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Novel molecular mechanisms for cardiotonic action, their involvement in diseases and application for treatment

Research Project

Project/Area Number 19390211
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionMie University

Principal Investigator

ITO Masaaki (MASAAKI Ito)  Mie University, 大学院・医学系研究科, 教授 (00223181)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Ryuji  三重大学, 大学院・医学系研究科, 助教 (60378346)
ONISHI Katsuya  三重大学, 大学院・医学系研究科, 助教 (40343222)
Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2008: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords心筋ミオシン / リン酸化 / ミオシン軽鎖キナーゼ / ミオシンホスファターゼ / 心不全
Research Abstract

The regulatory mechanism, function and the involvement in pathologic conditions of cardiac myosin light chain (MLC2) phosphorylation were investigated. Cardiac MLC2 was found to be phosphorylated by cardiac myosin light chain kinase (cMLCK), but not by smooth MLCK nor ZIP-kinase. However, cMLCK was not detected in several animal species, suggesting the existence of another (iso)forms of cardiac MLCK. Biochemical characteristics of cMLCK were different from those of smMLCK including the enzyme kinetics and the sensitivity for antagonists. The overexpression of cardiac myosin phosphatase in heart induced a reduction of MLC2 phosphorylation levels concomitant with a Ca^<2+> desensitization of contraction and decreased LV contractility, resulting in LV enlargement. Thus the phosphorylation of cardiac MLC2 plays a significant role in maintaining normal cardiac function. Agonist stimulation including endothelin-1 induced the expression of cMLCK and increased the phosphorylation level of MLC2. In addition, the expression of cMLCK and the phosphorylation levels of MLC2 were varied in several animal models, suggesting the phosphorylation of MLC2 might be involved in the several pathologic conditions in heart.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (69 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (36 results) (of which Peer Reviewed: 36 results) Presentation (32 results) Remarks (1 results)

  • [Journal Article] Efficacy of linear block at the left atrial roof in atrial fibrillation.2010

    • Author(s)
      Senga M, Fujii E, Sugiura S, Yamazato S, Sugiura E, Nakamura M, Miyahara M, Ito M.
    • Journal Title

      J.Cardiol. 55

      Pages: 322-327

    • NAID

      10027052544

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Left ventricular contraction-relaxation coupling in normal, hypertrophic, and failing myocardium quantified by speckle-tracking global strain and strain rate imaging.2010

    • Author(s)
      Takamura T, Dohi K, Onishi K, Kurita T, Tanabe M, Tanigawa T, Isaka N, Ito M.
    • Journal Title

      J.Am.Soc.Echocardol. 23

      Pages: 747-754

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique myocardial fibrosis pattern by late gadolinium enhanced magnetic resonance imaging in a patient with isolated noncompaction of the ventricular myocardium.2010

    • Author(s)
      Kurita T, Matsuoka K, Hoshida K, Nakamori S, Ichikawa Y, Tanigawa T, Onishi K, Nakamura T, Sakuma H, Ito M.
    • Journal Title

      Circ.J. 74

      Pages: 381-382

    • NAID

      10025942866

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of myosin phosphatase reduced Ca2+ sensitivity of contraction and impairs cardiac function.2010

    • Author(s)
      Mizutani H, Okamoto R, Moriki N, Konishi K, Taniguchi M, Fujita S, Dohi K, Onishi K, Suzuki M, Satoh S, Makino N, Itoh T, Hartshorne DJ, Ito M.
    • Journal Title

      Circ.J. 74

      Pages: 120-128

    • NAID

      10025941436

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Left ventricular contraction-relaxation coupling in normal, hypertrophic, and failing myocardium quantified by speckle-tracking global strain and strain rate imaging2010

    • Author(s)
      Takamura T., et al.
    • Journal Title

      J Am Soc Echocardol

      Volume: 23 Pages: 747-754

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of linear block at the left atrial roof in atrial fibrillation2010

    • Author(s)
      Senga M., et al.
    • Journal Title

      J Cardiol

      Volume: 55 Pages: 322-327

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of myosin phosphatase reduced Ca^<2+> sensitivity of contraction and impairs cardiac function2010

    • Author(s)
      Mizutani H., Okamoto R., Moriki N., Konishi K., Taniguchi M., Fujita S., Dohi K., Onishi K., Suzuki N., Satoh S., Makino N., Itoh T., Hartshorne D. J., Ito M.
    • Journal Title

      Circ J. 74

      Pages: 120-128

    • NAID

      10025941436

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Overexpression of myosin phosphatase reduced Ca2+ sensitivity of contraction and impairs cardiac function2010

    • Author(s)
      Mizutani H., et al.
    • Journal Title

      Circ J. 74

      Pages: 120-128

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique myocardial fibrosis pattern by late gadolinium enhanced magnetic resonance imaging in a patient with isolated noncompaction of the ventricular myocardium2010

    • Author(s)
      Kurita T., et al.
    • Journal Title

      Circ J. 74

      Pages: 381-382

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional myocardial perfusion reserve determined by quantitative analysis of myocardial perfusion MRI showed a good correlation with coronary flow velocity reserve by doppler flow wire.2009

    • Author(s)
      Kurita T, Sakuma H, Onishi K, Ishida M, Kitagawa K, Yamanaka T, Tanigawa T, Kitamura T, Takeda K, Ito M.
    • Journal Title

      Eur.Heart J. 30

      Pages: 444-452

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum intact parathyroid hormone levels predict hospitalization for heart failure.2009

    • Author(s)
      Sugimoto T, Tanigawa T, Onishi K, Fujimoto N, Matsuda A, Nakamori S, Matsuoka K, Nakamura T, Koji T, Ito M.
    • Journal Title

      Heart 95

      Pages: 395-398

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire2009

    • Author(s)
      Kurita T., et al.
    • Journal Title

      Eur Heart J. 30

      Pages: 444-452

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum intact parathyroid hormone levels predicthospitalization for heart failure2009

    • Author(s)
      Sugimoto T., et al.
    • Journal Title

      Heart 95

      Pages: 395-398

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional myocardial perfusin reserve determined by quantitative analysis of myocardial perfusion MRI showed a good correlation with coronay flow velocity reserve bydoppler flow wire.2009

    • Author(s)
      Kurita T., et al.
    • Journal Title

      Eur. Heart J. (CD-ROM)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic characteristics of patients with diastolic heart failure and hypertension.2008

    • Author(s)
      Fujimoto N, Onishi K, Dohi K, Tanabe M, Kurita T, Takamura T, Yamada N, Nobori T, Ito M.
    • Journal Title

      Hypertens.Res. 31

      Pages: 1727-1735

    • NAID

      10024362307

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myosin phosphatase targeting subunit regulates mitosis by antagonizing polo-like kianase1.2008

    • Author(s)
      Yamashiro S, Yamakita Y, Totsukawa G, Goto H, Kaibuchi K, Ito M, Hartshorne DJ, Matsumura F.
    • Journal Title

      Dev.Cell 14

      Pages: 787-797

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase- mediated NF-kB activation in bovine aortic endothelial cells.2008

    • Author(s)
      Iwasaki H, Okamoto R, Kato S, Konishi K, Mizutani H, Yamada N, Isaka N, Nakano T, Ito M.
    • Journal Title

      Atherosclerosis. 196

      Pages: 22-28

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging.2008

    • Author(s)
      Motoyasu M, Kurita T, Onishi K, Uemura S, Tanigawa T, Okinaka T, Takeda K, Nakano T, Ito M, Sakuma H.
    • Journal Title

      Circ.J. 72

      Pages: 378-383

    • NAID

      110006646489

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exaggerated hypertensive response to exercise in patients with diastolic heart failure.2008

    • Author(s)
      Kato S, Onishi K, Yamanaka T, Dohi K, Yamada N, Wada H, Ito M.
    • Journal Title

      Hypertens.Res. 31

      Pages: 679-684

    • NAID

      10021934638

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of radial strain and displacement imaging to quantify wall motion dyssynchronyin patients with left ventricular mechanical dyssynchrony and chronic right ventricular pressure overlord.2008

    • Author(s)
      Dohi K, Onishi K, Gorcsan J III, Lopez-Candales A, Takamura T, Ota S, Yamada N, Ito M.
    • Journal Title

      Am.J.Cardiol. 101

      Pages: 1206-1212

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patients with a hypertensive response to exercise have impaired left vetricular diastolic function.2008

    • Author(s)
      Takamura T, Onishi K, Sugimoto T, Kurita T, Fujimoto N, Dohi K, Tanigawa T, Isaka N, Nobori T, Ito M.
    • Journal Title

      Hypertens.Res. 31

      Pages: 257-263

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exaggerated hypertensive response to exercise in patients with diastolic heart failure2008

    • Author(s)
      Kato S., Onishi K., Yamanaka T., Dohi K., Yamada N., Wada H., Ito M.
    • Journal Title

      Hypertens. Res. 31

      Pages: 679-684

    • NAID

      10021934638

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Myosin phosphatase targeting subunit regulates mitosis by antagonizing polo-like kianasel2008

    • Author(s)
      Yamashiro S., Yamakita Y., Totsukawa G., Goto H., Kaibuchi K., Ito M., Hartshorne D. J., Matsumura F.
    • Journal Title

      Developmental Cell 14

      Pages: 787-794

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Role of adial strain and displacement imaging to quantify wall motion dyssynchrony in patients with left ventricular mechanical dyssynchrony and chronic right ventricular pressure overlord2008

    • Author(s)
      Dohi K., Onishi K., Gorcsan III J., Lopez-Candales A., Takamura T., Ota S., Yamada N., Ito M.
    • Journal Title

      Am J.Cardiol. 102

      Pages: 1206-1212

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Role of radial strain and displacement imaging to quantifywall motion dyssynchrony in patients with left ventricular mechanical dyssynchrony and chronic right ventricularpressure overlord2008

    • Author(s)
      Dohi K., et al.
    • Journal Title

      Am. J. Cardiol. 101

      Pages: 1206-1212

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase-mediated NF-kB activation in bovine aortic endothelial cells.2008

    • Author(s)
      Iwasaki H., et al.
    • Journal Title

      Atherosclerosis 196

      Pages: 22-28

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exaggerated hypertensive response to exercise in patients with diastolic heart failure2008

    • Author(s)
      Kato S., et al.
    • Journal Title

      Hypertens. Res. 31

      Pages: 679-684

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Myosin phosphatase targeting subunit regulates mitosis by antagonizing polo-like kianase12008

    • Author(s)
      Yamashiro S., et al.
    • Journal Title

      Developmental Cell 14

      Pages: 787-794

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic characteristics of patients with diastolic heart failure and hypertension2008

    • Author(s)
      Fujimoto N., et al.
    • Journal Title

      Hypertens. Res. 31

      Pages: 1727-173

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patients with a hypertensive response to exercise have impaired left vetricular diastolic function2008

    • Author(s)
      Takamura T, et. al.
    • Journal Title

      Hypertens.Res. 31

      Pages: 257-263

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of adial strain and displacement imaging to quantify wall motion dyssynchrony in patients with left entricular mechanical dyssynchrony and chronic right ventricular pressure overlord2008

    • Author(s)
      Dohi K., et. al.
    • Journal Title

      Am J.Cardiol. (掲載決定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exaggerated hypertensive response to exercise in patients with diastolic heart failure2008

    • Author(s)
      Kato S, et. al.
    • Journal Title

      Hypertens.Res. (掲載決定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging2008

    • Author(s)
      Motoyasu M, et. al.
    • Journal Title

      Circ.J. 72

      Pages: 378-383

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of heart rate on mechanical dyssynchrony and left ventricular contractility in patients with heart failure and normal QRS duration.2007

    • Author(s)
      Kurita T, Onishi K, Dohi K, Tanabe M, Fujimoto N, Tanigawa T, Setsuda M, Isaka N, Nobori T, Ito M.
    • Journal Title

      Eur.J.Heart Fail. 9

      Pages: 637-643

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impact of heart rate on mechanical dyssynchrony and left ventricular contractility in patients with heart failure and normal QRS duration2007

    • Author(s)
      Kurita T., Onishi K., Dohi K., Tanabe M., Fujimoto N., Tanigawa T., Setsuda M., Isaka N., Nobori T., Ito M.
    • Journal Title

      Eur.J.Heart Fail. 9

      Pages: 637-643

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Impact of heart rate on mechanical dyssynchrony and left ventricular contractility in patients with heart failure and normal QRS duration.2007

    • Author(s)
      Kurita T, et. al.
    • Journal Title

      Eur.J.Heart Fail. 9

      Pages: 637-643

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心筋ミオシン軽鎖キナーゼの生化学的性状解析2011

    • Author(s)
      谷口正弥, 岡本隆二, 後藤至, 藤田聡,小西克尚, 中村真潮, 伊藤正明
    • Organizer
      第40回日本心脈管作動物質学会
    • Place of Presentation
      高松
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ラット高血圧自然発症モデルに対する種々の降圧薬の効果とミオシン軽鎖リン酸レベルの変化とその機序に関する検討2010

    • Author(s)
      小西克尚, 岡本隆二, 藤田聡, 谷口正弥, 伊藤正明
    • Organizer
      第39回日本心脈管作動物質学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-02-05
    • Related Report
      2010 Final Research Report 2009 Annual Research Report 2009 Self-evaluation Report
  • [Presentation] Long term prognostic value of stress perfusion CMR study for the prediction of cardiovascular death and nonfatal acute myocardial infarction in patients with or without preserved left ventricular ejection fraction.2010

    • Author(s)
      Kurita T, Sakuma H, Nakajima H, Kato S, Nakamori S, Kitagawa K, Onishi K, Ito M
    • Organizer
      American Heart Association 2010 Scientifc Sessions.
    • Place of Presentation
      Chicago, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Impaired myocardial perfusion reserve in patients with fatty liver disease assessed by quantitative myocardial perfusion MRI.2010

    • Author(s)
      Nakamori S, Onishi K, Nakajima H, Kato S, Yoon YE, Kitagawa K, Dohi K, Nakamura M, Sakuma H, Ito M
    • Organizer
      American Heart Association 2010 Scientifc Sessions.
    • Place of Presentation
      Chicago, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット高血圧自然発症モデルにおける各種降圧薬のミオシン軽鎖リン酸化レベルに対する効果2010

    • Author(s)
      小西克尚, 岡本隆二, 後藤至, 藤田聡, 谷口正弥, 水谷英夫, 宮原眞敏, 中村真潮, 伊藤正明
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Role of hemodialytic therapy on left venatirular mechanical dyssynchrony in patients with end-stage renal failure quantified by speckle-tracking strain imaging.2010

    • Author(s)
      Dohi K, Murata T, Onishi K, Sugiura E, Sugimoto T, Yamada N, Nomura S, Miyahara M, Nakamura M, Ito M
    • Organizer
      European Society of Cardiology Congress 2010.
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Final Research Report
  • [Presentation] Diagnostic utility of serum intact parathyroid hormone in predicting impaired cardiac hemodynamics combined with brain natriuretic peptide in patients with heart failure.2010

    • Author(s)
      Sugimoto T, Dohi K, Nakajima H, Ichikawa K, Nakamori S, Tanabe M, Onishi K, Miyahara M, Nakamura M, Ito M
    • Organizer
      European Society of Cardiology Congress 2010.
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Final Research Report
  • [Presentation] Olmesartan, hydralazine and carvedilol decrease myosin light chain phosphorylation in vascular smooth muscle and Partly Exert Their Antihypertensive Effects.2010

    • Author(s)
      Konishi K, Okamoto R, Fujita S, Taniguchi M, Mizutani H, Miyahara M, Nakamura M, Ito M
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] Impaired Myocardial Perfusion Reserve in Patients with Fatty Liver Disease Assessed by Quantitative Myocardial Perfusion MRI2010

    • Author(s)
      Nakamori S, et al.
    • Organizer
      American Heart Association 2010 Scientific Sessions
    • Place of Presentation
      Chicago, U.S.A.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Long Term Prognostic Value of Stress Perfusion CMR Study for the Prediction of Cardiovascular Death and NonFatal Acute Myocardial Infarction in Patients with or without Preserved Left Ventricular Ejection Fraction2010

    • Author(s)
      Kurita T., et al.
    • Organizer
      American Heart Association 2010 Scientific Sessions
    • Place of Presentation
      Chicago, U.S.A.
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diagnostic Utility of Serum Intact Parathyroid Hormone in Predicting Impaired Cardiac Hemodynamics Combined with Brain Natriuretic Peptide in Patients with Heart Failure2010

    • Author(s)
      Sugimoto T., et al.
    • Organizer
      ESC Congress 2010
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Annual Research Report
  • [Presentation] Role of Hemodialytic Therapy on Left Venatirular Mechanical Dyssynchrony in Patients with End-stage Renal Failure Quantified by Speckle-tracking Strain Imaging2010

    • Author(s)
      Dohi K., et al.
    • Organizer
      ESC Congress 2010
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット高血圧自然発症モデルにおける、各種降圧薬のミオシン軽鎖リン酸化レベルに対する効果2010

    • Author(s)
      小西克尚, 他
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] Olmesartan, Hydralazine and Carvedilol Decrease Myosin Light Chain Phosphorylation in Vascular Smooth Muscle and Partly Exert Their Antihypertensive Effects2010

    • Author(s)
      Konishi K., et al.
    • Organizer
      第42回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report
  • [Presentation] Long term prognostic value of stress perfusion CMR study for the prediction of cardiovascular death and nonfatal acute myocardial infarction in 1009 asian patients.2009

    • Author(s)
      Kurita T, Sakuma H, Nakajima H, Kato S, Miyagi H, Nakamori S, Kitagawa K, Onishi K, Nakamura M, Ito M
    • Organizer
      American Heart Association 2009 Scientifc Sessions.
    • Place of Presentation
      Orlando, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Human atrial natriuretic peptide preserved infract-related myocardial blood flow quantified by perfusion MRI in patients with acute myocardial infarction.2009

    • Author(s)
      Kurita T, Tanigawa T, Sakuma H, Sato K, Nakajima H, Nakamori S, Ichikawa Y, Kitagawa K, Matsuoka K, Onishi K, Nakamura T, Ito M
    • Organizer
      American Heart Association 2009 Scientifc Sessions.
    • Place of Presentation
      Orlando, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Coupling of systolic and diastolic function and regional synchrony in normal, hypertrophic, and failing myocardium quantified by speckle-tracking echocardiography.2009

    • Author(s)
      Dohi K, Onishi K, Takamura T, Sugiura E, Nakajima H, Ichikawa K, Tanabe M, Miyahara M, Nakamura M, Ito M
    • Organizer
      European Society of Cardiology Congress 2009.
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Final Research Report
  • [Presentation] Presence of myocardial scar is strongly associated with abnormal regional myocardial blood flow in hypertrophic cardiomyopathy.2009

    • Author(s)
      Nakajima H, Onishi K, Kurita T, Ishida M, Nagata M, Kitagawa K, Dohi K, Nakamura M, Sakuma H, Ito M
    • Organizer
      European Society of Cardiology Congress 2009.
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantification of left ventricular contraction and relaxation in patients with diastolic heart failure by speckle-tracking strain and strain rateechocardiography.2009

    • Author(s)
      Ogawa E, Dohi K, Onishi K, Takamura T, Nakajima H, IchikawaK, Tanabe M, Tamada H, Miyahara M, Nakamura M, Ito M
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Quantification of left ventricular mechanical dyssynchrony in normal, hypertrophied, and dilated myocardium quantified by speckle-tracking strain echocardiography.2009

    • Author(s)
      Dohi K, Onishi K, Takamura T, Ogawa E, Nakajima H, Ichikawa K, Tanabe M, Tamada H, Miyahara M, Nakamura M, Ito M
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Human atrial natriuretic peptide preserved infract-related myocardial blood flow quantified by perfusion MRI in patients with acute myocardial infarction2009

    • Author(s)
      Kurita T., et al.
    • Organizer
      American Heart Association 2009 Scientifc Sessions
    • Place of Presentation
      Orlando, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Long term prognostic value of stress perfusion CMR study for the prediction of cardiovascular death and non fatal acute myocardial infarction in 1009 asian patients2009

    • Author(s)
      Kurita T., et al.
    • Organizer
      American Heart Association 2009 Scientifc Sessions
    • Place of Presentation
      Orlando, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Presence of myocardial scar is strongly associated with abnormal regional myocardial blood flow in hypertrophic cardiomyopathy2009

    • Author(s)
      Nakajima H., et al.
    • Organizer
      European Society of Cardiology Congress 2009
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2009 Annual Research Report
  • [Presentation] Coupling of systolic and diastolic function and regional synchrony in normal, hypertrophic, and failing myocardium quantified by speckle-tracking echocardiography2009

    • Author(s)
      Dohi K., et al.
    • Organizer
      European Society of Cardiology Congress 2009
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2009 Annual Research Report
  • [Presentation] Quantification of Left Ventricular Mechanical Dyssynchrony in Normal, Hypertrophied, and Dilated Myocardium Quantified by Speckle-Tracking strain Echocardiography2009

    • Author(s)
      Dohi K, et al.
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Quantification of Left Ventricular Contraction and Relaxation in Patients with Diastolic Heart Failure by Speckle-Tracking strain and strain Rate Echocardiography2009

    • Author(s)
      Ogawa E, et al.
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 心筋ミオシンホスファターゼの分子性状とその機能2008

    • Author(s)
      水谷英夫, 森木宣行, 岡本隆二, 井阪直樹,中野赳, 伊藤正明, 大西勝也, 鈴木昇, 佐藤真司, 牧野直樹, David Hartshorne.
    • Organizer
      第37回日本心脈管作動物質学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-02-02
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] 心筋ミオシンボスファターゼの分子性状とその機能2008

    • Author(s)
      水谷 英夫
    • Organizer
      第37回日本心脈管作動物質学会
    • Place of Presentation
      仙台
    • Year and Date
      2008-02-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Subendmyocardial perfusion reserve correlated with left ventricular diastolic function in patients with various types of left ventricular hypertrophy.2008

    • Author(s)
      Kurita T, Onishi K, Sakuma H, Takamura T, Nagata M, Nakajima H, Ishida M, Fujimoto N, Dohi K, Takeda K, Ito M
    • Organizer
      American Heart Association 2008 Scientifc Sessions.
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Hypertension plays an important role on the impairment of myocardial perfusion reserve determined by quantitative analysis of myocardial perfusion MRI.2008

    • Author(s)
      Nakajima H, Onishi K, Kurita T, Ishida M, Takamura T, Ishida N, Dohi K, Nakamura M, Sakuma H, Ito M
    • Organizer
      American Heart Association 2008 Scientifc Sessions.
    • Place of Presentation
      New Orleans, U.S.A.
    • Related Report
      2010 Final Research Report
  • [Presentation] Hypertension Plays an Important Role on the Impairment of Myocardial Perfusion Reserve Determined by Quantitative Analysis of Myocardial Parfusion MRI2008

    • Author(s)
      Nakajima H., et al.
    • Organizer
      American Heart Association 2008 Scientifc Sessions
    • Place of Presentation
      New Orleans, U. S. A
    • Related Report
      2008 Annual Research Report
  • [Presentation] Subendmyoqardial Perfusion Reserve Correlated with Left Ventricular Diastolic Function in Patients with Marious Types of Left Ventricular Hypertrophy2008

    • Author(s)
      Kurita T., et al.
    • Organizer
      American Heart Association 2008 Scientifc Sessions
    • Place of Presentation
      New Orleans, U. S. A
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.medic.mie-u.ac.jp/naika1/classroom/research/a01.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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