Mechanism of fibrolysis and effect on cancer by autologus bone marrow cell infusion therapy for liver cirrhosis

• Project/Area Number: 19390199
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Yamaguchi University
• Principal Investigator: SAKAIDA Isao Yamaguchi University, 大学院・医学系研究科, 教授 (80263763)
• Co-Investigator(Kenkyū-buntansha): YAMASAKI Takahiro 山口大学, 大学院・医学系研究科, 准教授 (00304478) ; TERAI Shuji 山口大学, 大学院・医学系研究科, 講師 (00332809) ; YAMAMOTO Naoki 山口大学, 大学院・医学系研究科, 助教 (90448283)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 再生医学 / 肝線維化 / 肝発癌 / 電子顕微鏡 / 発癌 / サイトカイン / MMP9 / 肝腺維化 / 癌 / 移植 / 細胞・組織

Research Abstract

We have previously reported the effects of autologous bone marrow cell (BMC) infusion (ABMi) therapy in liver cirrhosis patients.The results showed that cell therapy using autologous BMC has the potential to become an effective treatment for patients with liver failure due to advanced liver cirrhosis.To analyze the cellular phenomena of involved in this process and the mechanism of dissolve in fibrosis, we checked the damaged liver using electron microscopy and estimated some kind of serum cytokines. We showed that G-CSF and IL1b is important and concerned about the proliferation of BMC in damage liver. We showed continuous high XBP1 and GRP78 expression might be essential for the survival and proliferation of BMC in liver damage environment.

Research Products

• [Journal Article] A multicenter, open-label, dose-ranging study to exploratively evaluate the efficacy, safety, and dose-response of tolvaptan in patients with decompensated liver cirrhosis. (2010)
  • Author(s): Okita K
  • Journal Title: J Gastroenterol (in press)
  • Peer Reviewed
• [Journal Article] Medaka as a model for human nonalcoholic steatohepatitis. (2010)
  • Author(s): Matsumoto T
  • Journal Title: Dis Model Mech (in press)
  • Peer Reviewed
• [Journal Article] Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. (2010)
  • Author(s): Negishi T
  • Journal Title: Hepatology 51(3) Pages: 1037-1045
  • Peer Reviewed
• [Journal Article] Diagnosis and treatment of portal hypertension. (2009)
  • Author(s): Segawa M, Sakaida I
  • Journal Title: Hepatol Res. Oct 39(10) Pages: 1039-43
  • NAID: 10027405349
  • Peer Reviewed
• [Journal Article] Usefulness of Sonazoid contrast-enhanced ultrasonography for hepatocellular carcinoma: comparison with pathological diagnosis and superparamagnetic iron oxide magnetic resonance images. (2009)
  • Author(s): Korenaga K, Korenaga M, Furukawa M, Yamasaki T, Sakaida I
  • Journal Title: J Gastroenterol 44(7) Pages: 733-41
  • NAID: 10025176213
  • Peer Reviewed
• [Journal Article] Current status of autologous bone marrow cell infusion therapy for liver cirrhosis patients. (2009)
  • Author(s): Terai S, Sakaida I
  • Journal Title: Hepatol Res 38 Pages: 72-75
  • NAID: 10025323416
  • Peer Reviewed
• [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. (2009)
  • Author(s): Ohata S, Nawa M, Kasama T, Yamasaki T, Sawanobori K, Hata S, Nakamura T, Asaoka Y, Watanabe T, Okamoto H, Hara T, Terai S, Sakaida I, Katada T, Nishina H
  • Journal Title: Biochem Biophys Res Commun 379(4) Pages: 817-23
  • Peer Reviewed
• [Journal Article] Hepatol Res (2009)
  • Author(s): Takaki-Hamabe S, Yamasaki T, Saeki I, Harima Y, Okita K, Terai S, Sakaida I
  • Journal Title: 39(3) Pages: 223-30
  • Peer Reviewed
• [Journal Article] Continuos intravenous infusion of atrial natriuretic peptide (ANP) prevented liver fibrosis in rat. (2009)
  • Author(s): Ishigaki N, Yamamoto N, Jin H, Uchida K, Terai S, Sakaida I
  • Journal Title: 378(3) Pages: 354-9
  • Peer Reviewed
• [Journal Article] Diagnosis and treatment of portal hypertension. (2009)
  • Author(s): Segawa M
  • Journal Title: Hepatol Res 39(10) Pages: 1039-1043
  • Peer Reviewed
• [Journal Article] Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. (2009)
  • Author(s): Tanaka Y
  • Journal Title: Nat Genet 41(10) Pages: 1105-1109
  • Peer Reviewed
• [Journal Article] Usefulness of Sonazoid contrast-enhanced ultrasonography for hepatocellular carcinoma : comparison with pathological diagnosis and superparamagnetic iron oxide magnetic resonance images. (2009)
  • Author(s): Korenaga K
  • Journal Title: J Gastroenterol 44(7) Pages: 733-741
• [Journal Article] Current status of autologous bone marrow cell infusion therapy for liver cirrhosis patients. (2009)
  • Author(s): Terai S
  • Journal Title: Hepatol Res. 38
  • Peer Reviewed
• [Journal Article] Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. (2009)
  • Author(s): Ohata S
  • Journal Title: Biochem Biophys Res Commun. 379(4) Pages: 817-823
  • Peer Reviewed
• [Journal Article] Pilot study of combination therapy with transcatheter arterial infusion chemotherapy using iodized oil and percutaneous radiofrequency ablation during occlusion of hepatic blood flow for hepatocellular carcinoma. (2008)
  • Author(s): Shiraishi R, Yamasaki T, Saeki I, Okita K, Yamaguchi Y, Uchida K, Terai S, Sakaida I
  • Journal Title: Am J Clin Oncol 31(4) Pages: 311-6
  • Peer Reviewed
• [Journal Article] Effects of a late evening snack combined with alpha-glucosidase inhibitor on liver cirrhosis. (2008)
  • Author(s): Korenaga K, Korenaga M, Uchida K, Yamasaki T, Sakaida I
  • Journal Title: Hepatol Res 38(11) Pages: 1087-97
  • Peer Reviewed
• [Journal Article] Autologous bone marrow cell infusion therapy for liver cirrhosis. (2008)
  • Author(s): Sakaida I
  • Journal Title: J GastroenterolHepatol 23(9) Pages: 1349-53
  • NAID: 40019163679
  • Peer Reviewed
• [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl4-treated cirrhotic liver. (2008)
  • Author(s): Marumoto Y, Terai S, Urata Y, Matsumoto T, Mizunaga Y, Yamamoto N, Jin H, Fujisawa K, Murata T, Shinoda K, Nishina H, Sakaida I
  • Journal Title: Biochem Biophys Res Commun 367(3) Pages: 546-52
  • Peer Reviewed
• [Journal Article] Serum S100b (astrocyte-specific protein) is a useful marker of hepatic encephalopathy in patients with fulminant hepatitis. (2008)
  • Author(s): Isobe-Harima Y, Terai S, Segawa M, Uchida K, Yamasaki T, Sakaida I
  • Journal Title: Liver Int 28(1) Pages: 146-7
  • Peer Reviewed
• [Journal Article] Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. (2008)
  • Author(s): Nishina S, Hino K, Korenaga M, Vecchi C, Pietrangelo A, Mizukami Y, Furutani T, Sakai A, Okuda M, Hidaka I, Okita K, Sakaida I
  • Journal Title: Gastroenterology 134(1) Pages: 226-38
  • Peer Reviewed
• [Journal Article] A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behaviour disorder. (2008)
  • Author(s): Isobe-Harima Y, Terai S, Miura I, Segawa M, Murata T, Itamoto K, Taura Y, Shinoda K, Sakaida I
  • Journal Title: Liver Int 28(1) Pages: 117-25
  • Peer Reviewed
• [Journal Article] Continuos intravenous infusion of atrial natriuretic peptide (ANP) prevented liver fibrosis in rat. (2008)
  • Author(s): Ishigaki N
  • Journal Title: Biochem Biophys Res Commun. 378(3) Pages: 354-359
  • Peer Reviewed
• [Journal Article] Autologous bone marrow cell infusion therapy for liver cirrhosis. (2008)
  • Author(s): Sakaida I
  • Journal Title: J Gastroenterol Hepatol. 23(9) Pages: 1349-1353
  • NAID: 40019163679
  • Peer Reviewed
• [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl_4-treated cirrhotic liver. (2008)
  • Author(s): Marumoto Y
  • Journal Title: Biochem Biophys Res Commun. 367(3) Pages: 546-552
  • Peer Reviewed
• [Journal Article] Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. (2008)
  • Author(s): Nishina S
  • Journal Title: Gastroenterology 134(1) Pages: 226-238
  • Peer Reviewed
• [Journal Article] Continuous high expression of XBP1 and GRP78 is important for the survival of bone marrow cells in CCl_4-treated cirrhotic liver. (2008)
  • Author(s): Marumoto Y
  • Journal Title: BBRC 367(3) Pages: 564-552
  • Peer Reviewed
• [Journal Article] Serum S100b(astrocyte-specific protein)is a useful marker of hepatic encephalopathy in patients with fulminant hepatitis. (2008)
  • Author(s): Isobe-Harima Y
  • Journal Title: Liver International 28(1) Pages: 146-7
  • Peer Reviewed
• [Journal Article] A new hepatic encephalopathy model to monitor the change of neural amino acids and astrocytes with behavior disorder (2008)
  • Author(s): Isobe-Harima Y
  • Journal Title: Liver International 28(1) Pages: 117-25
  • Peer Reviewed
• [Journal Article] Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet. (2007)
  • Author(s): Jin H, Yamamoto N, Uchida K, Terai S, Sakaida I
  • Journal Title: Biochem Biophys Res Commun 364(4) Pages: 801-7
  • Peer Reviewed
• [Journal Article] Screening of hepatocellular cancer: Japanese strategy. (2007)
  • Author(s): Okita K, Kurokawa F, Yamasaki T, Sakaida I
  • Journal Title: Hepatol Res Suppl2 Pages: 142-5
  • NAID: 10019772793
  • Peer Reviewed
• [Journal Article] The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis. (2007)
  • Author(s): Jin H, Terai S, Sakaida I
  • Journal Title: J Gastroenterol 42(6) Pages: 475-84
  • Peer Reviewed
• [Journal Article] Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. (2007)
  • Author(s): Duan Y, Catana A, Meng Y, Yamamoto N, He S, Gupta S, Gambhir SS, Zern MA
  • Journal Title: Stem cells 25(12) Pages: 3058-68
  • Peer Reviewed
• [Journal Article] Importance of inhibitor of DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation. (2007)
  • Author(s): Tajima K, Terai S, Takami T, Kawaguchi K, Okita K, Sakaida I
  • Journal Title: HepatolRes 7(8) Pages: 647-55
  • Peer Reviewed
• [Journal Article] The effect of supplementation with branched-chain amino acids in patients with liver cirrhosis. (2007)
  • Author(s): Urata Y, Okita K, Korenaga K, Uchida K, Yamasaki T, Sakaida I
  • Journal Title: Hepatol Res 37(7) Pages: 510-6
  • Peer Reviewed
• [Journal Article] Effect of a late evening snack on outpatients with liver cirrhosis. (2007)
  • Author(s): Aoyama K, Tsuchiya M, Mori K, Kubo Y, Shiraishi K, Sakaguchi E, Yamashita S, Sakaida I
  • Journal Title: Hepatol Res 37(8) Pages: 608-14
  • Peer Reviewed
• [Journal Article] Circulating cell-free DNA as a predictive marker for distant metastasis of hepatitis C virus-related hepatocellular carcinoma. (2007)
  • Author(s): Tokuhisa Y
  • Journal Title: Br J Cancer. 97(10) Pages: 1399-403
  • Peer Reviewed
• [Journal Article] Telmisartan prevents hepatic fibrosis and enzyem-altered lesions in rat liver cirrhosis induced by a choline-deficient L-aminoacid-defined. (2007)
  • Author(s): Jin H
  • Journal Title: BBRC 364(4): Pages: 801-7
  • Peer Reviewed
• [Journal Article] Importance of inhibitor DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation. (2007)
  • Author(s): Tajima K
  • Journal Title: Hepatol Res. 37(8): Pages: 647-55
  • Peer Reviewed
• [Journal Article] The iron chelator deferoxamine causes activated hepatic stellate cells to become quiescent and to undergo apoptosis. (2007)
  • Author(s): Jin H
  • Journal Title: J Gastroenterol. 42(6) Pages: 475-84
  • Peer Reviewed
• [Journal Article] 骨髄幹細胞を用いた肝臓再生療法の開発の試み (2007)
  • Author(s): 寺井 崇二
  • Journal Title: 日本再生医療学会雑誌 6(4) Pages: 381-384
• [Presentation] GFP/CCl4モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析 (2010)
  • Author(s): 山本直樹寺井崇二坂井田功
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 脾臓摘出によるABMI療法の肝線維化、肝再生効果に対する臨床、基礎的検討 (2010)
  • Author(s): 岩本拓也山本直樹寺井崇二坂井田功
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 骨髄細胞投与による肝修復機構におけるTNFαシグナルの関与についての検討 (2010)
  • Author(s): 久永拓郎山本直樹寺井崇二坂井田功
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 脾臓摘出術の自己骨髄細胞投与療法に対する臨床、基礎的検討 (2010)
  • Author(s): 岩本拓也
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 免疫電顕を用いた骨髄由来肝幹細胞の肝硬変の修復時の各種細胞の動態 (2010)
  • Author(s): 山本直樹
  • Organizer: 第9回日本再生医療学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-03-18
• [Presentation] 脾臓摘出術の自己骨髄細胞投与療法に対する臨床、基礎的検討 (2009)
  • Author(s): 岩本拓也
  • Organizer: 第23回肝類洞壁細胞研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-23
• [Presentation] 免疫電顕を用いた骨髄由来肝幹細胞の肝硬変の修復時の各種細胞の動態 (2009)
  • Author(s): 山本直樹
  • Organizer: 第23回肝類洞壁細胞研究会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-23
• [Presentation] 非代償性肝硬変症に対する自己骨髄細胞投与療法の現状と今後の展開 (2009)
  • Author(s): 高見太郎
  • Organizer: 第38回日本肝臓学会西部会
  • Place of Presentation: 鳥取
  • Year and Date: 2009-12-04
• [Presentation] HE ELECTRON MICROSCOPICAL ANALYSIS FOR CELL LINEAGE OF BONE MARROW CELL DIFFERENTIATION IN CIRRHOSIS MICE (2009)
  • Author(s): 山本直樹
  • Organizer: 第17回UEGW/G/Gastro 2009(United European Gastroenterology Week)
  • Place of Presentation: London UK
  • Year and Date: 2009-11-26
• [Presentation] THE ELECTRON MICROSCOPICAL ANALYSIS FOR CELL LINEAGE OF BONE MARROW CELL DIFFERENTIATION IN CIRRHOSIS MICE. (2009)
  • Author(s): Yamamoto N, Terai S, Sakaida I
  • Organizer: 第17回UEGW/Gastro 2009(United European Gastroenterology Week)
  • Place of Presentation: London UK
  • Year and Date: 2009-11-25
• [Presentation] Current status of ABMI (Autologous Bone Marrow Cell Infusion) therapy for liver cirrhosis patient (2009)
  • Author(s): 坂井田功
  • Organizer: 第3回ISGSCT(International Study Group For Stem Cell Therapy)
  • Place of Presentation: Cairoo Egypt
  • Year and Date: 2009-11-19
• [Presentation] THE ELECTRON MICROSCOPICAL ANALYSIS FOR CELL LINEAGE OF BONE MARROW CELL DIFFERENTIATION IN CIRRHOSIS MICE (2009)
  • Author(s): 山本直樹
  • Organizer: 第60回AASLD(The American Association for the Study of Liver Disease)
  • Place of Presentation: Boston USA
  • Year and Date: 2009-11-03
• [Presentation] Splenectomy enhances the effect of bone marrow cell infusion on the repair of the microenvironment in mice and patients with liver cirrhosis (2009)
  • Author(s): 岩本拓也
  • Organizer: 第60回AASLD(The American Association for the Study of Liver Disease)
  • Place of Presentation: Boston USA
  • Year and Date: 2009-11-03
• [Presentation] Bone marrow cell derived Mesenchyaml Cells reduce liver fibrosis and improved liver function in CC14-treated cirrhosis mice (2009)
  • Author(s): 岩本拓也
  • Organizer: 第60回AASLD(The American Association for the Study of Liver Disease)
  • Place of Presentation: Boston USA
  • Year and Date: 2009-11-03
• [Presentation] THE ELECTRON MICROSCOPICAL ANALYSIS FOR CELL LINEAGE OF BONE MARROW CELL DIFFERENTIATION IN CIRRHOSIS MICE. (2009)
  • Author(s): Yamamoto N, Terai S, Sakaida I
  • Organizer: 第60回AASLD(The American Association for the Study of Liver Disease)
  • Place of Presentation: Boston USA
  • Year and Date: 2009-11-02
• [Presentation] TNF-alpha signal is important to repair cirrhotic liver by bone marrow cell infusion (2009)
  • Author(s): Hisanaga T, Terai S, Iwamoto T, Takami T, Yamamoto N, Nishina H, Sakaida I
  • Organizer: 第60回AASLD(The American Association for the Study of Liver Disease)
  • Place of Presentation: Boston USA
  • Year and Date: 2009-11-01
• [Presentation] plenectomy enhances the effect of bone marrow cell infusion on the repair of the microenvironment in mice and patients with liver cirrhosis (2009)
  • Author(s): Iwamoto T, Terai S, Yamamoto N, Sakaida I
  • Organizer: 第60回AASLD(The American Association for the Study of Liver Disease)
  • Place of Presentation: Boston USA
  • Year and Date: 2009-10-31
• [Presentation] 硬変肝におけるHHM(Maid)によるTGF-betaシグナルの制御の可能性について (2009)
  • Author(s): 寺井崇二
  • Organizer: JDDW(DDW-Japan 2009)
  • Place of Presentation: 京都
  • Year and Date: 2009-10-14
• [Presentation] 免疫電顕を用いた骨髄由来細胞の肝硬変修復時の動熊と各種特徴 (2009)
  • Author(s): 山本直樹
  • Organizer: 第5回広島肝臓プロジェクト研究センターシンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2009-09-15
• [Presentation] 免疫電顕を用いた骨髄由来肝幹細胞の肝硬変の修復時の各種細胞の動態 (2009)
  • Author(s): 山本直樹寺井崇二坂井田功
  • Organizer: 第16回肝細胞研究会
  • Place of Presentation: 山形
  • Year and Date: 2009-06-26
• [Presentation] 免疫電顕を用いた骨髄由来肝幹細胞の肝硬変の修復時の各種細胞の動熊 (2009)
  • Author(s): 山本直樹
  • Organizer: 第16回肝細胞研究会
  • Place of Presentation: 山形
  • Year and Date: 2009-06-19
• [Presentation] 免疫電顕を用いた骨髄由来肝幹細胞の肝硬変の修復時の各種細胞の動態 (2009)
  • Author(s): 山本直樹寺井崇二坂井田功
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-05
• [Presentation] 脾臓摘出術の自己骨髄細胞投与療法に対する臨床、基礎的検討 (2009)
  • Author(s): 岩本拓也山本直樹寺井崇二坂井田功
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-05
• [Presentation] 骨髄細胞投与による肝修復機構におけるTNFαシグナルの関与についての検討 (2009)
  • Author(s): 久永拓郎山本直樹寺井崇二坂井田功
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-05
• [Presentation] 脾臓摘出術の自己骨髄細胞投与療法に対する臨床、基礎的検討 (2009)
  • Author(s): 岩本拓也
  • Organizer: 第45回 日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-05
• [Presentation] 免疫電顕を用いた骨髄由来肝幹細胞の肝硬変の修復時の各種細胞の動熊 (2009)
  • Author(s): 山本直樹
  • Organizer: 第45回 日本肝臓学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-06-05
• [Presentation] GFP/CCl4モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析 (2009)
  • Author(s): 山本直樹寺井崇二坂井田功
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-05
• [Presentation] 脾臓摘出によるABMI療法の肝線維化、肝再生効果に対する臨床、基礎的検討 (2009)
  • Author(s): 岩本拓也山本直樹寺井崇二坂井田功
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-05
• [Presentation] 肝硬変症に対するラエンネックの肝機能改善効果に対する検討 (2009)
  • Author(s): 久永拓郎山本直樹寺井崇二坂井田功
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-05
• [Presentation] Current status of ABMI therapy for liver cirrhosis patient (2009)
  • Author(s): Shuji Terai
  • Organizer: Choshu International Liver sumposium2008
  • Place of Presentation: Yamaguchi Japan
  • Year and Date: 2009-02-14
• [Presentation] GFP/CC14モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析 (2009)
  • Author(s): 山本 直樹
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] 脾臓摘出によるABMi療法の肝線維化・肝再生効果に対する臨床・基礎的検討 (2009)
  • Author(s): 岩本 拓也
  • Organizer: 第8回日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] 肝硬変症に対する自己骨髄細胞投与療法 (2008)
  • Author(s): 寺井 崇二
  • Organizer: 国立医薬品食品衛生研究所 特別セミナー
  • Place of Presentation: 東京
  • Year and Date: 2008-12-25
• [Presentation] ABMI therapy combined with splenectomy is an effective for liver cirrhosis (2008)
  • Author(s): Iwamoto T, Terai S, Yamamoto N, Sakaida I
  • Organizer: 第59回AASLD(The American Association for the Study of Liver Disease)
  • Place of Presentation: San Francisco USA
  • Year and Date: 2008-11-01
• [Presentation] G-CSF is a candidate serum marker for ABMI therapy for liver cirrhosis patient (2008)
  • Author(s): Mizunaga Y, Terai S, Yamamoto N, Sakaida I
  • Organizer: 第59回AASLD(The American Association for the Study of Liver Disease)
  • Place of Presentation: San Francisco USA
  • Year and Date: 2008-11-01
• [Presentation] Hepatic stem cellとcancer stem cell (2008)
  • Author(s): 寺井崇二藤澤浩一坂井田功
  • Organizer: 第12回日本肝臓学会大会(JDDW)
  • Place of Presentation: 東京
  • Year and Date: 2008-10-15
• [Presentation] GFP/CCl4モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析 (2008)
  • Author(s): 山本直樹寺井崇二坂井田功
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛
  • Year and Date: 2008-06-04
• [Presentation] 脾臓摘出術併用骨髄細胞投与による肝硬変の改善の検討 (2008)
  • Author(s): 岩本拓也山本直樹寺井崇二坂井田功
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛
  • Year and Date: 2008-06-04
• [Presentation] 骨髄細胞から肝細胞への分化過程におけるサイトカインの動態解析 (2008)
  • Author(s): 水永 裕子
  • Organizer: 第94回日本消化器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-05-15
• [Presentation] 肝臓領域における臨床再生医療研究 (2008)
  • Author(s): 寺井 崇二
  • Organizer: 山口大学産学公連携セミナー
  • Place of Presentation: 山口
  • Year and Date: 2008-04-05
• [Presentation] sao ABMi therapy for Liver Cirrhosis. (2008)
  • Author(s): Sakaida I
  • Organizer: 5th Symposium in Stem Cell Repair & Regeneration in Imperial College of London.
  • Place of Presentation: London UK
• [Presentation] GFP/CC14モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態 (2008)
  • Author(s): 山本 直樹
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛
• [Presentation] GFP/CC14モデルにおける骨髄細胞投与による肝再生過程におけるサイトカインの関与についての検討 (2008)
  • Author(s): 水永 裕子
  • Organizer: 第44回日本肝臓学会総会
  • Place of Presentation: 愛媛
• [Presentation] 骨髄細胞投与による肝硬変症の修復過程におけるサイトカインの関与の検討 (2008)
  • Author(s): 水永 裕子
  • Organizer: 第15回日本肝細胞研究会
  • Place of Presentation: 静岡
• [Presentation] Maid分子からみた幹細胞の分化と癌化の接点に関する研究 (2008)
  • Author(s): 寺井 崇二
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: 東京
• [Presentation] 脾臓摘出による自己骨髄細胞投与療法の効果増強に対する基礎的検討 (2008)
  • Author(s): 岩本 拓也
  • Organizer: 第12回日本肝臓学会大会
  • Place of Presentation: 東京
• [Presentation] ABMI therapy combined with splenectomy is an effective for liver cirrhosist (2008)
  • Author(s): Iwamoto Takuya
  • Organizer: 59^<th> AASLD 2008
  • Place of Presentation: San Francisco, USA
• [Presentation] G-CSF is a candidate serum marker for ABMI therapy for liver cirrhosis patient (2008)
  • Author(s): Mizunaga Yuko
  • Organizer: 59^<th> AASLD 2008
  • Place of Presentation: San Francisco, USA
• [Presentation] Long time follow up for the patient of autologous bone marrow cell infusion(ABMI)therapy for liver cirrhosis. (2007)
  • Author(s): Terai S
  • Organizer: The liver meetiong 2007 Parallel Session(Oral presentation)
  • Place of Presentation: Boston, USA
  • Year and Date: 2007-11-04
• [Presentation] The American Association for the Study of Liver Disease (2007)
  • Author(s): Terai S, Iwamoto T, Mizunaga Y, Omori K, Yamamoto N, Uchida K, Yamasaki T, Sakaida I
  • Organizer: 第58回AASLD
  • Place of Presentation: Boston USA
  • Year and Date: 2007-11-01
• [Presentation] Autologous bone marrow cell infusion (ABMI) therapy for liver cirrhosis patient. (2007)
  • Author(s): Terai S, Ishikawa T, Sakaida I, et. al.
  • Organizer: APASL 2007
  • Place of Presentation: Kyoto
  • Year and Date: 2007-10-16
• [Presentation] Current status of ABMI therapy for liver cirrhosis patient Japan Single Topic Conference. (2007)
  • Author(s): Terai Shuji Sakaida Isao
  • Organizer: H Iwate
  • Year and Date: 2007-10-05
• [Presentation] Current status of ABMI therapy for liver cirrhosis patient. (2007)
  • Author(s): Terai S
  • Organizer: Japan Single Topic Conference
  • Place of Presentation: (Iwate, Morioka)
  • Year and Date: 2007-09-28
• [Presentation] Recent advance in nutritional therapy for liver cirrhosis including cell therapy Hong Kong Association for the Study of Liver Disease. (2007)
  • Author(s): Sakaida Isao
  • Place of Presentation: Hong Kong
  • Year and Date: 2007-09-05
• [Presentation] GFP/CCl4モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析 (2007)
  • Author(s): 山本直樹寺井崇二坂井田功
  • Organizer: 第14回肝細胞研究会
  • Place of Presentation: 鹿児島
  • Year and Date: 2007-06-20
• [Presentation] GFP/CCl4モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析 (2007)
  • Author(s): 山本直樹寺井崇二坂井田功
  • Organizer: 第43回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-06-04
• [Presentation] 肝硬変症に対する自己骨髄細胞投与療法の現状および今後の展望について (2007)
  • Author(s): 寺井 崇二
  • Organizer: 第43回日本肝臓学会総会ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2007-05-31
• [Presentation] GFP/CCl4モデルにおける微細構造解析からの骨髄中の肝幹細胞の動態解析 (2007)
  • Author(s): 山本直樹寺井崇二坂井田功
  • Organizer: 第6回日本再生医療学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-04-04
• [Book] 消化器疾患最新の治療2009-2010 肝硬変症に対する自己骨髄細胞投与療法 (2008)
  • Author(s): 水永 裕子
  • Total Pages: 5
  • Publisher: 南江堂
• [Book] 自己骨髄細胞投与療法の開発 (2007)
  • Author(s): 寺井 崇二
  • Total Pages: 4
  • Publisher: 治療学
• [Remarks]
  • URL: http://www.ichinai-yamaguchi.jp/contents4/?categoryId=7
• [Remarks]
  • URL: http://www.ichinai-yamaguchi.jp/contents4/?categoryId=7
• [Remarks]
  • URL: http://www.ichinai-yamaguchi.jp/contents4/?categoryId=7
• [Remarks]
  • URL: http://www.ichinai-yamaguchi.jp/contents4/?categoryId=7
• [Patent(Industrial Property Rights)] ナトリウム利尿ペプチドを有効性成分とする肝硬変、前癌病変の抑制剤 (2008)
  • Inventor(s): 山本直樹, 寺井崇二, 坂井田功
  • Industrial Property Rights Holder: 山口大学
  • Industrial Property Number: 2007-114293
  • Acquisition Date: 2008-04-24
• [Patent(Industrial Property Rights)] ナトリウム利尿ペプチドを有効性成分とする肝硬変、前癌病変の抑制剤 (2007)
  • Inventor(s): 山本 直樹、寺井 崇二、坂井 田功
  • Industrial Property Rights Holder: 山口大学
  • Industrial Property Number: 2007-114293
  • Filing Date: 2007-04-24