Research Projects to Clarify the Molecular Pathogenesis and to Develop Therapeutic or Preventive Strategy for Cardiomyopathy

• Project/Area Number: 19390208
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KIMURA Akinori Tokyo Medical and Dental University, 難治疾患研究所, 教授 (60161551)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2008: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
• Keywords: 心筋症 / 遺伝子変異 / サルコメア / 筋収縮 / カルシウム感受性 / Z帯 / CARP / ミオパラジン / ミオシン脱リン酸化酵素 / M21 / 原因遺伝子変異 / Ca感受性 / ミオシンフォスファターゼ / 性ホルモン / ZASP / Cypher / PP1M / トランスジェニックマウス / 網羅的発現解析 / 結合ドメイン

Research Abstract

In this research, we have identified CARP mutations as the molecular basis of cardiomyopathy. We also found PGM1 as a binding partner of ZASP and revealed that DCM-associated ZASP mutations impaired the binding to PGM1. In addition, PGM1 was found to be localized to Z-disc upon metabolic stress of cardiomyocytes. On the other hand, we reveled that M21 enhanced the phosphorylation of M110. Finally, we demonstrated that calcium sensitizer could prevent the pathological changes in the hearts of a model mice for dilated cardiomyopathy.

Research Products

• [Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function (2010)
  • Author(s): Neelyl GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM.
  • Journal Title: Cell 141(1) Pages: 142-153
• [Journal Article] Molecular basis of hereditary cardiomyopathy : abnormalities in calcium sensitivity, stretch response, stress response and beyond (2010)
  • Author(s): Kimura A.
  • Journal Title: J Hum Genet 55(2) Pages: 81-90
  • NAID: 10030733482
• [Journal Article] Improvement of left ventricular dysfunction and of survival prognosis of dilated cardiomyopathy by administration of calcium sensitizer SCH00013 in a mouse model (2010)
  • Author(s): Arimura T, Sato R, Machida N, Bando H, Zhang DY, Morimoto S, Tanaka R, Yamane Y, Bonne G, Kimura A.
  • Journal Title: J Am Coll Cardiol 55(14) Pages: 1503-1505
• [Journal Article] A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene (2010)
  • Author(s): Matuda S, Arimura T, Kimura A, Takekura H, Ohta S, Nakano K.
  • Journal Title: Biochim Biophys Acta 1800(1) Pages: 31-39
• [Journal Article] A novel protein found in the I bands of myofibrils is produced by alternative splicing of the DLST gene (2010)
  • Author(s): Matuda S, Arimura T, Kimura A, Takekura H, Ohta S, Nakano K
  • Journal Title: Biochim Biophys Acta 1800 Pages: 31-39
  • Peer Reviewed
• [Journal Article] Improvement of left ventricular dysfunction and of survival prognosis of dilated cardiomyopathy by administration of calcium sensitizer SCH00013 in a mouse model (2010)
  • Author(s): Arimura T, Sato R, Machida N, Bando H, Zhang DY, Morimoto S, Tanaka R, Yamane Y, Bonne G, Kimura A
  • Journal Title: J Am Coil Cardiol 55 Pages: 1503-1505
  • Peer Reviewed
• [Journal Article] Molecular basis of hereditary cardiomyopathy : abnormalities in calcium sensitivity, stretch response, stress response and beyond (2010)
  • Author(s): Kimura A
  • Journal Title: J Hum Genet 55 Pages: 81-90
  • NAID: 10030733482
  • Peer Reviewed
• [Journal Article] A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function (2010)
  • Author(s): Neelyl GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmen L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NA, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks A, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM
  • Journal Title: Cell (印刷中)
  • Peer Reviewed
• [Journal Article] Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome (2009)
  • Author(s): Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y, Ushinohama H, Aizawa Y, Kimura A.
  • Journal Title: J Biol Chem 284(50) Pages: 35122-35133
• [Journal Article] Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease (2009)
  • Author(s): Hinohara K, Ohtani H, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A.
  • Journal Title: J Hum Genet 54(11) Pages: 642-646
  • NAID: 10030732421
• [Journal Article] Validation of the association between AGTRL1 polymorphism and coronary artery disease in Japanese and Korean populations (2009)
  • Author(s): Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A.
  • Journal Title: J Hum Genet 54(9) Pages: 554-556
  • NAID: 10030731859
• [Journal Article] Megakaryoblastic leukemia factor-1gene in the susceptibility to coronary artery disease (2009)
  • Author(s): Hinohara K, Nakajima T, Yasunami M, Houda S, Sasaoka T, Yamamoto K, Lee BS, Shibata H, Takahashi TY, Arimura T, Sato A, Naruse T, Ban J, Inoko H, Yamada Y, Sawabe M, Park JE,, Izumi T, Kimura A.
  • Journal Title: Hum Genet 126(4) Pages: 539-547
• [Journal Article] Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy (2009)
  • Author(s): Arimura T, Bos MJ, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Moulik M, Doi YL, Towbin JA, Ackerman MJ, Kimura A.
  • Journal Title: J Am Coll Cardiol 54(4) Pages: 334-342
• [Journal Article] ANKRD-the gene encoding cardiac ankyrin repeat protein-is a novel dilated cardiomyopathy gene (2009)
  • Author(s): Moulik M, Vatta M, Witt SH, Alora AM, Murphy RT, McKenna WJ, Boriek A, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA.
  • Journal Title: J Am Coll Cardiol 54(4) Pages: 325-333
• [Journal Article] Does a gene polymorphism predisposing to the intermediate phenotype predict the risk of disease? (2009)
  • Author(s): Kimura A.
  • Journal Title: Circ J. 73(6) Pages: 1016-1017
• [Journal Article] Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy (2009)
  • Author(s): Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, Vatta M, Towbin JA, Chikamori T, Yamashina A, Kimura A.
  • Journal Title: Cardiovasc Res. 83(1) Pages: 80-88
• [Journal Article] Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations (2009)
  • Author(s): Hinohara K, Nakajima T, Sasaoka T, Sawabe M, Lee BS, Ban J, Park JE, Izumi T, Kimura A.
  • Journal Title: J Hum Genet 54(4) Pages: 248-251
  • NAID: 10030730150
• [Journal Article] Role of HCN4 channel in preventing ventricular arrhythmia (2009)
  • Author(s): Ueda K, Hirano Y, Higashiuesato Y, Aizawa Y, Hayashi T, Inagaki N, Tana T, Ohya Y, Takishita S, Muratani H, Hiraoka M, Kimura A.
  • Journal Title: J Hum Genet 54(2) Pages: 115-121
  • NAID: 10030729305
• [Journal Article] HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis (2009)
  • Author(s): Kominami S, Tanabe N, Ota M, Naruse T, Katsuyama Y, Nakanishi N, Tomoike H, Sakuma M, Shirato K, Takahashi M, Shibata H, Yasunami M, Chen Z, Kasahara Y, Tatsumi K, Kuriyama T, Kimura A.
  • Journal Title: J Hum Genet 54(2) Pages: 108-114
  • NAID: 10030729271
• [Journal Article] Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy (2009)
  • Author(s): Arimura T, Hayashi YK, Murakami T, Oya Y, Funabe S, Hirasawa EA, Hattori N, Nishino I, Kimura A.
  • Journal Title: Circ J. 73(1) Pages: 158-161
  • NAID: 110007007967
• [Journal Article] Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy (2009)
  • Author(s): Arimura T, Inagaki N, Hayashi T, Shichi D, Sato A, Hinohara K, Vatta M, Towbin JA, Chikamori T, Yamashina A, Kimura A
  • Journal Title: Cardiovasc Res 83 Pages: 80-88
  • Peer Reviewed
• [Journal Article] ANKRD-the gene encoding cardiac ankyrin repeat protein-is a novel dilated cardiomyopathy gene (2009)
  • Author(s): Moulik M, Vatta M, Witt SH, Alora AM, Murphy RT, McKenna WJ, Boriek A, Oka K, Labeit S, Bowles NE, Arimura T, Kimura A, Towbin JA
  • Journal Title: J Am Coll Cardiol 54 Pages: 325-333
  • Peer Reviewed
• [Journal Article] Cardiac ankyrin repeat protein gene(ANKRD1)mutations in hypertrophic cardiomyopathy (2009)
  • Author(s): Arimura T, Bos MJ, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Moulik M, Doi YL, Towbin JA, Ackerman MJ, Kimura A
  • Journal Title: J Am Coll Cardiol 54 Pages: 334-342
  • Peer Reviewed
• [Journal Article] Mutational analysis of fukutin gene in dilated cardiomyopathy and hypertrophic cardiomyopathy (2009)
  • Author(s): Arimura T
  • Journal Title: Circ J 73 Pages: 158-161
  • Peer Reviewed
• [Journal Article] Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations. (2009)
  • Author(s): Hinohara K
  • Journal Title: J Hum Genet (印刷中)
  • Peer Reviewed
• [Journal Article] Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy (2009)
  • Author(s): Arimura T
  • Journal Title: J Am Coll Cardiol (印刷中)
  • Peer Reviewed
• [Journal Article] Molecular etiology and pathogenesis of hereditary cardiomyopathy (2008)
  • Author(s): Kimura A.
  • Journal Title: Circ J. 72(Suppl A)
  • NAID: 110006935630
• [Journal Article] Replication of association between a chromosome 9p21 polymorphism with coronary artery disease in Japanese and Korean populations (2008)
  • Author(s): Hinohara K, Nakajima T, Takahashi M, Hohda S, Sasaoka T, Nakahara K, Chida K, Sawabe M, Arimura T, Sato A, Lee BS, Ban J, Yasunami M, Park JE, Izumi T, Kimura A.
  • Journal Title: J Hum Genet 53(4) Pages: 357-359
• [Journal Article] High-density association study and nomination of susceptibility genes for hypertension in the Japanese national project (2008)
  • Author(s): Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Hohara K, Takeuchi F, Mano H, Yasunami M, Kimura A, Kita Y, Ueshima H, Nakamura T, Soma M, Hata A, Fujioka A, Kawano Y, Nakao K, Sekine A, Yoshida T, Nakamura Y, Saruta T, Ogihara T, Sugano S, Miki T, Tomoike H.
  • Journal Title: Hum Mol Genet 17(4) Pages: 617-627
• [Journal Article] Molecular etiology and pathogenesis of hereditary cardiomyopathy (2008)
  • Author(s): Kimura A
  • Journal Title: Circ J 72
  • NAID: 110006935630
  • Peer Reviewed
• [Journal Article] Replication of association between a chromosome 9p21 polymorphism with coronary artery disease in Japanese and Korean populations (2008)
  • Author(s): Hinohara K
  • Journal Title: J Hum Genet 53 Pages: 357-359
  • Peer Reviewed
• [Journal Article] Molecular etiology and pathogenesis of hereditary cardiomyopathy (2008)
  • Author(s): Kimura A
  • Journal Title: Circ J (印刷中)
  • NAID: 110006935630
  • Peer Reviewed
• [Journal Article] Molecular etiology of idiopathic cardiomyopathy (2007)
  • Author(s): Arimura T, Hayashi T, Kimura A.
  • Journal Title: Acta Myologica 26(3) Pages: 153-158
• [Journal Article] Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy (2007)
  • Author(s): Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, Sawabe M, Chida K, Arai T, Nakahara K, Kubo T, Sugimoto K, Katsuya T, Ogihara T, Doi Y, Izumi T, Kimura A.
  • Journal Title: Am J Physiol Heart Card Physiol 293(6)
• [Journal Article] Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload (2007)
  • Author(s): Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrabdt A, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenoviv V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R, Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM.
  • Journal Title: Circ Res. 101(4)
• [Journal Article] Structural analysis of obscurin gene in hypertrophic cardiomyopathy (2007)
  • Author(s): Arimura T, Matsumoto Y, Okazaki O, Hayashi T, Takahashi M, Inagaki N, Hinohara K, Ashizawa N, Yano K, Kimura A.
  • Journal Title: Biochem Biophys Res Commun 362(2) Pages: 281-287
• [Journal Article] Synergistic contribution of CD14 and HLA loci to the susceptibility to Buerger disease (2007)
  • Author(s): Chen Z, Takahashi M, Naruse T, Nakajima T, Chen YW, Inoue Y, Ishilkawa I, Iwai T, Kimura A.
  • Journal Title: Hum Genet 122(3-4) Pages: 367-372
• [Journal Article] Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and in endothelial cells (2007)
  • Author(s): Knoll R, Postel R, Wang J, Kraetzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Dieter K, Gudrun K, Schaefer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nuemberg P, Schultheiss P, Schaper W, Schaper J, Bos E, Hertog JD, van Eeden F, Peters P, Hasenfuss G, Chien KR, Bakkers J.
  • Journal Title: Circulation 116(5) Pages: 515-525
• [Journal Article] A novel mutation in KCNQ1 associated with a potent dominant negative effect as the basis for the LQT1 form of the long QT syndrome (2007)
  • Author(s): Aizawa Y, Ueda K, Scornik F, Cordeiro JM, Wu Y, Desai M, Guerchicoff A, Pollevick GD, Sicouri S, Sato A, Nagata Y, Iesaka Y, Aizawa Y, Kimura A, Hiraoka M, Anzelevitch C.
  • Journal Title: J Cardiovasc Electrophysiol 18(9) Pages: 972-977
• [Journal Article] Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy (2007)
  • Author(s): Arimura T, Hayashi T, Matsumoto Y, Shibata H, Hiroi S, Nakamura T, Inagaki N, Hinohara K, Takahashi M, Itoh-Satoh M, Bonne G, Schwartz K, Kimura A.
  • Journal Title: Biochem Biophys Res Commun 357(1) Pages: 162-167
• [Journal Article] Structural analysis of four and half LIM protein-2 in dilated cardiomyopathy (2007)
  • Author(s): Arimura T, et. al.
  • Journal Title: Biochem Biophys Res Commun 357 Pages: 162-167
  • Peer Reviewed
• [Journal Article] Laminin alpha 4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and in endothelial cells (2007)
  • Author(s): Knoll R, et. al.
  • Journal Title: Circulation 116 Pages: 515-525
  • Peer Reviewed
• [Journal Article] Structural analysis of obscurin gene in hypertrophic cardiomyopathy (2007)
  • Author(s): Arimura T, et. al.
  • Journal Title: Biochem Biophys Res Commun 362 Pages: 281-287
  • Peer Reviewed
• [Journal Article] Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload (2007)
  • Author(s): Kuba K, et. al.
  • Journal Title: Circ Res 101
  • Peer Reviewed
• [Journal Article] Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy (2007)
  • Author(s): Nakano N, et. al.
  • Journal Title: Am J Physiol Heart Card Physiol 293
  • Peer Reviewed
• [Journal Article] HLA-DP beta chain may confer the susceptibility to hepatitis Cvirus-associated hypertrophic cardiomyopathy (2007)
  • Author(s): Shichi D, et. al.
  • Journal Title: Int J Immunogenet 35 Pages: 37-43
  • Peer Reviewed
• [Journal Article] Long-term outcome of four Korean families with hypertrophic cardiomyopathy caused by four different mutations
  • Author(s): Choi JO, You CW, Nah JC, Park JR, Lee BS, Choi BY, Cho BY, Lee SC, Park SW, Kimura A, Park JE.
  • Journal Title: Clin Cardiol (In Press)
• [Journal Article] Losartan inhibits LPS-induced inflammatory signaling by PPAR-gamma-dependent mechanism in human THP-1 macrophage
  • Author(s): An J, Nakajima T, Kuba K, Kimura A.
  • Journal Title: Hypertension Res. (In Press)
• [Presentation] Molecular analysis of arrhythmia associated with HCN4 mutations (2009)
  • Author(s): Kimura A, Ueda K, Aizawa Y, Sato A, Arimura T, Makita N, Ishikawa T, Aizawa Y
  • Organizer: 12th Cardiovascular Genomics and Atherosclerosis Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2009-10-17
• [Presentation] Improvement of Left Ventricular Dysfunction and Survival Prognosis of Dilated Cardiomyopathy by Administration of a Novel Calcium Sensitizer in a Mouse Model. (2009)
  • Author(s): 有村卓朗, 木村彰方
  • Organizer: 12th Cardiovascular Genomics and Atherosclerosis Symposium
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2009-10-17
• [Presentation] テストステロンはラミンA/C遺伝子変異LmnaH222P/H222Pマウスにおける拡張型心筋症を増悪させる (2009)
  • Author(s): 有村卓朗, 木村彰方
  • Organizer: 第54回日本人類遺伝学会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-24
• [Presentation] Identification of a novel gene for hypertrophic cardiomyopathy (2009)
  • Author(s): Arimura T, Bos JM, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Doi YL, Ackerman MJ, Kimura A
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Overview : Molecular pathogenesis of hereditary cardiomyopathy (2008)
  • Author(s): Kimura A
  • Organizer: 11th Cardiovascular Genomics and Atherosclerosis Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2008-11-01
• [Presentation] Genome-wide association study to identify the disease-associated genes for coronary artery disease (2008)
  • Author(s): Kimura A
  • Organizer: 11th Cardiovascular Genomics and Atherosclerosis Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2008-10-31
• [Presentation] CARPおよびタイチンN2A領域内変異は肥大型心筋症を引き起こす (2008)
  • Author(s): 有村卓朗, 佐藤光希, 久保亨, 岡本洋, 西宏文, 原田晴仁, 古賀義則, 土居義典, 木村彰方
  • Organizer: 第53回日本人類遺伝学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-28
• [Presentation] Testicular hormone accelerates the development and progress of dilated cardiomyopathy in an animal model (2008)
  • Author(s): Arimura T, Kimura A
  • Organizer: 第73回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-29
• [Presentation] 心筋特異的因子BMP10の活性機構の解明 (2007)
  • Author(s): 安部美奈子, 他
  • Organizer: BMS2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-13
• [Presentation] 男性ホルモンは横紋筋特異的ラミノパチーモデルLmnaH222P/H222Pマウスにおける心不全を増悪させる (2007)
  • Author(s): 有村卓朗, 他
  • Organizer: BMB2007
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-12
• [Presentation] 心筋特異的ミオシン軽鎖脱リン酸化酵素サブユニットM21(hHS-M21)の強発現は肥大型心筋症を引き起こす (2007)
  • Author(s): 有村卓朗, 他
  • Organizer: 日本人類遺伝学会第52回大会
  • Place of Presentation: 東京
  • Year and Date: 2007-09-13
• [Presentation] HLA-DP遺伝子はC型肝炎ウイルス陽性肥大型心筋症と関連する (2007)
  • Author(s): 志知大輔, 他
  • Organizer: 第16回日本組織適合性学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-11
• [Presentation] 難治性循環器疾患の病因と病態形成機構の解明に向けて (2007)
  • Author(s): 木村彰方
  • Organizer: 第16回日本組織適合性学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-09-10
• [Presentation] Molecular pathogenesis of hereditary cardiomyopathy (2007)
  • Author(s): Kimura A
  • Organizer: The 41st Lake Kawaguchi Conference of Cardiology
  • Place of Presentation: Fukuoka
  • Year and Date: 2007-07-29
• [Presentation] Genome-wide microsatellite association study to identify the disease-related loci for myocardial infarction (2007)
  • Author(s): Kimura A
  • Organizer: The 10th Cardiovascular Genomics and Atherosclerosis Symposium
  • Place of Presentation: Seoul
  • Year and Date: 2007-04-10
• [Presentation] Molecular etiology of hypertrophic cardiomyopathy (2007)
  • Author(s): Kimura A
  • Organizer: The 1st International Congress of Cardiomyopathies and Heart Failure
  • Place of Presentation: Kyoto
  • Year and Date: 2007-03-12