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Interrelationship of estrogen, melatonin and circadian rhythm

Research Project

Project/Area Number 19390172
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionGifu University

Principal Investigator

NAGATA Chisato  Gifu University, 大学院・医学系研究科, 教授 (30283295)

Co-Investigator(Kenkyū-buntansha) SHIMIZU Hiroyuki  岐阜大学, 大学院・医学系研究科, 非常勤講師 (90073139)
TAKEDA Noriyuki  朝日大学, 歯学部, 教授 (20163412)
FUJITA Hiroshi  岐阜大学, 大学院・医学系研究科, 教授 (10124033)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords成人保健 / がん疫学 / 乳がん / 睡眠 / エストラジオール / テストステロン / メラトニン / 妊娠 / 幼児 / サーカディアンリズム / エストロゲン / 乳腺組織密度
Research Abstract

乳がんリスクの指標としての血中・尿中エストロゲン値と生活環境要因の中からサーカディアンリズムに関わる睡眠・夜間照明・夜勤・生活リズム等、サーカディアンリズムの指標である尿中メラトニン値との関連性を成人女性、妊婦、幼児を対象に評価した。成人女性において、夜間照明への暴露あるいはサーカディアンリズムの乱れが内因性エストロゲン値を変化させ、ひいては乳がんリスクに影響を及ばす可能性を示唆した。

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (10 results)

All 2009 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Light exposure at night, urinary 6-sulfatoxymelatonin, and serum estrogens and androgens in postmenopausal Japanese women.2008

    • Author(s)
      Nagata C, Nagao Y, Yamamoto S, Shibuya C, Kashiki Y, Shimizu H
    • Journal Title

      Cancer Epidemiol Biomarkers Prev. 17

      Pages: 1418-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light exposure at night, urinary 6-sulfatoxymelatonin, and serumestrogens and androgens in postmenopausal Japanese women.2008

    • Author(s)
      Nagata, et al.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev. 17

      Pages: 1418-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women.2007

    • Author(s)
      Nagata C, Matsubara T, Hara T, Fujita H, Nagao Y, Yamamoto S, Shibuya C, Kashiki Y, Shimizu H
    • Journal Title

      Cancer Epidemiol Biomarkers Prev. 16

      Pages: 2509-12

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women.2007

    • Author(s)
      Nagata, et. al.
    • Journal Title

      Cancer Epidemiol Biomarkers Prev. 16

      Pages: 2509-12

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Associations of sleep habits with maternal and umbilical cord hormone levels in pregnant Japanese women.2009

    • Author(s)
      Nakamura N, Wada K, Nagata C, Shimizu H
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Association of dietary soy intake with urinary sex steroid among Japanese young children.2009

    • Author(s)
      Wada K, Nakamura K, Oba S, Nagata C
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-11-03
    • Related Report
      2009 Final Research Report
  • [Presentation] 日本人妊娠女性における睡眠習慣と血清おわび臍帯血ホルモン値との関連2009

    • Author(s)
      中村こず枝、和田恵子、永田知里, ら.
    • Organizer
      癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Risk factors for breast cancer in Japanese women.2008

    • Author(s)
      Nagata C.
    • Organizer
      第67回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2009 Final Research Report
  • [Presentation] JCA-AACR Cancer Research Conference.2008

    • Author(s)
      永田知里
    • Organizer
      The Latest Advances in Breast Cancer Research: From Basic Science to Therapeutics
    • Place of Presentation
      Hyogo, Japan
    • Year and Date
      2008-07-15
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www1.gifu-u.ac.jp/~ph/

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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