Preventive effects of dietary compounds for cancer develpment
| Project/Area Number |
19390165
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MURE Kanae Wakayama Medical University, 医学部, 講師 (90268491)
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHITA Tatsuya 和歌山県立医科大学, 医学部, 教授 (20150310)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | がん予防 / 食品由来物質 / 発がん予防 / 突然変異 / DNA修復 / アポトーシス / シグナル伝達 / 遺伝子発現 / 発がん |
|---|
| Research Abstract |
We have investigated the effects of dietary compounds for cancer prevention in the cell culture system. Tomato-derived lycopene, vitamin E and tea-catechin showed significant t effects on reducing spontaneous and carcinogen-induced mutagenesis in human colorectal and skin cells by up-regulating DNA repair related genes. Those compounds also showed effects on apoptosis mechanism.
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Report
(4 results)
Research Products
(40 results)
