Development of Single Nucleotide Polymorphism Based Tailor Made Therapy in Patients with Acute Myocardial Infarction

• Project/Area Number: 19390215
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: SATO Hiroshi (2008) Osaka University, 医学系研究科, 講師 (10294092); 堀 正二 (2007) Osaka University, 医学系研究科, 教授 (20124779)
• Co-Investigator(Kenkyū-buntansha): SAKATA Yasuhiko 大阪大学, 医学系・研究科, 助教 (90379206) ; 佐藤 洋 大阪大学, 医学系研究科, 講師 (10294092)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2008: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2007: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
• Keywords: 心筋梗塞 / 遺伝子多型 / 疫学調査

Research Abstract

遺伝子解析の承諾を得た2441例において既知の心筋梗塞関連73遺伝子89単塩基多型の解析を行った。レニン・アンジオテンシン系阻害薬、β遮断薬、HMG-CoA還元酵素阻害薬(スタチン)処方・非処方例における心血管事故発生率と遺伝子多型との関連を検討した結果、これら心筋梗塞二次予防薬の予後改善効果に影響を及ぼす遺伝子多型の存在が示唆され、遺伝子多型に基づいた個別医療の可能性が示された。

Research Products

• [Journal Article] SNPs in BRAP associated with risk of myocardial infarction in Asian populations (2009)
  • Author(s): Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T.
  • Journal Title: Nat Genet 41(3)(Epub) Pages: 329-33
  • Peer Reviewed
• [Journal Article] Lipid profile, plasma apolipoproteins, and risk of a first myocardial infarction among Asians : an analysis from the INTERHEART Study (2009)
  • Author(s): Karthikeyan G, Teo KK, Islam S, McQueen MJ, Pais P, Wang X, Sato H, Lang CC, Sitthi-Amorn C, Pandey MR, Kazmi K, Sanderson JE, Yusuf S.
  • Journal Title: J Am Coll Cardiol 53(3) Pages: 244-53
  • Peer Reviewed
• [Journal Article] Impact of Diabetes Mellitus on Rehospitalization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous Coronary Intervention Era (2009)
  • Author(s): Nakatani D, Sakata Y, Mizuno H, Shimizu M, Suna S, Usami M, Ito H, Yasumura Y, Hirayama A, Takeda H, Hori M, Sato H
  • Journal Title: the Osaka Acute Coronary Insufficiency Study (OACIS) Group. Circ J. 73(4)(Epub) Pages: 662-666
  • NAID: 10025929227
  • Peer Reviewed
• [Journal Article] Lymphotoxin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling (2009)
  • Author(s): Suna S, Sakata Y, Shimizu M, Nakatani D, Usami M, Matsumoto S, Mizuno H, Ozaki K, Takashima S, Takeda H, Tanaka T, Hori M, Sato H.
  • Journal Title: Biochem Biophys Res Commun 379(2)(Epub) Pages: 374-8
  • Peer Reviewed
• [Journal Article] SNPs in BRAP associated with risk of myocardial infarction in Asian populations. (2009)
  • Author(s): Ozaki K, Sato H, Inoue K, etal.
  • Journal Title: Nature Genetics Feb 8. [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Lipid profile, plasma apolipoproteins, and risk of a first myocardialinfarction among Asians : an analysis from the INTERHEART Study. (2009)
  • Author(s): Karthikeyan G, Teo KK, Sato H, et al.
  • Journal Title: J Am Coll Cardiol 53(3) Pages: 244-253
  • Peer Reviewed
• [Journal Article] Impact of Diabetes Mellitus on Rehospitぱlization for Heart Failure Among Survivors of Acute Myocardial Infarction in the Percutaneous CoronaryIntervention Era. (2009)
  • Author(s): Nakatani D, Sakata Y, … andSato H, the Osaka Acute Coronary Insufficiency Study (OACIS)Group.
  • Journal Title: Circ J Feb 19. [Epub aheadof print]
  • Peer Reviewed
• [Journal Article] Lymphotoχin-alpha3 mediates monocyte-endothelial interaction by TNFR I/NF-kappaB signaling. (2009)
  • Author(s): Suna s, Sakata Y, … and, Sato H.
  • Journal Title: Biochem Biophys Res Commun 379(2) Pages: 374-378
  • Peer Reviewed
• [Journal Article] Up-regulation of cell adhesion molecule genes in human endothelial cells stimulated by lymphotoxin alpha : DNA microarray analysis (2008)
  • Author(s): Suna S, Sakata Y, Sato H, Mizuno H, Nakatani D, Shimizu M, Usami M, Takashima S, Takeda H, Hori M. J
  • Journal Title: Atheroscler Thromb 15(3) Pages: 160-5
  • NAID: 10022608417
  • Peer Reviewed
• [Journal Article] Effect of early use of low-dose pravastatin on major adverse cardiac events in patients with acute myocardial infarction : the OACIS-LIPID Study (2008)
  • Author(s): Study. Sato H, Kinjo K, Ito H, Hirayama A, Nanto S, Fukunami M, Nishino M, Lim YJ, Kijima Y, Koretsune Y, Nakatani D, Mizuno H, Shimizu M, Hori M
  • Journal Title: M ; Osaka Acute Coronary Insufficiency Study (OACIS)-LIPID Study Investigators. Circ J. 72(1) Pages: 17-22
  • NAID: 110006533907
  • Peer Reviewed
• [Journal Article] Effect of Early Use of Low-dose Pravastatin on Major Adverse CardiacEvents in Patients with Acute Myocardial Infarction : The OACIS-LIPIDstudy (2008)
  • Author(s): Sato H, Kinjo K, Ito H, et al
  • Journal Title: Circ J 72 Pages: 17-22
  • Peer Reviewed
• [Journal Article] Up-regulation of Cell Adhesion Molecule Genes in Human EndothelialCells Stimulated by Lymphotoxin alpha : a DNA Microarray Analysis. (2008)
  • Author(s): Suna s, Sakata Y, Sato H, et al.
  • Journal Title: J Atheroscler Thromb 15(3) Pages: 160-165
  • Peer Reviewed
• [Journal Article] Effect of Early Use of Low-dose Pravastatin on Major Adverse Cardiac Events in Patients with Acute Myocardial Infarction: The OACIS-LIPID study (2008)
  • Author(s): Sato H, Kinjo K, Ito H, et. al.
  • Journal Title: Circ J 72 Pages: 17-22
  • NAID: 110006533907
  • Peer Reviewed
• [Journal Article] Up-regulation of Cell Adhesion Molecule Genes in Human Endothelial Cells Stimulated by Lymphotoxin alpha: a DNA Microarray Analysis. (2008)
  • Author(s): Suna S, Sakata Y, Sato H, et. al.
  • Journal Title: J Atheroscler Thromb. (in press)
  • NAID: 10022608417
  • Peer Reviewed
• [Journal Article] Effect on outcome of an increase of serum cardiac troponin T in patients with healing or healed ST-elevation myocardial infarction (2007)
  • Author(s): Shimizu M, Sato H, Sakata Y, Nakatani D, Mizuno H, Suna S, Fujii K, Ueda Y, Nanto S, Hori M
  • Journal Title: Osaka Acute Coronary Insufficiency Study (OACIS) Group. Am J Cardiol 100(12)(Epub) Pages: 1723-6
  • Peer Reviewed
• [Journal Article] Effect of intracoronary thrombectomy on 30-day mortality in patients with acute myocardial infarction (2007)
  • Author(s): Nakatani D, Sato H, Sakata Y, Mizuno H, Shimizu M, Suna S, Nanto S, Hirayama A, Ito H, Fujii K, Hori M.
  • Journal Title: Am J Cardiol 100(8)(Epub) Pages: 1212-7
  • Peer Reviewed
• [Journal Article] Clinical impact of metabolic syndrome and its additive effect with smoking on subsequent cardiac events after acute myocardial infarction (2007)
  • Author(s): Nakatani D, Sakata Y, Sato H, Mizuno H, Shimizu M, Suna S, Ito H, Koretsune Y, Hirayama A, Hori M
  • Journal Title: Osaka Acute Coronary Insufficiency Study (OACIS) Group. Am J Cardiol 99(7)(Epub) Pages: 885-9
  • Peer Reviewed
• [Journal Article] A functional SNP in ITIH3 is associated with susceptibility to myocardial infarction (2007)
  • Author(s): Ebana Y, Ozaki K, Inoue K, Sato H, Iida A, Lwin H, Saito S, Mizuno H, Takahashi A, Nakamura T, Miyamoto Y, Ikegawa S, Odashiro K, Nobuyoshi M, Kamatani N, Hori M, Isobe M, Nakamura Y, Tanaka T.
  • Journal Title: J Hum Genet 52(3)(Epub) Pages: 220-9
  • NAID: 10018554093
  • Peer Reviewed
• [Journal Article] Clinical Impact of Metabolic Syndrome and Its Additive Effect with Smoking on Subsequent Cardiac Events after Acute Myocardial Infarction (2007)
  • Author(s): Nakatani D, Sakata Y, Sato H, et. al.
  • Journal Title: Am J Cardiol 99 Pages: 885-889
  • Peer Reviewed
• [Journal Article] A functional SNP in ITIH3 is associated with susceptibility to Myocardial infarction. (2007)
  • Author(s): Ebana Y, Ozaki 1 K, Inoue K, Sato H, et. al.
  • Journal Title: J Hum Gen 52 Pages: 220-229
  • NAID: 10018554093
  • Peer Reviewed
• [Journal Article] Effect on Outcome of an Increase of Serum Cazdiac Troponin T in Patients with Healing or Healed ST-Elevation Myocardial Infarction. (2007)
  • Author(s): Shimizu M, Sato H, Sakata Y, Nakatani D, et. al.
  • Journal Title: Am J Cardiol 100 Pages: 172-6
  • Peer Reviewed
• [Journal Article] Effect of intracoronary thrombectomy on 30-day mortality in patients with acute myocardial infarction. (2007)
  • Author(s): Nakatani D, Sato H, Sakata Y, et. al.
  • Journal Title: Am J Cardiol. 100 Pages: 1212-7
  • Peer Reviewed
• [Presentation] The Management of Vulunerable Patients After Acute Myocardial Infarction (2009)
  • Author(s): 佐藤洋
  • Organizer: 第73回日本循環器学会学術集会シンポジウム16
  • Place of Presentation: 大阪リーガロイヤルホテル
  • Year and Date: 2009-03-22
• [Presentation] Impact of Single Nucleotide Polymorphisms on Cardiovascular Risk in Ptients with Acute Myocardial Infarction (2009)
  • Author(s): 佐藤洋
  • Organizer: 第73回日本循環器学会学術集会トピック1
  • Place of Presentation: 大阪リーガロイヤルホテル
  • Year and Date: 2009-03-20
• [Presentation] Biomarkers, Single Nucleotide Polymorphisms and Cardiovascular Risk After Acute Myocardial Infarction : Observations from the Osaka Acute Coronary Insufficiency Study (OACIS) (2009)
  • Author(s): 坂田泰彦、佐藤洋
  • Organizer: 第73回日本循環器学会学術集会シンポジウム1
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2009-03-20
• [Presentation] 急性冠症候群の治療法の進歩 (2008)
  • Author(s): 佐藤洋
  • Organizer: 第56回日本心臓病学会学術集会パネルディスカッション
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-09-09
• [Presentation] 急性冠症候群の治療法の進歩 (2008)
  • Author(s): 佐藤洋
  • Organizer: 第56回曰本心臓病学会学術集会パネルディスカッション
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-09-09
• [Presentation] 心筋梗塞後の心不全進展予防におけるβ遮断薬に対する反応性と遺伝子多型 (2008)
  • Author(s): 坂田泰彦、佐藤洋
  • Organizer: 第56回日本心臓病学会学術集会シンポジウム
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 遺伝子多型による心筋梗塞二次予防治療の個別化の試み (2007)
  • Author(s): 佐藤洋
  • Organizer: 日本内科学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2007-04-04
• [Book] 循環器疾患最新の治療 (2008)
  • Author(s): 堀 正二
  • Total Pages: 561
  • Publisher: 南江堂
• [Book]
  • Author(s): 堀正二 : 循環器疾患最新の治療.南江堂2008年総561頁
• [Patent(Industrial Property Rights)] 遺伝子多型による心筋梗塞発症後の心不全発症リスクの診断法 (2009)
  • Inventor(s): 佐藤洋、坂田泰彦
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2009-026315
  • Filing Date: 2009-02-06
• [Patent(Industrial Property Rights)] 遺伝子多型による心筋梗塞発症後の心不全発症リスクの診断法 (2009)
  • Inventor(s): 佐藤洋坂田泰彦
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Number: 2009-026315
  • Filing Date: 2009-02-06