A novel mechanism of resistance to methylmercury toxicity in central nerves systems

• Project/Area Number: 19390159
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Tohoku University
• Principal Investigator: NAKAI Kunihiko Tohoku University, 大学院・医学系研究科, 准教授 (00291336)
• Co-Investigator(Kenkyū-buntansha): SATOH Hiroshi 東北大学, 大学院・医学系研究科, 教授 (40125571) ; KUROKAWA Naoyuki 東北大学, 大学院・医学系研究科, 助教 (30431505) ; 亀尾 聡美 群馬大学, 大学院・医学系研究科, 助教 (40312558)
• Research Collaborator: YAGINUMA Kozue 東北大学, 大学院・医学系研究科, 大学院生 ; SHIMADA Miyuki 東北大学, 大学院・医学系研究科, 大学院生
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000); Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2008: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2007: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: 環境保健 / メチル水銀 / 胎児期曝露 / マイクロアレイ / 遺伝子発現 / 急性毒性 / ストレス応答 / メチル水

Research Abstract

A novel mechanism of resistance to methylmercury (MeHg) toxicity in central nerve system has been examined using mice exposed to MeHg prenatally. As a preliminary examination, acute and chronic gene expression after MeHg exposure has been examined, and revealed that the altered genes were related to the functional categories of development, inflammation, and cell death. The next examination had performed by the combined exposures during prenatal and adulthood periods, and gene expression profiling had been examined.

Research Products

• [Journal Article] Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls (2010)
  • Author(s): Shimada M, Kameo S, Sugawara N, Yaginuma-Sakurai K, Kurokawa N, Mizukami-Murata S, Nakai K, Iwahashi H, Satoh H.
  • Journal Title: Ach Toxicol 84 Pages: 271-286
  • Peer Reviewed
• [Journal Article] Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls. (2010)
  • Author(s): Shimada M., S.Kameo, et al.
  • Journal Title: Archives of Toxicology 84 Pages: 271-286
  • Peer Reviewed
• [Journal Article] Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice (2008)
  • Author(s): Sugawara N, Ohba T, Nakai K, Kakita A, Nakamura T, Suzuki K, Kameo S, Shimada M, Kurokawa N, Satoh C, Satoh H.
  • Journal Title: Arch Toxicol. 82 Pages: 387-397
  • Peer Reviewed
• [Journal Article] Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice (2008)
  • Author(s): Sugawara N, et.al.
  • Journal Title: Arch Toxicol 82 Pages: 387-397
  • Peer Reviewed
• [Journal Article] Effects of perinatal coexposure to methylmercury and polychlorinated biphenyls on neurobehavioral development in mice. (2008)
  • Author(s): Sugawara N, et. al.
  • Journal Title: Arch Toxicol (In press)
• [Journal Article] Effects of perinatal exposure to methylmercury and/or polychlorinated biphenyls on mouse neurobehavioral development and analysis of gene expression in the brain (2007)
  • Author(s): Kameo S, Shimada M, Sugawara N, Murata-Mizukami S, Ohba T, Nakai K, Iwahashi H, Satoh H.
  • Journal Title: Organohalogen Compounds 69 Pages: 1813-1816
• [Journal Article] Effects of perinatal exposure to methylmercury and/or polychlorinaled biphenyls on mouse neurobehavioral development and analysis of geneexpression in the brain. (2007)
  • Author(s): Kameo S, et. al.
  • Journal Title: Organohalogen Compounds 69 Pages: 1813-1816