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Comparative studies of a clinical features and genomic analysis in patients with interstitial lung disease and drug induced lung injury

Research Project

Project/Area Number 19390224
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionHiroshima University

Principal Investigator

KOHNO Nobuoki  Hiroshima University, 大学院・医歯薬学総合研究科, 教授 (80215194)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Akihito  高知大学, 医学部, 教授 (30191513)
HATTORI Noboru  広島大学, 大学院・医歯薬学総合研究科, 准教授 (00283169)
ISHIKAWA Nobuhisa  広島大学, 大学院・医歯薬学総合研究科, 助教 (90423368)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2007: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Keywords呼吸器病学 / 間質性肺炎 / バイオマーカー / 薬剤性肺障害 / 人種差 / 医療・福祉 / ゲノム / 糖鎖 / マイクロアレイ
Research Abstract

We elucidate a racial difference of the interstitial lung disease (ILD) by international collaborative investigation with Germany. The serum levels of KL-6 in European healthy volunteers were significantly higher than Japanese. On the other hands, serum levels of KL-6 in European ILD patients were not significantly higher than Japanese. Serum levels of KL-6 in European patients with idiopathic interstitial pneumonia (IIP) were significantly higher than European controls, and were correlated with inversely with some pulmonary function tests and BALF findings. Microarray analysis revealed that gene expression patterns clearly distinguished IIP from chronic hypersensitivity pneumonia.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (70 results)

All 2010 2009 2008 2007 Other

All Journal Article (48 results) (of which Peer Reviewed: 48 results) Presentation (12 results) Book (10 results)

  • [Journal Article] Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis.2010

    • Author(s)
      Senoo T, Hattori N, Tanimoto T, Furonaka M, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Yokoyama A, Kohno N
    • Journal Title

      Thorax 2010 65

      Pages: 334-340

    • NAID

      120002398984

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum KL-6 as a novel disease marker in adolescent and adult cystic fibrosis.2009

    • Author(s)
      Ohshimo S, Bonella F, Grammann N, Starke K, Cui A, Bauer PC, Teschler H, Kohno N, Guzman J, Costabel U
    • Journal Title

      Sarcoidosis Vasc Diffuse Lung Dis 2009 26

      Pages: 47-53

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymphocyte transformation test is not helpful for the diagnosis of methotrexate-induced pneumonitis in patients with rheumatoid arthritis.2009

    • Author(s)
      Hirata S, Hattori N, Kumagai K, Haruta Y, Yokoyama A, Kohno N
    • Journal Title

      Clin Chim Acta 2009 407

      Pages: 25-29

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: role of IL-6.2009

    • Author(s)
      animoto T, Hattori N, Senoo T, Furonaka M, Ishikawa N, Fujitaka K, Haruta Y, Yokoyama A, Igarashi K, Kohno N
    • Journal Title

      Free Radic Biol Med 2009 46

      Pages: 1119-1126

    • NAID

      120001700407

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis.2009

    • Author(s)
      Ohshimo S, Bonella F, Cui A, Beume M, Kohno N, Guzman J, Costabel U
    • Journal Title

      Am J Respir Crit Care Med 2009 179

      Pages: 1043-1047

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-12p40 is essential for the down-regulation of airway hyperresponsiveness in a mouse model of bronchial asthma with prolonged antigen exposure.2009

    • Author(s)
      Onari Y, Yokoyama A, Haruta Y, Nakashima T, Iwamoto H, Hattori N, Kohno N
    • Journal Title

      Clin Exp Allergy 2009 39

      Pages: 290-298

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Airflow limitation in smokers is associated with subclinical atherosclerosis.2009

    • Author(s)
      Iwamoto H, Yokoyama A, Kitahara Y, Ishikawa N, Haruta Y, Yamane K, Hattori N, Hara H, Kohno N
    • Journal Title

      Am J Respir Crit Care Med 2009 179

      Pages: 35-40

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice.2009

    • Author(s)
      Furonaka M, Hattori N, Tanimoto T, Senoo T, Ishikawa N, Fujitaka K, Haruta Y, Yokoyama A, Kohno N
    • Journal Title

      J Pharmacol Exp Ther 2009 328

      Pages: 55-61

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic approaches for studying human parenchymal lung diseases.2009

    • Author(s)
      Kinnula VL, Ishikawa N, Bergmann U, Ohlmeier S
    • Journal Title

      Expert Rev Proteomics 2009 6

      Pages: 619-629

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice2009

    • Author(s)
      Furonaka M, Hattori N, Tanimoto T, et al.
    • Journal Title

      J Pharmacol Exp Ther 328

      Pages: 55-61

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Airflow Limitation in Smokers is Associated with Subclinical Atherosclerosis2009

    • Author(s)
      Iwamoto H, Yokoyama A, Kitahara Y, et al
    • Journal Title

      Am J Respir Crit Care Med 179

      Pages: 35-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis2009

    • Author(s)
      Ohshimo S, Bonella F, Cui A, et al
    • Journal Title

      Am J Respir Crit Care Med 179

      Pages: 1043-1047

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer2009

    • Author(s)
      Takano A, Ishikawa N, Nishino R, et al
    • Journal Title

      Cancer Res 69

      Pages: 6694-6703

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic ablation of Bach1 gene reduces hyperoxic lung injury in mice : role of IL-62009

    • Author(s)
      Tanimoto T, Hattori N, Senoo T, et al
    • Journal Title

      Free Radic Biol Med 179

      Pages: 1119-1126

    • NAID

      120001700407

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays2009

    • Author(s)
      Ueda K, Fukase Y, Katagiri T, et al
    • Journal Title

      Proteomics 9

      Pages: 2182-2192

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic ablation of Bach 1 gene reduces hyperoxic lung injury in mice : role of IL-6 article type2009

    • Author(s)
      Tanimoto T
    • Journal Title

      Free Radical Biology & Medicine 46

      Pages: 1119-1126

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Airflow Limitation in Smokers is Associated with Subclinical Atheros clerosis.2009

    • Author(s)
      Iwamoto H
    • Journal Title

      Am J Respir Crit Care Med 179

      Pages: 35-40

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice.2009

    • Author(s)
      Furonaka M
    • Journal Title

      J Pharmacol Exp Ther 328

      Pages: 55-61

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-12p40 is essential for the down-regulation of airway hyperresponsi veness in a mouse model of bronchial asthma with prolonged antigen exposure.2009

    • Author(s)
      Onari Y
    • Journal Title

      Clin Exp Allergy 39

      Pages: 290-298

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of bronchoalveolar lavage for the diagnosis of idiopathic pulmonary fibrosis.2009

    • Author(s)
      Ohshimo S
    • Journal Title

      Am J Respir Crit Care Med (Epub aheadof print)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease.2008

    • Author(s)
      Kanehara M, Yokoyama A, Tomoda Y, Shiota N, Iwamoto H, Ishikawa N, Taooka Y, Haruta Y, Hattori N, Kohno N
    • Journal Title

      Pulm Pharmacol Ther 2008 21

      Pages: 874-878

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppressor of cytokine signaling 1 inhibits pulmonary inflammation and fibrosis2008

    • Author(s)
      Nakashima T, Yokoyama A, Onari Y, Shoda H, Haruta Y, Hattori N, Naka T, Kohno N
    • Journal Title

      J Allergy Clin Immunol 2008 121

      Pages: 1269-1276

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.2008

    • Author(s)
      Ishikawa N, Hattori N, Yokoyama A, Tanaka S, Nishino R, Yoshioka K, Ohshimo S, Fujitaka K, Ohnishi H, Hamada H, Arihiro K, Kohno N
    • Journal Title

      nt J Cancer 2008 122

      Pages: 2612-2620

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome.2008

    • Author(s)
      Nakashima T, Yokoyama A, Ohnishi H, Hamada H, Ishikawa N, Haruta Y, Hattori N, Tanigawa K, Kohno N
    • Journal Title

      J Intern Med 2008 263

      Pages: 432-439

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of monitoring the circulating Krebs von den Lungen-6(KL-6)levels to predict the clinical outcome of patients with advanced non-small cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI).2008

    • Author(s)
      Ishikawa N
    • Journal Title

      Int J Cancer 122

      Pages: 2612-2620

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating KL-6/MUCl as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome2008

    • Author(s)
      Nakashima T
    • Journal Title

      J Intern Med 263

      Pages: 432-439

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressor of cytokine signaling 1 inhibits pulmonary inflammation and fibrosis2008

    • Author(s)
      Nakashima T
    • Journal Title

      J Allergy Clin Immunol 121

      Pages: 1269-1276

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease.2008

    • Author(s)
      Kanehara M
    • Journal Title

      Pulm Pharmacol Ther 21

      Pages: 874-878

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype.2008

    • Author(s)
      Iwamoto H
    • Journal Title

      Eur Respir J 31

      Pages: 1379-1380

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of pulmonary asbestosis presenting with temporal arteritis involving multiple medium-sized vessels.2008

    • Author(s)
      Hirata S
    • Journal Title

      Mod Rheumatol 18

      Pages: 100-104

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of pulmonary asbestosis presenting with temporal arteritis involving multiple medium-sized vessels2008

    • Author(s)
      Hirata S
    • Journal Title

      Mod Rheumatol 18

      Pages: 100-104

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tiotropium bromide is effective for severe asthma with non-eosinophilic phenotype.2008

    • Author(s)
      Iwamoto H
    • Journal Title

      Eur Respir J (letter)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness monitoring of circulating KL-6 in patients with advanced non-small cell lung cancers treated with gefitinib therapy.2008

    • Author(s)
      Ishikawa N
    • Journal Title

      Int J Cancer 122

      Pages: 2612-2620

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppressor of cytokine signaling1 inhibits pulmonary inflammation and fibrosis2008

    • Author(s)
      Nakashima T
    • Journal Title

      J Allergy Clin Immun (Epub ahead of print)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating KL-6/MUC1 as an independent predictor for disseminated intravascular coagulation in acute respiratory distress syndrome.2008

    • Author(s)
      Nakashima T
    • Journal Title

      J Intern Med 263

      Pages: 432-439

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DEC1 modulates circadian phase of clock gene expression2008

    • Author(s)
      Nakashima A
    • Journal Title

      Mol Cell Biol (Epub ahead of print)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia.2007

    • Author(s)
      Ohtsuki Y, Fujita J, Hachisuka Y, Uomoto M, Okada Y, Yoshinouchi T, Lee GH, Furihata M, Kohno N
    • Journal Title

      Med Mol Morphol 2007 40

      Pages: 198-202

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of the glycosylated forms of MUC1 during lung development.2007

    • Author(s)
      Sakurai J, Hattori N, Nakajima M, Moriya T, Suzuki T, Yokoyama A, Kohno N
    • Journal Title

      Eur J Histochem 2007 51

      Pages: 95-102

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating KL-6/MUC1 mucin carrying sialy1 Lewisa oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma.2007

    • Author(s)
      Inata J
    • Journal Title

      Int J Cancer 120

      Pages: 2643-2649

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differetial expression of the glycosylated forms of MUC1 during lung Development.2007

    • Author(s)
      Sakurai J
    • Journal Title

      Eur J Histochem 51

      Pages: 95-102

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis.2007

    • Author(s)
      Shoda H
    • Journal Title

      Biochem Biophys Res Commun 353

      Pages: 1004-1010

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer-testis antigen lymphocyte antigen 6 complex locus K is a serologic biomarker and a therapeutic target for lung and esophageal carcinomas.2007

    • Author(s)
      Ishikawa N
    • Journal Title

      Cancer Research 67

      Pages: 11601-11611

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer2007

    • Author(s)
      Taniwaki M
    • Journal Title

      Clin Cancer Res 13

      Pages: 6624-6631

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of serum uric acid in patients with chronic respiratory failure treated with non-invasive positive pressure ventilation.2007

    • Author(s)
      Kadowaki T
    • Journal Title

      Intern Med 46

      Pages: 691-698

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice.2007

    • Author(s)
      Ohshima M
    • Journal Title

      Clin Exp Allergy 37

      Pages: 735-742

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas.2007

    • Author(s)
      Yamabuki T
    • Journal Title

      Cancer Res 67

      Pages: 2517-2525

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia.2007

    • Author(s)
      Ohtsuki Y
    • Journal Title

      Med Mol Morphol 40

      Pages: 198-202

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Productive cough is an independent risk factor for the development of COPD in former smokers.

    • Author(s)
      Yamane T, Hattori N, Kitahara Y, Haruta Y, Sasaki H, Yokoyama A, Kohno N
    • Journal Title

      Respirology 2010 15

      Pages: 313-318

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 間質性肺炎と肺癌2009

    • Author(s)
      河野修興
    • Organizer
      日本内科学会総会
    • Place of Presentation
      東京・東京国際フォーラム
    • Year and Date
      2009-04-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 間質性肺炎と肺癌2009

    • Author(s)
      河野修興
    • Organizer
      日本内学会総会
    • Place of Presentation
      東京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Krebs von den Lungen-6(KL-6) is a Serologic and Prognostic Biomarker and a Possible Therapeutic Target for IPF (International Symposium)2009

    • Author(s)
      河野修興
    • Organizer
      第48回日本呼吸器学会総会
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] KL-6の発見から臨床応用まで2008

    • Author(s)
      河野修興
    • Organizer
      第28回日本糖質学会年会
    • Place of Presentation
      つくば
    • Year and Date
      2008-08-18
    • Related Report
      2009 Final Research Report
  • [Presentation] KL-6の発見から臨床応用まで(シンポジウムI : 糖質科学とバイオマーカー)2008

    • Author(s)
      河野修興
    • Organizer
      第28回日本糖質学会年会
    • Place of Presentation
      つくば国際会議場・つくば市
    • Year and Date
      2008-08-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Krebs von den Lungen-6 (KL-6)is a Serologic and Prognostic Biomarker and a Possible Therapeutic Target for IPF (International Symposium)2008

    • Author(s)
      河野修興
    • Organizer
      第48回日本呼吸器学会総会
    • Place of Presentation
      名古屋国際会議場・名古屋市
    • Year and Date
      2008-06-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血清マーカーによる薬剤性肺炎の診断2007

    • Author(s)
      河野 修興
    • Organizer
      第49回日本内科学会東北支部主催生涯教育講演会
    • Place of Presentation
      仙台
    • Year and Date
      2007-06-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] 呼吸はメタボリック症候群克服のキーファクターである2007

    • Author(s)
      河野 修興
    • Organizer
      第61回日本交通医学会総会
    • Place of Presentation
      広島
    • Year and Date
      2007-06-09
    • Related Report
      2007 Annual Research Report
  • [Presentation] 薬物性肺障害の種類と診断の要点2007

    • Author(s)
      河野 修興
    • Organizer
      第104回日本内科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-04-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of coagulation and fibrinolytic systems in pulmonary fibrosis2007

    • Author(s)
      Hattori N
    • Organizer
      The 12th Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      Gold Coast, Australia
    • Related Report
      2009 Final Research Report
  • [Presentation] Serum markers in acute exacerbation of IPF2007

    • Author(s)
      Hattori N
    • Organizer
      4th International WASOG Conference on Diffuse Lung Diseases
    • Place of Presentation
      Tokyo
    • Related Report
      2009 Final Research Report
  • [Presentation] 薬物性肺障害の種類と診断の要点2007

    • Author(s)
      河野修興
    • Organizer
      第104回日本内科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Book] んがで読み解く呼吸器症例1002009

    • Author(s)
      河野修興監修,横山彰仁,森山美智子,服部登(編集)
    • Total Pages
      284
    • Publisher
      メディカルビュー社
    • Related Report
      2009 Final Research Report
  • [Book] がん化学療法・分子標的治療 update2009

    • Author(s)
      石川暢久, 河野修興
    • Total Pages
      736
    • Publisher
      中外医学社
    • Related Report
      2009 Annual Research Report
  • [Book] BAL法の臨床応用. 気管支肺胞洗浄(BAL)の手引き2008

    • Author(s)
      服部登, 河野修興監修
    • Publisher
      京誠堂出版社
    • Related Report
      2009 Final Research Report
  • [Book] 気管支肺胞洗浄(BAL)の手引き2008

    • Author(s)
      服部登
    • Publisher
      克誠堂出版社
    • Related Report
      2008 Annual Research Report
  • [Book] 呼吸器症候群(第2版)I-その他の呼吸器疾患を含めて-2008

    • Author(s)
      春田吉則
    • Publisher
      日本臨床社
    • Related Report
      2008 Annual Research Report
  • [Book] 呼吸器疾患のバイオマーカー. 内科学第9版(杉本恒明・矢崎義雄総編集)2007

    • Author(s)
      河野修興
    • Publisher
      朝倉書店
    • Related Report
      2009 Final Research Report
  • [Book] 内科学第9版2007

    • Author(s)
      河野 修興
    • Publisher
      朝倉書店,東京
    • Related Report
      2007 Annual Research Report
  • [Book] 呼吸器疾患最新の治療2007-20092007

    • Author(s)
      横山 彰仁
    • Publisher
      南江堂,東京
    • Related Report
      2007 Annual Research Report
  • [Book] 呼吸器専門医テキスト2007

    • Author(s)
      服部 登
    • Publisher
      南江堂,東京
    • Related Report
      2007 Annual Research Report
  • [Book] 呼吸器専門医テキスト2007

    • Author(s)
      横山 彰仁
    • Publisher
      南江堂,東京
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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