Identification of molecular mechanisms underlying the common pathogenesis of atherosclerosis and obesity
| Project/Area Number |
19390218
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
OIKE Yuichi Kumamoto University, 大学院・医学薬学研究部, 教授 (90312321)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2008: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2007: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | 動脈硬化 / 肥満 / アンジオポエチン様因子 / マクロファージ / 炎症 |
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| Research Abstract |
ANGPTL2濃度は、健常人より糖尿病患者群で血中有意に高いこと、健常人及び糖尿病患者の両群で肥満(BMIもしくは内臓脂肪面積)の程度、炎症(血中CRP濃度)の程度、インスリン抵抗性の程度に比例して上昇することを見出し、ANGPTL2と肥満、動脈硬化性疾患の連関の可能性を見出した。さらにANGPTL2遺伝子改変マウスを用いた研究でAngptl2は、肥満病態でみられる脂肪組織の炎症、それに随伴する耐糖能異常、インスリン抵抗性の誘発因子であり、発現上昇抑制が治療標的になりうることを見出した。
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis2009
Author(s)
Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, & ArakiE.
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Journal Title
Biochem Biophys Res Commun 379
Pages: 806-811
Related Report
Peer Reviewed
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[Journal Article] Hepatic AdiopoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice2008
Author(s)
Tomita K, Oike Y, Teratani T, Taguchi T, Noguchi M, Suzuki T, Mizutani A, Yokoyama H, Irie R, Sumimoto H, Takayanagi A, Miyashita K, Akao M, Tabata M, Tamiya G, Ohkura T, & Hibi T.
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Journal Title
Hepatology 48
Pages: 458-473
Related Report
Peer Reviewed
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[Journal Article] Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model2008
Author(s)
Urano T, Ito Y, Akao M, Sawa T, Miyata K, Tabata M, Morisada T, Hato T, Kadomatsu T, Yano T, Yasunaga K, Shibata R, Murohara T, Akaike T, Tanihara H, Suda T. & Oike Y.
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Journal Title
Arterioscler Thromb Vasc Biol 28
Pages: 827-834
Related Report
Peer Reviewed
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[Journal Article] AngiogenicRole of LYVE-1-positive Macrophagesin Adipose Tissue2007
Author(s)
Cho CH, Jun Koh Y, Han J, Sung HK, Jong Lee H, Morisada T, Schwendener RA, Brekken RA, Kang G, Oike Y, Choi TS, Suda T, Yoo OJ, & Koh, GY.
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Journal Title
Circ Res 100
Pages: 47-57
Related Report
Peer Reviewed
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