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Genotype-phenotype relation study on inherited cardiac arrhythmias as ion hcannel diseases

Research Project

Project/Area Number 19390212
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

HORIE Minoru  Shiga University of Medical Science, 医学部, 教授 (90183938)

Co-Investigator(Kenkyū-buntansha) ITOH Hideki  滋賀医科大学, 医学部, 助教 (30402738)
TSUJI Keiko  滋賀医科大学, 医学部, 特任助教 (70432309)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2008: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords生理学 / 遺伝子 / 蛋白質 / イオンチャネル
Research Abstract

A part of inherited arrhythmias is now known to result from a variety of genetic variants in genes encoding cardiac ion channels and their modulating proteins. There are at least two different types of genetic variants: mutations and single nucleotide polymorphism (SNP). Among the inherited arrhythmia, congenital long QT syndrome (LQTS) is a disorder defined by prolongation of the QT interval. Patients with LQTS are predisposed to fatal ventricular tachycardia - torsade de pointes (TdP) - leading to recurrent syncope or sudden cardiac death. Syncope or sudden death could be the first and the only manifestation. LQTS affects an estimated 1 in 2,000 people.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (272 results)

All 2010 2009 2008 2007 Other

All Journal Article (150 results) (of which Peer Reviewed: 140 results) Presentation (102 results) Book (17 results) Remarks (3 results)

  • [Journal Article] High prevalence of early repolarization in short QT syndrome2010

    • Author(s)
      Watanabe H, Itoh H, Horie M, et al
    • Journal Title

      Heart Rhythm 7

      Pages: 647-652

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] P-wave and the development of atrial fibrillation2010

    • Author(s)
      Ishida K, Horie M, et al
    • Journal Title

      Heart Rhythm 7

      Pages: 289-294

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] QTc prolongation and antipsychotic medication in 1017 patients with schizophrenia2010

    • Author(s)
      Ozeki Y, Horie M, et al
    • Journal Title

      Progress in Neuro-Psychopharmacology & BiologicalPsychiatry 34

      Pages: 401-405

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and genetic background of congenital long QT syndrome diagnosed in fetal, neonatal and infantile life. A nation-wide questionnaire survey in Japan2010

    • Author(s)
      Horigome H, Horie M, et al
    • Journal Title

      Journal of American College of Cardiology 3

      Pages: 10-17

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] KCNE2 modulation of Kv4. 3 current and its potential role in fatal rhythm disorders2010

    • Author(s)
      Wu J, Itoh H, Horie M, et al
    • Journal Title

      Heart Rhythm 7

      Pages: 199-205

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of early repolarization in short QT syndrome2010

    • Author(s)
      Watanabe H, Makiyama T, Koyama T, Kannankeril PJ, Seto S, Okamura K, Oda H, Itoh H, Okada M, Tanabe N, Yagihara N, Kamakura S, Horie M, Aizawa Y, Shimizu W.
    • Journal Title

      Heart Rhythm 7

      Pages: 647-652

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] P-wave and the development of atrial fibrillation2010

    • Author(s)
      Ishida K, Hayashi H, Miyamoto A, Sugimoto Y, Ito M, Murakami Y, Horie M
    • Journal Title

      Heart Rhythm 7

      Pages: 289-294

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QTc prolongation and antipsychotic medication in 1017 patients with schizophrenia2010

    • Author(s)
      Ozeki Y, Fujii K, Kuromoto N, Yamada N, Okawa M, Aoki T, Takahashi J, Narita M, Ishida N, Saito O, Horie M, Kunugi H
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 34

      Pages: 401-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and genetic background of congenital long QT syndrome diagnosed in fetal, neonatal and infantile life. A nation-wide questionnaire survey in Japan2010

    • Author(s)
      Horigome H, Nagashima M, Sumitomo N, Yoshinaga M, Ushinohama H, Iwamoto M, Shiono J, Ichihashi K, Hasegawa S, Yoshikawa T, Matsunaga T, Goto H, Waki K, Arima M, Takasugi H, Tanaka Y, Miura M, Ogawa K, Suzuki H, Yamagishi H, Ikoma M, Suda K, Takagi J, Sato J, Shimizu H, Saiki H, Hoshiai M, Ichida F, Takeda S, Takigiku K, Inamura N, Kajino H, Murakami T, Shimizu W, Horie M
    • Journal Title

      Circ Arrhythm Electrophysiol. 3

      Pages: 10-17

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] デスモゾーム病としての不整脈源性右室心筋症-デスモゾーム分子遺伝子異常2010

    • Author(s)
      堀江稔
    • Journal Title

      医学のあゆみ 223

      Pages: 588-592

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子異常と不整脈2010

    • Author(s)
      伊藤英樹, 堀江稔
    • Journal Title

      臨床と研究 87

      Pages: 98-101

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QTが長ければQT延長症候群か?2010

    • Author(s)
      伊藤英樹, 堀江稔
    • Journal Title

      medicina 47

      Pages: 66-68

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KCNE2 modulation of KV4.3 current and its potential role in fatal rhythm disorders2010

    • Author(s)
      Wu J, Shimizu W, Ding W-G, Ohno S, Toyada F, Itoh H, Zang W-J, Miyamoto Y, Kamakura S, Matsuura H, Nademanee J, Brugada J, Brugada P, Brugada R, Vatta M, Towbin JA, Antzelevitch C, Horie M.
    • Journal Title

      Heart Rhythm 7

      Pages: 199-205

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      堀江稔
    • Journal Title

      今日の治療方針 : 心房細動(医学書院)

      Pages: 300-302

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      堀江稔
    • Journal Title

      Annual Review 循環器 : ARB/ACE-1による心房細動抑止効果(中外医学)

      Pages: 182-188

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel2009

    • Author(s)
      Irar T, Horie M, et al
    • Journal Title

      BBRC 378(3)

      Pages: 589-94

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adrenergic regulation of the rapid component of delayed rectifier K+ current : Implications for arrhythmogenesis in LQT2 patients2009

    • Author(s)
      Zankov DP, Tsuji K, Horie M, et al
    • Journal Title

      Heart Rhythm 6(7)

      Pages: 1038-1046

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aorto-Pulmonary artery dissection.2009

    • Author(s)
      Itoh H, Horie M, et al
    • Journal Title

      Journal of American College of Cardiology 54(21)

      Pages: 1990-1990

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel KCNH2 mutation as a modifier for short QT interval2009

    • Author(s)
      Itoh H, Horie M, et al
    • Journal Title

      Int J Cardiol 137(1)

      Pages: 83-5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome2009

    • Author(s)
      Ohno S, Tsuji K, Horie M, et al
    • Journal Title

      Hum Mutat 30

      Pages: 557-563

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optimal treatment strategy for patients with paroxysmal atrial fibrillation2009

    • Author(s)
      Ogawa S, J-RHYTHM Investigators, et al
    • Journal Title

      Circ J(J-RHYTHM Study) 73

      Pages: 242-8

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of IKs current in guinea pig atrium2009

    • Author(s)
      Zankov DP, Horie M, et al
    • Journal Title

      Pflugers Archiv-European Journal of Physiology 458

      Pages: 837-849

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome2009

    • Author(s)
      Nishio Y, Horie M, et al
    • Journal Title

      Journal of American College of Cardiology 54(9)

      Pages: 812-9

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term prognosis of probands of Brugada-pattern ST-Elevation in leads V1-V32009

    • Author(s)
      Kamakura S, Horie M, et al
    • Journal Title

      Circulation Arrhythmia and Electrophysiology 2(5)

      Pages: 495-503

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Latent genetic backgrounds and molecular pathogenesis in drug-induced long QT syndrome2009

    • Author(s)
      Itoh H, Horie M, et al
    • Journal Title

      Circulation Arrhythmia and Electrophysiology 2(5)

      Pages: 511-23

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel2009

    • Author(s)
      Ikrar T, Hanawa H, Watanabe H, Aizawa Y, Ramadan MM, Chinushi M, Horie M, Aizawa Y
    • Journal Title

      BBRC 378

      Pages: 589-594

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenergic regulation of the rapid component of delayed rectifier K^+ current : Implications for arrhythmogenesis in LQT2 patients2009

    • Author(s)
      Zankov DP, Yoshida H, Tsuji K, Toyoda F, Ding WG, Matsuura H, Horie M
    • Journal Title

      Heart Rhythm 6

      Pages: 1038-1046

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aortopulmonary artery dissection2009

    • Author(s)
      Itoh H, Yamamoto T, Sugihara H, Saotome T, Eguchi Y, Asai T, Horie M
    • Journal Title

      JACC 54

      Pages: 1990-1990

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endothelin-1 as a predictor of atrial fibrillation recurrence after pulmonary vein isolation2009

    • Author(s)
      Nakazawa Y, Ashihara T, Tsutamoto T, Ito M, Horie M
    • Journal Title

      Heart Rhythm 6

      Pages: 725-730

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal treatment strategy for patients with paroxysmal atrial fibrillation : J-RHYTHM Study2009

    • Author(s)
      Ogawa S, Yamashita T, Yamazaki T, Aizawa Y, Atarashi H, Inoue H, Ohe T, Ohtsu H, Okumura K, Katoh T, Kamakura S, Kumagai K, Kurachi Y, Kodama I, Koretsune Y, Saikawa T, Sakurai M, Sugi K, Tabuchi T, Nakaya H, Nakayama T, Hirai M, Fukatani M, Mitamura H, J-RHYTHM Investigators
    • Journal Title

      Circ J 73

      Pages: 242-248

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of IKs current in guinea pig atrium2009

    • Author(s)
      Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura M, Horie M
    • Journal Title

      Pflugers Arch. 458

      Pages: 837-849

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] D85N, a KCNE1 polymorphism, is a disease-causing gene variant in long QT syndrome2009

    • Author(s)
      Nishio Y, Makiyama T, Itoh H, Sakaguchi T, Ohno S, Gong Y-Z, Yamamoto S, Ozawa T, Ding W-G, Toyoda F, Kawamura M, Akao M, Matsuura H, Kita T, Horie M
    • Journal Title

      JACC 54

      Pages: 812-819

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)2009

    • Author(s)
      Tamaki S, Nakamura Y, Tabara Y, Okamura T, Kanda H, Kita Y, Kadowaki T, Tsujita Y, Turin T C, Horie M, Miki T, Ueshima H.
    • Journal Title

      Int J Cardiol 136

      Pages: 354-355

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of atrial fibrillation in the general population of Japan : An analysis based on periodic health examination2009

    • Author(s)
      Inoue H, Fujiki A, Origasa H, Ogawa S, Okumura K, Kubota I, Aizawa Y, Yamashita T, Atarashi H, Horie M, Ohe T, Doi Y, Shimizu A, Chishaki A, Saikawa T, Yano K, Kitabatake A, Mitamura H, Kodama I, Kamakura S.
    • Journal Title

      Int J Cardiol 137

      Pages: 102-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholesteryl ester transfer protein, coronary calcium and intima-media thickness of the carotid artery in middle-aged Japanese men2009

    • Author(s)
      Okamura T, Sekikawa A, Kadowaki T, El-Saed A, Abbott DR, Curb JD, Edmundowicz D, Nakamura Y, Murata K, Kashiwagi A, Kim ST, Evans RW, Zmuda JM, Maegawa H, Hozawa A, Mitsunami K, Nisio Y, Iva MG, Horie M, Miyamastu N, Murakami Y, Kuller LH, Ueshima H.
    • Journal Title

      Am J Cardiol. 104

      Pages: 818-822

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term prognosis of probands with brugada-pattern ST-Elevation in leads V1-V32009

    • Author(s)
      Kamakura S, Ohe T, Nakazawa K, Aizawa Y, Shimizu A, Horie M, Ogawa S, Okumura K, Tsuchihashi K, Sugi K, Makita N, Hagiwara N, Inoue H, Atarashi H, Aihara N, Shimizu W, Kurita T, Suyama K, Noda T, Satomi K, Okamura H, Tomoike H.
    • Journal Title

      Circulation Arrhythmia & EP 2

      Pages: 495-503

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Latent genetic backgrounds and molecular pathogenesis in drug-induced long QT syndrome2009

    • Author(s)
      Itoh H, Sakaguchi T, Ding WS, Watanabe E, Watanabe I, Nishio Y, Makiyama T, Ohno S, Akao M, Higashi Y, Zenda N, Kubota T, Mori C, Okajima K, Haruna T, Miyamoto A, Kawamura M, Ishida K, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Sugimoto Y, Ashihara T, Hayashi H, Ito M, Imoto K, Matsuura H, Horie M
    • Journal Title

      Circulation Arrhythmia & EP 2

      Pages: 511-523

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory actions of LY294002, a phosphatidylinositol 3-kinase inhibitor, on the human Kv1.5 channel2009

    • Author(s)
      Wu J, Ding WG, Matsuura H, Tsuji K, Zang WJ, Horie M.
    • Journal Title

      Brit J Pharm 56

      Pages: 377-387

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel KCNE3mutations interact with KCNQ1and cause long QT syndrome2009

    • Author(s)
      Ohno S, Toyoda F, Zankov D, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Matsuura H, Shimizu W, Miyamoto Y, Kamakura S, Kita T, Horie M.
    • Journal Title

      Hum Muta 30

      Pages: 557-563

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel KCNH2 mutation as a modifier for short QT interval2009

    • Author(s)
      Itoh H, Sakaguchi T, Ashihara T, Ding G W, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ito M, Matsuura H, Horie M.
    • Journal Title

      Int J Cardiol. 137

      Pages: 83-85

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤性QT延長症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      ICUとCCU 33

      Pages: 19-24

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TOP-不整脈研究の流れ2009

    • Author(s)
      堀江稔
    • Journal Title

      BIO Clinica 24

      Pages: 405-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Romano-Ward 症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      小児科診療 72

      Pages: 221-221

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Jervell lange Nielsen2009

    • Author(s)
      堀江稔
    • Journal Title

      小児科診療 72

      Pages: 215-215

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Andersen 症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      Current Therapy 27

      Pages: 458-459

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] アップストリーム治療2009

    • Author(s)
      堀江稔
    • Journal Title

      診断と治療 97

      Pages: 1022-1027

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤性QT延長症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      循環器科 65

      Pages: 546-550

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不整脈研究の流れ2009

    • Author(s)
      堀江稔
    • Journal Title

      BIO Clinica 310

      Pages: 405-405

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical mapping による spiral wave の解析2009

    • Author(s)
      本荘晴明, 山崎正俊, 石黒有子, 神谷香一郎, 佐久間一郎, 芦原貴司, 堀江稔, 児玉逸雄
    • Journal Title

      心電図 29

      Pages: 231-235

    • NAID

      10026293138

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長症候群2009

    • Author(s)
      堀江稔
    • Journal Title

      小児科 50

      Pages: 1083-1087

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝性不整脈2009

    • Author(s)
      堀江稔
    • Journal Title

      Heart View 13

      Pages: 47-51

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長の潜在的危険性の予知-遺伝子多型 : KCNE1-D85N-2009

    • Author(s)
      西尾由貴子, 堀江稔
    • Journal Title

      循環器専門医 17

      Pages: 237-242

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      堀江稔
    • Journal Title

      循環器疾患最新の治療2010-2011 : 脚ブロック(南江堂)

      Pages: 287-290

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      堀江稔
    • Journal Title

      重篤副作用疾患別対応マニュアル : 心室頻拍(厚生労働省)

      Pages: 1-20

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      堀江稔
    • Journal Title

      最新医学別冊新しい診断と治療のABC15循環器2心房細動 (改訂第2版) : 心房リモデリング(最新医学社)

      Pages: 59-66

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      堀江稔
    • Journal Title

      遺伝性不整脈 4. QT延長症候群(最新医学社)

      Pages: 105-112

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Endothelin-1 as a Predictor of Atrial Fibrillation Recurrence after Pulmonary Vein Isolation.2009

    • Author(s)
      Nakazawa Y
    • Journal Title

      Heart Rhythm (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome.2009

    • Author(s)
      Ohno S
    • Journal Title

      Hum Mutat 30

      Pages: 557-63

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A family of hereditary long QT syndrome caused by Q738X HERG mutation.2009

    • Author(s)
      Yasuda S
    • Journal Title

      Int J Cardiol (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic change in ST-segment and spontaneous occurrence of ventricular fibrillation in brugada syndrome with a novel nonsense mutation in the SCN5AGene during long-term follow-up.2009

    • Author(s)
      Kawamura M
    • Journal Title

      Circ J 73

      Pages: 584-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Channel Function after Alteration of Amino Acid Residues at the Pore Center of KCNQl Channel.2009

    • Author(s)
      Irar T
    • Journal Title

      BBRC 378

      Pages: 589-94

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory actions of LY294002, a phosphatidylinositol 3-kinase inhibitor, on the human Kv1.5 channel.2009

    • Author(s)
      Wu J
    • Journal Title

      Br J pharmacol 156

      Pages: 377-87

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenergic regulation of the rapid component of delayed rectifier K+current : Implications for arrhythmogenesis in LQT2 patients.2009

    • Author(s)
      Zankov DP
    • Journal Title

      Heart Rhythm (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Novel KCNH2 Mutation as a Modifier for Short QT Interval.2009

    • Author(s)
      Itoh H
    • Journal Title

      Int J Cardiol (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aorto-Pulmonary Artery Dissection.2009

    • Author(s)
      Itoh H
    • Journal Title

      JACC (掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤性QT延長症候群.2009

    • Author(s)
      堀江稔
    • Journal Title

      ICUとCCU 33

      Pages: 19-24

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arrhythmias and sudden death in heart failure2009

    • Author(s)
      堀江稔
    • Journal Title

      AHA Highlights 2008

      Pages: 136-40

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子変異と多型2009

    • Author(s)
      牧山武
    • Journal Title

      Brugada症候群-病態解明から診断・治療指針の決定-

      Pages: 210-223

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mutation associated with Jervell and Lange-Nielsen syndrome in a Japanese family2008

    • Author(s)
      Ohno S, Horie M, et al
    • Journal Title

      Circ J 72(5)

      Pages: 687-693

    • NAID

      110006680543

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Age-and genotype-specific triggers for life-threatening arrhythmia in the genotyped long-QT syndrome2008

    • Author(s)
      Sakaguchi T, Itoh H, Tsuji K, Horie M, et al
    • Journal Title

      J Cardiovasc Electrophysiol 19(8)

      Pages: 794-799

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation site dependent variability of cardiac events in LQT2 form of congenital long-QT syndrome2008

    • Author(s)
      Nagaoka I, Itoh H, Horie M, et al
    • Journal Title

      Circ J 72(5)

      Pages: 694-699

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel SCN5Again-of-function mutation M1875T associated with familial atrial fibrillation2008

    • Author(s)
      Makiyama T, Tsuji K, Itoh H, Horie M, et al
    • Journal Title

      J Am Coll Cardiol 52(16)

      Pages: 1326-1334

    • NAID

      10024457085

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The factors contributing to whether or not hypertensive patients bring their home blood pressure record to the outpatient exam2008

    • Author(s)
      Tamaki S, Horie M, et al
    • Journal Title

      Intern Med 47(18)

      Pages: 1561-1565

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome2008

    • Author(s)
      Makiyama T, Tsuji K, Horie M, et al
    • Journal Title

      Circ J 72

      Pages: 1705-1706

    • NAID

      110006935616

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome2008

    • Author(s)
      Makita N, Horie M, Itoh H, et al
    • Journal Title

      J Clin Invest 118(6)

      Pages: 2219-2229

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go?Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation2008

    • Author(s)
      Sakaguchi T, Itoh H, Tsuji K, Horie M, et al
    • Journal Title

      J Pharmacol Sci 108

      Pages: 462-471

    • NAID

      130000075877

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic background of arrhythmogenic right ventricular dysplasia/Cardiomyopathy:Time to start asian registry!2008

    • Author(s)
      Horie M, et al
    • Journal Title

      Journal of Arrhythmia 24

      Pages: 195-199

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel mutation associated with Jervell and Lange-Nielsen syndrome in a Japanese family.2008

    • Author(s)
      Ohno S
    • Journal Title

      Circ J 72

      Pages: 687-93

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-and genotype-specific triggers for life-threatening arrhythmia in the genotyped long-QT syndrome.2008

    • Author(s)
      Sakaguchi T
    • Journal Title

      J Cardiovasc Electrophysiol 19

      Pages: 794-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation site dependent variability of cardiac events in LQT2 form of congenital long-QT syndrome.2008

    • Author(s)
      Nagaoka I
    • Journal Title

      Circ J 72

      Pages: 694-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel SCN5Again-of-function mutation M1875T associated with familial atrial fibrillation.2008

    • Author(s)
      Makiyama T
    • Journal Title

      J Am Coll Cardiol 52

      Pages: 1326-34

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPDIL)gene in Japanese patients with Brugada syndrome.2008

    • Author(s)
      Makiyama T
    • Journal Title

      Circ J 72

      Pages: 1705-6

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome.2008

    • Author(s)
      Makita N
    • Journal Title

      J Clin Invest 118

      Pages: 2219-29

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cinnamyl-3, 4-dihydroxy-alpha-cyanocinnamate and nordihydroguaiaretic acid inhibit human Kv1.5 currents independently of lipoxygenase.2008

    • Author(s)
      Gong YZ
    • Journal Title

      Eur J Pharmacol 600

      Pages: 18-25

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不整脈予防におけるARB, ACE阻害薬とアルドステロン拮抗薬.2008

    • Author(s)
      堀江稔
    • Journal Title

      心電図 28

      Pages: 5-5

    • NAID

      10021301200

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心電学マイルストーン2008

    • Author(s)
      堀江稔
    • Journal Title

      心電図 28

      Pages: 80-80

    • NAID

      130004245532

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LIFE研究の重要なサブ解析 : Cornell積と心不全入院リスク.2008

    • Author(s)
      堀江稔
    • Journal Title

      The Mainichi Medical Journal 4

      Pages: 193-193

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroxyzine, a First Generation H1-Receptor Antagonist, Inhibits Human Ether-a-go-go? Related Gene (HERG) Current and Causes Syncope in a Patient With the HERG Mutation2008

    • Author(s)
      Sakaguchi T
    • Journal Title

      J Pharmacol Sci 108

      Pages: 462-71

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic background of arrhythmogenic right ventricular dysplasia/Cardiomyopathy : Time to start asian registry! .2008

    • Author(s)
      Horie M
    • Journal Title

      Journal of Arrhythmia 24

      Pages: 195-9

    • NAID

      10027080585

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長症候群の遺伝子変異2008

    • Author(s)
      伊藤英樹
    • Journal Title

      Heart View 12

      Pages: 84-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 遺伝子PKP2の変異が確認された不整脈源性右室心筋症の1例2008

    • Author(s)
      三宅誠
    • Journal Title

      心電図 28

      Pages: 295-302

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長症候群の治療2008

    • Author(s)
      大野聖子
    • Journal Title

      JIM 18

      Pages: 764-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 循環器疾患の遺伝子学2008

    • Author(s)
      堀江稔
    • Journal Title

      最新医学 63

      Pages: 1814-26

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤性QT延長症候群の遺伝子異常と分子病態2008

    • Author(s)
      伊藤英樹
    • Journal Title

      循環器専門医 16

      Pages: 227-227

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 虚血性心疾患の概念と病態生理2008

    • Author(s)
      堀江稔
    • Journal Title

      日本臨床 66

      Pages: 349-53

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 第13回日本心電学会学術奨励賞総評2008

    • Author(s)
      堀江稔
    • Journal Title

      心電図 28

      Pages: 606-606

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心房筋リモデリングを考慮したヒト心房細動in silicoモデルにおけるアミオダロンの短作用と長期作用.2008

    • Author(s)
      芦原貴司
    • Journal Title

      PROGRESS IN MEDICINE 28

      Pages: 562-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺静脈隔離術後患者の心房細動再発の検出における携帯型心電計の有用性.2008

    • Author(s)
      芦原貴司
    • Journal Title

      心電図 28

      Pages: 77-77

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家庭用心電計による不整脈の検出-非電送携帯型心電計による検討-2008

    • Author(s)
      伊藤誠
    • Journal Title

      心電図 28

      Pages: 21-2

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 第72回日本循環器学会・学術集会緊急レポート New findings of mechanism and therapeutic strategies of idiopathic ventricular fibrillation2008

    • Author(s)
      堀江稔
    • Journal Title

      医学のあゆみ 225

      Pages: 328-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動悸がする2008

    • Author(s)
      堀江稔
    • Journal Title

      臨床研修プラクティス 5

      Pages: 33-8

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長症候群の関連遺伝子をわが国で始めて同定2008

    • Author(s)
      堀江稔
    • Journal Title

      Medical Tribune circulation tuday

      Pages: 87-87

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胸痛症候群の鑑別診断2008

    • Author(s)
      松本鉄也
    • Journal Title

      心臓 40

      Pages: 596-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不整脈の遺伝子診断の歴史と変遷2008

    • Author(s)
      堀江稔
    • Journal Title

      心臓 40

      Pages: 1055-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 不整脈源性右室異形成・心筋症(ARVC/C)2008

    • Author(s)
      堀江稔
    • Journal Title

      循環器 9

      Pages: 194-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ニュースレター第26回日本心電学会学術集会第24回日本不整脈学会学術大会合同学術集会2008

    • Author(s)
      堀江稔
    • Journal Title

      Journal of Arrhythmia 24

      Pages: 1-1

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mutation associated with Jervell and Lange-Nielsen syndrome in a Japanese family2008

    • Author(s)
      Ohno S
    • Journal Title

      Circ J (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overlap Between LQT3 and Brugada Syndrome:Clinical Features in a Common Mutation and Underlying Biophysical Mechanisms2008

    • Author(s)
      Makita N
    • Journal Title

      Journal of Clinical Investigation (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel KCNE3mutations interact with KCNQ1 and cause long QT syndrome2008

    • Author(s)
      Ohno S
    • Journal Title

      Human Mutation (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age- and genotype-specific triggers for life-threatening arrhythmia in the genotyped long-QT syndrome2008

    • Author(s)
      Sakaguchi T
    • Journal Title

      Journal of Cardiovascular Electrophysiology (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation site dependent variability of cardiac events in LQT2 form of congenital long-QT syndrome2008

    • Author(s)
      Nagaoka I
    • Journal Title

      Circulation Journal (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel SCN5Again-of-function mutation M1875T associated with familialatrial fibrillation2008

    • Author(s)
      Makiyama T
    • Journal Title

      Journal of American College of Cardiology (掲載確定)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1(AT) receptor and swelling-activated increase of the slow component of the delayed rectifier K+ current (Iks)in guinea pig atrial cells2007

    • Author(s)
      Zankov D, Horie M, et al
    • Journal Title

      J Physiol Sci 57

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genotype-phenotype correlations of KCNJ2 mutations in Japanese patients with Andersen-Tawil syndrome2007

    • Author(s)
      Haruna Y, Tsuji K, Horie M, et al
    • Journal Title

      Hum Mutat 28(2)

      Pages: 208-208

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome2007

    • Author(s)
      Ohno S, Tauji K, Itoh H, Horie M, et al
    • Journal Title

      Heart Rhythm 4(3)

      Pages: 332-40

    • Related Report
      2009 Final Research Report
  • [Journal Article] Stimulatory action of protein kinase Cvarepsilon isoform on the slow component of delayed rectifier K(+) current in guinea-pig atrial myocytes2007

    • Author(s)
      Toda H, Horie M, et al
    • Journal Title

      Br J Pharmacol 150

      Pages: 1011-1021

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanistic basis for the pathogenesis of long QT syndrome associated with a common splicing mutation in KCNQ1 gene2007

    • Author(s)
      Tsuji K, Horie M, et al
    • Journal Title

      J Mol Cell Cardiol 42(3)

      Pages: 662-669

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome2007

    • Author(s)
      Itoh H, Tsuji K, Horie M, Imoto K.
    • Journal Title

      Int J Cardiol 121(3)

      Pages: 249-252

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Disorders of Cardiac Repolarization-Long QT and Short QT Syndromes-2007

    • Author(s)
      Horie M, Ito H.
    • Journal Title

      Circ J 71

    • NAID

      110006318433

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Common Long QT Syndrome Mutation KCNQ1/A341V Causes Unusually Severe Clinical Manifestations in Patients with Different Ethnic Backgrounds2007

    • Author(s)
      Crotti L, Horie M, et al
    • Journal Title

      Toward a Mutation-specific Risk Stratification. Circulation 116

      Pages: 2366-2375

    • Related Report
      2009 Final Research Report
  • [Journal Article] on of Atrial Arrhythmia and Sinus Node Dysfunction in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia2007

    • Author(s)
      Sumitomo N, Horie M, et al
    • Journal Title

      Circ J 71(10)

      Pages: 1606-1609

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory actions of LY294002,a PI3kinase inhibitor,on the human Kv1.5channel2007

    • Author(s)
      Wu Jie
    • Journal Title

      The Journal of Physiological Scienses 57

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] II type 1(AT) receptor and swelling-activated increase of the slow component of the delayed rectifier K+ current (Iks)in guinea pig atrial cells2007

    • Author(s)
      Zankov D
    • Journal Title

      The Journal of Physiological Scienses 57

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotype-phenotype correlations of KCNJ2mutations in Japanese patients with Andersen-Tawil syndrome2007

    • Author(s)
      Haruna Y
    • Journal Title

      Hum Mutat 28

      Pages: 208-208

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N- and C-terminal KCNE1 mutations cause distinct phenotypes of long Q Tsyndrome2007

    • Author(s)
      Ohno S
    • Journal Title

      Heart Rhythm 4

      Pages: 332-40

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulatory action of protein kinase Cvarepsilon isoform on the slow component of delayed rectifierK(+)current in guinea-pig atrial myocytes2007

    • Author(s)
      Toda H
    • Journal Title

      Br J Pharmacol 150

      Pages: 1011-1021

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanistic basis for the pathogenesis of long QT syndrome associated with a common splicing mutation in KCNQ1 gene2007

    • Author(s)
      Tsuji K
    • Journal Title

      J Mol Cell Cardiol 42

      Pages: 662-669

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A paradoxical effect of lidocaine for the N406S mutation of SCN5A associated with Brugada syndrome2007

    • Author(s)
      Itoh H
    • Journal Title

      Int J Cardiol 121

      Pages: 249-252

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disorders of Cardiac Repolarization-Long QT and Short QT Syndromes2007

    • Author(s)
      Horie M
    • Journal Title

      Circ J 71

      Pages: 50-53

    • NAID

      110006318433

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective mechanism of adenosine to the rat arterial endothelial dysfunction induced by hydrogen peroxide2007

    • Author(s)
      Lu J
    • Journal Title

      Biol Pharm Bull 30

      Pages: 1206-1211

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Common Long QT Syndrome Mutation KCNQ1/A341V Causes Unusually Severe Clinical Manifestations in Patients with Different Ethnic Backgrounds:Toward a Mutation-specific Risk Stratification2007

    • Author(s)
      Crotti L
    • Journal Title

      Circulation 116

      Pages: 2366-2375

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and risk stratification in symptomatic and asymptomatic patients with brugada syndrome2007

    • Author(s)
      Takagi M
    • Journal Title

      Journal of cardiovascular electrophysiology 18

      Pages: 1244-1251

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ablation for AF:Techniques,Results and Risks2007

    • Author(s)
      堀江 稔
    • Journal Title

      AHA Highlights2006

      Pages: 174-179

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brugada症候群と遺伝子病-Brugada症候群とQT延長症候群など他の遺伝子病との関連について-2007

    • Author(s)
      牧山 武
    • Journal Title

      Heart View 11

      Pages: 54-61

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心房筋細胞におけるAT1受容体を介した緩徐活性型遅延整流性K+電流(IKs)のト増大と活動電位の短縮-心房細動治療におけるAT1受容体遮断薬の有効性との関連-2007

    • Author(s)
      松浦 博
    • Journal Title

      心電図 27

      Pages: 145-153

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心臓イオンチャネル遺伝子の転写制御機構エピジェネティ2007

    • Author(s)
      鷹野 誠
    • Journal Title

      心電図 27

      Pages: 15-28

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 家族性心房細動を識る2007

    • Author(s)
      堀江 稔
    • Journal Title

      Heart View 11

      Pages: 84-86

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長症候群(先天性、後天性)2007

    • Author(s)
      坂口 知子
    • Journal Title

      臨床検査 51

      Pages: 764-768

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Jervell and Lange-Nielsen症候群2007

    • Author(s)
      堀江 稔
    • Journal Title

      目本臨床 別冊4

      Pages: 205-208

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Romano-Ward症候群.2007

    • Author(s)
      堀江 稔
    • Journal Title

      日本臨床 別冊4

      Pages: 230-233

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 先天性QT延長症候群2007

    • Author(s)
      堀江 稔
    • Journal Title

      Long QT Syndrome

      Pages: 1-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RASが電気生理学的特性と線維化に与える影響2007

    • Author(s)
      堀江 稔
    • Journal Title

      心房細動

      Pages: 98-105

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] QT延長症候群2007

    • Author(s)
      伊藤 英樹
    • Journal Title

      QT間隔の診かた・考え方

      Pages: 131-132

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心房リモデリングの予防と改善は可能か2007

    • Author(s)
      堀江 稔
    • Journal Title

      日本内科学会雑誌 96

      Pages: 109-111

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤性QT延長症候群2007

    • Author(s)
      堀江 稔
    • Journal Title

      Long QT Syndrome

      Pages: 1-6

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] チャネル病の修飾因子2007

    • Author(s)
      伊藤 英樹
    • Journal Title

      心臓 39

      Pages: 576-579

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A family of hereditary long QT syndrome caused by Q738X HERG mutation

    • Author(s)
      Yasuda S, Tsuji K, Horie M, et al
    • Journal Title

      Int J Cardiol. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel SCN5A mutation associated with the linker between III and IV domains of Na(v)1. 5 in a neonate with fatal long QT syndrome

    • Author(s)
      Yamamura K, Horie M, et al
    • Journal Title

      Int J Cardiol. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A family of hereditary long QT syndrome caused by Q738X HERG mutation

    • Author(s)
      Yasuda S, Hiramatsu S, Odashiro K, Maruyama T, Tsuji K, Horie M.
    • Journal Title

      Int J Cardiol. (in press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] A novel SCN5A mutation associated with the linker between III and IV domains of Na(v)1.5 in a neonate with fatal long QT syndrome

    • Author(s)
      Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahato Y, Shiokawa Y, Yoshikane Y, Makiyama T, Horie M, Hara T.
    • Journal Title

      Int J Cardiol. (in press)

    • Related Report
      2009 Annual Research Report
  • [Presentation] ICD植え込み後にVF onset が明らかとなった心肺蘇生後の一例2009

    • Author(s)
      八尾武憲, 宮本証, 中澤優子, 伊藤英樹, 芦原貴司, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      ICD公開研究会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心房細動を巡る最近の話題2009

    • Author(s)
      堀江稔
    • Organizer
      第2回東西循環器懇話会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多量の心嚢水を認めた好酸球性心筋炎の1例2009

    • Author(s)
      吉井理一郎, 高山幸一郎, 山下寛人, 中澤優子, 伊藤英樹, 高島弘行, 伊藤誠, 堀江稔
    • Organizer
      第189回日本内科学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多量の心嚢水貯留を認めた好酸球性心筋炎の一例2009

    • Author(s)
      吉井理―郎, 伊藤英樹, 高山幸一郎, 山下寛人, 八尾武憲, 谷口晋, 中澤優子, 芦原貴司, 山本孝, 高島弘行, 藤井応理, 中江一郎, 林秀樹, 杉本喜久, 松本鉄也, 蔦本尚慶, 伊藤誠, 堀江稔
    • Organizer
      第67回 滋賀県循環器疾患研究会
    • Place of Presentation
      滋賀
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] ポストゲノム時代の不整脈診療を考える2009

    • Author(s)
      堀江稔
    • Organizer
      第29回福島心疾患治療談話会
    • Place of Presentation
      福島
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺静脈隔離術後の心房細動再発予測におけるエンドセリン1の有用性2009

    • Author(s)
      中澤優子, 芦原貴司, 八尾武憲, 伊藤英樹, 城日加里, 杉本喜久, 蔦本尚慶, 伊藤誠, 堀江稔, 八木崇文
    • Organizer
      第7回滋賀呼吸循環器フォーラム
    • Place of Presentation
      大津
    • Year and Date
      2009-08-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心臓突然死を巡る不整脈診療の話題2009

    • Author(s)
      堀江稔
    • Organizer
      第6回西海不整脈フォーラム
    • Place of Presentation
      長崎
    • Year and Date
      2009-08-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 循環器診療におけるARB治療を考える-Beyond Blood Pressure-2009

    • Author(s)
      堀江稔
    • Organizer
      アバプロ錠1周年記念講演会
    • Place of Presentation
      滋賀
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 劇症型心筋炎の2例~診断のポイント~2009

    • Author(s)
      酒井宏, 寺村真範, 高山智行, 環愼二, 岡林旅人, 川嶋剛史, 山本孝, 高島弘行, 堀江稔
    • Organizer
      第24回滋賀心不全研究会
    • Place of Presentation
      滋賀
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病でみられる不整脈の特徴とその管理2009

    • Author(s)
      堀江稔
    • Organizer
      第52回 日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 下肢機能性血流障害を伴う2型糖尿病患者の冠動脈造影像2009

    • Author(s)
      大村寧, 鈴木英司, 坂口正芳, 貴志明生, 吉村達, 高島弘行, 卯木智, 西尾善彦, 前川聡, 堀江稔, 武田純, 柏木厚典
    • Organizer
      第52回 日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multiple mechanisms underlie long QT syndrome by the change of amino acid R259 in the intracellular S4-S5 linker of KCNQ12009

    • Author(s)
      Ohno S, Tsuji K, Makiyama T, Nishio Y, Akao M, Kita T, Horie M
    • Organizer
      Cardiorhythm2009
    • Place of Presentation
      Hong Kong
    • Related Report
      2009 Final Research Report
  • [Presentation] Overlap syndromes in inherited arrhythmia disorders2009

    • Author(s)
      Horie M
    • Organizer
      ISHNE 2009
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Structure-function relationships of K channels2009

    • Author(s)
      Horie M.
    • Organizer
      2nd Asia pacific heart rhythm society science session(APHRS2009)
    • Place of Presentation
      Beijin, China
    • Related Report
      2009 Final Research Report
  • [Presentation] Mechanistic basis of heart rhythm disorders in ion channel diseases2009

    • Author(s)
      Hoire M
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Event ECG recording is useful tool for atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI)2009

    • Author(s)
      Ito M, Nakazawa Y, Yao T, Ashihara T, Joh H, Itoh H, Sugimoto Y, Horie M
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Latent genetic backgrounds and molecular pathogenesis of drug-induced long QT syndrome2009

    • Author(s)
      Itoh H, Watanabe E, Watanabe I, Sakaguchi T, Makiyama T, Akao M, Oono S, Zenda N, Higashi Y, Mori C, Okajima K, Matsuura H, Horie M
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Severer phenotypes of long QT syndrome are associated with compound mutations: A multicenter study2009

    • Author(s)
      Itoh H, Shimizu W, Yamagata K, Sakaguchi T, Oono S, Makiyama T, Akao M, Noda T, Miyamoto Y, Kamakura S, Horie M
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] Structure-function relationships of K channels. 2nd Asia pacific heart rhythm society science session2009

    • Author(s)
      堀江稔
    • Organizer
      APHRS2009
    • Place of Presentation
      Beijin, China
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical Phenotype and Prognosis of Probands With Brugada Syndrome in Relation to SCN5A Mutation. -Japanese Brugada Syndrome Multicenter Registry2009

    • Author(s)
      Yamagata K, Horie M, Ogawa S, Aizawa Y, Kusano K F, Ohe T, Yamagishi M, Makita N, Tanaka T, Makiyama T, Akao M, Hagiwara N, Kishi Y, Yamada Y, Okamura H, Noda T, Satomi K, Suyama K, Aihara N, Miyamoto Y, Kamakura S, Shimizu W
    • Organizer
      AHA Scientific Sessions 2009
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel KCNE5 Mutations Are Associated With Brugada Syndrome and Idiopathic Ventricular Fibrillation2009

    • Author(s)
      Ohno S, Zankov DP, Ding W-G, Makiyama T, Hattori T, Doi T, Shizuta S, Kimura T, Matsuura H, Horie M
    • Organizer
      AHA Scientific Sessions 2009
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] Association of Early Repolarization With Arrhythmic Events in Short QT Syndrome2009

    • Author(s)
      Watanabe H, Makiyama T, Prince J K, Seto S, Okamura S, Oda H, Ito H, Horie M, Aizawa Y, Shimizu W
    • Organizer
      AHA Scientific Sessions 2009
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] A Novel Gain-of-function KCNJ2 Mutation Associated With Short QT Syndrome Impairs Inward Rectification of Kir 2.1 Currents2009

    • Author(s)
      Hattori T, Makiyama T, Akao M, Ehara E, Ohno S, Nishio Y, Itoh H, Yokode M, Kimura T, Horie M
    • Organizer
      AHA Scientific Sessions 2009
    • Place of Presentation
      Orlando, Florida, U.S.A.
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺静脈隔離術後の心房細動再発検出における携帯型心電計の有用性2009

    • Author(s)
      中澤優子, 芦原貴司, 八尾武憲, 城日加里, 伊藤英樹, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      第29回日本ホルター・ノンインベイシブ心電学研究会 (JASHNE 2009)
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 早期再分極の解析2009

    • Author(s)
      林秀樹, 石田勝也, 宮本証, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多種類の上室頻拍を合併した心臓手術後の一例2009

    • Author(s)
      城日加里, 八尾武憲, 山科聡, 中澤優子, 伊藤英樹, 芦原貴司, 杉本喜久, 伊藤誠, 堀江稔, 八木崇文
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 先天性QT延長症候群の遺伝子診断-複数変異例の検討-2009

    • Author(s)
      伊藤英樹, 清水渉, 林研至, 山形研一郎, 坂口知子, 大野聖子, 牧山武, 赤尾昌治, 藍智彦, 野田崇, 宮崎彩, 宮本恵宏, 山岸正和, 鎌倉史郎, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] At-Home AED : ICD植込みが困難な患者に対する代替法としてのAED利用について2009

    • Author(s)
      八尾武憲, 城日加里, 中澤優子, 伊藤英樹, 芦原貴司, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] V1誘導は Brugada 症候群の risk stratification となるか?: spontaneous coved-type ST-segment elevation を呈した症例の検討2009

    • Author(s)
      宮本証, 林秀樹, 石田勝也, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 家族性進行性心臓伝導障害に同定された connexin 40遺伝子GJA5異変の機能異常2009

    • Author(s)
      蒔田直昌, 住友直方, 関明子, 萩原誠久, 渡部裕, 福原茂明, 望月直樹, 牧山武, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] SCN5A遺伝子異常を伴った洞不全症候群合併 Brugada 症候群の一例2009

    • Author(s)
      早野譲, 静田聡, 牧山武, 中尾哲史, 根津知行, 山口孝之, 塚本学, 土井孝治, 西山慶, 赤尾昌治, 木村剛, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 家族性ペースメーカー植込み症例における遺伝的背景の検討-心臓NA+チャネル病、lamin A/C関連心筋症-2009

    • Author(s)
      牧山武, 横出正之, 赤尾昌治, 静田聡, 土井孝浩, 池田智之, 大野聖子, 服部哲久, 西尾由貴子, 木村剛, 北徹, 宮本証, 伊藤英樹, 堀江稔
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Overlap between LQT3 and syndrome : Clinical features in a common mutation and underlying biophysical mechanisms2009

    • Author(s)
      Makita N, Shimizu W, Miyamoto K, Kamakura S, Horie M, Itoh H, Crotti L, Schwartz PJ, George AL Jr, Roden DM
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] Brugada 症候群におけるSCN5A遺伝子変異と臨床像-他施設登録による検討-2009

    • Author(s)
      山形研―郎, 堀江稔, 赤尾昌治, 大江透, 草野研吾, 相澤義房, 山岸正和, 蒔田直日, 小川聡, 田中敏博, 萩原誠久, 岸良示, 宮本恵宏, 鎌倉史郎, 清水渉
    • Organizer
      第24回日本不整脈学会学術大会 第26回日本心電学会学術集会合同学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] 冠動脈洞開口以上を合併した防湿回帰性頻拍にカテーテル・アブレーションを施行し根治しえた1例2009

    • Author(s)
      伊藤英樹, 八尾武憲, 宮本証, 中澤優子, 城日加里, 水澤有香, 芦原貴司, 八木崇文, 横田良司, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      第21回 カテーテル・アブレーション委員会公開研究会
    • Place of Presentation
      埼玉
    • Related Report
      2009 Annual Research Report
  • [Presentation] Early Repolarization に関連した特発性心室細動の検討2009

    • Author(s)
      八尾武憲, 宮本証, 中津優子, 伊藤英樹, 芦原貴司, 杉本喜久, 伊藤誠, 堀江稔
    • Organizer
      第25回心電情報処理ワークショップ
    • Place of Presentation
      有馬
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multiple Mechanisms underlie Long QT Syndrome by the Change of Amino Acid R259 in the intracellular S4-S5 Linker of KCNQl2009

    • Author(s)
      Ohno S
    • Organizer
      Cardiorhythm2009
    • Place of Presentation
      Hong Kong
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mechanistic basis of heart rhythm disorders in ion channel diseases.2009

    • Author(s)
      Hoire M
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動中の心臓性突然死 : 成人の不整脈2009

    • Author(s)
      堀江稔
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Event ECG recording is useful tool for atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI).2009

    • Author(s)
      Ito M
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Latent genetic backgrounds and molecular pathogenesis of drug-inducedlong QT syndrome.2009

    • Author(s)
      Itoh H
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Severer phenotypes of long QT syndrome are associated with compound mutations : A multicenter study.2009

    • Author(s)
      Itoh H
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Relation between P terminal force and the development of atrial fibrillation : Outcome derived from long-term follow-up.2009

    • Author(s)
      Ishida K
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Comparison of serum levels of cardiac tropnin I and T in patients with chronic heart failure2009

    • Author(s)
      Kawahara C
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] SCN5A and lamin A/C gene mutations are highly prevalent in patients with familial bradyarrhythmic disorders.2009

    • Author(s)
      Makiyama T
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Multiple mechanisms underlie long QT syndrome by the change of amino acid R259 in the intracellular S4-S5 linker of KCNQ12009

    • Author(s)
      Ohno S
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] A novel genetic marker for potential risk of QT prolongation and cardiac sudden death - KCNE1-D85N polymorphism.2009

    • Author(s)
      Nishio Y
    • Organizer
      第73回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identification and functional characterization of a novel intronic splicing mutation in KCNQl associated with long QT syndrome2009

    • Author(s)
      Tsuji K
    • Organizer
      第7 3回日本循環器学会総会・学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] Plakophili-2 mutations are common in Japanese arrhythmogenic right ventricular dvsplasia/cardiomyopathy2008

    • Author(s)
      Horie M
    • Organizer
      2008 Tokyo-Taipei-Seoul Arrhythmia Joint Conference
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2008-10-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 3回目のアプレーションにより根治し得たWPW症候群の一例2008

    • Author(s)
      城日加里
    • Organizer
      第18回 京滋奈良ハートリズム研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 不整脈診療の最新動向2008

    • Author(s)
      堀江稔
    • Organizer
      第38回 日本内科学会近畿支部生涯教育講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2008-06-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 最近の不整脈診療を巡るトピックス2008

    • Author(s)
      堀江稔
    • Organizer
      第43回 東海支部主催生涯教育講演会
    • Place of Presentation
      静岡
    • Year and Date
      2008-06-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] A KCNEl polymorphism, D85N, is a disease-causing gene variant in congenital long QT syndrome2008

    • Author(s)
      Horie M
    • Organizer
      ESC Congress 2008
    • Place of Presentation
      Munchen, Germany
    • Related Report
      2008 Annual Research Report
  • [Presentation] LQT3とBrugada症候群のオーバーラップを規定する要因に関する多施設国際共同研究2008

    • Author(s)
      蒔田直昌
    • Organizer
      第23回 日本不整脈学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 薬剤誘発性QT延長症例の原因薬剤と遺伝子異常同定率2008

    • Author(s)
      伊藤英樹
    • Organizer
      第23回 日本不整脈学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 催不整脈右室心筋症(ARVC/C)の病態と治療に関する研究2008

    • Author(s)
      梶本克也
    • Organizer
      第23回 日本不整脈学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 心房細動に対する肺静脈隔離術の前後における自覚症状の変化 -携帯型心電計による検討-2008

    • Author(s)
      中澤優子
    • Organizer
      第23回 日本不整脈学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 房室ブロックによる後天性QT延長症候群の遺伝学的背景とその臨床像2008

    • Author(s)
      岡優子
    • Organizer
      第23回 日本不整脈学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 3型先天性QT延長症候群における遺伝子変異部位別の臨床的特徴-日本国内多施設登録による検討-2008

    • Author(s)
      山形研一郎
    • Organizer
      第23回 日本不整脈学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] 右室中隔ペーシングによるR波高の変化 -ICDとペースメーカーとの比較2008

    • Author(s)
      八尾武憲
    • Organizer
      第23回 日本不整脈学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] SCN5Aの遺伝子異常(R179X)を有した下壁誘導ST上昇型Brugada症候群の1例2008

    • Author(s)
      川村美朋子
    • Organizer
      第23回 日本不整脈学会学術大会
    • Place of Presentation
      神奈川
    • Related Report
      2008 Annual Research Report
  • [Presentation] SCN5Aのgain-of-functionによる家族性心房細動の発症メカニズム : コンピュータシミュレーションによる検討2008

    • Author(s)
      芦原貴司
    • Organizer
      第25回 日本心電学会学術集会
    • Place of Presentation
      新潟
    • Related Report
      2008 Annual Research Report
  • [Presentation] 心房細動に対する肺静脈隔離術前後における自覚症状と心電図の変化 : 携帯型心電計による検討.2008

    • Author(s)
      中澤優子
    • Organizer
      第25回 日本心電学会学術集会
    • Place of Presentation
      新潟
    • Related Report
      2008 Annual Research Report
  • [Presentation] Brugada症候群、Brugada様心電図患者におけるSCN5A遺伝子解析2008

    • Author(s)
      牧山武
    • Organizer
      第25回 日本心電学会学術集会
    • Place of Presentation
      新潟
    • Related Report
      2008 Annual Research Report
  • [Presentation] 徐脈に伴うトルサードポアンツに対するデバイス治療2008

    • Author(s)
      奥田健太郎
    • Organizer
      第25回 日本心電学会学術集会
    • Place of Presentation
      新潟
    • Related Report
      2008 Annual Research Report
  • [Presentation] 致死的不整脈と心房細動に対する低用量アミオダロンの有用性と安全性について2008

    • Author(s)
      城日加里
    • Organizer
      第25回 日本心電学会学術集会
    • Place of Presentation
      新潟
    • Related Report
      2008 Annual Research Report
  • [Presentation] 濃厚な心突然死の家族歴を持つ徐脈性心房細動でlamin A/C gene異常を認めEPSでVfが誘発されICDを植え込んだ1例2008

    • Author(s)
      若月大輔
    • Organizer
      第25回 日本心電学会学術集会
    • Place of Presentation
      新潟
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mutant KCNE3 Reduces Repolarizing Potassium Current And Causes Long QT Syndrome2008

    • Author(s)
      Ohno S
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Molecular Pathogenesis of Genotyped Drug-lnduced Long QT Syndrome2008

    • Author(s)
      Itoh H
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Overlap Between LQT3 and Brugada Syndrome:Clinical Features in a Common Mutation and Underlying Biophysical Mechanisms2008

    • Author(s)
      Makita N
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Brugada Syndrome and Diverse Phenotypes of Cardiac Sodium Channelopathies2008

    • Author(s)
      Makiyama T
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] TA novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation2008

    • Author(s)
      Makiyama
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Familial Dilated Cardiomyopathy with Conduction Disease Caused by Lamin A/C Mutations:Efficacy of the Cardiac Resynchronization Therapy with a Defibrillator2008

    • Author(s)
      Makiyama
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cardiac sodium channel gene mutations are prevalent in Japanese patienis with familial sick sinus syndrome2008

    • Author(s)
      Makiyama T
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] A Common KCNEl Polymorphism,D85N,is a Genetic Modifier of Long QT Syndrome2008

    • Author(s)
      Nishio Y
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mutation Analysis of the Glycerol-3 Phosphate Dehydrogenase-1 Like (GPDIL) Gene in Japanese Patients with Brugada Syndrome2008

    • Author(s)
      Makiyama T
    • Organizer
      第72回目本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Different Response to Exercise Testing between LQT7 Form of Congenital Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia2008

    • Author(s)
      Yamada Y
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] Impact of Frameshift Mutation and Nonsense-mediated mRNA Decay on Clinical Phenotype in LQT2 Form of Congenital Long QT Syndrome2008

    • Author(s)
      Noda T
    • Organizer
      第72回日本循環器学会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心房細動の診断と治療を巡る最近の話題2007

    • Author(s)
      堀江 稔
    • Organizer
      The 2nd meet the Expert in Toyohashi
    • Place of Presentation
      愛知
    • Year and Date
      2007-12-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心室細動後の心肺蘇生に成功し、遺伝子診断により確定した先天性QT延長症候群(LQT1)の1例2007

    • Author(s)
      松本 真
    • Organizer
      第20回心臓性急死研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-12-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] 薬剤性QT延長症候群の遺伝的背景2007

    • Author(s)
      堀江 稔
    • Organizer
      第28回日本臨床薬理学会年会
    • Place of Presentation
      栃木
    • Year and Date
      2007-11-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 遺伝子変異が固定された不整脈源性右室心筋症(ARVC)の1剖検例2007

    • Author(s)
      長岡 伊織
    • Organizer
      第64回滋賀県循環器疾患研究会
    • Place of Presentation
      滋賀
    • Year and Date
      2007-11-10
    • Related Report
      2007 Annual Research Report
  • [Presentation] Angiotensin II Type l Receptor Partially Mediates Stretch-lnduced Potentiation of the Slow Component of Delayed Rectifier Potassium Current in Guinea Pig Atrium2007

    • Author(s)
      Zankov DP
    • Organizer
      The American Heart Association Scientific Sessions 2007
    • Place of Presentation
      U.S.A
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Age-Related Triggers for Life-Threatning Arrhythmia in the Genotyped Long QT Syndrome2007

    • Author(s)
      Sakaguchi T
    • Organizer
      The American Heart Association Scientific Sessions 2007
    • Place of Presentation
      U.S.A
    • Year and Date
      2007-11-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] Clinical Features in a Common Mutation and Underlying Biophysical Mechanisms2007

    • Author(s)
      Makita N, Behr E, Shimizu W, Horie M, Crotti L, Itoh H, Miyamoto K, Kamakura S, Tsutsui H, Schwartz PJ, George AL Jr, Roden DM.Overlap Between LQT3, Brugada Syndrome:
    • Organizer
      The American Heart Association Scientific Sessions 2007
    • Place of Presentation
      U.S. A
    • Year and Date
      2007-11-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Familial Dilated Cardiomyopathy with Conduction Disease Caused by a Lamin A/C Mutation: Efficacy of the Cardiac Resynchronization Therapy with a Defibrillator2007

    • Author(s)
      Makiyama T, Akao M, Shizuta S, Doi T, Ohno S, Nishio Y, Kimura T, Horie M.
    • Organizer
      The American Heart Association Scientific Sessions 2007
    • Place of Presentation
      U.S. A
    • Year and Date
      2007-11-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Overlap Between LQT3 and Brugada Syndrome:Clinical Features in a Common Mutation and Underlying Biophysical Mechanisms2007

    • Author(s)
      Makita N
    • Organizer
      The America nHeart Association Scientific Sessions 2007
    • Place of Presentation
      U.S.A
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] Familial Dilated Cardiomyopathy with Conduction Disease Caused by a Lamin A/C Mutation:Efficacy of the Cardiac Resynchronization Therapy with a Defibrillator2007

    • Author(s)
      Makiyama T
    • Organizer
      The American Heart Association Scientific Sessions 2007
    • Place of Presentation
      U.S.A
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] The same genetics for Brugada syndrome and AF2007

    • Author(s)
      Horie M
    • Organizer
      The 3rd Asia-Pacific Atrial Fibrillation Symposiu
    • Place of Presentation
      TAIWAN
    • Year and Date
      2007-10-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 先天性2型QT延長症候群の不整脈発症リスク評価:遺伝子検索から臨床へ2007

    • Author(s)
      長岡 伊織
    • Organizer
      第12回京滋不整脈研究会
    • Place of Presentation
      京都
    • Year and Date
      2007-10-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] QT延長症候群の遺伝的背景〜先天性と後天性の比較検討2007

    • Author(s)
      伊藤 英樹
    • Organizer
      第27回近畿循環器疾患治療研究会
    • Place of Presentation
      大阪
    • Year and Date
      2007-08-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] QT延長症候群の診断と治療-最近の知見を中心に2007

    • Author(s)
      堀 江稔
    • Organizer
      第27回日本ホルター・ノンインベイシブ心電学研究会
    • Place of Presentation
      大分
    • Year and Date
      2007-07-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Cardiac arrhythmias and ion channel diseases2007

    • Author(s)
      Horie M
    • Organizer
      East Asia International Cardiovascular Symposium
    • Place of Presentation
      Harbin, China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Bradycardia before beta-blocker therapy as an arrhythmic risk in LQT2 form of congenital long-QT syndrome2007

    • Author(s)
      Nagaoka I
    • Organizer
      ESC Congress 2007
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2007 Annual Research Report
  • [Presentation] Diagnostic criteria for the long QT syndrome2007

    • Author(s)
      Horie M
    • Organizer
      World Congress on Cardiac Pacing and Electrophysiology
    • Place of Presentation
      Rome, Italy
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心房リモデリングの予防と改善は可能か2007

    • Author(s)
      堀江 稔
    • Organizer
      第104回日本内科学会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Presentation] KCNQ1遺伝子上の高頻度スプライス変異によるQT延長症候群発症のメカニズム2007

    • Author(s)
      辻 啓子
    • Organizer
      第9回日本RNA学会
    • Place of Presentation
      名古屋
    • Related Report
      2007 Annual Research Report
  • [Presentation] Brugada症候群とLQT3のオーバーラップ:SCN5A変異の臨床的特徴と分子メカニズム2007

    • Author(s)
      蒔田 直昌
    • Organizer
      第55回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心筋Naチャネルの遺伝子異常と薬剤誘発性不整脈2007

    • Author(s)
      蒔田 直昌
    • Organizer
      第24回日本心電学会学術集会
    • Place of Presentation
      愛知
    • Related Report
      2007 Annual Research Report
  • [Presentation] 家族性洞不全症候群の1家系に認めた心臓Naチャネル(SCN5A)遺伝子異常の電気生理学的機能解析2007

    • Author(s)
      牧山 武
    • Organizer
      第24回日本心電学会学術集会
    • Place of Presentation
      愛知
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低浸透圧刺激による心筋緩徐活性型遅延整流性K+電流(IKs)の増大におけるAT1受容体の関与にっいて2007

    • Author(s)
      Dimitar P Zankov
    • Organizer
      第24回日本心電学会学術集会
    • Place of Presentation
      愛知
    • Related Report
      2007 Annual Research Report
  • [Presentation] P2Y-受容体アイソフォームによる心筋GIRK1/GIRK4チャネルの調節2007

    • Author(s)
      丁 維光
    • Organizer
      第24回日本心電学会学術集会
    • Place of Presentation
      愛知
    • Related Report
      2007 Annual Research Report
  • [Book] 心房細動今日の治療方針私はこう治療している2010年度版2010

    • Author(s)
      堀江稔
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] Annual Review循環器2010:ARB/ACE-Iによる心房細動抑止効果2010

    • Author(s)
      堀江稔
    • Publisher
      中外医学社
    • Related Report
      2009 Final Research Report
  • [Book] 脚ブロック循環器疾患最新の治療2010-20112010

    • Author(s)
      堀江稔
    • Publisher
      南江堂
    • Related Report
      2009 Final Research Report
  • [Book] QT延長症候群循環器疾患のサイエンス2010

    • Author(s)
      堀江稔
    • Publisher
      南山堂
    • Related Report
      2009 Final Research Report
  • [Book] 今日の治療方針私はこう治療している2010年度版:心房細動2010

    • Author(s)
      堀江稔
    • Publisher
      医学書院
    • Related Report
      2009 Final Research Report
  • [Book] 重篤副作用疾患別対応マニュアル:心室頻拍2009

    • Author(s)
      堀江稔
    • Publisher
      厚生労働省
    • Related Report
      2009 Final Research Report
  • [Book] 心房リモデリング. 最新医学別冊新しい診断と治療のABC15循環器2心房細動(改訂第2版)2009

    • Author(s)
      堀江稔
    • Publisher
      最新医学社
    • Related Report
      2009 Final Research Report
  • [Book] 不整脈治療薬の催不整脈作用.循環器病疾患最新の治療2008

    • Author(s)
      堀江稔
    • Publisher
      南江堂
    • Related Report
      2009 Final Research Report
  • [Book] 不整脈予防におけるARB,ACE阻害薬とアルドステロン拮抗薬2008

    • Author(s)
      堀江稔,奥村謙,小野克重,平岡昌和
    • Publisher
      株式会社ライフメディコム
    • Related Report
      2009 Final Research Report
  • [Book] 不整脈とイオン・チャネル病.循環器内科治療ガイドライン-最新の診療指針-2008

    • Author(s)
      堀江稔
    • Publisher
      総合医学社
    • Related Report
      2009 Final Research Report
  • [Book] 循環器病疾患最新の治療2008

    • Author(s)
      堀江稔
    • Publisher
      南江堂
    • Related Report
      2008 Annual Research Report
  • [Book] 不整脈予防におけるARB, ACE阻害薬とアルドステロン拮抗薬2008

    • Author(s)
      堀江稔
    • Publisher
      株式会社ライフメディコム(編集)
    • Related Report
      2008 Annual Research Report
  • [Book] 循環器内科治療ガイドライン-最新の診療指針-2008

    • Author(s)
      堀江稔
    • Publisher
      総合医学社
    • Related Report
      2008 Annual Research Report
  • [Book] 致死性不整脈の遺伝子診断.Annual Review循環器20072007

    • Author(s)
      伊藤英樹,堀江稔
    • Publisher
      中外医学社
    • Related Report
      2009 Final Research Report
  • [Book] Annual Review循環器2007

    • Author(s)
      伊藤 英樹
    • Publisher
      中外医学社
    • Related Report
      2007 Annual Research Report
  • [Book] 新心臓病診療プラクチイス2007

    • Author(s)
      蔦本 尚慶
    • Publisher
      文光堂
    • Related Report
      2007 Annual Research Report
  • [Book] 循環器症候群 (II)-その他の循環器疾患を含めて-2007

    • Author(s)
      松本 鉄也
    • Publisher
      日本臨牀
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/~hqmed1/shiga_image/top.html

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/~hqmedl/shiga_image/top.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/~hqmedl/shiga_image/top.html

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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