Gut microbiota and Host Stress Response

• Project/Area Number: 19390192
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kyushu University
• Principal Investigator: KUBO Chiharu Kyushu University, 大学病院, 教授 (80117100)
• Co-Investigator(Kenkyū-buntansha): SUDO Nobuyuki 九州大学, 大学院・医学研究院, 教授 (60304812) ; YOSHIHARA Kazufumi 九州大学, 大学病院, 助教 (20444854) ; KOGA Yasuhiro 東海大学, 医学部, 教授 (60170221)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2007: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 生理学 / ストレス / 神経科学 / 腸内細菌

Research Abstract

Our previous works on germ-free and gnotobiotic mice demonstrate that gut microbiota can affect the development of hypothalamic-pituitary-adrenal reaction to stress. In this study, behavioral analysis was further investigated using these mice. In addition, we also examined the effects of maternal fecal and vaginal flora on infant salivary cortisol levels. As a result, germ-free mice were more anxious than Ex-GF mice which were reconstituted with SPF feces. Regarding salivary cortisol levels in human babies, they were negatively correlated with the ratio of Bifidobacterium to Lactobacillus in maternal cervical swabs.

Research Products

• [Journal Article] Mood and gut feelings (2010)
  • Author(s): Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J
  • Journal Title: Brain Behav Immun 24 Pages: 9-16
  • Peer Reviewed
• [Journal Article] Mood and gut feelings (2010)
  • Author(s): Forsythe PSudo N, Dinan T, Taylor VH, Bienenstock J
  • Journal Title: Brain Behav Immun 24 Pages: 9-16
  • Peer Reviewed
• [Journal Article] Influence of maternal bifidobacterial microbiota on the establishment of intestinal bifidobacterial microbiota in infants (2009)
  • Author(s): Mikami K, Takahashi H, Kimura M, Isozaki M, Izuchi K, Shibuta R, Sudo N, Matsumoto H, Koga Y
  • Journal Title: Pediatric Research 65 Pages: 669-674
  • Peer Reviewed
• [Journal Article] Long-term administration of probiotics to asymptomatic pre-school children for either the eradication or the prevention of helicobacter pylori Infection. (2009)
  • Author(s): Boonyaritichaikij S, Kuwabara K, J Nagano J, Kobayashi K, Koga Y
  • Journal Title: Helicobacter 14 Pages: 202-207
  • Peer Reviewed
• [Journal Article] Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants (2009)
  • Author(s): Shibata R, Kimura M, Takahashi H, Mikami K, Aiba Y, Takeda H, Koga Y
  • Journal Title: Clin Exp Allergy 39 Pages: 1397-1403
  • Peer Reviewed
• [Journal Article] 腸内フローラによるストレス反応の制御:腸内フローラと脳機能 (2009)
  • Author(s): 須藤信行
  • Journal Title: 医学のあゆみ 228 Pages: 223-226
• [Journal Article] Relationship between the body position-specific apnea-hypopnea index and subiective sleepiness (2009)
  • Author(s): Tanaka F, Nakano H, Sudo N, Kubo C
  • Journal Title: Respiration 78 Pages: 185-190
  • Peer Reviewed
• [Journal Article] Influence of maternal bifidobacterial microbiota on the establishment of intestinal bifidobacterial microbiota in infants (2009)
  • Author(s): Mikami K, Takahashi H, Kimura M, Isozaki M, Izuchi K, Shibata R, Sudo N, Matsumoto H, Koga Y
  • Journal Title: Pediatric Research (In press)
  • Peer Reviewed
• [Journal Article] Relationship between the body position-specific apnea-hypopnea index and subjective sleepiness (2009)
  • Author(s): Tanaka F, Nakano H, Sudo N, Kubo C
  • Journal Title: Respiration (In press)
  • Peer Reviewed
• [Journal Article] 腸内フローラによるストレス反応の制御 : 腸内フローラと脳機能 (2009)
  • Author(s): 須藤信行
  • Journal Title: 医学のあゆみ 228 Pages: 223-226
• [Journal Article] The hepatic vagus nerve attenuates Fas-induced apoptosis in the mouse liver via alpha7 nicotinic acetylcholine recepto (2008)
  • Author(s): Hiramoto T, Chida Y, Sonoda J, Yoshihara K, Sudo N, Kubo C
  • Journal Title: astroenterology 134 Pages: 2122-2131
  • Peer Reviewed
• [Journal Article] The hepatic vagus nerve attenuates Fas-induced apoptosis in the mouse liver via a7 nicotinic acetylcholine receptor (2008)
  • Author(s): Hiramoto T, Chida Y, Sonoda J, Yoshihara K, Sudo N, Kubo C.
  • Journal Title: Gastroenterology (in press)
  • Peer Reviewed
• [Journal Article] IL-15 exacerbates collagen-induced an enhanced CD4(+) T cell response arthritis with to produce IL-17 (2007)
  • Author(s): Yoshihara K, Yamada H, Hori A, Yajima T, Kubo C, Yoshikai Y
  • Journal Title: European Journal of Immunology 37 Pages: 2744-2752
  • Peer Reviewed
• [Journal Article] IL-15 exacerbates collagen-induced an enhanced CD4(+) T cell response arthritis witht oproduce IL-17. (2007)
  • Author(s): Yoshihara K, Yamada H, Hori A, Yajima T, Kubo C, Yoshikai Y.
  • Journal Title: European Journal of Immunology 37 Pages: 2744-3752
  • Peer Reviewed
• [Presentation] 脳腸相関からみたプロバイオティクスの展望 (2010)
  • Author(s): 須藤信行
  • Organizer: プロバイオティクスシンポジウム2010
  • Place of Presentation: 東京
• [Presentation] 精神神経免疫学とアレルギーの最前線 (2009)
  • Author(s): 須藤信行, 久保千春
  • Organizer: 第59回日本アレルギー学会総会
  • Place of Presentation: 秋田
• [Presentation] ストレスと腸内フローラ (2009)
  • Author(s): 須藤信行
  • Organizer: 第13回腸内細菌学会
  • Place of Presentation: 東京
• [Presentation] The microbiome Brain-Gut axis: The ability of gut flora to influence the host hypothalamic-pituitary-adrenal axis (2008)
  • Author(s): Sudo N
  • Organizer: Digestive Disease Week 2008
  • Place of Presentation: San Diego, USA
• [Presentation] The microbiome Brain-Gut axis : The ability of gut flora to influence the host hypothalamic-pituitary-adrenal axis (2008)
  • Author(s): Sudo N
  • Organizer: Digestive Disease Week 2008
  • Place of Presentation: San Diego, USA