Mechanism of fibrolysis and effect on cancer by autologus bone marrow cell infusion therapy for liver cirrhosis
| Project/Area Number |
19390199
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SAKAIDA Isao Yamaguchi University, 大学院・医学系研究科, 教授 (80263763)
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Takahiro 山口大学, 大学院・医学系研究科, 准教授 (00304478)
TERAI Shuji 山口大学, 大学院・医学系研究科, 講師 (00332809)
YAMAMOTO Naoki 山口大学, 大学院・医学系研究科, 助教 (90448283)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 再生医学 / 肝線維化 / 肝発癌 / 電子顕微鏡 / 発癌 / サイトカイン / MMP9 / 肝腺維化 / 癌 / 移植 / 細胞・組織 |
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| Research Abstract |
We have previously reported the effects of autologous bone marrow cell (BMC) infusion (ABMi) therapy in liver cirrhosis patients.The results showed that cell therapy using autologous BMC has the potential to become an effective treatment for patients with liver failure due to advanced liver cirrhosis.To analyze the cellular phenomena of involved in this process and the mechanism of dissolve in fibrosis, we checked the damaged liver using electron microscopy and estimated some kind of serum cytokines. We showed that G-CSF and IL1b is important and concerned about the proliferation of BMC in damage liver. We showed continuous high XBP1 and GRP78 expression might be essential for the survival and proliferation of BMC in liver damage environment.
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Report
(4 results)
Research Products
(106 results)
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[Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.2009
Author(s)
Ohata S, Nawa M, Kasama T, Yamasaki T, Sawanobori K, Hata S, Nakamura T, Asaoka Y, Watanabe T, Okamoto H, Hara T, Terai S, Sakaida I, Katada T, Nishina H
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Journal Title
Biochem Biophys Res Commun 379(4)
Pages: 817-23
Related Report
Peer Reviewed
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[Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver.2008
Author(s)
Marumoto Y, Terai S, Urata Y, Matsumoto T, Mizunaga Y, Yamamoto N, Jin H, Fujisawa K, Murata T, Shinoda K, Nishina H, Sakaida I
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Journal Title
Biochem Biophys Res Commun 367(3)
Pages: 546-52
Related Report
Peer Reviewed
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[Journal Article] Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription.2008
Author(s)
Nishina S, Hino K, Korenaga M, Vecchi C, Pietrangelo A, Mizukami Y, Furutani T, Sakai A, Okuda M, Hidaka I, Okita K, Sakaida I
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Journal Title
Gastroenterology 134(1)
Pages: 226-38
Related Report
Peer Reviewed
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