| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Research Abstract |
In cases of open head injuries, a foreign body may remain in the brain for a period of time after the trauma and causes brain dysfunction. We developed an animal model incorporating a foreign body in the brain. A lead or a glass ball was implanted in the cerebral cortex of rats. Brains were analyzed at various times between 12 hours and 4 weeks after implantation. The immunoreactivity of metallothionein, a metal binding protein, increased significantly in the brain with increasing time after implantation of a lead ball. Apoptotic cells were identified at 2 weeks, but had mostly disappeared at 4 weeks after implantation of a lead ball. Moreover, N-methyl-D-aspartate receptor genes were significantly suppressed at 1 to 3 weeks after implantation of a lead ball. This study showed that lead leached from a lead ball induces metallothionein expression, apoptosis and N-methyl-D-aspartate receptor gene suppression in the brain.
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