| Co-Investigator(Kenkyū-buntansha) |
OHGAMI Nobutaka 中部大学, 生命健康科学部, 講師 (80424919)
川本 善之 中部大学, 生命健康科学部, 講師 (10410664)
山ノ下 理 中部大学, 生命健康科学部, 講師 (50424924)
後藤 友二 中部大学, 生命健康科学部, 助手 (70362522)
浅井 直也 名古屋大学, 医学系研究科, 准教授 (80273233)
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| Budget Amount *help |
¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
We found that congenital syndromic hearing loss was induced by the loss of function of c-RET, a regulator of growth of neuron and melanocytes, in humans. We then showed that c-Ret-mediated congenital hearing loss was caused of degeneration of spiral ganglion neurons in inner ear in mice. We also examined whether c-Ret is correlated with age-related and noise-induced hearing loss. Moreover, we performed epidemiological study to investigate the correlation between noise and hearing loss in young adults.
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