp8 in multi-functionality2007

    • Author(s)
      Matsui T., Kodera Y., Miyauchi E., Tanaka H., Endoh H., Komatsu H., Tanaka T., Kohno T., Maeda T.
    • Journal Title

      Biochem.Biophys.Res.Commun. 678

      Pages: 373-378

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RNA Recognition Mechanism of the Minimal Active Domain of the Human Immunodeficiency Virus Type-2 Nucleocapsid Protein.2007

    • Author(s)
      Matsui T., Kodera Y., Endoh H., Miyauchi E, Komatsu H, Sato K., Tanaka T., Kohno, K and Maeda T
    • Journal Title

      J Biochem. 141

      Pages: 269-277

    • NAID

      10020101562

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of biomarkers for alcoholism by two-dimensional differential gel electrophoresis.2007

    • Author(s)
      Wu D, Tomonaga T, Sogawa K, Satoh M, Sunaga M, Nezu M, Oh-Ishi M, Kodera Y, Maeda T, Ochiai T, Nomura F.
    • Journal Title

      Alcohol Clin Exp Res. 31

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Search for Novel Markers of Alcohol Abuse Using Magnetic beads and MALDI-TOF /TOF Mass Spectrometry

    • Author(s)
      Sogawa K., Kodera Y., Nomura F.(他3名)
    • Journal Title

      Proteomics-Clinical applications (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] YKL-40 identified by proteomic analysis as a biomarker of sepsis

    • Author(s)
      Hattori N, Kodera Y, Sogawa K, Satoh M, Hirasawa H.(他8名)
    • Journal Title

      Shock (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] The RNA recognition mechanism of human immunodeficiency virus (HIV) type 2 NCp8 is different from that of HIV-1 NCp7

    • Author(s)
      Matsui T., Maeda M., and Kodera Y., (他9名)
    • Journal Title

      Biochemistry (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] 質量分析計を用いた診断を目指して2009

    • Author(s)
      小寺義男
    • Organizer
      第11回次世代医療システム産業化フォーラム2008(招待)
    • Place of Presentation
      大阪商工会議所
    • Year and Date
      2009-02-19
    • Related Report
      2008 Final Research Report
  • [Presentation] がんの体外診断用プローブの迅速かつ系統的開発2009

    • Author(s)
      前田忠計
    • Organizer
      第11回次世代医療システム産業化フォーラム2008
    • Place of Presentation
      大阪商工会議所
    • Year and Date
      2009-02-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 質量分析計を用いた診断を目指して2009

    • Author(s)
      小寺義男
    • Organizer
      第11回次世代医療システム産業化フォーラム2008
    • Place of Presentation
      大阪商工会議所
    • Year and Date
      2009-02-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血清中のペプチドを対象とした診断法の確立を目指して2008

    • Author(s)
      小寺義男(シンポジウム)
    • Organizer
      日本分析化学会 第217 回液体クロマトグラフィー研究懇談会
    • Place of Presentation
      東京理科大学
    • Year and Date
      2008-11-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 血清中のペプチドを対象とした診断法の確立を目指して2008

    • Author(s)
      小寺義男
    • Organizer
      日本分析化学会第217回液体クロマトグラフィー研究懇談会
    • Place of Presentation
      東京理科大学
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 特別講演 : 北里大学での疾患プロテオミクスの歩み、これまでとこれから Clinical Proteomics in Chiba 20082008

    • Author(s)
      前田忠計(招待)
    • Organizer
      第5回千葉疾患プロテオミクス研究会
    • Place of Presentation
      千葉
    • Year and Date
      2008-11-16
    • Related Report
      2008 Final Research Report
  • [Presentation] 北里大学での疾患プロテオミクスの歩み、これまでとこれから2008

    • Author(s)
      前田忠計
    • Organizer
      第5回千葉疾患プロテオミクス研究会
    • Place of Presentation
      千葉大学
    • Year and Date
      2008-11-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 独自のペプチド分析法による大腸癌マーカーペプチドの探索と評価2008

    • Author(s)
      小寺義男, 川島祐介, 福冨俊之, 高橋広樹, 相野谷学, 丸橋正弘, 松井崇, 平賀啓介, 曽川一幸, 朝長毅, 野村文夫, 前田忠計
    • Organizer
      日本ヒトプロテオーム機構(JHUPO)第6回大会(シンポジウム)
    • Place of Presentation
      大阪府茨木市
    • Year and Date
      2008-07-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 独自のペプチド分析法による大腸癌診断マーカーペプチドの探索と評価2008

    • Author(s)
      小寺義男, 川島祐介, 福冨俊之, 高橋広樹, 相野谷学, 丸橋正弘, 松井崇, 平賀啓介, 曽川一幸3, 朝長毅, 野村文夫, 前田忠計
    • Organizer
      日本ヒトプロテオーム機構第6回大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 量子ドット技術を用いた複数のタンパク質翻訳後修飾の同時検出2008

    • Author(s)
      大石正道, 小寺義男, 前田忠計
    • Organizer
      日本ヒトプロテオーム機構(JHUPO)第6回大会(シンポジウム)
    • Place of Presentation
      大阪府茨木市
    • Year and Date
      2008-07-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 量子ドット技術を用いた複数のタンパク質翻訳後修飾の同時検出2008

    • Author(s)
      大石正道, 小寺義男, 前田忠計
    • Organizer
      日本ヒトプロテオーム機構第6回大会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 体液を対象とした診断システムの開発2008

    • Author(s)
      小寺義男
    • Organizer
      第58回日本電気泳動学会シンポジウム(シンポジウム)
    • Place of Presentation
      東京都港区
    • Year and Date
      2008-06-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 有用プロダクト創出を目指した疾患プロテオーム解析 第58 回日本電気泳動学会シンポジウム2008

    • Author(s)
      前田忠計
    • Organizer
      基礎研究から様々な応用研究へ飛躍する最先端プロテオミクス(シンポジウム)
    • Place of Presentation
      東京都港区
    • Year and Date
      2008-06-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 有用プロダクト創出を目指した疾患プロテオーム解析2008

    • Author(s)
      前田 忠計
    • Organizer
      第58回日本電気泳動学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 体液を対象とした診断システムの開発2008

    • Author(s)
      小寺 義男
    • Organizer
      第58回日本電気泳動学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Development of the basic strategy for the comparative analysis of serum proteomes and its application in thediscovery of hepatic injury biomarkers2008

    • Author(s)
      Kodera, Y., Maeda, T.(他9名)
    • Organizer
      17th Meeting of Methods in Protein Structure Analysis (MPSA2008)
    • Place of Presentation
      Sapporo
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 独自の基盤技術の確立と臨床応用可能なプロダクトの創出を目指して2008

    • Author(s)
      小寺義男
    • Organizer
      第35回BMSコンファランス(招待)
    • Place of Presentation
      裏磐梯ロイヤルホテル
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of novel serum peptidomic strategy and its application in the discovery of colon cancer tumor marker peptides2008

    • Author(s)
      Kodera, Y., Maeda, T.(他6名)
    • Organizer
      PepTalk2008
    • Place of Presentation
      San-Diego
    • Related Report
      2008 Final Research Report
  • [Presentation] Use of gel-based low molecular weight proteomic approach to discover potential biomarkers in serum2008

    • Author(s)
      Kawashima, Y., Kodera, Y., Maeda, T.(他8 名)
    • Organizer
      PepTalk2008
    • Place of Presentation
      San-Diego
    • Related Report
      2008 Final Research Report
  • [Presentation] Development of the basic strategy for the comparative analysis of serum proteomes to discover potential biomarkers2008

    • Author(s)
      Fukuno, T., Kodera, Y., Maeda, T., (他9名)
    • Organizer
      PepTalk2008
    • Place of Presentation
      San-Diego
    • Related Report
      2008 Final Research Report
  • [Presentation] 独自の基盤技術の確立と臨床応用可能なプロダクトの創出を目指して2008

    • Author(s)
      小寺 義男
    • Organizer
      第35回BMSコンファランス(BMS : Biological Mass Spectroscopy)
    • Place of Presentation
      第35回BMSコンファランス(BMS : Biological Mass Spectroscopy)
    • Related Report
      2008 Annual Research Report
  • [Presentation] HIV-2ヌクレオキャプシドタンパク質(NCp8)のRNA認識機構の解明2007

    • Author(s)
      宮内 絵美、松井 崇、遠藤 弘、川島 祐介、小松 博義、小寺 義男、前田 忠計
    • Organizer
      第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2007 Annual Research Report
  • [Presentation] 酸化傷害タンパク質の定量的蛍光検出法の開発と応用2007

    • Author(s)
      芦澤 一穂、小寺 義男、川島 祐介、澤田 晃、上野 剛、松井 崇、宮内 絵美、前田 忠計、小松 博義、佐藤 守、清宮 正徳、朝長 毅、野村 文夫
    • Organizer
      第58回日本電気泳動学会総会
    • Place of Presentation
      山口
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血清を対象とした疾患プロテオミクス2007

    • Author(s)
      高橋 広樹、小寺 義男、川島 祐介、福野 智之、松井 崇、前田 忠計、佐藤 守、清宮 正徳、小松 博義、朝長 毅、野村 文夫、
    • Organizer
      第58回日本電気泳動学会総会
    • Place of Presentation
      山口
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロテオミクスの手法を用いた膀胱癌新規マーカー探索2007

    • Author(s)
      大草 洋、松本 和将、馬場 志郎、大石 正道、小寺 義男、前田 忠計
    • Organizer
      第58回日本電気泳動学会総会
    • Place of Presentation
      山口
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] High molecular mass proteomics of human renal cell carcinoma by 2-DE using agarose gels for IEF (Agarose 2-DE) and HPLC/MS/MS HUPO 6th Annual World Congress2007

    • Author(s)
      Oh-Ishi M, Kodera Y, Baba S, Maeda T (他4名)
    • Organizer
      第6回国際ヒトプロテオーム機構年会
    • Place of Presentation
      Seoul, Korea : 韓国, ソウル
    • Year and Date
      2007-10-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Urinary proteomics of high-molecular-mass proteins by 2-DE with agarose gels in the first dimension (Agarose 2-DE) and LC-MS/MS Human Kidney & Urine Proteome Project2007

    • Author(s)
      Okusa H, Kodera Y, Kondo R, Matsumoto K, Iwamura M, Oh-Ishi M, Baba S, Maeda T
    • Organizer
      HUPO 6^<th> Annual World Congress
    • Place of Presentation
      Seoul, Korea : 韓国, ソウル
    • Year and Date
      2007-10-06
    • Related Report
      2008 Final Research Report
  • [Presentation] 大腸癌のペプチド腫瘍マーカーの開発2007

    • Author(s)
      小寺 義男、朝長 毅、野村 文夫、前田 忠計
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 質量分析計による原発注肝細胞癌血清の包括的プロテオーム解析2007

    • Author(s)
      劉 洋、須永 雅彦、曽川 一幸、佐藤 守、西村 基、根津 雅彦、小寺 義男、順良 毅、野村 文夫
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] 尿を対象としたプロテオミクスの最前線2007

    • Author(s)
      小寺 義男、大草 洋、前田 忠計、野村 文夫
    • Organizer
      第8回日本臨床検査自動化学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] ClinProt Systemを用いた血清ペプチドーム解析の基礎検討2007

    • Author(s)
      根津 雅彦、梅村 啓史、木村 明佐子、佐藤 守、小寺 義男、朝良 毅、野村 文夫
    • Organizer
      第8回日本臨床検査自動化学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 血清ペプチドーム解析用サンプル調製プロトコールの作成:MALDI-TOF MSを中心として2007

    • Author(s)
      梅村 啓史、根津 雅彦、小寺 義男、佐藤 守、木村 明佐子、朝長 毅、野村 文夫
    • Organizer
      第8回日本臨床検査自動化学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-09-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] アガロース2-DEとLC-MS/MSによるヒト腎細胞癌の疾患プロテオミクス2007

    • Author(s)
      大石 正道、二井 祥仁、小寺 義男、大草 洋、藤田 哲夫、岩村 正嗣、馬場 志郎、前田 忠計
    • Organizer
      日本ヒトプロテオーム機構第5回大会
    • Place of Presentation
      東京
    • Year and Date
      2007-07-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] 尿を対象としたプロテオミクスの最前線2007

    • Author(s)
      小寺義男(招待)
    • Organizer
      日本臨床検査自動化学会第39回大会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 大腸癌マーカーペプチド、及び大腸癌の診断2008

    • Inventor(s)
      小寺義男、川島祐介、前田忠計、朝長毅、野村文夫
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Filing Date
      2008-08-15
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 体液試料における、低分子量タンパク質及びペプチドの濃縮方法2008

    • Inventor(s)
      小寺義男、川島裕介、前田忠計
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Filing Date
      2008-08-08
    • Related Report
      2008 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 膀胱癌の診断2008

    • Inventor(s)
      松本和将、大草洋、馬場志郎、小寺義男、前田忠計
    • Industrial Property Rights Holder
      学校法人北里研究所
    • Industrial Property Number
      2008-066122
    • Filing Date
      2008-03-14
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 1. 特願2008-066122「膀胱癌の診断」2008

    • Inventor(s)
      松本和将, 大草洋, 馬場志郎, 小寺義男, 前田忠計
    • Industrial Property Rights Holder
      松本和将, 大草洋, 馬場志郎, 小寺義男, 前田忠計
    • Industrial Property Number
      2008-066122
    • Filing Date
      2008-03-14
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 膀胱癌の診断2008

    • Inventor(s)
      松本 和将、大草 洋、馬場 志郎、小寺 義男、前田 忠計
    • Industrial Property Rights Holder
      松本 和将、大草 洋、馬場 志郎、小寺 義男、前田 忠計
    • Industrial Property Number
      2008-066122
    • Filing Date
      2008-03-14
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 大腸癌マーカーペプチド、及び大腸癌の診断2007

    • Inventor(s)
      小寺義男、川島祐介、前田忠計、朝長毅、野村文夫
    • Industrial Property Rights Holder
      学校法人北里学園、国立大学法人千葉大学
    • Industrial Property Number
      2007-213211
    • Filing Date
      2007-08-18
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 体液試料における、低分子量タンパク質及びペプチドの濃縮方法2007

    • Inventor(s)
      小寺義男、川島裕介、前田忠計
    • Industrial Property Rights Holder
      学校法人北里学園
    • Industrial Property Number
      2007-206602
    • Filing Date
      2007-08-08
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 体液試料における、低分子量タンパク質及びペプチドの濃縮方法2007

    • Inventor(s)
      小寺 義男、川島 祐介、前田 忠計
    • Industrial Property Rights Holder
      小寺 義男、前田 忠計
    • Industrial Property Number
      2007-206602
    • Filing Date
      2007-08-18
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 大腸がんマーカーペプチド、及び大腸癌の診断2007

    • Inventor(s)
      小寺 義男、前田 忠計、朝長 毅、野村 文夫
    • Industrial Property Rights Holder
      小寺 義男、前田 忠計、朝長 毅、野村 文夫
    • Industrial Property Number
      2007-021311
    • Filing Date
      2007-08-18
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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