Clock in the brain : neural substrates of time perception

• Project/Area Number: 19390242
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyushu University
• Principal Investigator: TOBIMATSU Shozo Kyushu University, 大学院・医学研究院, 教授 (40164008)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA Yoshitaka 九州大学, 大学院・芸術工学研究院, 教授 (90127267) ; SHIGETOU Hiroshi 九州大学, 大学病院, 講師 (50335965) ; OGATA Katsuya 九州大学, 大学院・医学研究院, 助教 (50380613) ; MAEKAWA Toshihiko 九州大学, 大学病院, 助教 (40448436) ; 齊藤 崇子 九州大学, 大学院・芸術工学研究院, 特別研究員 (70423522)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000); Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2007: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 脳の時計 / 時間知覚 / 時間縮小錯覚 / 非侵襲的脳機能計測法 / 神経・精神疾患 / 神経疾患 / 精神疾患

Research Abstract

Time is a fundamental dimension of life. It is now proposed that the brain represents time in a distributed manner and tells the time by detecting the coincidental activation of different neural populations. In this project, we used event-related potentials (ERPs) to explore the mechanisms of auditory and visual temporal assimilation as well as preattentive process. Our preliminary results suggest that right dorsolateral prefrontal cortex plays an important role of temporal assimilation.

Research Products

• [Journal Article] Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in humans. (2010)
  • Author(s): Hagiwara K, Okamoto T, Shigeto H, Ogata K, Somehara Y, Matsushita T, Kira JI, Tobimatsu S
  • Journal Title: Neuroimage 51 Pages: 412-420
• [Journal Article] A Neural Decoding Approach to Auditory Temporal Assimilation (2010)
  • Author(s): Takeichi H, et al
  • Journal Title: Neural Comput Appl (印刷中)
  • Peer Reviewed
• [Journal Article] ミスマッチ陰性電位とP300を用いた双極性障害の視覚情報自動処理過程の検討 (2009)
  • Author(s): 角田智哉, 前川敏彦, 織部直弥, 鬼塚俊明, 平野羊嗣, 平野昭吾, 大林長二, 飛松省三, 神庭重信
  • Journal Title: 臨床神経生理学 36 Pages: 607-614
  • NAID: 10027056076
• [Journal Article] Electrophysiological evidence of auditory temporal perception related to the assimilation between neighboring two time intervals. (2009)
  • Author(s): Mitsudo T, Nakajima Y, Remijn GB, Takeichi H, Goto Y, Tobimatsu S
  • Journal Title: NeuroQuantology 7 Pages: 114-127
• [Journal Article] Decreased spatial frequency sensitivities for processing faces in male patients with chronic schizophrenia. (2009)
  • Author(s): Obayashi C, Nakashima T, Onitsuka T, Maekawa T, Hirano Y, Hirano S, Oribe N, Kaneko K, Kanba S, Tobimatsu S
  • Journal Title: Clin Neurophysiol 120 Pages: 1525-1533
• [Journal Article] Preattentive visual change detection as reflected by the mismatch negativity (MMN) -evidence for a memory-based process. (2009)
  • Author(s): Maekawa T, Tobimatsu S, Ogata K, Onitsuka T, Kanba S
  • Journal Title: Neurosci Res 65 Pages: 107-112
  • NAID: 10027500613
• [Journal Article] 統合失調症患者と健常者における視覚刺激でのERPの定量解析 (2009)
  • Author(s): 杉剛直, 後藤和彦, 前川敏彦, 緒方勝也, 後藤純信, 飛松省三, 中村政俊
  • Journal Title: 臨床神経生理学 37 Pages: 432-440
  • NAID: 10029427937
• [Journal Article] 視覚刺激のイノベーション (2009)
  • Author(s): 後藤純信, 山崎貴男, 飛松省三
  • Journal Title: 臨床脳波 51 Pages: 713-720
• [Journal Article] Electrophysiological evidence of auditory temporal perception related to the assimilation between neighboring two time intervals (2009)
  • Author(s): Mitsudo T, et al
  • Journal Title: NeuroQuantology 7 Pages: 114-127
  • Peer Reviewed
• [Journal Article] Preattentive visual change detection as reflected by the mismatch negativity(MMN)- evidence for a memory-based process. (2009)
  • Author(s): Maekawa T, et al
  • Journal Title: Neurosci Res 65 Pages: 107-112
  • NAID: 10027500613
  • Peer Reviewed
• [Journal Article] ミスマッチ陰性電位を用いた統合失調症の視覚情報自動処理過程の検討. (2008)
  • Author(s): 前川敏彦, 平野昭吾, 大林長二, 平野羊嗣, 鬼塚俊明, 飛松省三, 神庭重信
  • Journal Title: 臨床脳波 50 Pages: 202-208
• [Journal Article] Electrophysiological evidence for sequential discrimination of positive and negative facial expressions. (2008)
  • Author(s): Nakashima T, Goto Y, Abe T, Kaneko K, Saito T, Makinouchi A, Tobimatsu, S
  • Journal Title: Clin Neurophysiol 119 Pages: 1803-1811
• [Journal Article] Tobimatsu S: Early ERP components differentially extract facial features: Evidence for spatial frequency-and-contrast detectors. (2008)
  • Author(s): Nakashima T, Kaneko K, Goto Y, Abe T, Mitsudo T, Ogata K, Makinouchi A
  • Journal Title: Neurosci Res 62 Pages: 225-235
• [Journal Article] 非侵襲的脳機能検査法の進歩と臨床神経生理学 (2008)
  • Author(s): 飛松省三
  • Journal Title: 福岡医誌 99 Pages: 7-12
• [Journal Article] Electrophysiological evidence for sequential discrimination of positive and negative facial expressions (2008)
  • Author(s): Nakashima T, et al
  • Journal Title: Clin Neurophysiol 119 Pages: 1808-1811
  • Peer Reviewed
• [Journal Article] Early ERP components differentially extract facial features : Evidence for spatial frequency-and-contrast detectors (2008)
  • Author(s): Nakashima T, et al
  • Journal Title: Neurosci Res 62 Pages: 225-235
  • Peer Reviewed
• [Journal Article] 視覚認知に対するボトムアップ的アプローチ (2007)
  • Author(s): 飛松省三
  • Journal Title: 認知神経科学 9 Pages: 182-188
  • NAID: 130004388084
• [Journal Article] 認知神経科学と人工知能 (2007)
  • Author(s): 岡本 剛, 飛松 省三
  • Journal Title: 人工知能学会誌 22 Pages: 195-200
• [Journal Article] 視覚認知に対するボトムナップ的アプローチ (2007)
  • Author(s): 飛松 省三
  • Journal Title: 認知神経科学 9 Pages: 182-188
• [Journal Article] A Neural Decoding Approach to Auditory Temporal Assimilation.
  • Author(s): Takeichi H, Mitsudo T, Nakajima Y, Remijn GB, Goto Y, Tobimatsu S
  • Journal Title: Neural Comput Appl (in press)
• [Journal Article] Top-down and bottom-up visual information processing of non-social stimuli in high-functioning autism spectrum disorder.
  • Author(s): Maekawa T, Tobimatsu S, Inada N, Oribe N, Onitsuka T, Kanba S, Yoko Kamio Y
  • Journal Title: Research in Autism Spectrum Disorders. (in press)
  • NAID: 120004951562
• [Journal Article] Parvocellular pathway impairment in autism spectrum disorder: Evidence from visual evoked potentials.
  • Author(s): Fujita T, Yamasaki T, Kamio Y, Hirose S, Tobimatsu S
  • Journal Title: Research in Autism Spectrum Disorders (in press)
• [Journal Article] International Federation for Clinical Neurophysiology: Recommendations for Visual System Testing.
  • Author(s): Holder GE, Celesia GG, Miyake Y, Tobimatsu S, Weleber RG
  • Journal Title: Clin Neurophysiol (in press)
• [Presentation] Visual information processing of face perception. (2010)
  • Author(s): Tobimatsu S
  • Organizer: Workshop on Microwave Devices, Systems and their Applications
  • Place of Presentation: KASTEC, Kyushu University
  • Year and Date: 2010-03-16
• [Presentation] 視覚情報処理: What, Where, When. (2010)
  • Author(s): 飛松省三
  • Organizer: 札幌医科大学シンポジウム「脳機能検索法の未来」
  • Place of Presentation: 札幌
  • Year and Date: 2010-02-06
• [Presentation] Visual gnosis and face perception. (2009)
  • Author(s): Tobimatsu S
  • Organizer: 2009 International Symposium on Early Detection and rehabilitation Technology
  • Place of Presentation: Okayama, Japan
  • Year and Date: 2009-12-19
• [Presentation] 多モダリテイー視覚刺激による脳機能推定と臨床応用の現状 (2009)
  • Author(s): 飛松省三
  • Organizer: 平成21年度統計数理研究所共同利用共同研究集会, 医用診断のための応用統計数理の新展開
  • Year and Date: 2009-12-03
• [Presentation] Magnetoencephalographic evidence for parallel somatosensory processing in humans. (2009)
  • Author(s): Hagiwara K, Okamoto T, Shigeto H, Somehara Y, Ogata K, Kira J, Tobimatsu S
  • Organizer: International Society for the Advancement of Clinical Magnetoencephalography (ISACM 2009)
  • Place of Presentation: Athens, Greece
  • Year and Date: 2009-09-04
• [Presentation] EEG/MEG exploration on human auditory temporal assimilation. (2009)
  • Author(s): Mitsudo T, Nakajima Y, Remijn GB, Nagaike Y, Goto Y, Tobimatsu S
  • Organizer: The 18th International Congress on Brain Electromagnetic Topography (ISBET 2009)
  • Place of Presentation: Kyoto
  • Year and Date: 2009-09-01
• [Presentation] EEG/MEG exploration on human auditory temporal assimilation (2009)
  • Author(s): Mitsudo T, et al
  • Organizer: The 18th International Congress on Brain Electromagnetic Topography(ISBET 2009)
  • Place of Presentation: 日本, 京都
  • Year and Date: 2009-09-01
• [Presentation] A classifier analysis of electrophysiological evidence of auditory temporal assimilation. (2009)
  • Author(s): Takeichi H, Mitsudo T, Nakajima Y, Remijn GB, Goto Y, Tobimatsu S
  • Organizer: International Conference of Asia Pacific Psychology (ICAPP 2009)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2009-08-25
• [Presentation] A classifier analysis of electrophysiological evidence of auditory temporal assimilation (2009)
  • Author(s): Takeichi H, et al
  • Organizer: International Conference of Asia Pacific Psychology(ICAPP 2009)
  • Place of Presentation: 韓国, ソウル
  • Year and Date: 2009-08-25
• [Presentation] Electrophysiological Substrates of Auditory Temporal Assimilation Between Two Neighboring Time Intervals. (2009)
  • Author(s): Mitsudo T, Nakajima Y, Remijn GB, Takeichi H, Goto Y, Tobimatsu S
  • Organizer: The Rhythm Perception and Production Workshop (RPPW 2009)
  • Place of Presentation: Lille, France
  • Year and Date: 2009-07-16
• [Presentation] Electrophysiological Substrates of Auditory Temporal Assimilation Between Two Neighboring Time Intervals (2009)
  • Author(s): Mitsudo T, et al
  • Organizer: The Rhythm Perception and Production Workshop(RPPW 2009)
  • Place of Presentation: フラシス, リール
  • Year and Date: 2009-07-16
• [Presentation] Memory trace formation underlies preattentive visual change detection. (2009)
  • Author(s): Maekawa T, Tobimatsu S, Ogata K, T Onitsuka T, S Kanba S
  • Organizer: Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
  • Place of Presentation: Budapest
  • Year and Date: 2009-04-04
• [Presentation] An ERP study about altered visual attentional system in bipolar disorder. (2009)
  • Author(s): Maekawa T, Tsunoda T, Oribe N, Fukushima N, Onitsuka T, Tobimatsu S, Kanba S
  • Organizer: Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
  • Place of Presentation: Budapest
  • Year and Date: 2009-04-04
• [Presentation] Visual mismatch negativity and P300 to a windmill stimulus in schizophrenia. (2009)
  • Author(s): Maekawa T, Tsunoda T, Fukushima N, Onitsuka T, Tobimatsu S, Kanba S
  • Organizer: Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications.
  • Place of Presentation: Budapest
  • Year and Date: 2009-04-04
• [Presentation] 視覚刺激のイノベーション (2008)
  • Author(s): 後藤純信, 山崎貴男, 飛松省三
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-14
• [Presentation] 無意識と意識の中の時間:心理的、電気生理学的アプローチ (2008)
  • Author(s): 飛松省三
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-13
• [Presentation] 視覚刺激を用いた「時間知覚の同化現象」に関する研究. (2008)
  • Author(s): 長池淳, 光藤崇子, 中島祥好, 緒方勝也, 山崎貴男, 後藤純信, 飛松省三
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-13
• [Presentation] 視覚刺激を用いた「時間知覚の同化現象」に関する研究 (2008)
  • Author(s): 長池淳, 他
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-13
• [Presentation] 聴覚における時間的同化現象の脳内メカニズム. (2008)
  • Author(s): 光藤崇子, 中島祥好, Gerard Remijn, 後藤純信, 飛松省三
  • Organizer: 第38回日本臨床神経生理学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-11-12
• [Presentation] A psychophysiological approach to auditory temporal assimilation. (2008)
  • Author(s): Mitsudo T, Nakajima Y, Remijn GB, Goto Y, Tobimatsu S
  • Organizer: The 10th International Conference on Music Perception and Cognition.
  • Place of Presentation: Sapporo
  • Year and Date: 2008-08-27
• [Presentation] 頭を開けずに脳を見る、測る、探る (2008)
  • Author(s): 飛松省三
  • Organizer: JSTイノベーションプラザ福岡 異分野交流セミナー「生体工学研究の最新動向と展望―V」
  • Place of Presentation: 福岡
  • Year and Date: 2008-07-30
• [Presentation] 視覚における時間知覚の同化現象 (2008)
  • Author(s): 長池淳, 光藤崇子, 中島祥好, 緒方勝也, 山崎貴男, 後藤純信, 飛松省三
  • Organizer: 第13回認知神経科学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-12
• [Presentation] 視覚における2つの隣接する時間感覚の知覚について (2008)
  • Author(s): 長池淳, 齋藤崇子, 中島祥好, 緒方勝也, 山崎貴男, 飛松省三
  • Organizer: 平成19年度日本生体医工学会九州支部講演会
  • Year and Date: 2008-03-01
• [Presentation] 視覚における2つの隣接する時間感覚の知覚について (2008)
  • Author(s): 長池 淳, 齋藤 崇子, 中島 祥好, 緒方 勝也, 山崎 貴男, 飛松 省三
  • Organizer: 平成19年度日本生体医工学会九州支部講演会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-01
• [Presentation] 脳は騙されない-特にボトムアップ的情報検出について (2008)
  • Author(s): 飛松省三
  • Organizer: 第7回京都脳機能研究会
  • Place of Presentation: 京都
  • Year and Date: 2008-02-07
• [Presentation] Neural correlates of asymmetrical auditory temporal assimilation. (2007)
  • Author(s): Saito T, Nakajima Y, Remijn GB, Goto Y, Tobimatsu S
  • Organizer: The Second International Symposium on Design of Artificial Environments.
  • Place of Presentation: Fukuoka
  • Year and Date: 2007-12-01
• [Presentation] Effects of spatial frequency on recognition of facial expressions: An ERP study. (2007)
  • Author(s): Nakashima T, Yamasaki T, Goto Y, Kaneko K, Tobimatsu S
  • Organizer: The Second International Symposium on Design of Artificial Environments.
  • Place of Presentation: Fukuoka
  • Year and Date: 2007-12-01
• [Presentation] Neural correlates of asymmetrical auditory temporal assimilation (2007)
  • Author(s): Saito T, Nakajima Y, Remijn GB, Goto Y, Tobimatsu S
  • Organizer: The Second International Symposium on Design of Artificial Environments
  • Place of Presentation: 福岡
  • Year and Date: 2007-12-01
• [Presentation] 時間縮小錯覚による聴覚時間知覚機構 (2007)
  • Author(s): 齋藤崇子, 中島祥好, Remijn Gerard B, 後藤純信, 飛松省三
  • Organizer: 第37回日本臨床神経生理学会学術大会
  • Place of Presentation: 宇都宮
  • Year and Date: 2007-11-22
• [Presentation] 統合失調症における視覚性P300とミスマッチ陰性電位の検討 (2007)
  • Author(s): 前川俊彦, 角田智哉, 平野羊嗣, 平野昭吾, 大林長二, 吉田猛, 鬼塚俊明, 神庭重信, 飛松省三
  • Organizer: 第37回日本臨床神経生理学会学術大会
  • Place of Presentation: 宇都宮
  • Year and Date: 2007-11-22
• [Presentation] 視覚認知に対するボトムアップ的アプローチ. (2007)
  • Author(s): 飛松省三
  • Organizer: 第12回認知神経科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2007-07-21
• [Presentation] Evidence for Visual Analogue of Auditory Mismatch Negativity. (2007)
  • Author(s): Maekawa T, Kanba S, Tobimatsu S
  • Organizer: 2007 IEEE/ICME
  • Place of Presentation: Beijing
• [Presentation] Visual ERPs and cortical functions. (2007)
  • Author(s): Tobimatsu S
  • Organizer: International Workshop on "Event Related Potentials in Patients with Epilepsy
  • Place of Presentation: Kyoto
• [Book] EEG/MEG exploration on human auditory temporal assimilation (2009)
  • Author(s): Mitsudo T, Nakajima Y, Remijn GB, Nagaike Y, Goto Y, Tobimatsu S
  • Publisher: In: Kobayashi T, Ozaki I, Nagata K (eds), Brain Topography and Multimodal Imaging
• [Book] 認知神経科学と神経学 (2009)
  • Author(s): 飛松省三
  • Publisher: 呉景龍, 津本周作(編)
• [Book] 認知神経科学と神経学. 呉景龍, 本周作(編), 神経医工学 (2009)
  • Author(s): 飛松省三
  • Total Pages: 58
  • Publisher: オーム社
• [Book] Visual ERPs and cortical function. (2008)
  • Author(s): Tobimatsu S, Goto Y, Yamasaki T, Nakashima T, Tomoda Y, Mitsudome A
  • Publisher: In: Ikeda A, Inoue Y (eds), Progress in epileptic disorders Vol. 5, Event-related potentials in patients with epilepsy: from current state to future prospects
• [Book] Visual ERPs and cortical function.In : Ikeda A, Inoue Y(eds), Progress in epileptic disorders Vol.5, Event-related potentials in patients with epilepsy : from current state to future prospects (2008)
  • Author(s): Tobimatsu S, et al
  • Total Pages: 291
  • Publisher: John Libbey Eurotext, Paris.
• [Remarks] ホームページ等
  • URL: http://www.med.kyushu-u.ac.jp/neurophy/
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  • URL: http://www.med.kyushu-u.ac.jp/neurophy/
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