Research on the Regulation of Cardiovascular and Metabolic System by p53

• Project/Area Number: 19390206
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Chiba University
• Principal Investigator: TOHRU Minamino Chiba University, 医学部附属病院, 助教 (90328063)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000); Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: 血管病態学 / 老化 / 血管老化 / SIRT1 / 高血糖 / 糖尿病 / 血圧の日内変動 / 時計遺伝子 / 一酸化窒素 / リン酸化 / ニトロシル化

Research Abstract

ヒトは老化するにしたがって様々な疾患、例えば、動脈硬化や糖尿病、高血圧とそれに伴う心不全などを発症する.しかしこれまで老化の側面から見たこれらの疾患の治療開発は行われていなかった.本研究では、細胞の老化分子であるp53が心不全や糖尿病の発症に重要な役割を果たしていることを明らかにした.

Research Products

• [Journal Article] Long-term outcome of Long-term outcome of peripheral blood mononuclear cells for limb ischemia (2009)
  • Author(s): Moriya J, Minamino T, Tateno K, Shimizu N, Kuwabara Y, Sato Y, Saito Y and Komuro I
  • Journal Title: Circulation : Cardiovascular Intervent ions (in press)
  • Peer Reviewed
• [Journal Article] Protective role of SIRT1 in diabetic vascular dysfunction (2009)
  • Author(s): Orimo M, Minamino T, Miyauchi H, Tateno K, Okada S, Moriya J, Komuro I
  • Journal Title: Arterioscler Thromb Vasc Biol (in press)
  • Peer Reviewed
• [Journal Article] Protective role of SIRT1 in diabetic vascular dysfunction (2009)
  • Author(s): Orimo M. Minamino T et al.
  • Journal Title: Arterioscler Thromb Vase Biol (印刷中)
  • Peer Reviewed
• [Journal Article] Vascular Endothelial Growth Factor Receptor-1 Regulates Postnatal Angiogenesis Through Inhibition of the Excessive Activation of Akt (2008)
  • Author(s): Nishi JI, Minamino T, Miyauchi H, Nojima A, Tateno K, Okada S, Orimo M, Moriya J, Fong GH, Sunagawa K, Shibuya M, Komuro I
  • Journal Title: Circ Res 103 Pages: 261-268
  • Peer Reviewed
• [Journal Article] IGFBP-4 is an inhibitor of canonical Wnt signaling required for cardiogenesis (2008)
  • Author(s): Zhu W, Shiojima I, Ito Y, Li Z, Ikeda H, Yoshida M, Naito AT, Nishi J, Ueno H, Umezawa A, Minamino T, Nagai T, Kikuchi A, Asashima M and Komuro I
  • Journal Title: Nature 454 Pages: 345-349
  • NAID: 120007069172
  • Peer Reviewed
• [Journal Article] Reduced nitric oxide causes age-associated impairment of circadian rhythmicity (2008)
  • Author(s): Kuni eda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I
  • Journal Title: Circ Res 102 Pages: 607-614
  • Peer Reviewed
• [Journal Article] Vascular aging : insights from studies on cellular senescence, stem cell aging, progeroid syndromes (2008)
  • Author(s): Minamino T and Komuro I
  • Journal Title: Nat Clin Pract Cardiovasc Med 5 Pages: 637-648
  • NAID: 40016585397
  • Peer Reviewed
• [Journal Article] Role of heat shock transcriptional factor 1, heat shock proteins in cardiac hypertrophy (2008)
  • Author(s): Toko H, Minamino T, Komuro I
  • Journal Title: Trends Cardiovasc Med 18 Pages: 88-93
  • Peer Reviewed
• [Journal Article] Role of telomeres in vascular senescence (2008)
  • Author(s): Minamino T and Komuro I
  • Journal Title: Front Biosci 13 Pages: 2971-2979
  • Peer Reviewed
• [Journal Article] 【細胞老化の多彩な機構と役割DNA損傷応答・SASPから癌抑制-老化現象へ細胞老化シグナルと動脈硬化】 (2008)
  • Author(s): 南野徹, 小室一成
  • Journal Title: 細胞工学 27巻9号 Pages: 894-898
• [Journal Article] Vascular Endothelial Growth Factor Receptor-1 Regulates Postnatal An giogenesis Through Inhibition of the Excessive Activation of Akt (2008)
  • Author(s): Nishi J, Minamino T et al.
  • Journal Title: Circ Res 103 Pages: 261-268
  • Peer Reviewed
• [Journal Article] IGFBP-4 is an inhibitor of canonical Wnt signaling required for cardio genesis (2008)
  • Author(s): Zhu W, Minamino T et al.
  • Journal Title: Nature 454 Pages: 345-349
  • NAID: 120007069172
  • Peer Reviewed
• [Journal Article] Reduced nitric oxide causes age-associated impairment of circadian rhythmicity (2008)
  • Author(s): Kunieda T, Minamino T, et. al.
  • Journal Title: Circulation Research 102 Pages: 607-614
  • Peer Reviewed
• [Journal Article] Role of telomeres in vascular senescence (2008)
  • Author(s): Minamino T, et. al.
  • Journal Title: Front Biosci 13 Pages: 2971-2979
  • Peer Reviewed
• [Journal Article] 【解明が進むメタボリックシンドローム脂肪細胞の機能からエネルギー代謝・摂食・心血管系の制御機構、予防と治療まで】血管とメタボリックシンドローム メタボリックシンドロームにおける血管老化の分子メカニズム (2007)
  • Author(s): 南野徹, 小室一成
  • Journal Title: 実験医学 25巻15号 Pages: 2401-2407
• [Journal Article] Critical roles of insulin-induced senescence in diabetic vasculopathy (2007)
  • Author(s): Milamino T, et. al.
  • Journal Title: Vascular Disease Prevention 4 Pages: 194-200
  • Peer Reviewed
• [Presentation] Role of Cellular Aging in Cardiovascular and Metabolic Disease (2009)
  • Author(s): 南野徹
  • Organizer: 第73回日本循環器学会総会・学術集会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Long-term Qutcome of therapeutic neovascularization using eripheral blood mononuclear cells for limb ischemia (2009)
  • Author(s): Minamino T
  • Organizer: 第73回日本循環器学会総会・学術集会 Symposium(Circulation Journal Supplement I)
  • Place of Presentation: 大阪
• [Presentation] p53 as a new therapeutic target for heart failure (2009)
  • Author(s): Minamino T
  • Organizer: 第73回日本循環器学会総会・学術集会 KSC-JCS Joint Symposium(Circulation Journal Supplement I)
  • Place of Presentation: 大阪
• [Presentation] Impact of Cellular Aglng on Cardiovascular Regeneration (2009)
  • Author(s): Minamino T
  • Organizer: 第73回日本循環器学会総会・学術集会 Topic(Circulatiorl Journal Supplement I)
  • Place of Presentation: 大阪
• [Presentation] Role of Cellular Aging in Cardiovascular, Metabolic Disease (2009)
  • Author(s): Minamino T
  • Organizer: 第73回日本循環器学会総会・学術集会 Topic(Circulation Journal Supplement I)
  • Place of Presentation: 大阪
• [Presentation] Role of adipose p53 in regulating insulin resistance (2009)
  • Author(s): Minamino T
  • Organizer: Gordon Research Conference
  • Place of Presentation: Ventura,CA,USA
• [Presentation] Role of Cellular Agingin CardiovascuLar Disease the Annual Spring (2008)
  • Author(s): Minamino T
  • Organizer: Scientific Conference of the Korean Society of Lipidology, Atherosclerosis(Circulation Journal Supplement I)
  • Place of Presentation: Busan
  • Year and Date: 2008-04-18
• [Presentation] Critfcal role of adiposetissue p53 in regulating insulin resistance (2008)
  • Author(s): Minamino T, Orimo M, Komuro L
  • Organizer: Keystorle Symposia
  • Place of Presentation: Copper Mountain
• [Presentation] p53の血管新生抑制作用による心不全発症のメカニズム (2007)
  • Author(s): 南野 徹
  • Organizer: 第30回日本分子生物学会年会ワークショップ
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-14
• [Presentation] Contribution of cellular senescence to cardiovascular disease (2007)
  • Author(s): Minamino T
  • Organizer: The 10th Anniversary International Symposium Kangwon National UniversityCollege of Medicine
  • Place of Presentation: Chuncheon, Korea
  • Year and Date: 2007-04-03
• [Presentation] 老化シグナルによって制御される心血管代謝ネットワークの解明(高峰譲吉研究奨励賞受賞講演) (2007)
  • Author(s): Minamino T
  • Organizer: 第11回日木心血管内分泌代謝学会学術総会
  • Place of Presentation: 東京
• [Presentation] ノバルティス老化および老年医学研究基金2006年度受賞講演老化シグナル制御による生活習慣病治療に関する基盤研究 (2007)
  • Author(s): Minamino T
  • Organizer: 第49同日本老年医学会学術集会(日本老年医学会雑誌)
  • Place of Presentation: 札幌
• [Presentation] Role of P53 in regulating cardiacrunction (2007)
  • Author(s): Minamino T, Sano M, Komuro I
  • Organizer: Gordon Research Conference(The Biology of Aging)
  • Place of Presentation: Les Diablerets, Switzerland
• [Book] アンチエイジング医学の基礎と臨床 (2009)
  • Author(s): 南野徹
  • Total Pages: 455
  • Publisher: 株式傘社メデイカルビュー社
• [Book] 2.前駆細胞,組織幹細胞6)末梢血単核球移植による血管再生治療進み続ける細胞移植治療の実際-再生医療の実現に向けた科学・技術とその周辺要素の理解-株式会礼メディカルドゥ (2008)
  • Author(s): 南野徹、小室一成
  • Publisher: 田畑泰彦
• [Book] 実験医学【解明が進むメタボリックシンドローム脂肪細胞の機能からエネルギー代謝・摂食・心血管系の制御機構、予防と治療まで】 (2007)
  • Author(s): 南野 徹
  • Total Pages: 6
  • Publisher: 羊土社
• [Patent(Industrial Property Rights)] ノッチシグナルを利用した虚血組織再生方法 (2009)
  • Inventor(s): 舘野馨、南野徹
  • Industrial Property Rights Holder: 千葉大学
  • Industrial Property Number: 2009-067021
  • Filing Date: 2009-03-18
• [Patent(Industrial Property Rights)] 虚血性心血管系疾患の治療剤(PlexinD1-Fc) (2008)
  • Inventor(s): 森谷純治、南野徹、小室一成、古閑比佐志、岡田光浩
  • Industrial Property Rights Holder: 千葉大学
  • Industrial Property Number: 2008-286293
  • Filing Date: 2008-11-07
• [Patent(Industrial Property Rights)] 虚血性心血管系疾患の治療剤(PlexinDl-Fc) (2008)
  • Inventor(s): 森谷純治,南野徹,小室一成,古閑比佐志,岡田光浩
  • Industrial Property Rights Holder: 千葉大学
  • Industrial Property Number: 2008-286293
  • Filing Date: 2008-11-07