Development of forensic neuropathology through a study on brain changes after intracerebral implantation of foreign body
| Project/Area Number |
19390186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Tokyo Women's Medical University (2008-2009)
Saga University (2007) |
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Principal Investigator |
KIBAYASHI Kazuhiko Tokyo Women's Medical University, 医学部, 教授 (20244113)
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| Research Collaborator |
NAKAO Ken-ichiro 佐賀大学, 大学院・医学研究科・博士課程
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Keywords | 法医病理学 / 法医神経病理学 / 法医病理 / 神経病理 / 頭部外傷 / 穿通性脳損傷 / 病態生理 |
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| Research Abstract |
In cases of open head injuries, a foreign body may remain in the brain for a period of time after the trauma and causes brain dysfunction. We developed an animal model incorporating a foreign body in the brain. A lead or a glass ball was implanted in the cerebral cortex of rats. Brains were analyzed at various times between 12 hours and 4 weeks after implantation. The immunoreactivity of metallothionein, a metal binding protein, increased significantly in the brain with increasing time after implantation of a lead ball. Apoptotic cells were identified at 2 weeks, but had mostly disappeared at 4 weeks after implantation of a lead ball. Moreover, N-methyl-D-aspartate receptor genes were significantly suppressed at 1 to 3 weeks after implantation of a lead ball. This study showed that lead leached from a lead ball induces metallothionein expression, apoptosis and N-methyl-D-aspartate receptor gene suppression in the brain.
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Report
(4 results)
Research Products
(28 results)
