Molecular epidemiology on obesity and colorectal carcinogenesis

• Project/Area Number: 19390175
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyushu University
• Principal Investigator: KONO Suminori Kyushu University, 大学院・医学研究院, 教授 (70128015)
• Co-Investigator(Kenkyū-buntansha): OHNAKA Keizo 九州大学, 大学院・医学研究院, 講師 (30325518) ; NAGANO Jun 九州大学, 健康科学センター, 准教授 (10325483)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000); Fiscal Year 2008: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2007: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
• Keywords: 大腸がん / 大腸腺腫 / 肥満 / 炎症 / 分子疫学 / アディポサイトカイン / 炎症マーカー

Research Abstract

肥満は大腸がん危険度を高めることが、国内外の疫学研究で指摘されている。しかし、どのようなメカニズムで肥満が大腸がんを起こすのかははっきりしていない。前がん病変である大腸腺腫の患者及び大腸がん患者と健常者を比較する症例対照研究の手法により、肥満関連の血中物質と大腸腺腫及び大腸がんとの関連を検討した。善玉物質であるアディポネクチンが高い者では大腸腺腫危険度の低下傾向がみられたが、肥満に起因するものであった。一方、大腸がんに対しては、アディポネクチンは肥満を考慮しても予防的であった。CRP濃度が高い者では大きな腺腫の危険度が高まっていた。炎症が大腸発がんに関与していることを示す知見である。若さの指標ホルモンDHEA-Sが高い人では大腸がんになりにくいことを示す結果が得られた。

Research Products

• [Journal Article] C-reactive protein and colorectal adenomas : The Self Defense Forces Health Study (2009)
  • Author(s): Otake T, Uezono K, Takahashi R, Fukumoto J, Tabata S, Abe H, Tajima O, Mizoue T, Ohnaka K, Kono S.
  • Journal Title: Cancer Sci 99(4) Pages: 781-786
  • NAID: 10025144591
  • Peer Reviewed
• [Journal Article] Waist circumference and insulin resistance : a cross-sectional study of Japanese men (2009)
  • Author(s): Tabata S, Shinichiro Yoshimitsu S, Hamachi T, Abe H, Ohnaka K, Kono S
  • Journal Title: BMC Endocrine Disorders 9 Pages: 1-1
  • Peer Reviewed
• [Journal Article] C-reactive protein and colorectal adenomas : The Self Defense Forces Health Study. (2009)
  • Author(s): Otake T, et al.
  • Journal Title: Cancer Sci 99 Pages: 781-786
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms of CYP2E1 and risk of colorectal cancer : The Fukuoka Colorectal Cancer Study. (2009)
  • Author(s): Morita M, et al.
  • Journal Title: Cancer Epidemiol Biomarkers Prev 18 Pages: 235-241
  • Peer Reviewed
• [Journal Article] Adiponectin and colorectal adenomas : The Self Defense Forces Health Study (2008)
  • Author(s): Fukumoto J, Otake T, Tajima O, Tabata S, Abe H, Mizoue T, Ohnaka K, Kono S.
  • Journal Title: Cancer Sci 99(4) Pages: 781-786
  • NAID: 10024005116
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study (2008)
  • Author(s): Morita M, Tabata S, Tajima O, Yin G, Abe H, Kono S.
  • Journal Title: Cancer Epidemiol Biomarkers Prev 17(7) Pages: 1800-1807
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms of CYP2E1 and risk of colorectal adenomas in the Self Defense Forces Health Study. (2008)
  • Author(s): Morita M, et al.
  • Journal Title: Cancer Epidemiol Biomarkers Prev 17 Pages: 1800-1807
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms of cyclooxygenase-2 and colorectal adenomas:The Self Defense Forces Health Study. (2008)
  • Author(s): Ueda N
  • Journal Title: Cancer Science 2008 Pages: 576-581
  • Peer Reviewed
• [Journal Article] Adiponectin and colorectal adenomas:The Self Defbnse Forces Health Study. (2008)
  • Author(s): Fukumoto J
  • Journal Title: Cancer Science (印刷中)
  • Peer Reviewed
• [Journal Article] Impact of C-reactive protein on disease risk and its relation to dietarv factors:Literature review.2007:(2):167-77. (2007)
  • Author(s): Nanri A
  • Journal Title: Asian Pacific Journal Cancer Prevention 8 Pages: 167-177
  • Peer Reviewed
• [Presentation] Lifestyle factors and genetic polymorphisms in colorectal carcinogenesis : evidence from the Fukuoka Colorectal Cancer Study (2008)
  • Author(s): Kono S.
  • Organizer: The 15th Seoul International Cancer Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2008-12-05
• [Presentation] Plasma adiponectin, genetic polymorphisms and colbrectal cancer : the Fukuoka Colorectal Cancer Study. (2008)
  • Author(s): Guang Y, et al.
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Presentation] Plasma adiponectin, genetic polymorphisms and colorectal cancer : the Fukuoka Colorectal cancer Study (2008)
  • Author(s): 銀光、古野純典
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Obesity, physical activity and related molecules in colorectal carcinogenesis (2008)
  • Author(s): Kono S.
  • Organizer: The 39th International Symposium of the Princess Takamatsu Cancer Research Fund
  • Place of Presentation: Tokyo
• [Presentation] High-sensitivity C-reactive protein and colorectal adenomas (2007)
  • Author(s): Otake T
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-04
• [Presentation] Adiponectin and colorectal adenomas : Self Defense Forces Health Study (2007)
  • Author(s): 福元仁、大竹登志江、溝上哲也、古野純典
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] High-sensitivity C-reactive protein and colorectal adenomas : Self Defense Forces Health Study (2007)
  • Author(s): 大竹登志江、福元仁、溝上哲也、古野純典
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/phealth/kono.html
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/phealth/kono.html
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/phealth/kono.html