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Bio-kinetics of Metal Nano Particle via Olfactory Neurons after Inhalation to Mice

Research Project

Project/Area Number 19390162
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKyoto University

Principal Investigator

UCHIYAMA Iwao  Kyoto University, 大学院・工学研究科, 教授 (20151897)

Co-Investigator(Kenkyū-buntansha) TAKAOKA Masaki  京都大学, 大学院・工学研究科, 准教授 (80252485)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2007: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsディーゼル排気 / ナノ粒子 / 嗅覚神経 / マッピング / 放射光 / 嗅神経 / 透過型電子顕微鏡 / 蛍光X線分析 / 金属元素 / コロイダルゴールド / ディーゼル排気中ナノ粒子 / マイクロビーム
Research Abstract

ディーゼル排気中ナノ粒子曝露を行ったマウスを用い, 嗅覚系ニューロンを介在した大脳辺縁系への曝露経路を形態的に解明することを目的とし, 実験を行った。測定は, 放射光施設SPring-8にて, 嗅上皮, 嗅球における各種金属(Ca, Cu, Fe, Ni, Zn)の蛍光X線マッピングをおこなった。その結果, Fe, Ni, Znの値が, 神経の存在する組織層で高い値を示した。粒子の侵入がある可能性が高いことが確認された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (24 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (18 results) Book (2 results)

  • [Journal Article] Tracking the Pathway of Diesel Exhaust Particles (DEP) from the Olfactory Bulb to the Central Nervous System by X-ray Fluorescence Analysis2008

    • Author(s)
      Yasuto Matsui
    • Journal Title

      Spectrochimica Acta PartB 63

      Pages: 433-440

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tracking the Pathway of Diesel ExhaustParticles (DEP) from the Olfactory Bulb tothe Central Nervous System by X-rayFluorescence Analysis2007

    • Author(s)
      Y. Matsui, N. Sakai, A. Tsuda, Y. Terada, M. Takaoka, H. Fujimaki, I. Uchiyama
    • Journal Title

      Spectrochimica Acta PartB 29(3)

      Pages: 428-433

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 二酸化チタン超微小粒子曝露によるマウス体内分布に関する研究2007

    • Author(s)
      坂井 伸光
    • Journal Title

      産業医科大学雑誌 29(3)

      Pages: 428-433

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk assessment of Ti02 photocatalyst by individua1 micrometer-size particle analysis with on-site combination of SEK-EDX and SH-XANES microscope2007

    • Author(s)
      Jun Kawai
    • Journal Title

      Spectrochimica Acta PartB 62

      Pages: 677-681

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Tracking a Pathway Diesel Exhaust Particle from Nose to Brain2009

    • Author(s)
      Yasuto Matsui
    • Organizer
      American Thoracic Society
    • Place of Presentation
      San Diego/USA
    • Year and Date
      2009-05-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Determination of formaldehyde hemoglobin adducts in mice as a biological exposure index for multiple chemical sensitivity2008

    • Author(s)
      Keisuke Kodera
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Toronto/CANADA
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Uptake of Nanoparticles by the Sensory Nerves in the Pulmonary Alveoli of Mice2008

    • Author(s)
      Yasuto Matsui
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Toronto/CANADA
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Imaging of Olfactory Nerves after Intranasal Administration of Ultrafine Colloidal Gold in Mouse2008

    • Author(s)
      Nobumitsu Sakai
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Toronto/CANADA
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Synchrotron imaging of Diesel Exhaust Particles in the Olfactory Nerve2008

    • Author(s)
      Yasuto Matsui
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Toronto/CANADA
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Determination of formaldehyde hemoglobin adducts in mice as a biological exposure index for multiple chemical sensitivity2008

    • Author(s)
      Keisuke Kodera
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Tronto, Canada
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Uptake of Nanoparticles by the Sensory Nerves in the Pulmonary Alveoli of Mice2008

    • Author(s)
      Yasuto Matsui
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Tronto, Canada
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Imaging of Olfactory Nerves after Intranasal Administration of Ultrafine Colloidal Gold in Mouse2008

    • Author(s)
      Nobumitsu Sakai
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Tronto, Canada
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synchrotron imaging of Diesel Exhaust Particles in the Olfactory Nerve2008

    • Author(s)
      Yasuto Matsui
    • Organizer
      American Thoracic Society
    • Place of Presentation
      Tronto, Canada
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pathway for ultrafine diesel exhaust particles from the nose to the brain2007

    • Author(s)
      Yasuto Matsui
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] Visualization of Nerves and Uptake of Particles to the Nerves in the Pulmonary Alveoli of Rat2007

    • Author(s)
      Keisuke Kodera
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] The imaging of olfactory nerves in the mouse after intranasal administration of colloidal gold by TEM-EELS2007

    • Author(s)
      Nobumitsu Sakai
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2007 Annual Research Report
  • [Presentation] To track a DEP path from the nose to brain by X-ray fluorescence analysis2007

    • Author(s)
      Yasuto Matsui
    • Organizer
      ICXOM
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] The X-ray absorption fine structure (XAFS) analys is of nann metal fumes trapped by Differential Mobility2007

    • Author(s)
      Nobumitsu Sakai
    • Organizer
      Neuroscience
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Olfactus-Mediated Transport of Diesel Exhaust Particles from nose to brain in Mice2007

    • Author(s)
      Yasuto Matsui
    • Organizer
      ATS 2007
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] 嗅神経を介在したディーゼル排気中ナノ粒子の曝露経路の検索2007

    • Author(s)
      松井 康人
    • Organizer
      大気環境学会
    • Place of Presentation
      岡山,日本
    • Related Report
      2007 Annual Research Report
  • [Presentation] 肺における神経を介したナノ粒子曝露経路の検索2007

    • Author(s)
      小寺 恵介
    • Organizer
      大気環境学会
    • Place of Presentation
      岡山,日本
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛍光粒子点鼻投与によるナノ粒子の嗅覚系ニューロンを介した嗅覚中枢への曝露経路の検索2007

    • Author(s)
      坂井 伸光
    • Organizer
      大気環境学会
    • Place of Presentation
      岡山,日本
    • Related Report
      2007 Annual Research Report
  • [Book] ナノ粒子の生理学的活性・呼吸器2009

    • Author(s)
      内山巌雄, 松井康人ほか
    • Total Pages
      296
    • Publisher
      中外医学社
    • Related Report
      2008 Final Research Report
  • [Book] ナノ粒子の生理学的活性・呼吸器20092009

    • Author(s)
      内山巌雄, 松井康人, ほか
    • Total Pages
      296
    • Publisher
      中外医学社
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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