Immuno-gene therapy for hepatocellular carcinoma : the arrangement of immunological surveillance system
| Project/Area Number |
19390200
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kagawa University |
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Principal Investigator |
DEGUCHI Akihiro Kagawa University, 医学部, 助教 (30380174)
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| Co-Investigator(Kenkyū-buntansha) |
正木 勉 香川大学, 医学部, 講師 (30335848)
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| Co-Investigator(Renkei-kenkyūsha) |
MASAKI Tsutomu 香川大学, 医学部, 教授 (30335848)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2007: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 肝癌 / 肝硬変 / サイトカイン / 樹状細胞 |
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| Research Abstract |
Expression of angiogenesis molecules in hepatocellular carcinoma
As compare with nontumorous tissue, enhanced FGF-・ or IL-8 expression was detected in hepatocellular carcinoma. In addition, FGF-・ or IL-8 was also increased in hepatocellular carcinoma cell lines.
Expression of cytokine molecules in hepatocellular carcinoma
Many cytokines enhanced in hepatocellular carcinoma is up-regulated, such as, activin, CD40, FGF, Glut, IL17 and FGF-・.
Profiling of micro-RNA in hepatocellular carcinoma
MicroRNA -527 was down-regulated in hepatocellular carcinoma.
In addition, the target gene of microRNA-527 was glypican-3.
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Report
(4 results)
Research Products
(45 results)
