Development of Single Nucleotide Polymorphism Based Tailor Made Therapy in Patients with Acute Myocardial Infarction
Project/Area Number |
19390215
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Osaka University |
Principal Investigator |
SATO Hiroshi (2008) Osaka University, 医学系研究科, 講師 (10294092)
堀 正二 (2007) Osaka University, 医学系研究科, 教授 (20124779)
|
Co-Investigator(Kenkyū-buntansha) |
SAKATA Yasuhiko 大阪大学, 医学系・研究科, 助教 (90379206)
佐藤 洋 大阪大学, 医学系研究科, 講師 (10294092)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2007: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
|
Keywords | 心筋梗塞 / 遺伝子多型 / 疫学調査 |
Research Abstract |
遺伝子解析の承諾を得た2441例において既知の心筋梗塞関連73遺伝子89単塩基多型の解析を行った。レニン・アンジオテンシン系阻害薬、β遮断薬、HMG-CoA還元酵素阻害薬(スタチン)処方・非処方例における心血管事故発生率と遺伝子多型との関連を検討した結果、これら心筋梗塞二次予防薬の予後改善効果に影響を及ぼす遺伝子多型の存在が示唆され、遺伝子多型に基づいた個別医療の可能性が示された。
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] SNPs in BRAP associated with risk of myocardial infarction in Asian populations2009
Author(s)
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T.
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Journal Title
Nat Genet 41(3)(Epub)
Pages: 329-33
Related Report
Peer Reviewed
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[Journal Article] Lipid profile, plasma apolipoproteins, and risk of a first myocardial infarction among Asians : an analysis from the INTERHEART Study2009
Author(s)
Karthikeyan G, Teo KK, Islam S, McQueen MJ, Pais P, Wang X, Sato H, Lang CC, Sitthi-Amorn C, Pandey MR, Kazmi K, Sanderson JE, Yusuf S.
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Journal Title
J Am Coll Cardiol 53(3)
Pages: 244-53
Related Report
Peer Reviewed
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[Journal Article] Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era2009
Author(s)
Nakatani D, Sakata Y, Mizuno H, Shimizu M, Suna S, Usami M, Ito H, Yasumura Y, Hirayama A, Takeda H, Hori M, Sato H
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Journal Title
the Osaka Acute Coronary Insufficiency Study (OACIS) Group. Circ J. 73(4)(Epub)
Pages: 662-666
NAID
Related Report
Peer Reviewed
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[Journal Article] Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling2009
Author(s)
Suna S, Sakata Y, Shimizu M, Nakatani D, Usami M, Matsumoto S, Mizuno H, Ozaki K, Takashima S, Takeda H, Tanaka T, Hori M, Sato H.
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Journal Title
Biochem Biophys Res Commun 379(2)(Epub)
Pages: 374-8
Related Report
Peer Reviewed
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[Journal Article] Effect of early use of low-dose pravastatin on major adverse cardiac events in patients with acute myocardial infarction : the OACIS-LIPID Study2008
Author(s)
Study. Sato H, Kinjo K, Ito H, Hirayama A, Nanto S, Fukunami M, Nishino M, Lim YJ, Kijima Y, Koretsune Y, Nakatani D, Mizuno H, Shimizu M, Hori M
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Journal Title
M ; Osaka Acute Coronary Insufficiency Study (OACIS)-LIPID Study Investigators. Circ J. 72(1)
Pages: 17-22
NAID
Related Report
Peer Reviewed
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[Journal Article] Effect of intracoronary thrombectomy on 30-day mortality in patients with acute myocardial infarction2007
Author(s)
Nakatani D, Sato H, Sakata Y, Mizuno H, Shimizu M, Suna S, Nanto S, Hirayama A, Ito H, Fujii K, Hori M.
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Journal Title
Am J Cardiol 100(8)(Epub)
Pages: 1212-7
Related Report
Peer Reviewed
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[Journal Article] A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction2007
Author(s)
Ebana Y, Ozaki K, Inoue K, Sato H, Iida A, Lwin H, Saito S, Mizuno H, Takahashi A, Nakamura T, Miyamoto Y, Ikegawa S, Odashiro K, Nobuyoshi M, Kamatani N, Hori M, Isobe M, Nakamura Y, Tanaka T.
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Journal Title
J Hum Genet 52(3)(Epub)
Pages: 220-9
NAID
Related Report
Peer Reviewed
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