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A novel mechanism of resistance to methylmercury toxicity in central nerves systems

Research Project

Project/Area Number 19390159
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionTohoku University

Principal Investigator

NAKAI Kunihiko  Tohoku University, 大学院・医学系研究科, 准教授 (00291336)

Co-Investigator(Kenkyū-buntansha) SATOH Hiroshi  東北大学, 大学院・医学系研究科, 教授 (40125571)
KUROKAWA Naoyuki  東北大学, 大学院・医学系研究科, 助教 (30431505)
亀尾 聡美  群馬大学, 大学院・医学系研究科, 助教 (40312558)
Research Collaborator YAGINUMA Kozue  東北大学, 大学院・医学系研究科, 大学院生
SHIMADA Miyuki  東北大学, 大学院・医学系研究科, 大学院生
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords環境保健 / メチル水銀 / 胎児期曝露 / マイクロアレイ / 遺伝子発現 / 急性毒性 / ストレス応答 / メチル水
Research Abstract

A novel mechanism of resistance to methylmercury (MeHg) toxicity in central nerve system has been examined using mice exposed to MeHg prenatally. As a preliminary examination, acute and chronic gene expression after MeHg exposure has been examined, and revealed that the altered genes were related to the functional categories of development, inflammation, and cell death. The next examination had performed by the combined exposures during prenatal and adulthood periods, and gene expression profiling had been examined.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (7 results)

All 2010 2008 2007

All Journal Article (7 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls2010

    • Author(s)
      Shimada M, Kameo S, Sugawara N, Yaginuma-Sakurai K, Kurokawa N, Mizukami-Murata S, Nakai K, Iwahashi H, Satoh H.
    • Journal Title

      Ach Toxicol 84

      Pages: 271-286

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls.2010

    • Author(s)
      Shimada M., S.Kameo, et al.
    • Journal Title

      Archives of Toxicology 84

      Pages: 271-286

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice2008

    • Author(s)
      Sugawara N, Ohba T, Nakai K, Kakita A, Nakamura T, Suzuki K, Kameo S, Shimada M, Kurokawa N, Satoh C, Satoh H.
    • Journal Title

      Arch Toxicol. 82

      Pages: 387-397

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice2008

    • Author(s)
      Sugawara N, et.al.
    • Journal Title

      Arch Toxicol 82

      Pages: 387-397

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice.2008

    • Author(s)
      Sugawara N, et. al.
    • Journal Title

      Arch Toxicol (In press)

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Effects of perinatal exposure to methylmercury and/or polychlorinated biphenyls on mouse neurobehavioral development and analysis of gene expression in the brain2007

    • Author(s)
      Kameo S, Shimada M, Sugawara N, Murata-Mizukami S, Ohba T, Nakai K, Iwahashi H, Satoh H.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 1813-1816

    • Related Report
      2009 Final Research Report
  • [Journal Article] Effects of perinatal exposure to methylmercury and/or polychlorinaled biphenyls on mouse neurobehavioral development and analysis of geneexpression in the brain.2007

    • Author(s)
      Kameo S, et. al.
    • Journal Title

      Organohalogen Compounds 69

      Pages: 1813-1816

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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