Host responses to stress and progression to disease
Project/Area Number |
19390191
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
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Research Institution | Nagoya University |
Principal Investigator |
ISOBE Ken-ichi Nagoya University, 大学院・医学系研究科, 教授 (20151441)
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Co-Investigator(Kenkyū-buntansha) |
鈴木 治彦 名古屋大学, 大学院・医学系研究科, 准教授 (90283431)
林 登志雄 名古屋大学, 医学部附属病院, 講師 (80303634)
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Project Period (FY) |
2007 – 2009
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Project Status |
Completed (Fiscal Year 2009)
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Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
Keywords | ストレス / マクロファージ / 生体応答 / 自己免疫 / 活性酸素 / 疾患 |
Research Abstract |
Stresses destruct tissues and wound repair processes begin. In wound healing, phagocytes such as neutrophils and macrophages clear damaged tissues, pathophysiologic processes which are also observed in atherosclerosis and autoimmune diseases. This process requires that phagocytes recognize specific surface receptors. Phagocytosis is enhanced by autoantibody-mediated opsonization of damaged tissues. We showed that Bleomycin or DSS prolong the wound healing processes and progress to systemic sclerosis and ulcerative colitis.
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Report
(4 results)
Research Products
(99 results)
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[Journal Article]2010
Author(s)
H.Sakurai, Y, Inami, N.Nishio, S.Ito, T.Yoshikai, H.Suzuki, K.Isobe
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Journal Title
Specific serum-free conditions can differentiate mouse embryonic stem cells into osteochondrogenic and myogenic progenitors(Micro Electronic and Mechanical Systems, ISBN 978-953-307-027-8)
Pages: 107-112
Related Report
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[Journal Article]2009
Author(s)
Sakurai H, Inami Y, Tamamura Y, Yoshikai T, Sehara-Fujisawa A, Isobe K
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Journal Title
Stem Cell Res 3(2-3)
Pages: 157-69
Related Report
Peer Reviewed
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[Journal Article] IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease2008
Author(s)
Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe K, Hibi T
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Overexpression of indoleamine 2, 3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model2008
Author(s)
Yoshida N, Ino K, Ishida Y, Kajiyama H, Yamamoto E, Shibata K, Terauchi M, Nawa A, Akimoto H, Takikawa O, Isobe K, Kikkawa F
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Journal Title
Clin Cancer Res 14(22)
Pages: 7251-9
Related Report
Peer Reviewed
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[Journal Article] Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model2008
Author(s)
Yoshida N, Ino K, Ishida Y, Kajiyama H, Yamamoto E, Shibata K, Terauchi M, Nawa A, Akimoto H, Takikawa O, Isobe K, Kikkawa F
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Journal Title
Clin Cancer Res 14(22)
Pages: 7251-7259
Related Report
Peer Reviewed
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[Journal Article] IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease2008
Author(s)
Kobayashi T, Okamoto S, Hisamatsu T, Kamada N, Chinen H, Saito R, Kitazume MT, Nakazawa A, Sugita A, Koganei K, Isobe K, Hibi T.
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Journal Title
Gut. 57(12)
Pages: 1682-1689
Related Report
Peer Reviewed
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[Journal Article] Suppression of Viral Replication by Stress-inducible GADD34 via the mTOR Pathway2007
Author(s)
Minami K, Tambe Y, Watanabe R, Isono T, Haneda M, Isobe KI, Kobayashi T, Hino O, Okabe H, Chano T, Inoue H.
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Journal Title
J Virol. 81
Pages: 11106-11115
Related Report
Peer Reviewed
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[Presentation] ブレオマイシンによる全身性強皮症モデル2007
Author(s)
Hideaki Ishikawa, Kozue Takeda, Masataka HANEDA, ISHIDA Yoshiyuki, Ken-ichi ISOBE
Organizer
第37回日本免疫学会総会
Place of Presentation
東京
Year and Date
2007-11-21
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