Loss of Renal Functional Reserve and Cardiovascular Events : The Key Mechanisms to Understand Cardio-Renal Connection

• Project/Area Number: 19390232
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Nagoya City University
• Principal Investigator: KIMURA Genjiro Nagoya City University, 大学院・医学研究科, 教授 (30315874)
• Co-Investigator(Kenkyū-buntansha): FUKUDA Michio 名古屋市立大学, 大学院・医学研究科, 准教授 (50363940) ; DOHI Yasuaki 名古屋市立大学, 大学院・医学研究科, 准教授 (40305529) ; OHTE Nobuyuki 名古屋市立大学, 大学院・医学研究科, 准教授 (10185332)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 高血圧学 / 心-腎連関 / 血圧日内リズム / 慢性腎臓病(CKD) / 夜間血圧 / 食塩 / RA系抑制薬 / 心血管事故 / 圧-利尿 / RA系抑制 / 臓器障害

Research Abstract

It is known as cardio-renal connection the phenomena that cardiovascular events occur frequently as a function of renal dysfunction. We have shown that as renal function deteriorates the nocturnal blood pressure is elevated and longer duration is required until nocturnal pressure falls below daytime averages. Since nocturnal hypertension is established as a strong cardiovascular risk, we propose that nocturnal hypertension and salt sensitivity play important roles in the genesis of cardio-renal connection.

Research Products

• [Journal Article] Impaired myocardial oxidative metabolism in the remote normal region in patients in the chronic phase of myocardial infarction and left ventricular remodeling. (2009)
  • Author(s): Ohte N, Narita H, Iida A, Wakami K, Asada K, Fukuta H, Kato T, Hyano J, Kimura G
  • Journal Title: J Nucl Cardiol 16(1) Pages: 73-81
  • Peer Reviewed
• [Journal Article] Elevated plasma levels of B-type natriuretic peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. (2009)
  • Author(s): Fukuta H, Ohte N, Mukai S, Saeki T, Asada K, Wakami K, Kimura G
  • Journal Title: Int Heart J 50 Pages: 301-312
  • NAID: 130000120815
  • Peer Reviewed
• [Journal Article] Correlation between left ventricular end-diastolic pressure and peak left atrial wall strain during left ventricular systole. (2009)
  • Author(s): Wakami K, Ohte N, Asada K, Fukuta H, Goto T, Mukai S, Narita H, Kimura G
  • Journal Title: Am Soc Echocardiogr 22 Pages: 847-851
  • Peer Reviewed
• [Journal Article] Impaired myocardial oxidative metabolism in the remote normal region in patients in the chronic phase of myocardial infarction and left ventricular remodeling (2009)
  • Author(s): Ohte N, et al
  • Journal Title: J Nucl Cardiol 16 Pages: 73-81
  • Peer Reviewed
• [Journal Article] Combination of low-does trichlormethiazide with conventional-does furosemide promotes natriuresis in patients with refractory heart failure (2009)
  • Author(s): Saeki T, et al
  • Journal Title: Ther Res 30 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Combination therapy with carperitide and furosemide promotes natriuresis in patients with cart failure (2009)
  • Author(s): Saeki T, et al
  • Journal Title: Ther Res 30 Pages: 107-112
  • Peer Reviewed
• [Journal Article] Tako-tsubo cardiomyopathy complicated by apical thrombus formation : A case report (2009)
  • Author(s): Yoshida T, et al
  • Journal Title: Int J Cardiol 132 Pages: 120-122
  • Peer Reviewed
• [Journal Article] A rare case of tako-tsubo cardiomyopathy documented during Holler monitoring (2009)
  • Author(s): Yoshida T, et al
  • Journal Title: Int J Cardiol 132 Pages: 105-108
  • Peer Reviewed
• [Journal Article] A rare case of tako-tsubo cardiomyopathy with variable forms of left ventricular dysfunction : a new entity (2009)
  • Author(s): Yoshida T, et al
  • Journal Title: Ther Res 134 Pages: 73-75
  • Peer Reviewed
• [Journal Article] Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease (2009)
  • Author(s): Fujimaki T, et al
  • Journal Title: Thromb Haemost 101 Pages: 963-968
  • Peer Reviewed
• [Journal Article] The recurrence tako-tsubo cardiomyopathy complicated by cardiogenic shock : A case report (2009)
  • Author(s): Yoshida T, et al
  • Journal Title: Clin J Am Soc Nephrol 134 Pages: 132-134
  • Peer Reviewed
• [Journal Article] Association of genetic variants with chronic kidney disease in Japanese individuals (2009)
  • Author(s): Yoshida T, et al
  • Journal Title: Int J Cardiol 4 Pages: 883-890
  • Peer Reviewed
• [Journal Article] Elevated plasma levels of B-type natriuretic peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease (2009)
  • Author(s): Fukuta H, et al
  • Journal Title: Int Heart J 50 Pages: 301-312
  • Peer Reviewed
• [Journal Article] Transient mid-ventricular ballooning syndrome complicated by syncope : A variant of tako-tsubo cardiomyopathy (2009)
  • Author(s): Yoshida T, et al
  • Journal Title: Int J Cardiol 135 Pages: 20-23
  • Peer Reviewed
• [Journal Article] On the mechanism for PPAR agonists to enhance ABCA1 gene expression (2009)
  • Author(s): Ogata M, et al
  • Journal Title: Atherosclerosis 205 Pages: 413-419
  • Peer Reviewed
• [Journal Article] Low Incident of Cardiac Events in Statin-Administered Patients in CAG Study (2009)
  • Author(s): Saeki T, et al
  • Journal Title: Journal Of Atherosclerosis and Thrombosis 16 Pages: 172-178
  • Peer Reviewed
• [Journal Article] Correlation between left ventricular end-diastolic pressure and peak left atrial wall strain during left ventricular systole (2009)
  • Author(s): Wakami K, et al
  • Journal Title: J Am Soc Echocardiogr 22 Pages: 847-851
  • Peer Reviewed
• [Journal Article] Within-person variation of the plasma concentration of B -type natriuretic peptide : Safety range in stable patients with heart failur (2009)
  • Author(s): Takeda Y, et al
  • Journal Title: American Heart Journal 157 Pages: 98-101
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor blocker, olmesartan, restores nocturnal blood pressure decline by enhancing daytime natriuresis. (2008)
  • Author(s): Fukuda M, Yamanaka T, Mizuno M, Motokawa M, Shirasawa Y, Miyagi S, Nishio T, Yoshida A, Kimura G
  • Journal Title: J Hypertension 26 Pages: 583-588
  • Peer Reviewed
• [Journal Article] Diuretics should be used as the second-line agent in combination with RAS inhibitors in proteinuric patients with CKD. (2008)
  • Author(s): Fukuda M, Kimura G
  • Journal Title: Kidney Int 74 Pages: 1358-1358
  • Peer Reviewed
• [Journal Article] Patients with renal dysfunction require a longer duration until blood pressure dips during the night. (2008)
  • Author(s): Fukuda M, Mizuno M, Yamanaka T, Motokawa M, Shirasawa Y, Nishio T, Miyagi S, Yoshida A, Kimura G
  • Journal Title: Hypertension 52 Pages: 1155-1160
  • Peer Reviewed
• [Journal Article] Does B-type natriuretic peptide predict the new onset of Hypertension? (2008)
  • Author(s): Takase H, Dohi H, Toriyama T, Okado T, Tanaka S, Sato K, Kimura G
  • Journal Title: Hypertens Res 31 Pages: 1737-1744
  • NAID: 10024362334
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor blocker, olmesartan, restores nocturnal blood pressure decline by enhancing daytime natriuresis (2008)
  • Author(s): Fukuda M, et al
  • Journal Title: J Hypertension 26 Pages: 583-588
  • Peer Reviewed
• [Journal Article] Nifedipine improves endothelial function : role of endothelial progenitor cells (2008)
  • Author(s): Sugiura T, et al
  • Journal Title: Hypertension 52 Pages: 491-498
  • Peer Reviewed
• [Journal Article] Diuretics should be used as the second -line agent in combination with RAS inhib itors in proteinuric patients with CKD (2008)
  • Author(s): Fukuda M, et al
  • Journal Title: Kidney Int 74 Pages: 1358-1358
  • Peer Reviewed
• [Journal Article] Patients with renal dysfunction require a longer duration until blood pressure dips during the night (2008)
  • Author(s): Fukuda M, et al
  • Journal Title: Hypertension 52 Pages: 1155-1160
  • Peer Reviewed
• [Journal Article] Kidney and circadian blood pressure rhythm (2008)
  • Author(s): Kimura G
  • Journal Title: Hypertension 51 Pages: 827-828
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor blocker, olmesartan, restores nocturnal blood pressure decline by enhancing daytime natriuresis (2008)
  • Author(s): Fukuda M, et. al.
  • Journal Title: J Hypertension 26 Pages: 583-588
  • Peer Reviewed
• [Journal Article] Predicted prevalence in Japan of chronic kidney disease (CKD). (2007)
  • Author(s): Kimura G
  • Journal Title: Clin Exp Nephrol 11 Pages: 188-189
  • NAID: 10024140718
  • Peer Reviewed
• [Journal Article] A pathophysiologic study of tako-tsubo cardiomyopathy with F-18 fluorodeoxyglucose positron emission tomography. (2007)
  • Author(s): Yoshida T, Hibino T, Kako N, Murai S, Oguri M, Kato K, Yajima K, Ohte N, Yokoi K, Kimura G
  • Journal Title: Eur Heart J 28 Pages: 2598-2604
  • Peer Reviewed
• [Journal Article] Predicted prevalence in Japan of chronic kidney disease(CKD) (2007)
  • Author(s): Kimura G
  • Journal Title: Clin Exp Nephrol 11 Pages: 188-189
  • NAID: 10024140718
  • Peer Reviewed
• [Journal Article] Chronic kidney disease and the renin-angiotensin system (2007)
  • Author(s): Kimura G
  • Journal Title: Intern Med 46 Pages: 1295-1298
  • NAID: 40016416572
  • Peer Reviewed
• [Presentation] Salt and Hypertension - Japanese View. International Symposium "Salt and Hypertension". Chaired by Michael Alderman. (2009)
  • Author(s): Genjiro Kimura
  • Organizer: 18th Annual Congress of Korean Society of Hypertension
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-17
• [Presentation] Salt and Hypertension-Japanese View. International Symposium "Salt and Hypertension". Chaired by Michael Alderman (2009)
  • Author(s): Genjiro Kimura
  • Organizer: 18^<th> Annual Congress of Korean Society of Hypertension
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-05-17
• [Presentation] The reason BP falls or does not fall when a person sleeps. Plenary Symposium "The importance of sleep BP at different times of the day", Chaired by Bryan Williams & Trefor Morgan. (2009)
  • Author(s): Genjiro Kimura
  • Organizer: 7th Asian-Pacific Congress of Hypertension 2009
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2009-02-22
• [Presentation] Renal protection with antihypertensive treatment. Symposium "Managing high risk hypertensive patients", Chaired by Pham Gia Khai & Nazar Luqman. (2009)
  • Author(s): Genjiro Kimura
  • Organizer: 7th Asian-Pacific Congress of Hypertension 2009
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2009-02-21
• [Presentation] Early predictors of renal protection with antihypertensive therapy. Educational Track Session: Kidney Disease and Transplantation, Chaired by Thomas Philipp & Otto Kuchel. (2008)
  • Author(s): Genjiro Kimura
  • Organizer: 22nd Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-06-19
• [Presentation] Early predictors of renal protection with antihypertensive therapy. Educational Track Session (Chaired by Thomas Philipp & Otto Kuchel) (2008)
  • Author(s): Genjiro Kimura
  • Organizer: 22^<nd> Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2008-06-19
• [Presentation] 食塩感受性と心血管事故 (2007)
  • Author(s): 木村 玄次郎
  • Organizer: 第50回日本腎臓学会学術総会
  • Place of Presentation: 浜松
• [Book] CKDとRAS.医学のあゆみ.レニン・アンジオテンシ系のすべて. (小室一成監修) (2009)
  • Author(s): 木村玄次郎
  • Publisher: 医歯薬出版株式会社:東京
• [Book] ワンポイントノートで学ぶ透析療法の基本改訂第2版 (2009)
  • Author(s): 木村玄次郎
  • Total Pages: 127
  • Publisher: 東京医学社:東京
• [Book] 腎実質性高血圧、腎血管性高血圧. 高血圧専門医ガイドブック(日本高血圧学会編) (2009)
  • Author(s): 木村玄次郎
  • Publisher: 診断と治療社:東京
• [Book] 腎と高血圧. 初学者から専門医までの腎臓学入門改訂第2版 (2009)
  • Author(s): 木村玄次郎
  • Publisher: 東京:東京医学社
• [Book] 腎と高血圧. 専門医のための腎臓病学第2版(下条文武) (2009)
  • Author(s): 木村玄次郎
  • Publisher: 東京:医学書院
• [Book] ワンポイントノートで学ぶ透析療法の基本 改訂第2版 (2009)
  • Author(s): 木村玄次郎
  • Total Pages: 127
  • Publisher: 東京医学社
• [Book] 腎と高血圧 初学者から専門医までの腎臓学入門 改訂第2版 (2009)
  • Author(s): 木村玄次郎
  • Total Pages: 244
  • Publisher: 東京医学社
• [Book] 医学のあゆみ. レニン・アンジオテンシ系のすべて. (小室一成 監修) (2009)
  • Author(s): 木村玄次郎
  • Total Pages: 588
  • Publisher: 医歯薬出版株式会社
• [Book] RENAAL. NAVIGATORー高血圧ナビゲーター第二版ー(熊谷裕生、小室一成、堀内正嗣、森下竜一編) (2008)
  • Author(s): 木村玄次郎
  • Publisher: メディカルビュー社
• [Book] 腎と高血圧. 日本腎臓学会創立50周年記念誌(日本腎臓学会50周年記念事業委員会編) (2007)
  • Author(s): 木村玄次郎
• [Book] 二次性高血圧の診断と治療. 内科学第9版(杉本恒明、矢崎義雄編) (2007)
  • Author(s): 木村玄次郎
  • Publisher: 東京:朝倉書店
• [Book] 内科学第9版 (2007)
  • Author(s): 木村玄次郎
  • Total Pages: 2008
  • Publisher: 朝倉書店
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