Development of preventive therapy of no-se-induced hearing loss through clarifying its mechanism

• Project/Area Number: 19390168
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Chubu University
• Principal Investigator: KATO MASASHI (KATO Masashi) Chubu University, 生命健康科学部, 教授 (10281073)
• Co-Investigator(Kenkyū-buntansha): OHGAMI Nobutaka 中部大学, 生命健康科学部, 講師 (80424919) ; 川本 善之 中部大学, 生命健康科学部, 講師 (10410664) ; 山ノ下 理 中部大学, 生命健康科学部, 講師 (50424924) ; 後藤 友二 中部大学, 生命健康科学部, 助手 (70362522) ; 浅井 直也 名古屋大学, 医学系研究科, 准教授 (80273233)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 環境ストレス / 労働衛生学 / 難聴 / 色素細胞 / 分子標的療法 / RET / 騒音 / 感音難聴 / 遺伝子改変マウス / シグナル伝達 / 騒音性難聴 / 感音性難聴 / 加齢性難聴 / 先天性難聴 / ラセン神経節 / 内耳性難聴 / メラニン

Research Abstract

We found that congenital syndromic hearing loss was induced by the loss of function of c-RET, a regulator of growth of neuron and melanocytes, in humans. We then showed that c-Ret-mediated congenital hearing loss was caused of degeneration of spiral ganglion neurons in inner ear in mice. We also examined whether c-Ret is correlated with age-related and noise-induced hearing loss. Moreover, we performed epidemiological study to investigate the correlation between noise and hearing loss in young adults.

Research Products

• [Journal Article] Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. (2011)
  • Author(s): Ohgami N, Ida-Etoh M, SakashitaN, Sone M, Nakashima N, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M
  • Journal Title: Neurobiol Aging (in press)
  • Peer Reviewed
• [Journal Article] Effects of light smoking on extra-high-frequency auditory thresholds in young adults. (2011)
  • Author(s): Ohgami N, Kondo T, Kato M
  • Journal Title: Toxicol Ind Health 27(2) Pages: 143-7
  • Peer Reviewed
• [Journal Article] L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects (2011)
  • Author(s): Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, Goto Y, Ohgami N
  • Journal Title: Toxcol In Vitro 25(3) Pages: 623-9
  • Peer Reviewed
• [Journal Article] Effects of light smoking on extra-high-frequency auditory thresholds in young adults. (2011)
  • Author(s): Ohgami N, Kondo T, Kato M.
  • Journal Title: Toxicol Ind Health Volume: 27 Pages: 143-7
  • Peer Reviewed
• [Journal Article] L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects. (2011)
  • Author(s): Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, Goto Y, Ohgami N.
  • Journal Title: Toxcol In Vitro Volume: 25 Pages: 623-9
  • Peer Reviewed
• [Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease. (2010)
  • Author(s): Ohgami N, Ida M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M
  • Journal Title: Proc Natl Acad Sci USA 107(29) Pages: 13051-6
  • Peer Reviewed
• [Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. (2010)
  • Author(s): Kato M, Takeda K, Hossain K, Thang D.Nguyen, Kaneko Y, Kumasaka M,Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y
  • Journal Title: J Cell Biochem 110 Pages: 399-407
  • Peer Reviewed
• [Journal Article] Resistance to anti-angiogenic therapy is directed by vascular phenotype, vessel stabilization and maturation in malignant melanoma. (2010)
  • Author(s): Helfrich I, Scheffrahn I, Bartling S, Weis J, von Felbert V, Middleton M, Kato M, Ergun S, Schadendorf D
  • Journal Title: J Exp Med 207(3) Pages: 491-503
  • Peer Reviewed
• [Journal Article] c-RET molecule in malignant melanoma from oncogenic RET carrying transgenic mice and human cell lines. (2010)
  • Author(s): Ohshima Y, Yajima I, Takeda K, Iida M, Kumasaka M, Matsumoto Y, Kato M.
  • Journal Title: PLoS ONE
  • Peer Reviewed
• [Journal Article] Tumor cells disseminate early but immunosurveillance limits metastatic outgrowth in a mouse model of melanoma. (2010)
  • Author(s): Eyles J, Puaux A, Wang J, Toh B, Prakash C, Hong M, Zheng L, Ong LC, Jin Y, Kato M, Blondel AP, Chow P, Yang H, Abastado J-P.
  • Journal Title: J Clin Invest Volume: 120 Pages: 2030-9
  • Peer Reviewed
• [Journal Article] c-Ret-mediated hearing loss in mice with Hirschsprung disease. (2010)
  • Author(s): Ohgami N, Ida M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue C, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M.
  • Journal Title: Proc Natl Acad Sci USA Volume: 107 Pages: 13051-6
  • Peer Reviewed
• [Journal Article] Targeting Surface Nucleolin with a Multivalent Pseudopeptide Delays Development of Spontaneous Melanoma in RET Transgenic Mice. (2010)
  • Author(s): Khoury DE, Destouches D, Lengagne R, Krust B, Hamma-Kourbali Y, Garcette M, Niro S, Kato M, Briand J-P, Courty J, Hovanessian AG, Prevost-Blondel A.
  • Journal Title: BMC Cancer Volume: 10 Pages: 325-36
  • Peer Reviewed
• [Journal Article] Toxic Elements in Well Water from Malaysia. (2010)
  • Author(s): Kato M, Ohnuma S, Kato Y, Thang D.Nguyen, Yajima I, Hoque Z.Md, Shekhar U.Hossain.
  • Journal Title: Toxicol Environ Chem Volume: 92 Pages: 1609-12
  • Peer Reviewed
• [Journal Article] A Novel Mouse Model for denovo melanoma (2010)
  • Author(s): Kumasaka YM, Yajima I, Hossain K, Iida M, Tsuzuki T, Ohno T, Takahashi M, Yanagisawa M, Kato M
  • Journal Title: Cancer Res 70(1) Pages: 24-9
  • Peer Reviewed
• [Journal Article] Resistance to ti-angiogenic therapy is directed by vascular phenotype, vessel stabilization and maturation in malignant melanoma (2010)
  • Author(s): Helfrich I, Scheffrahn I, Bartling S, Weis J, von Felbert V, Middleton M, Kato M, Ergun S, Schadendorf D
  • Journal Title: J Exp Med 207(3) Pages: 491-503
  • Peer Reviewed
• [Journal Article] A Novel Mouse Model for de novo melanoma. (2010)
  • Author(s): Kumasaka YM.
  • Journal Title: Cancer Res Volume: 70 Pages: 24-9
  • Peer Reviewed
• [Journal Article] Resistance to anti-angiogenic therapy is directed by vascular phenotype, vessel stabilization and maturation in malignant melanoma. (2010)
  • Author(s): Helfrich I.
  • Journal Title: J Exp Med Volume: (in press)
  • Peer Reviewed
• [Journal Article] Increased CD109 expression levels in human malignant melanoma. (2010)
  • Author(s): Ohshima Y
  • Journal Title: J Dermatol Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. (2010)
  • Author(s): Kato M.
  • Journal Title: J Cell Biochem Volume: (in press)
  • Peer Reviewed
• [Journal Article] Toxic Elements in Well Water from Malaysia. (2010)
  • Author(s): Kato M.
  • Journal Title: Toxicol Environ Chem Volume: (in press)
  • Peer Reviewed
• [Journal Article] Activation of p38 MAPK Drives Dendritic Cells to Become Tolerogenic in Ret Transgenic Mice Spontaneously Developing Melanoma. (2009)
  • Author(s): Zhao F, Falk C, Osen W, Kato M, Schadendorf D, Umansky V
  • Journal Title: Clin Cancer Res 15(13) Pages: 4382-90
  • Peer Reviewed
• [Journal Article] Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. (2009)
  • Author(s): Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F
  • Journal Title: Dev Cell 17(2) Pages: 199-209
  • Peer Reviewed
• [Journal Article] Skin Melanoma Development in Ret Transgenic Mice Despite the Depletion of CD25+FoxP3+Regulatory T-Cells in Lymphoid Organs. (2009)
  • Author(s): Kimpfler S, Ring S, Falk C, Osen W, Kato M, Mahnke K, Schadendorf D, Umansky V
  • Journal Title: J Immunol 183(10) Pages: 6330-7
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule. (2009)
  • Author(s): Yajima I, Kumasaka M, Thang ND, Yanagishita T, Ohgami N, Kallenberg D, Naito Y, Yoshikawa T, Sakashita N, Kato M
  • Journal Title: J Dermatol Sci 55(1) Pages: 68-70
  • NAID: 10025334344
  • Peer Reviewed
• [Journal Article] NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo (2009)
  • Author(s): Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, a Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Hoglund P, Kato M, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Karre K, Shibuya A, Carbone E, Colucci F.
  • Journal Title: J Clin Invest 119(5) Pages: 1251-63
  • Peer Reviewed
• [Journal Article] Ret-dependent cell rearrangements in the Wolffian duct pithelium initiate ureteric bud morphogenesis (2009)
  • Author(s): Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F
  • Journal Title: Dev Cell 17(2) Pages: 199-209
  • Peer Reviewed
• [Journal Article] Skin Melanoma Development in Ret Transgenic Mice Despite the Depletion of CD25+FoxP3+Regulatory T-Cells in Lymphoid Organs (2009)
  • Author(s): Kimpfler S, Ring S, Falk C, Osen W, Kato M, Mahnke K, Schadendorf D, Umansky V
  • Journal Title: J Immunol 183(10) Pages: 6330-7
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-related molecule. (2009)
  • Author(s): Yajima I.
  • Journal Title: J Dermatol Sci Volume: 55 Pages: 68-70
  • Peer Reviewed
• [Journal Article] NCRs and DNAM-I mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. (2009)
  • Author(s): Lakshmikanth T.
  • Journal Title: J Clin Invest Volume: 119 Pages: 1251-63
  • Peer Reviewed
• [Journal Article] Activation of p38 MAPK Drives Dendritic Cells to Become Tolerogenic in Ret Transgenic Mice Spontaneously Developing Melanoma. (2009)
  • Author(s): Zhao F.
  • Journal Title: Clin Cancer Res Volume: 15 Pages: 4382-90
  • Peer Reviewed
• [Journal Article] Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. (2009)
  • Author(s): Chi X.
  • Journal Title: Dev Cell Volume: 17 Pages: 199-209
  • Peer Reviewed
• [Journal Article] Skin Melanoma Development in Ret Transgenic Mice Despite the Depletion of CD25+FoxP3+ Reeulatory T-Cells in Lymphoid Organs. (2009)
  • Author(s): Kimpfler S.
  • Journal Title: J Immunol Volume: 183 Pages: 6330-7
  • Peer Reviewed
• [Journal Article] 1,4-butanediyl-bismethanethiosulfonate (BMTS) induces reactive oxygen species-mediated apoptotic signals independent of stress-activated MAPK cascade in Jurkat cells. (2009)
  • Author(s): Hossain K.
  • Journal Title: J Cell Biochem Volume: 108 Pages: 1059-65
  • Peer Reviewed
• [Journal Article] Receptor-mediated recognition of melanoma by natural killer cells and its implications for immunotherapy. (2009)
  • Author(s): Lakshmikanth T
  • Journal Title: J Clin Invest
  • Description: 印刷中
  • Peer Reviewed
• [Journal Article] Zinc finger protein 28 as a novel melanoma-relatedmolecule. (2009)
  • Author(s): Yajima I
  • Journal Title: J Dermatol Sci
  • Description: 印刷中
  • Peer Reviewed
• [Journal Article] Melanoma Specific Memory T Cells Are Functionally Active in Ret Transgenic Mice Without Macroscopical Tumors. (2008)
  • Author(s): Umansky V, Abschuetz O, Osen W, Ramacher M, Zhao F, Kato M, Schadendorf D
  • Journal Title: Cancer Res 68(22) Pages: 9451-8
  • Peer Reviewed
• [Journal Article] Melanoma Specific Memory T Cells Are Functionally Active in Ret Transgenic Mice Without Macroscopical Tumors. (2008)
  • Author(s): Umansky V.
  • Journal Title: Cancer Res Volume: 68 Pages: 9451-8
  • Peer Reviewed
• [Journal Article] Arsenic enhances matrix metalloproteinase-14 expression in fibroblasts. (2008)
  • Author(s): Kato M
  • Journal Title: J Toxicol Environ Health A Volume: 71 Pages: 1053-5
  • Peer Reviewed
• [Journal Article] BMP-4 Upregulates Kit Expression in Mouse Melanoblastsprior to the Kit-Dependent Cycle of Melanogenesis. (2008)
  • Author(s): Kawakami T
  • Journal Title: J Invest Dermatol Volume: 128 Pages: 1220-6
  • Peer Reviewed
• [Journal Article] Distinct role for CD8 T cells toward cutaneous tumors and visceral metastases. (2008)
  • Author(s): Lengagne R
  • Journal Title: J Immunol Volume: 180 Pages: 130-137
  • Peer Reviewed
• [Journal Article] BMP-4 Upregulates Kit Expression in Mouse Melanoblasts prior to the Kit-Dependent Cycle of Melanogenesis. (2008)
  • Author(s): Kawakami T
  • Journal Title: J Invest Dermatol
  • Description: 印刷中
  • Peer Reviewed
• [Journal Article] Protective Effect of Hyperpigmented Skin on Ultraviolet-Mediated Cutaneous Cancer Development. (2007)
  • Author(s): Kato M, (1番目/12人中), et al.
  • Journal Title: J Invest Dermatol Volume: 127 Pages: 1244-1249
  • Peer Reviewed
• [Presentation] 遺伝子が原因でおこる病気と環境により誘導される病気:臨床医学的考察 (2011)
  • Author(s): 加藤昌志
  • Organizer: 第59回東海小児がん研究会
  • Place of Presentation: 名古屋市(特別講演)
  • Year and Date: 2011-02-05
• [Presentation] 遺伝子が原因でおこる病気と環境により誘発される病気:臨床的考察 (2011)
  • Author(s): 加藤昌志
  • Organizer: 第59回 東海小児がん研究会
  • Place of Presentation: 名古屋大学医学部(特別講演)
  • Year and Date: 2011-02-05
• [Presentation] 新規先天性難聴遺伝子の解析 (2011)
  • Author(s): 大神信孝、下竹孝志、時々輪真由美、浅井直也、高橋雅英、加藤昌志
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京都(一般演題)
• [Presentation] 飲水投与した塩化バリウムが生体内の元素レベルに与える影響 (2011)
  • Author(s): 堀創二朗、大神信孝、大沼章子、藤昌志
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京都(一般演題)
• [Presentation] Novel regulatory molecules for malignant melanoma (2010)
  • Author(s): Masashi Kato
  • Organizer: 7^<th> International Melanoma Research Congress
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2010-11-05
• [Presentation] Pollution of inorganic substrates in Asian countries (2010)
  • Author(s): Masashi Kato
  • Organizer: The 1^<st> International Symposium of Environmental Health Sciences
  • Place of Presentation: Kasugai, Aichi, Japan
  • Year and Date: 2010-07-28
• [Presentation] 加齢とともに悪性黒色腫を発症する動物モデルを用いた病態解析と新規予防・治療法の開発 (2010)
  • Author(s): 加藤昌志
  • Organizer: 加齢皮膚医学研究会 ロート賞記念講演
  • Place of Presentation: 新潟大学医学部
  • Year and Date: 2010-07-03
• [Presentation] Pollution of inorganic substrates in Asian countries (2010)
  • Author(s): 加藤昌志
  • Organizer: JSPS AA Science Platform Program : The 1^<st> International Symposium of Environmental Health Sciences in Chubu University, JAPAN.
  • Place of Presentation: Kasugai, Aichi, Japan (Special lecture)
• [Presentation] 低周波音が協調運動に与える影響 (2010)
  • Author(s): 大神信孝、伊藤聖奈、山口碧、堀創二朗、加藤昌志
  • Organizer: 第80回日本衛生学会総会
  • Place of Presentation: 仙台市(一般演題)
• [Presentation] Volunteer Activities in Chubu University for Provision of Safe Drinking Water in Developing Countries. (2009)
  • Author(s): Masashi Kato
  • Organizer: Leadership for Environment and Development : Part icipatory Curriculum Development Network between the NGO and University (Symposium and Exper t Meeting).
  • Place of Presentation: 中部大学(愛知県春日井市)
  • Year and Date: 2009-09-17
  • Invited
• [Presentation] 第10回光老化研究会2009年7月25日特別講演 (2009)
  • Author(s): 加藤昌志
  • Organizer: 紫外線に対するメラノサイト機能の光と影
  • Place of Presentation: 大阪市
  • Year and Date: 2009-07-25
• [Presentation] 紫外線に対するメラノサイト機能の光と影 (2009)
  • Author(s): 加藤昌志
  • Organizer: 第10回光老化研究会
  • Place of Presentation: 梅田スカイビル(大阪市)
  • Year and Date: 2009-07-25
  • Invited
• [Presentation] 環境汚染が私たちの生存を脅かす (2009)
  • Author(s): 加藤昌志
  • Organizer: 中部大学国際ESDセンター主催 第3回キャンパス・エコミュージアムプロジェクト
  • Place of Presentation: 愛知県春日井市(特別講演)
  • Year and Date: 2009-07-11
• [Presentation] Volunteer Activities in Chubu University for Provision of Safe Drinking Water in Developing Countries (2009)
  • Author(s): 加藤昌志
  • Organizer: Leadership for Environment and Development : Participatory Curriculum Development Network between the NGO and University (Symposium and Expert Meeting)
  • Place of Presentation: Kasugai, Aichi, JAPAN (Oral presentation (Panelist))
• [Presentation] Volunteer Activities in Chubu University for Provision of Safe Drinking Water in Developing Countries (2009)
  • Author(s): Masashi Kato
  • Organizer: Leadership for Environment and Development : Participatory Curriculum Development Network between the NGO and University
  • Place of Presentation: Chubu University in Kasugai, Aichi
• [Presentation] Effect of hyperpigmented skin on ultraviolet-mediated cancer. (2008)
  • Author(s): Masashi Kato
  • Organizer: The 20^<th> International Pigment Cell Conference/5^<th> International Melanoma Research Congress
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2008-05-07
• [Presentation] The 20^<th> IPCC (International Pigment Cell Conference)/5^<th> IMRC (International Melanoma Research Congress) (2008)
  • Author(s): Masashi Kato, Nobutaka Ohgami, Ichiro Yajima, Mayuko Kumasaka, Osamu Yamanoshita
  • Organizer: Poster session Effect of hyperpigmented skinon ultraviolet-mediated cancer
  • Place of Presentation: Sapporo
• [Presentation] 心臓内メラノサイトの細胞系譜と動脈管開存症との相関に関する考察 (2007)
  • Author(s): 矢嶋伊知朗
  • Organizer: 日本色素細胞学会
  • Place of Presentation: 藤田保健衛生大学(名古屋市)
  • Year and Date: 2007-12-08
• [Book] モデル動物利用マニュアル(分担執筆:第I部疾患モデルの作成と利用、第2章がん、第2節多臓器発癌モデル、第7項Ret) (2011)
  • Author(s): 加藤昌志、高橋雅英
  • Publisher: 株式会社 エル・アイ・シー(印刷中)
• [Book] モデル動物利用マニュアル(分担執筆:第I部疾患モデルの作成と利用、第2章がん、第2節多臓器発癌モデル、第7項Ret)
  • Author(s): 加藤昌志、高橋雅英
  • Publisher: 株式会社 エル・アイ・シー(印刷中)
• [Remarks] ホームページ等
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• [Remarks] ホームページ
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• [Remarks]
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• [Remarks]
  • URL: http://www.chubu.ac.jp/about/faculty/profile/588a920fe73a44df04e50c9c3eda630d04e09e86.html
• [Remarks]
  • URL: http://www.chubu.ac.jp/about/faculty/profile/588a920fe73a44df04e50c9c3eda630d04e09e86.html
• [Patent(Industrial Property Rights)] 薬剤評価方法 (2010)
  • Inventor(s): 加藤昌志、飯田真智子、熊坂真由子、矢嶋伊知朗、田口暢彦
  • Industrial Property Rights Holder: 中部大学・ホーユー株式会社
  • Industrial Property Number: 2010-145179
  • Filing Date: 2010-06-25
• [Patent(Industrial Property Rights)] 白毛の予防・治療剤、非治療的な美容方法、エンドセリンレセプターB遺伝子発現促進剤及びMITF-M遺伝子発現促進剤 (2010)
  • Inventor(s): 加藤昌志、飯田真智子、上村規行、田口暢彦
  • Industrial Property Rights Holder: 中部大学・ホーユー株式会社
  • Industrial Property Number: 2010-145178
  • Filing Date: 2010-06-25
• [Patent(Industrial Property Rights)] 発癌毒性の評価方法及び発癌予防・治療剤 (2009)
  • Inventor(s): 加藤昌志
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Number: 2009-241197
  • Filing Date: 2009-10-20
• [Patent(Industrial Property Rights)] デノボ癌を自然発症するモデル動物及びその用途 (2009)
  • Inventor(s): 加藤昌志、熊坂真由子
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Number: 2009-199142
  • Filing Date: 2009-08-31
• [Patent(Industrial Property Rights)] 難聴又は耳鳴りの予防・治療剤 (2009)
  • Inventor(s): 加藤昌志、大神信孝、伊田みちる、田口暢彦
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Number: 2009-185334
  • Filing Date: 2009-08-08
• [Patent(Industrial Property Rights)] 難聴モデル動物及びその用途 (2009)
  • Inventor(s): 加藤昌志、大神信孝、高橋雅英、浅井直也、時々輪真由美
  • Industrial Property Rights Holder: 中部大学、名古屋大学
  • Industrial Property Number: 2009-053481
  • Filing Date: 2009-03-06
• [Patent(Industrial Property Rights)] 難聴モデル動物及びその用途 (2009)
  • Inventor(s): 加藤昌志, 大神信孝, 高橋雅英, 浅井直也, 時々輪真由美
  • Industrial Property Rights Holder: 中部大学、名古屋大学
  • Industrial Property Number: 2009-053481
  • Filing Date: 2009-03-06
• [Patent(Industrial Property Rights)] 難聴又は耳鳴りの予防・治療剤 (2009)
  • Inventor(s): 加藤昌志, 大神信孝, 伊田みちる, 田口暢彦
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Number: 2009-185334
  • Filing Date: 2009-08-08
• [Patent(Industrial Property Rights)] デノボ癌を自然発症するモデル動物及びその用途 (2009)
  • Inventor(s): 加藤昌志, 熊坂真由子
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Number: 2009-199142
  • Filing Date: 2009-08-31
• [Patent(Industrial Property Rights)] 難聴又は耳鳴りの予防・治療剤 (2009)
  • Inventor(s): 加藤昌志, 大神信孝, 伊田みちる, 田口暢彦
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2009-08-08
• [Patent(Industrial Property Rights)] デノボ癌を自然発症するモデル動物及びその用途 (2009)
  • Inventor(s): 加藤昌志, 熊坂真由子
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2009-08-31
• [Patent(Industrial Property Rights)] 発癌毒性の評価方法及び発癌予防・治療剤 (2009)
  • Inventor(s): 加藤昌志
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2009-10-20
• [Patent(Industrial Property Rights)] 難聴モデル動物及びその用途 (2009)
  • Inventor(s): 加藤昌志, 大神信孝, 高橋雅英, 浅井直也, 時々輪真由美
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2009-03-06
• [Patent(Industrial Property Rights)] 発癌予知マーカー及びその用途 (2007)
  • Inventor(s): 加藤昌志
  • Industrial Property Rights Holder: 中部大学
  • Industrial Property Number: 2007-110452
  • Filing Date: 2007-04-19
• [Patent(Industrial Property Rights)] 発癌予知マーカー及びその用途 (2007)
  • Inventor(s): 加藤昌志
  • Industrial Property Rights Holder: 加藤昌志
  • Industrial Property Rights Type: 特許
  • Filing Date: 2007-04-19