Evaluation of genetic instability and radiation sensitivity in human hematolymphoid cells among the atomic-bomb survivor cohort
| Project/Area Number |
19390170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
KUSUNOKI Yoichiro Radiation Effects Research Foundation, 放射線生物学/分子疫学部, 部長代理 (60333548)
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| Co-Investigator(Kenkyū-buntansha) |
HAMASAKI Kanya 財団法人放射線影響研究所, 遺伝学部, 研究員 (80443597)
IMAI Kazue 財団法人放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (80260230)
YOSHIDA Kengo 財団法人放射線影響研究所, 放射線生物学/分子疫学部, 研究員 (70443596)
京泉 誠之 安田女子大学, 家政学部, 教授 (50333547)
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| Co-Investigator(Renkei-kenkyūsha) |
KYOIZUMI Seishi 安田女子大学, 家政学部, 教授 (50333547)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2007: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | ゲノム / 放射線 / 突然変異 / 血液細胞 |
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| Research Abstract |
The human genome (the complete set of genetic information in people's DNA) somewhat differs among individuals, and such variation is in part responsible for how individuals differ in their susceptibility to radiation-related DNA damage and diseases. We detected radiation-related DNA damage in blood cells of A-bomb survivors and investigated associations between frequencies of DNA-damaged cells and genotypes of DNA repair genes. Our results suggest that the difference in the genotype of P53BP1 may be involved in the individual's difference in the frequency of GPA mutant blood cells.
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Report
(4 results)
Research Products
(58 results)
