Studies on metal toxicology and transport using omics approaches
| Project/Area Number |
19390169
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
HIMENO Seiichiro Tokushima Bunri University, 薬学部, 教授 (20181117)
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| Co-Investigator(Kenkyū-buntansha) |
FUJISHIRO Hitomi 徳島文理大学, 薬学部, 助教 (10389182)
MIYATAKA Hideki 徳島文理大学, 薬学部, 助教 (50157658)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2009: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2007: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | オミクス / 重金属 / 毒性 / 遺伝子 / 環境 / 衛生 / オミックス / 金属毒性 / 金属輸送 / カドミウム |
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| Research Abstract |
The mechanisms of toxicity and transport of heavy metals remain unclear. To solve this problem, we applied OMICS strategy in which DNA microarray and other high-throughput techniques are utilized to analyze the whole profiles of changes in the expression of gene, protein, and metabolites. As a result, we identified a novel transport system for cadmium, novel indicator for renal cadmium toxicity, and responsive factors against arsenic toxicity.
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Report
(4 results)
Research Products
(131 results)
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[Journal Article] The role of ZIP8 down-regulation in cadmium-resistant metallothionein-null cells2009
Author(s)
Fujishiro, H., Okugaki, S., Kubota, K., Fujiyama, T., Miyataka, H., Himeno, S.
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Journal Title
J.Appl.Toxicol. 29(5)
Pages: 367-373
Related Report
Peer Reviewed
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[Journal Article] Dichotomous effects of lead acetate on the expression of metallothionein in the liver and kidney of mice2009
Author(s)
Yu, J., Fujishiro, H., Miyataka, H., Oyama, M.T., Hasegawa, T., Seko, Y., Miura, N., Himeno S
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Journal Title
Biol.Pharm.Bull. 32(6)
Pages: 1037-1042
NAID
Related Report
Peer Reviewed
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[Journal Article] Arsenic biomethylation is obligatory for oxidative DNA damage2009
Author(s)
Kojima, C., Ramirez, D.C., Tokar, E.J., Himeno, S., Drobna, Z., Styblo, M., Mason, R.P., Waalkes, M.P.
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Journal Title
J.Nat.Cancer Inst. 101
Pages: 670-1681
Related Report
Peer Reviewed
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[Journal Article] Androgen-dependent Gene Expression of Prostate-specific Antigen Is Enhanced Synergistically by Hypoxia in Human Prostate Cancer Cells: Cross-talk between the Androgen Receptor and Hypoxia-inducible Factor-1 Signaling.2007
Author(s)
Horii, K., Suzuki, Y., Kondo, Y., Akimoto, M., Nishimura, T., Yamabe, Y., Sakaue, M., Sano, T., Kitagawa, T., Himeno, S., Imura, N., Hara, S.
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Journal Title
Mol. Cancer Res. 5(4)
Pages: 383-391
Related Report
Peer Reviewed
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[Journal Article] Induction of metallothionein by manganese is completely dependent on interleukin-6 production.2007
Author(s)
Kobayashi, K., Kuroda, J., Shibata, N., Hasegawa, T., Seko, Y., Satoh, M., Tohyama, C., Takano, H., Imura, N., Sakabe, K., Fujishiro, H., Himeno, S.
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Journal Title
J. Pharmacol. Exp. Ther. 320(2)
Pages: 721-727
Related Report
Peer Reviewed
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