| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
In the present study, we found that the increased oxidative stress in the brain, particularly in the cardiovascular center in the brainstem, enhanced sympathetic activity thereby causing hypertension in metabolic syndrome. As a major source of reactive oxygen species generation, we found that activation of the angiotensin type 1 receptors and related signaling pathway play an important role in the increased oxidative stress in the brain. In addition, we found that activation of the sympathetic nervous system and endothelial dysfunction occurred in patients with metabolic syndrome. Treatment with angiotensin receptor blockers improved these abnormalities.
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