Interrelationship of estrogen, melatonin and circadian rhythm

• Project/Area Number: 19390172
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Gifu University
• Principal Investigator: NAGATA Chisato Gifu University, 大学院・医学系研究科, 教授 (30283295)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Hiroyuki 岐阜大学, 大学院・医学系研究科, 非常勤講師 (90073139) ; TAKEDA Noriyuki 朝日大学, 歯学部, 教授 (20163412) ; FUJITA Hiroshi 岐阜大学, 大学院・医学系研究科, 教授 (10124033)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2007: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 成人保健 / がん疫学 / 乳がん / 睡眠 / エストラジオール / テストステロン / メラトニン / 妊娠 / 幼児 / サーカディアンリズム / エストロゲン / 乳腺組織密度

Research Abstract

乳がんリスクの指標としての血中・尿中エストロゲン値と生活環境要因の中からサーカディアンリズムに関わる睡眠・夜間照明・夜勤・生活リズム等、サーカディアンリズムの指標である尿中メラトニン値との関連性を成人女性、妊婦、幼児を対象に評価した。成人女性において、夜間照明への暴露あるいはサーカディアンリズムの乱れが内因性エストロゲン値を変化させ、ひいては乳がんリスクに影響を及ばす可能性を示唆した。

Research Products

• [Journal Article] Light exposure at night, urinary 6-sulfatoxymelatonin, and serum estrogens and androgens in postmenopausal Japanese women. (2008)
  • Author(s): Nagata C, Nagao Y, Yamamoto S, Shibuya C, Kashiki Y, Shimizu H
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 17 Pages: 1418-23
  • Peer Reviewed
• [Journal Article] Light exposure at night, urinary 6-sulfatoxymelatonin, and serumestrogens and androgens in postmenopausal Japanese women. (2008)
  • Author(s): Nagata, et al.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 17 Pages: 1418-23
  • Peer Reviewed
• [Journal Article] Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women. (2007)
  • Author(s): Nagata C, Matsubara T, Hara T, Fujita H, Nagao Y, Yamamoto S, Shibuya C, Kashiki Y, Shimizu H
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 16 Pages: 2509-12
  • Peer Reviewed
• [Journal Article] Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women. (2007)
  • Author(s): Nagata, et. al.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 16 Pages: 2509-12
  • Peer Reviewed
• [Presentation] Associations of sleep habits with maternal and umbilical cord hormone levels in pregnant Japanese women. (2009)
  • Author(s): Nakamura N, Wada K, Nagata C, Shimizu H
  • Organizer: 第68回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-03
• [Presentation] Association of dietary soy intake with urinary sex steroid among Japanese young children. (2009)
  • Author(s): Wada K, Nakamura K, Oba S, Nagata C
  • Organizer: 第68回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-03
• [Presentation] 日本人妊娠女性における睡眠習慣と血清おわび臍帯血ホルモン値との関連 (2009)
  • Author(s): 中村こず枝、和田恵子、永田知里, ら.
  • Organizer: 癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] Risk factors for breast cancer in Japanese women. (2008)
  • Author(s): Nagata C.
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] JCA-AACR Cancer Research Conference. (2008)
  • Author(s): 永田知里
  • Organizer: The Latest Advances in Breast Cancer Research: From Basic Science to Therapeutics
  • Place of Presentation: Hyogo, Japan
  • Year and Date: 2008-07-15
• [Remarks]
  • URL: http://www1.gifu-u.ac.jp/~ph/