Identification of novel regulator of atherosclerosis and development of molecular imaging technique

• Project/Area Number: 19390207
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: The University of Tokushima (2008); The University of Tokyo (2007)
• Principal Investigator: SATA Masataka The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 教授 (80345214)
• Co-Investigator(Kenkyū-buntansha): HIRATA Yasunobu 東京大学, 医学部附属病院, 准教授 (70167609) ; MOMOSE Toshimitsu 東京大学, 医学部附属病院, 准教授 (20219992)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2008: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2007: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
• Keywords: 血管病態学 / 動脈硬化 / 脂肪 / 血管新生 / 脂肪組織 / プラーク破綻 / 心筋梗塞 / 急性冠症候群 / サイトカイン / 炎症 / 外膜 / 血管 / 組織 / 内皮細胞

Research Abstract

動脈硬化進展と破綻に関する新規制御機構を明らかにすることを目的とした。特に、従来あまり注目されていなかった、外膜血管新生ならびに動脈周囲の脂肪組織の意義をモデル動物と手術中に得られるサンプルを用いて検討した。血管外周囲脂肪組織は、病的血管リモデリングに対して、通常防御的に機能すると考えられた。血管障害や生活習慣病によって、血管周囲脂肪組織の形質が変化し、内膜増殖や動脈硬化の病態に重要な役割を演ずることが示唆された。

Research Products

• [Journal Article] Fluvastatin accelerates re-endothelialization impaired by local sirolimus treatment (2009)
  • Author(s): Fukuda D, Enontoto S, Shirakawa I, Nagai R, Sata M.
  • Journal Title: Ear J Pharmacol 612 Pages: 87-92
  • Peer Reviewed
• [Journal Article] When p66<ShcA> is away, mice EPCs sweetly play (2009)
  • Author(s): Sainz J, Sata M.
  • Journal Title: Cardiovasc Res 82 Pages: 388-389
  • Peer Reviewed
• [Journal Article] Role of bone marrow renin angiotensin system in the pathogenesis of atherosclerosis (2008)
  • Author(s): Fukuda, D., Sata, M.
  • Journal Title: Pharmacol Ther 21 Pages: 70-78
  • Peer Reviewed
• [Journal Article] The origin of the cells that contribute to neointima growth (2008)
  • Author(s): Iwata, H., Sata, M.
  • Journal Title: Circulation 117 Pages: 3060-3061
  • Peer Reviewed
• [Journal Article] Contribution of circulating vascular progenitors in lesion formation and vascular healing : lessons from animal models (2008)
  • Author(s): Tanaka, K., Sata, M.
  • Journal Title: Curr Opin Lipidol. 19 Pages: 498-504
  • Peer Reviewed
• [Journal Article] A critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice (2008)
  • Author(s): Fukuda, D., Sata, M., Ishizaka, N., Nagai, R.
  • Journal Title: Arterioscler Thromb Vasc Biol 28 Pages: 90-96
  • Peer Reviewed
• [Journal Article] Open sesame! CXCR4 blockade recruits neutrophils into the plaque (2008)
  • Author(s): Sainz, J., Sata, M.
  • Journal Title: Circ Res 102 Pages: 154-156
  • Peer Reviewed
• [Journal Article] Circulating progenitor cells contribute to neointimal formation in non-irradiated chimeric mice (2008)
  • Author(s): Tanaka, K., Sata, M., Natori, T., Kim-Kaneyama, J-R., Nose, K., Shibanuma, M., Hirata, H., Nagai, R.
  • Journal Title: FASEB J22 Pages: 428-436
  • Peer Reviewed
• [Journal Article] Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice (2008)
  • Author(s): Matsumoto, M., Sata, M., Fukuda, D., Tanaka, K., Soma, M., Hirata, Y., Nagai, R.
  • Journal Title: Atherosclerosis 197 Pages: 524-533
  • Peer Reviewed
• [Journal Article] Periostin is essential for cardiac healing after acute myocardial infarction (2008)
  • Author(s): Shimazaki, M., Nakamura, K., Kii, I.Kashima, T., Amizuka, N., Li, M., Fukuda, K., Nishiyama, T, Kitajima, S., Saga, Y., Fukayama, M., Sata, M., Kudo, A.
  • Journal Title: J Exp. Med. 205 Pages: 295-303
  • Peer Reviewed
• [Journal Article] Anti-arrhythmogenic effect of reconstituted high-density lipoprotein against ischemia/reperfusion in rats (2008)
  • Author(s): Imaizumi, S., Miura, S., Nakamura, K., Kiya, Y., Uehara, Y., Zhang, B., Matsuo, Y., Urata, H., Ideishi, M., Rye, K.A., Sata, M., Saku, K.
  • Journal Title: J Am Coll Cardiol 51 Pages: 1604-1612
  • Peer Reviewed
• [Journal Article] Circulating progenitor cells contribute to neointimal formation in non-irradiated chimeric mice. (2008)
  • Author(s): Tanaka, K. ら
  • Journal Title: FASEB J 22 Pages: 428-436
  • Peer Reviewed
• [Journal Article] Orally administered eicosapentaenoic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice. (2008)
  • Author(s): Matsumoto, M. ら
  • Journal Title: Atherosclerosis 197 Pages: 524-533
  • Peer Reviewed
• [Journal Article] The origin of the cells that contribute to neointima growth (2008)
  • Author(s): Iwata, H. ら
  • Journal Title: Circulation 117 Pages: 3060-3061
  • Peer Reviewed
• [Journal Article] A critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice (2008)
  • Author(s): Fukuda, D., ら
  • Journal Title: Arterioscler Thromb Vasc Bio1 28 Pages: 90-96
  • Peer Reviewed
• [Journal Article] Circulating progenitor cells contribute to neointimal formation in non-irradiated chimeric mice (2008)
  • Author(s): Tanaka, K., ら
  • Journal Title: FASEB J 22 Pages: 428-436
  • Peer Reviewed
• [Journal Article] Orally administered eicosapentaenic acid reduces and stabilizes atherosclerotic lesions in ApoE-deficient mice (2008)
  • Author(s): Matsumoto, M., ら
  • Journal Title: Atherosclerosis 2008. 197. 524-533 197 Pages: 524-533
  • Peer Reviewed
• [Journal Article] Transplantation of adipose stromal cells, but not mature adipocytes, augments ischemia-induced angiogenesis (2007)
  • Author(s): Sumi, M., Sata, M., Toya, N., Yanaga, K., Ohki, T., Nagai, R.
  • Journal Title: Life Sci 80 Pages: 559-565
  • Peer Reviewed
• [Journal Article] CXCR4, a key modulator of vascular progenitor cells (2007)
  • Author(s): Sainz, J., Sata, M.
  • Journal Title: Arterioscler Thromb Vase Biol 27 Pages: 263-265
  • Peer Reviewed
• [Journal Article] Diverse contribution of bone marrow-derived cells to vascular remodeling associated with pulmonary arterial hypertension and arterial neointimal formation (2007)
  • Author(s): Sahara, M., Sata, M., Morita, T., Nakamura, K., Hirata, Y., Nagai, R.
  • Journal Title: Circulation 115 Pages: 509-517
  • Peer Reviewed
• [Journal Article] Mobilization of CD34-Positive bone marrow-derived cells after coronary stent implantation (2007)
  • Author(s): Inoue, T., Sata, M., Hikichi, Y., Sohma, R., Fukuda, D., Uchida, T., Shimizu, M., Komoda, H., Node, K.
  • Journal Title: impact on restenosis. Circulation 115 Pages: 553-561
  • Peer Reviewed
• [Journal Article] Reconstituted high-density lipoprotein stimulates differentiation of endothelial progenitor cells and enhances ischemia-induced angiogenesis (2007)
  • Author(s): Sumi, M., Sata, M., Miura, S.I., Rye, K.A., Toya, N., Kanaoka, Y., Yanaga, K., Ohki, T., Saku, K., Nagai, R.
  • Journal Title: Arterioscler Thromb Vase Biol 27 Pages: 813-818
  • Peer Reviewed
• [Journal Article] Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice (2007)
  • Author(s): Aihara, K, Azuma, H., Akaike, M., Ikeda, Y, Sata, M., Takamori, N., Yagi, S., Iwase, T., Sumitomo, Y., Kawano, H., Yamada, T., Fukuda, T., Matsumoto, T., Sekine, K., Sato, T., Nakainichi, Y., Yamamoto, Y., Yoshimura, K., Watanabe, T., Nakamura, T., Oonvzu, A., Tsukada, M., Hayashi, H., Sudo, T., Kato, S., Matsumoto, T.
  • Journal Title: J.Glin. Invest. 117 Pages: 1514-1526
  • Peer Reviewed
• [Journal Article] Angiotensin II receptor blocker inhibits neointimal hyperplasia through regulation of smooth muscle-like progenitor cells (2007)
  • Author(s): Yamada, T., Kondo, T., Numaguchi, Y., Tsuzuki, M., Matsubara, T., Manabe, I., Sata.M., Nagai, R., Murohara, T.
  • Journal Title: Arteriascler Thromb Vase Biol. 11 Pages: 2363-2369
  • Peer Reviewed
• [Journal Article] Renin-angiotensin system : a potential modulator of endothelial progenitor cells (2007)
  • Author(s): Fukuda, D., Sata, M.
  • Journal Title: Hypertens Res. 30 Pages: 1017-1018
  • NAID: 10021259723
  • Peer Reviewed
• [Presentation] Endovascular injury alters adipocytokine profile of the periadventitial adipose tissue (2008)
  • Author(s): Takaoka M, Nagai R, Sata M.
  • Organizer: American Heart Association
  • Place of Presentation: New Orleans
• [Presentation] Endovascular injury alters adipocytokine profile of the periadventitial adipose tissue. (2008)
  • Author(s): Takaoka Mら
  • Organizer: American Heart Association 2008
  • Place of Presentation: 米国 New Orleans
• [Presentation] Potential role of periadventitial adipose tissue in regulation of vascular homeostasis and remodeling (2007)
  • Author(s): Masataka Sata
  • Organizer: The SEOUL(Stem cell, angiogEnesis, HypertepsiOn, Heart FailUre, Vascular BioLogy)Conference
  • Place of Presentation: SEOUL,Korea
  • Year and Date: 2007-10-06
• [Presentation] Eicosapentaenoic Acid Up-regulates Adiponectin Expression In Peri-adventitial Adipose Tissue And Suppresses Atherosclerotic Lesion Formation In Apoe-deficient Mice (2007)
  • Author(s): Matsumoto M
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orland
• [Presentation] Nagai R. Endovascular Injury Affects Adipocytokine Profile Of The Periadventitial Adipose Tissue (2007)
  • Author(s): Takaoka M, Sata M
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orland
• [Presentation] Acceleration of Hyperlipidemia-induced Atherosclerosis in Apolipoprotein E and Angiotensin-converting Enzyme 2 Double-Knockout Mice (2007)
  • Author(s): Sahara M, Sata M, Morita T, Hirata Y, Nagai R.
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Orland
• [Book] 薬剤による血管再生血管の再生-血管再生医学の夜明け : 近づく実用化 (2008)
  • Author(s): 佐田政隆、(森下竜一編集)
  • Publisher: 真興交易(株)医書出版部
• [Book] 分担章「薬剤による血管再生」 血管の再生-血管再生医学の夜明け : 近づく実用化 (2008)
  • Author(s): 佐田政隆 (森下竜一編集)
  • Total Pages: 12
  • Publisher: 真興交易(株)医書出版部2008:118-129.
• [Book] B慢性心不全の治療21. 再生医療にエビデンスはあるのか-EBM循環器疾患の治療2008-2009 (2007)
  • Author(s): 田中君枝、佐田政隆、三田村秀雄、山科章、川名正敏、桑島巌(編集)
  • Publisher: 中学医学社
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~msata/