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Decrease of type II pneumocyte function by aging in the process oflung fibrosis : multi-aspect evaluation of STAM1 gene

Research Project

Project/Area Number 19390223
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

NUKIWA Toshihiro  Tohoku University, 大学院・医学系研究科, 教授 (40129036)

Co-Investigator(Kenkyū-buntansha) EBINA Masahito  東北大学, 大学院・医学系研究科, 准教授 (10280885)
田澤 立之  東北大学, 病院, 助教 (70301041)
兼平 雅彦  東北大学, 加齢医学研究所, 研究員 (90374941)
田中 伸幸  東北大学, 宮城県立がんセンター, 部長 (60280872)
Co-Investigator(Renkei-kenkyūsha) TAZAWA Ryushi  新潟大学, 医歯学総合病院, 講師 (70301041)
KANEHIRA Masahiko  東北大学, 加齢医学研究所, 技術補佐 (90374941)
TANAKA Nobuyuki  宮城県県立がんセンター, 部長 (60280872)
HISATA Shu  東北大学, 高等教育開発推進センター, 助教 (60466571)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2008: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2007: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Keywords肺線維症 / 加齢変化 / DNAメチル化 / STAM1遺伝子 / II型肺胞上皮細胞
Research Abstract

肺線維症は高齢者を中心とする、進行性の予後不良な肺疾患である。本研究は本病態形成に関与する遺伝子として、アダプター蛋白として細胞内輸送に関与するSTAM1遺伝子に着目し、総合的に検討した。その結果、末梢血細胞のSTAM1遺伝子mRNAは肺線維症患者で発現低下をみた。しかし、STAM1の上流CpG領域のDNAメチル化を詳細に検討したが、健常者との差はなかった。最近、本病態関連遺伝子としてテロメレース遺伝子が報告された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (31 results)

All 2010 2009 2008 2007

All Journal Article (17 results) (of which Peer Reviewed: 16 results) Presentation (10 results) Book (4 results)

  • [Journal Article] Inhaled Granulocyte/Macrophage-Colony Stimulating Factor as Therapy of Pulmonary Alveolar Proteinosis2010

    • Author(s)
      Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ishii H, Yokoba M, Tanaka N, Yamaguchi E, Eda R, Tsuchihashi Y, Morimoto K, Akira M, Terada M, Otsuka J, Ebina M, Kaneko C, Nukiwa T, Krischer JP, Akazawa K, Nakata K.
    • Journal Title

      Am J Respir Crit Care Med. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation2010

    • Author(s)
      Damayanti T, Kikuchi T, Zaini J, Daito H, Kanehira M, Kohu K, Ishii N, Satake M, Sugamura K, Nukiwa T.
    • Journal Title

      Am J Respir Crit Care Med. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pirfenidone in idiopathic pulmonary fibrosis2010

    • Author(s)
      Taniguchi H, Ebina M, Kondoh Y, Ogura T, Azuma A, Suga M, Taguchi Y, Takahashi H, Nakata K, Sato A, Takeuchi M, Raghu G, Kudoh S, Nukiwa T, Pirfenidone Clinical Study Group in Japan
    • Journal Title

      Eur Respir J. (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of lecithinized superoxide dismutase on bleomycin-induced pulmonary fibrosis2010

    • Author(s)
      Tanaka K, Ishihara T, Azuma A, Kudoh S, Ebina M, Nukiwa T, Sugiyama Y, Tasaka Y, Namba T, Ishihara T, Sato K, Mizushima Y, Mizushima T.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol 298(3)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pirfenidone in idiopathic pulmonary fibrosis2010

    • Author(s)
      Taniguchi H, Ebina M, Kondoh H, et al
    • Journal Title

      Eur Respir J 35

      Pages: 821-829

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic effect of lecitinized superoxide dismutase on bleomycin-induced pulmonary fibrosis2010

    • Author(s)
      Tanaka K, Ishihara T, Azuma A, et al
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol 298

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis2008

    • Author(s)
      Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, Kudoh S, Ogura T, Taniguchi H, Kubo M, Kamatani N, Nakamura Y, Pirfenidone Clinical Study Group
    • Journal Title

      J Med Genet. 45(10)

      Pages: 654-656

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of surfactant protein A by an epidermal growth factor receptor tyrosine kinase inhibitor exacerbates lung inflammation2008

    • Author(s)
      Inoue A, Xin H, Suzuki T, Kanehira M, Kuroki Y, Fukuhara T, Kikuchi T, Maemondo M, Nukiwa T, Saijo Y.
    • Journal Title

      Cancer Sci. 99(8)

      Pages: 1679-1684

    • NAID

      10024010194

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Secretory leukocyte peptidase inhibitor and lung cancer2008

    • Author(s)
      Nukiwa T, Suzuki T, Fukuhara T, Kikuchi T.
    • Journal Title

      Cancer Sci. 99(5)

      Pages: 849-855

    • NAID

      10024005504

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan2008

    • Author(s)
      Inoue Y, Trapnell BC, Tazawa R, Arai T, Takada T, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ichiwata T, Tanaka N, Yamaguchi E, Eda R, Oishi K, Tsuchihashi Y, Kaneko C, Nukiwa T, Sakatani M, Krischer JP, Nakata K, Japanese Center of the Rare Lung Diseases Consortium
    • Journal Title

      Am J Respir Crit Care Med. 177(7)

      Pages: 752-762

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of sarcoidosis in Japan2008

    • Author(s)
      Morimoto T, Azuma A, Abe S, Usuki J, Kudoh S, Sugisaki K, Oritsu M, Nukiwa T.
    • Journal Title

      Eur Respir J. 31(2)

      Pages: 372-379

    • NAID

      130004246704

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genome wide association study identifies an associate on of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis2008

    • Author(s)
      Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, et al
    • Journal Title

      J Med Genet 45

      Pages: 654-656

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      貫和敏博, 他(日本呼吸器学会びまん性肺疾患学術部会他)
    • Journal Title

      気管支肺胞洗浄「BAL(bronchoalveolar lavage)」法の手引き(克誠堂出版)

      Pages: 3-4

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan.2008

    • Author(s)
      Inoue Y., et. al.
    • Journal Title

      Am J Respir Crit Care Med. 177

      Pages: 752-762

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of sarcoidosis in Japan.2008

    • Author(s)
      Morimoto T., et. al.
    • Journal Title

      Eur Respir J. 31

      Pages: 372-379

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis2007

    • Author(s)
      Huqun, Izumi S, Miyazawa H, Ishii K, Uchiyama B, Ishida T, Tanaka S, Tazawa R, Fukuyama S, Tanaka T, Nagai Y, Yokote A, Takahashi H, Fukushima T, Kobayashi K, Chiba H, Nagata M, Sakamoto S, Nakata K, Takebayashi Y, Shimizu Y, Kaneko K, Shimizu M, Kanazawa M, Abe S, Inoue Y, Takenoshita S, Yoshimura K, Kudo K, Tachibana T, Nukiwa T, Hagiwara K.
    • Journal Title

      Am J Respir Crit Care Med. 175(3)

      Pages: 263-268

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis.2007

    • Author(s)
      Huqun, et. al.
    • Journal Title

      Am J Respir Crit Care Med. 175

      Pages: 263-268

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Translational medicine in lung fibrosis2010

    • Author(s)
      Nukiwa T
    • Organizer
      PIPKRA VIII
    • Place of Presentation
      Jakarta
    • Year and Date
      2010-02-14
    • Related Report
      2008 Final Research Report
  • [Presentation] 特発性間質性肺炎2009

    • Author(s)
      貫和敏博
    • Organizer
      第49回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Simultaneous Alterations of Gene Expressions in Different Cell Types of Alveolar Septa Induced by Transforming Growth Factor-beta 1 and Recovered by Cyclosporin A2009

    • Author(s)
      Hirota N, Ohta H, Tamai T, Nukiwa T, Ebina M
    • Organizer
      American Thoracic Society International conference
    • Place of Presentation
      San Diego
    • Year and Date
      2009-05-17
    • Related Report
      2008 Final Research Report
  • [Presentation] 特発性肺線維症2008

    • Author(s)
      貫和敏博
    • Organizer
      第48回日本呼吸器学会学術講演会 Respiratory Year in Review5
    • Place of Presentation
      東京
    • Year and Date
      2008-06-16
    • Related Report
      2008 Final Research Report
  • [Presentation] OX40L-OX40 Interactions contribute to NKT Activation in a Mouse Model of Allergic Airway disease2008

    • Author(s)
      Zaini J, Andarini S, Kikuchi T, Nukiwa T
    • Organizer
      American Thoracic Society International conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] A Phase III, Double-Blind, Placebo-Controlled clinical Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis in Japan2008

    • Author(s)
      Ogura T, Ebina M, Taniguchi H, Azuma A, Suga M, Taguchi Y, Nakata K, Sato A, Nukiwa T, Kudoh S
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Toronto
    • Year and Date
      2008-05-16
    • Related Report
      2008 Final Research Report
  • [Presentation] Idiopathic Pulmonary Fibrosis and Acute Exacerbations Current Concept and Possible Interventions2008

    • Author(s)
      Nukiwa T
    • Organizer
      Bangladesh Lung Foundation Pulmocon 2008
    • Place of Presentation
      Bangladesh
    • Year and Date
      2008-02-17
    • Related Report
      2008 Final Research Report
  • [Presentation] Idiopathic Pulmonary Fibrosis and acute Exacerbations current concept and possible inter ventions2008

    • Author(s)
      Nukiwa T
    • Organizer
      Bangladesh Lung Foundation Pulmocon
    • Place of Presentation
      Dhaka(Bangladesh)
    • Year and Date
      2008-02-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] Accumulation of Activating Mutations in EGF Receptor Kinase among Patients with Lung Adenocarcinoma in Asia: Biological Implication and Clinical Aspects2007

    • Author(s)
      Toshihiro Nukiwa
    • Organizer
      Asian Pacific Society of Respirology
    • Place of Presentation
      Gold Coast Convention, Australia
    • Year and Date
      2007-12-02
    • Related Report
      2007 Annual Research Report
  • [Presentation] Exacerbation in interstitial lung disease : A clear picture?2007

    • Author(s)
      Nukiwa T
    • Organizer
      European Respiratory Society Annual Meeting 2007
    • Place of Presentation
      Stockholm
    • Year and Date
      2007-09-18
    • Related Report
      2008 Final Research Report
  • [Book] 呼吸器疾患最新の治療 2010-2012. (貫和敏博、杉山幸比古、門田淳一編集)2010

    • Author(s)
      貫和敏博, 他
    • Publisher
      南江堂
    • Related Report
      2008 Final Research Report
  • [Book] The role of biomarkers in management of interstitial lung disease : implication of biomarkers derived from type II pneumocytes. Du Bois RM and Richeldi L Edt. The European Respiratory Monograph2009

    • Author(s)
      Nukiwa T
    • Publisher
      European Respiratory Society
    • Related Report
      2008 Final Research Report
  • [Book] 気管支肺胞洗浄法「BAL」の手引き. (日本呼吸器学会びまん性肺疾患学術部会、厚生労働省難治性疾患克服研究事業びまん性肺疾患調査研究班、編集 : 貫和敏博)2008

    • Author(s)
      貫和敏博, 他
    • Publisher
      克誠堂出版
    • Related Report
      2008 Final Research Report
  • [Book] 内科診断学第2版2008

    • Author(s)
      貫和敏博(共著、福井次矢、奈良信雄編集)
    • Publisher
      医学書院
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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