| Project/Area Number |
19390222
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
KUBO Hiroshi Tohoku University, 大学院・医学系研究科, 准教授 (20332504)
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| Co-Investigator(Kenkyū-buntansha) |
加藤 英政 東北大学, 先進医工学研究機構, 准教授 (50292123)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Hidemasa 埼玉医科大学, ゲノム医学研究センター, 講師 (50292123)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2007: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 呼吸器病学 / 組織幹細胞 / 分化 / 再生医療 / 細胞治療 / 遺伝子発現 / 培養細胞 / 老化 |
|---|
| Research Abstract |
We established a method to isolate lung endogenous stem cells from human and murine lungs. These stem cells had differential potentials into multi-lineage. At the same time, they had an alveolar epithelial phenotype. In murine elastase-induced lung injury model, administration of lung endogenous stem cells attenuated the injury and improved the survival ratio, suggesting a potential cell therapy to lung diseases. In addition, lung endogenous stem cells, which have a potential to differentiate into alveolar epithelium, have been discovered from adult human lungs for the first time. These cells are useful for a drug discovery.
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