Therapeutic approach for kidney diseases by regenerative medicine

• Project/Area Number: 19390229
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Kochi University (2008-2010); Tokyo Medical and Dental University (2007)
• Principal Investigator: TERADA Yoshio Kochi University, 教育研究部・医療学系, 教授 (30251531)
• Research Collaborator: INOSHITA Seiji 東京医科歯科大学, 医学部附属病院, 助手 (00345307)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 腎臓 / 再生医学 / 急性腎不全 / 尿細管 / オートファジー / アポトーシス / 虚血 / 慢性腎障害 / 腎尿細管 / 幹細胞 / 血液透析 / 透析療法 / 再生 / ES細胞 / 糸球体 / 脱分化 / 増殖 / 急性腎障害 / 尿細管細胞 / 胎生期 / Deddiferentiation / Wnt4 / Etsl

Research Abstract

The patients of chronic renal failure increase up-to 300,000 in Japan. However the therapeutic methods are still limited. We tried novel regenerative methodology to develop new therapies to kidney diseases. Our result shows that Delta/Notch/Hes pathway is activated after ischemic acute kidney injury and plays a role in the proliferation of renal tubules. To regulate embryonic genes could provide a renewable source of cells for use in regenerative therapy for renal diseases.

Research Products

• [Journal Article] F-18 FDG PET/CT provides the earliest findings of enthesitis in reactive arthritis. (2011)
  • Author(s): Taniguchi Y, Kumon Y, Nakayama S, Arii K, Ohnishi T, Ogawa Y, Kobayashi S, Terada Y.
  • Journal Title: Clin Nucl Med. 36
  • Peer Reviewed
• [Journal Article] Possible involvement of intracellular angiotensin II receptor in high-glucose-induced damage in renal proximal tubular cells. (2010)
  • Author(s): Takao T, Horino T, Kagawa T, Matsumoto R, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Taguchi T, Morita T, Terada Y.
  • Journal Title: J Nephrol. 15
  • Peer Reviewed
• [Journal Article] Regulation of glucocorticoid receptor transcription and nuclear translocation during single and repeated immobilization stress. (2010)
  • Author(s): Noguchi T, Makino S, Matsumoto R, Nakayama S, Nishiyama M, Terada Y, Hashimoto K.
  • Journal Title: Endocrinology. 151
  • Peer Reviewed
• [Journal Article] Serum fetuin-A is an independent marker of insulin resistance in Japanese men. (2010)
  • Author(s): Ishibashi A, Ikeda Y, Ohguro T, Kumon Y, Yamanaka S, Takata H, Inoue M, Suehiro T, Terada Y
  • Journal Title: J Atheroscler Thromb. 17
  • NAID: 130004444455
  • Peer Reviewed
• [Journal Article] Glucocorticoid receptor-β and receptor-γ exert dominant negative effect on gene repression but not on gene induction. (2010)
  • Author(s): Taniguchi Y, Iwasaki Y, Tsugita M, Nishiyama M, Taguchi T, Okazaki M, Nakayama S, Kambayashi M, Hashimoto K, Terada Y
  • Journal Title: Endocrinology. 151
  • Peer Reviewed
• [Journal Article] Coincidental double erythema caused by Vibrio vulnificus. (2010)
  • Author(s): Taguchi T, Mizobuchi M, Terada Y.
  • Journal Title: J Infect. 61
  • Peer Reviewed
• [Journal Article] Rapid recurrence of craniopharyngioma following recombinant human growth hormone replacement. (2010)
  • Author(s): Taguchi T, Takao T, Iwasaki Y, Pooh K, Okazaki M, Hashimoto K, Terada Y.
  • Journal Title: J Neurooncol. 100
  • Peer Reviewed
• [Journal Article] Hypoglycemic encephalopathy as a result of an attempted suicide. (2010)
  • Author(s): Taguchi T, Mizobuchi M, Terada Y.
  • Journal Title: Clin Neurol Neurosurg. 112
  • Peer Reviewed
• [Journal Article] PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1. (2010)
  • Author(s): Okazaki M, Iwasaki Y, Nishiyama M, Taguchi T, Tsugita M, Nakayama S, Kambayashi M, Hashimoto K, Terada Y.
  • Journal Title: Endocr J. 57
  • Peer Reviewed
• [Journal Article] Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. (2010)
  • Author(s): Zhao LF, Iwasaki Y, Zhe W, Nishiyama M, Taguchi T, Tsugita M, Kambayashi M, Hashimoto K, Terada Y.
  • Journal Title: Endocr J. 57
  • NAID: 10029584337
  • Peer Reviewed
• [Journal Article] The activity of carotidynia syndrome is correlated with the soluble intracellular adhesion molecule-1 (sICAM-1) level. (2010)
  • Author(s): Taniguchi Y, Horino T, Terada Y, Jinnouchi Y.
  • Journal Title: South Med J. 103
  • Peer Reviewed
• [Journal Article] IgA nephropathy in a patient with systemic lupus erythematosus. (2010)
  • Author(s): Horino T, Takao T, Terada Y.
  • Journal Title: Lupus. 19
  • Peer Reviewed
• [Journal Article] Clinical implication of 18F- fluorodeoxyglucose PET/CT in monitoring disease activity in spondyloarthritis. (2010)
  • Author(s): Taniguchi Y, Kumon Y, Arii K, Tsugita M, Fukumoto M, Ohnishi T, Kobayashi S, Terada Y.
  • Journal Title: Rheumatology (Oxford). 49
  • Peer Reviewed
• [Journal Article] Acute pulmonary arterial hypertension associated with anti-synthetase syndrome. (2010)
  • Author(s): Taniguchi Y, Horino T, Kato T, Terada Y.
  • Journal Title: Scand J Rheumatol. 39
  • Peer Reviewed
• [Journal Article] Role of protein kinase C in pitavastatin-induced human paraoxonase I expression in Huh7 cells. (2010)
  • Author(s): Arii K, Suehiro T, Ikeda Y, Kumon Y, Inoue M, Inada S, Takata H, Ishibashi A, Hashimoto K, Terada Y.
  • Journal Title: Metabolism. 59
  • NAID: 120002003638
  • Peer Reviewed
• [Journal Article] A case of post-streptococcal reactive arthritis in which lesions were detected with [18F]-fluorodeoxyglucose positron emission tomography-CT imaging and magnetic resonance imaging. (2010)
  • Author(s): Horino T, Takao T, Terada Y.
  • Journal Title: Mod Rheumatol. 20 Pages: 287-290
  • NAID: 10027169450
  • Peer Reviewed
• [Journal Article] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. (2010)
  • Author(s): Inoue K, Kuwana H, Shimamura Y, Ogata K, Taniguchi Y, Kagawa T, Horino T, Takao T, Morita T, Sasaki S, Mizushima N, Terada Y.
  • Journal Title: Clin Exp Nephrol. 14 Pages: 112-122
  • NAID: 10027228406
  • Peer Reviewed
• [Journal Article] Positron emission tomography/computed tomography : a clinical tool for evaluation of enthesitis in patients with spondyloarthritides. (2010)
  • Author(s): Taniguchi Y, Arii K, Kumon Y, Fukumoto M, Ohnishi T, Horino T, Kagawa T, Kobayashi S, Ogawa Y, Terada Y.
  • Journal Title: Rheumatology (Oxford). 49
  • Peer Reviewed
• [Journal Article] HLA-B51-related seronegative spondyloarthropathy associated with membranous nephropathy. (2010)
  • Author(s): Horino T, Nakayama S, Takao T, Terada Y.
  • Journal Title: Rheumatology (Oxford). 49
  • Peer Reviewed
• [Journal Article] Diagnostic value of 18F-dihydroxyphenylalanine positron emission tomography for growth hormone-producing pituitary adenoma. (2010)
  • Author(s): Taguchi T, Takao T, Iwasaki Y, Oyama K, Yamada S, Inoue M, Terada Y.
  • Journal Title: Pituitary. 13
  • Peer Reviewed
• [Journal Article] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo (2010)
  • Author(s): Inoue K, Terada Y., et al
  • Journal Title: Clinical and experimental Nephrology Volume: 14 Pages: 112-122
  • NAID: 10027228406
  • Peer Reviewed
• [Journal Article] IgA nephropathy in a patient with systemic lupus erythematosus (2010)
  • Author(s): Horino T, Takao T, Terada Y
  • Journal Title: Lupus Volume: 19 Pages: 650-654
  • Peer Reviewed
• [Journal Article] A case of post-streptococcal reactive arthritis in which lesions were detected with[18F]-fluorodeoxyglucose positron emission tomography-CT imaging and magnance imaging (2010)
  • Author(s): Horino T, Takao T, Terada Y
  • Journal Title: Mod Rheumatol Volume: 20 Pages: 287-290
  • Peer Reviewed
• [Journal Article] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo (2010)
  • Author(s): Inoue K, Kuwana H, Shinahara Y, Ogata K, Taniguchi Y, Kagawa T, Horino T, Takada T, Morita T, Sasaki S, Mizushima N, Terada Y
  • Journal Title: Clin Exp Nephrol 14 Pages: 12-122
  • NAID: 10027228406
  • Peer Reviewed
• [Journal Article] Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo (2010)
  • Author(s): Inoue K, Terada Y, et al
  • Journal Title: Clinical and Experimental Nephrology 14 Pages: 112-122
  • NAID: 10027228406
  • Peer Reviewed
• [Journal Article] Glucocorticoid receptor plays an indispensable role in mineralocorticoid receptor-dependent transcription in GR-deficient BE(2)C and T84 cells in vitro. (2009)
  • Author(s): Tsugita M, Iwasaki Y, Nishiyama M, Taguchi T, Shinahara M, Taniguchi Y, Kambayashi M, Nishiyama A, Gomez-Sanchez CE, Terada Y, Hashimoto K.
  • Journal Title: Mol Cell Endocrinol. 302 Pages: 18-25
  • Peer Reviewed
• [Journal Article] Insulin exhibits short-term antiinflammatory but long-term proinflammatory effects in vitro. (2009)
  • Author(s): Iwasaki Y, Nishiyama M, Taguchi T, Asai M, Yoshida M, Kambayashi M, Terada Y, Hashimoto K.
  • Journal Title: Mol Cell Endocrinol. 298 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Plasma adiponectin level is increased despite insulin resistance in corticotropin-releasing hormone transgenic mice, an animal model of Cushing syndrome. (2009)
  • Author(s): Shinahara M, Nishiyama M, Iwasaki Y, Nakayama S, Noguchi T, Kambayashi M, Okada Y, Tuda M, Stenzel-Poore MP, Hashimoto K, Terada Y
  • Journal Title: Endocr J. 56 Pages: 879-886
  • Peer Reviewed
• [Journal Article] Hormonal regulation of glycolytic enzyme gene and pyruvate dehydrogenase dinase/phosphatase gene transcription. (2009)
  • Author(s): Wang Z, Iwasaki Y, Zhao LF, Nishiyama M, Taguchi T, Tsugita M, Kambayashi M, Hashimoto K, Terada Y
  • Journal Title: Endocr J. 56 Pages: 1019-1030
  • Peer Reviewed
• [Journal Article] Pitavastation induces PON1 expression through P44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells. (2009)
  • Author(s): Arii K, Suehiro T, Ikeda Y, Kumon Y, Osaki F, Inoue M, Inada S, Ogami N, Takada H, Hashimoto K, Terada Y
  • Journal Title: Atherosclerosis. 202 Pages: 439-445
  • Peer Reviewed
• [Journal Article] Visceral obesity is associated with the metabolic syndrome and elevated plasma retinol binding protein-4 level in obstructive sleep apnea syndrome. (2009)
  • Author(s): Makino S, Fujiwara M, Suzukawa K, Handa H, Fujie T, Ohtaka Y, Komatsu Y, Aoki Y, Maruyama H, Terada Y, Hashimoto K, Sugimoto T
  • Journal Title: Horm metab res. 41 Pages: 221-226
  • Peer Reviewed
• [Journal Article] Effects of angiotensin II type 1 receptor blocker on albumin-induced cell damage in human renal proximal tubular epithelial cells. (2009)
  • Author(s): Takao T, Horino T, Kagawa T, Matsumoto R, Inoue K, Taguchi T, Morita T, Iwasaki Y, Hashimoto K, Terada Y
  • Journal Title: Am J Nephrol. 29 Pages: 102-108
  • Peer Reviewed
• [Journal Article] Effect of Sevelamer Hydrochloride on Bone in Experimental Uremic Rats. (2009)
  • Author(s): Kuwahara M, Inoshita S, Terada Y, Sasaki S
  • Journal Title: Therapeutic Apheresis and Dialysis. 13(1) Pages: 42-48
  • Peer Reviewed
• [Journal Article] A case with spontaneous bladder rupture mimicking acute kidney injury. (2009)
  • Author(s): Horino T, Okazaki M, Nishikawa H, Takao T, Taniguchi Y, Morita T, Terada Y
  • Journal Title: Clinical Nephrology. 72 Pages: 391-393
  • Peer Reviewed
• [Journal Article] Cutaneous amyloidosis associated with amyopathic dermatomyositis. (2009)
  • Author(s): Taniguchi Y, Horino T, Terada Y.
  • Journal Title: J Rheumatol. 36 Pages: 1088-1089
  • Peer Reviewed
• [Journal Article] Symmetric giant xanthogranulomas in Erdheim-Chester disease. (2009)
  • Author(s): Taguchi T, Sano S, Iwasaki Y, Terada Y
  • Journal Title: Eur Nucl Med Mol lmaging. 36 Pages: 1198-1198
  • Peer Reviewed
• [Journal Article] 酸塩基平衡(産生量,肺・腎での調節,腎のトランスポーターなど) (2009)
  • Author(s): 森田達仁, 寺田典生
  • Journal Title: 綜合臨牀 58 Pages: 780-784
• [Journal Article] ネフローゼ症候群:診断と治療の進歩.II.一次性ネフローゼ症候群の病態・診断・治療. 5.メサンギウム増殖性糸球体腎炎,管内増殖性糸球体腎炎,半月体形成性糸球体腎炎 (2009)
  • Author(s): 堀野太郎, 寺田典生
  • Journal Title: 日本内科学会雑誌 98 Pages: 1036-1041
• [Journal Article] 急性腎障害とは(特集腎疾患-最近の進展) (2009)
  • Author(s): 堀野太郎, 寺田典生
  • Journal Title: セフィーロ 9 Pages: 23-26
  • NAID: 40016751428
• [Journal Article] 食塩の吸収・調節と排泄、その異常 (2009)
  • Author(s): 次田誠、寺田典生
  • Journal Title: 成人病と生活習慣病 第39巻第3号別刷 Pages: 233-237
• [Journal Article] Glucocorticoid receptor plays an indispensable role in mineralocorticoid receptor-dependent transcription in GR-deficient BE(2)C and T84 cells in vitro (2009)
  • Author(s): Tsugita M, Terada Y, et al.
  • Journal Title: Mol Cell Endocrinol 302 Pages: 18-25
  • Peer Reviewed
• [Journal Article] Effects of angiotensin II type 1 receptor blocker on albumin-induced cell damage in human renal proximal tubular epithelial cells (2009)
  • Author(s): Takao T, Terada Y, et al.
  • Journal Title: Am J Nephrol 29 Pages: 102-108
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 堀野太郎, 寺田典生
  • Journal Title: 電解質異常. 高・低Na血症, 高・低Cl血症. 専門医のための腎臓病学(医学書院) Pages: 115-121
• [Journal Article] A familial case of mitochondrial disease resembling Alport syndrome. (2008)
  • Author(s): Fujii H, Mori Y, Kayamori K, Igari T, Ito E, Akashi T, Noguchi Y, Kitamura K, Okado T, Terada Y, Kanda E, Rai T, Uchida S, Sasaki S.
  • Journal Title: Clin.Exp.Nephrol. 12 Pages: 159-163
  • NAID: 10025352293
  • Peer Reviewed
• [Journal Article] Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. (2008)
  • Author(s): Kobayashi T, Terada Y, Kuwana H, Tanaka H, Okado T, Kuwahara M, Tohda S, Sakano S, Sasaki S.
  • Journal Title: Kidney Int. 73 Pages: 1240-1250
  • NAID: 120001905099
  • Peer Reviewed
• [Journal Article] The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. (2008)
  • Author(s): Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, Irie-Sasaki J, Sasaki T, Sasaki S.
  • Journal Title: Kidney Int. 73 Pages: 430-445
  • Peer Reviewed
• [Journal Article] Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium. (2008)
  • Author(s): Terada Y, Kuwana H, Kobayashi T, Okado T, Suzuki N, Yoshimoto T, Hirata Y, Sasaki S.
  • Journal Title: J.Am.Soc.Nephrol. 19 Pages: 298-309
  • Peer Reviewed
• [Journal Article] Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury (2008)
  • Author(s): Kobayashi T, Terada Y, Kuwana H, Tanaka H, Okado T, Kuwahara M, Tohda S, Sakano S, Sasaki S.
  • Journal Title: Kidney Int. 73 Pages: 1240-50
  • NAID: 120001905099
  • Peer Reviewed
• [Journal Article] The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity (2008)
  • Author(s): Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, Irie-Sasaki J, Sasaki T, Sasaki S.
  • Journal Title: Kidney Int. 73 Pages: 430-445
  • Peer Reviewed
• [Journal Article] A familial case of mitochondrial disease resembling Alport syndrome. (2008)
  • Author(s): Fujii H, Terada Y., et al.
  • Journal Title: Clin. Exp. Nephrol. 12 Pages: 159-163
  • NAID: 10025352293
  • Peer Reviewed
• [Journal Article] Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury. (2008)
  • Author(s): Kobayashi T, Terada Y, et al
  • Journal Title: Kidney International 73 Pages: 1240-1250
  • NAID: 120001905099
  • Peer Reviewed
• [Journal Article] Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium (2008)
  • Author(s): Terada Y, Kuwana H, et al.
  • Journal Title: J. Am. Soc. Nephrol. 19 Pages: 298-309
  • Peer Reviewed
• [Journal Article] Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury. (2007)
  • Author(s): Terada Y, Inoshita S, Kuwana H, Kobayashi T, Okado T, Ichijo H, Sasaki S.
  • Journal Title: Biochemical and Biophysical Research Communications. 364 Pages: 1043-1049
  • Peer Reviewed
• [Journal Article] Expression of bone type 1 PTH receptor in rats with chronic renal failure. (2007)
  • Author(s): Kuwahara M, Inoshita S, Nakao Y, Terada Y, Takano Y, Sasaki S
  • Journal Title: Clinical and Experimental Nephrology. 11 Pages: 34-40
  • NAID: 10024140027
  • Peer Reviewed
• [Journal Article] Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury. (2007)
  • Author(s): Terada Y, et. al.
  • Journal Title: Biochemical and Biophysical Research Communications 364 Pages: 1043-1049
  • Peer Reviewed
• [Journal Article] Expression of bone type 1 PTH receptor in rats with chronic rena 1 failure. (2007)
  • Author(s): Kuwahara M, Terada Y, et. al.
  • Journal Title: Clinical and Experimental Nephrology 11 Pages: 34-37
  • Peer Reviewed
• [Presentation] 尿細管再生における脱分化 (2010)
  • Author(s): 寺田典生
  • Organizer: 第53回日本腎臓学会学術総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-06-16
• [Presentation] Aldosterone Stimulates NF-κB Activity and Transcription of ICAM-1 via SGK-1 in Rat Mesangial Cells in vivo and in vitro (2009)
  • Author(s): Terada Y
  • Organizer: IUPS2009 Satellite Symposium "The Kidney and Hypertension"
  • Place of Presentation: 東京銀行協会ビル(東京都)
  • Year and Date: 2009-07-24
• [Presentation] Cisplatin-Induced Macroautophagy Occurs Prior to Apoptosis in Proximal Tubules In Vivo. (2009)
  • Author(s): Inoue K, Kuwana H, Shimamura Y, Ogata K, Taniguchi Y, Kagawa T, Horino T, Takao T, Morita T, Ikeda Y, Sasaki S, Terada Y
  • Organizer: The American society of Nephrology, Renal week
  • Place of Presentation: San Diego
• [Presentation] Aldosterone Stimulates NF-κ B Activity and Transcription of ICAM-1 via SGK-1 in Rat Mesangial Cells in vivo and in vitro (2009)
  • Author(s): Terada Y
  • Organizer: IUPS2009 Satellite Symposium "The Kidney and Hypertension"
  • Place of Presentation: Tokyo
• [Presentation] Aldosterone Stimulates NF-kB Activity and Transcription of ICAM-1 via Serum and Glucocorticoid-inducible Protein Kinase (SGK) in Rat Mesangial Cells (2008)
  • Author(s): Yoshio Terada
  • Organizer: The 1^<st> International Aldosterone Forum
  • Place of Presentation: Takanawa Prince Hotel, Tokyo
  • Year and Date: 2008-05-11
• [Book] 急性腎不全・AKIハンドブック (2010)
  • Author(s): 香川亨, 寺田典生(菱田明:編集)
  • Total Pages: 6
  • Publisher: 一般の急性腎不全・原因と鑑別診断の進め方
• [Book] 専門医のための腎臓病学 第2版(電解質異常.高・低Na血症,高・低Cl血症)(内山聖, 富野康日己, 今井裕一編) (2009)
  • Author(s): 堀野太郎, 寺田典生
  • Publisher: 医学書院
• [Book] 輸液療法パーフェクト(電解質異常.高ナトリウム血症)(飯野靖彦編) (2009)
  • Author(s): 堀野太郎, 寺田典生
  • Publisher: 羊土社
• [Book] 内分泌代謝専門医ガイドブック(Bartter症候群)(成瀬光栄、平田結喜緒、島津章編) (2009)
  • Author(s): 香川亨, 寺田典生
  • Publisher: 診断と治療社
• [Book] 電解質異常. 高・低Na血症, 高・低Cl血症. 専門医のための腎臓病学 第2版(内山聖, 富野康日己, 今井裕一編) (2009)
  • Author(s): 堀野太郎, 寺田典生
  • Publisher: 医学書院