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Analysis of the pleiotropic effects of TFE3 on metabolic syndrome

Research Project

Project/Area Number 19390245
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionUniversity of Tsukuba

Principal Investigator

SHIMANO Hitoshi  University of Tsukuba, 大学院・人間総合科学研究科, 教授 (20251241)

Co-Investigator(Kenkyū-buntansha) 中川 嘉  筑波大学, 大学院・人間総合科学研究科, 講師 (80361351)
松坂 賢  筑波大学, 大学院・人間総合科学研究科, 助教 (70400679)
Co-Investigator(Renkei-kenkyūsha) NAKAGAWA Yoshimi  筑波大学, 大学院・人間総合科学研究科, 講師 (80361351)
松坂 賢  筑波大学, 大学院・人間総合科学研究科, 助教 (70400679)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2008: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2007: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywords転写因子 / TFE3 / 骨格筋 / 脂肪 / 遺伝子発現 / 生活習慣病 / 糖代謝 / グリコーゲン / 糖尿病
Research Abstract

肝臓において生活習慣病の治療効果を有する転写因子TFE3がエネルギー代謝責任臓器において、糖・脂質代謝を調節し生活習慣病病態の改善に機能するかを検討した。骨格筋および脂肪組織におけるTFE3の機能を解析した。TFE3は骨格筋ではT筋肉内グリコーゲン量の上昇活性、脂肪組織では脂肪分化、蓄積の抑制活性を有する。TFE3が様々な組織で多面的に生活習慣病の改善に機能することが示された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (41 results)

All 2008 2007 Other

All Journal Article (26 results) (of which Peer Reviewed: 24 results) Presentation (13 results) Remarks (2 results)

  • [Journal Article] Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice : a new model for lipotoxicity.2008

    • Author(s)
      Ishikawa M, Iwasaki Y, Yatoh S, Kato T, Kumadaki S, Inoue N, Yamamoto T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Yamada N, Shimano H.
    • Journal Title

      J Lipid Res. 49(12)

      Pages: 2524-34

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis2008

    • Author(s)
      Sekiya M, Osuga J, Yahagi N, Okazaki H, Tamura Y, Igarashi M, Takase S, Harada K, Okazaki S, Iizuka Y, Ohashi K, Yagyu H, Okazaki M, Gotoda T, Nagai R, Kadowaki T, Shimano H, Yamada N
    • Journal Title

      Ishibashi S. J Lipid Res. 49(8)

      Pages: 1829-38

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets2008

    • Author(s)
      Kato T, Shimano H, Yamamoto T, Ishikawa M, Kumadaki S, Matsuzaka T, Nakagawa Y, Yahagi N, Nakakuki M, Hasty AH, Takeuchi Y, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Sone H, Yamada N
    • Journal Title

      Diabetes 57(9)

      Pages: 2382-92

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance2008

    • Author(s)
      Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, Nakagawa Y, Takeuchi Y, Kobayashi K, Takahashi A, Suzuki H, Hasty AH, Toyoshima H, Yamada N, Shimano H
    • Journal Title

      J Biol Chem. 283(30)

      Pages: 21220-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] MSREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing2008

    • Author(s)
      Diraison F, Ravier MA, Richards SK, Smith RM, Shimano H Rutter GA.
    • Journal Title

      J Lipid Res. 49(4)

      Pages: 814-22

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP2008

    • Author(s)
      Park HJ, Georgescu SP, Du C, Madias C, Aronovitz MJ, Welzig CM, Wang B, Begley U, Zhang Y, Blaustein RO, Patten RD, Karas RH, Van Tol HH, Osborne TF, Shimano H, Liao R, Link MS, Galper JB.
    • Journal Title

      J Clin Invest 118(1)

      Pages: 259-71

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocy to differentiation and hypertrophy, linking to obesity and insulin resistance..2008

    • Author(s)
      Inoue N, et al.
    • Journal Title

      J Biol Chem. 283

      Pages: 21220-9

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-lc in pancreatic islets.2008

    • Author(s)
      Kato T, et al.
    • Journal Title

      Diabetes. 57

      Pages: 2382-92

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hormone-sensitive lipase is involved in hepatic cholesterol ester hydrolysis.2008

    • Author(s)
      Sekiya M, et al.
    • Journal Title

      J Lipid Res 49

      Pages: 1829-38

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mouse Elov1-6 promoter is an SREBP target.2008

    • Author(s)
      Kumadaki S, Matsuzaka T, Shimano H, et. al.
    • Journal Title

      Biochem Biophys Res Commun (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing.2008

    • Author(s)
      Diraison F, Shimano H, Rutter GA, et. al.
    • Journal Title

      J Lipid Res 118(1)(in press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP.2008

    • Author(s)
      Park HJ, Shimano H, Galper JB., et. al.
    • Journal Title

      J Clin Invest. 118(1)

      Pages: 259-271

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance2007

    • Author(s)
      Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N.
    • Journal Title

      Nat Med. 13(10)

      Pages: 1193-202

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status2007

    • Author(s)
      de Preux AS, Goosen K, Zhang W, Sima AA, Shimano H, Ouwens DM, Diamant M, Hillebrands JL, Rozing J, Lemke G, Beckmann JS, Smit AB, Verheijen MH, Chrast R.
    • Journal Title

      Mol Cell Neurosci 35(4)

      Pages: 525-34

    • NAID

      120007139126

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] SREBP-1-independent regulation of lipogenic gene expression in adipocytes2007

    • Author(s)
      Sekiya M, Yahagi N, Matsuzaka T, Takeuchi Y, Nakagawa Y, Takahashi H, Okazaki H, Iizuka Y, Ohashi K, Gotoda T, Ishibashi S, Nagai R, Yamazaki T, Kadowaki T, Yamada N, Osuga J, Shimano H.
    • Journal Title

      J Lipid Res. 48(7)

      Pages: 1581-91

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver2007

    • Author(s)
      Yamamoto T, Shimano H, Inoue N, Nakagawa Y, Matsuzaka T, Takahashi A, Yahagi N, Sone H, Suzuki H, Toyoshima H, Yamada N.
    • Journal Title

      J Biol Chem. 282(16)

      Pages: 11687-95

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irradiation Ameliorates Obesity in ob/ob Mice.2007

    • Author(s)
      Okada S, Shimano H, et. al.
    • Journal Title

      J Clin Biochem Nutr. 40

      Pages: 123-30

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of glomerular SREBP-lc in diabetic nephropathy.2007

    • Author(s)
      Ishigaki N, Shimano H., et. al.
    • Journal Title

      Biochem Biophys Res Commun. 364(3)

      Pages: 502-8

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of a long-chain fatty acid elongase, Elov16, in obesity-induced insulin resistance2007

    • Author(s)
      Matsuzaka T, Shimano H, Nakagawa Y, et. al.
    • Journal Title

      Nat Med. 13(10)

      Pages: 1193-1202

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo promoter analysis on refeeding response of hepatic sterol regulatory element-binding protein-lc expression.2007

    • Author(s)
      Takeuchi Y, Nakagawa Y, Matsuzaka T, Shimano H., et. al.
    • Journal Title

      Biochem Biophys Res Commun. 363(2)

      Pages: 329-35

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A transcription factor of lipid synthesis, sterol regulatory element-binding protein(SREBP)-la causes G(l) cell-cycle arrest after accumulation of cyclin-dependent kinase(cdk)inhibitors.2007

    • Author(s)
      Nakakuki M, Shimano H Matsuzaka T, Nakagawa Y, et. al.
    • Journal Title

      FEBS J. 274(17)

      Pages: 4440-4452

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of ISG 12b as a Putative Interferon-inducible Adipocytokine which is Highly Expressed in White Adipose Tissue.2007

    • Author(s)
      Ohgaki S, Shimano H, et. al.
    • Journal Title

      J Atheroscler Thromb. 14(4)

      Pages: 179-84

    • NAID

      10022606840

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Even low-intensity and low-volume exercise training may improve insulin resistance in the elderly.2007

    • Author(s)
      Kodama S, Shimano H, Sone H., et. al.
    • Journal Title

      Intern Med. 46(14)

      Pages: 1071-7

    • NAID

      130000076125

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SREBP-lc expression in Schwann cells is affected by diabetes and nutritional status.2007

    • Author(s)
      de Preux AS, Shimano H, Verheijen MH, et. al.
    • Journal Title

      Mol Cell Neurosci 35(4)

      Pages: 525-34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sterol regulatory element-binding protein-lc and pancreatic beta-cell dysfunction.2007

    • Author(s)
      Shimano H, et. al.
    • Journal Title

      Diabetes Obes Metab. 9 Suppl 2

      Pages: 133-9

    • Related Report
      2007 Annual Research Report
  • [Journal Article] SREBP-lc and TFE3, energy transcription factors that regulate hepatic insulin signaling.2007

    • Author(s)
      Shimano H, et. al.
    • Journal Title

      J Mol Med. 85(5)

      Pages: 437-444

    • Related Report
      2007 Annual Research Report
  • [Presentation] 骨格筋におけるTFE3の機能解析2008

    • Author(s)
      岩崎仁, 島野仁, 中川嘉, 松坂賢, 石井清朗, 小林和人, 矢藤繁, 高橋昭光, 鈴木浩明, 山田信博
    • Organizer
      BMB2008(第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝臓特異的発現転写因子CREB-Hの生活習慣病病態への機能解析2008

    • Author(s)
      中川嘉
    • Organizer
      BMB2008(第31回目本分子生物学会年会・第81回日本生化学会大会合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨格筋特異的に発現するTFE3 の解析2008

    • Author(s)
      岩崎仁, 島野仁, 中川嘉, 松坂賢, 小林和人, 矢藤繁, 高橋昭光, 鈴木浩明, 山田信博
    • Organizer
      第51回日本糖尿病学会年次学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-22
    • Related Report
      2008 Final Research Report
  • [Presentation] 肝臓におけるエネルギー代謝調節因子TFE3のメタボリックシンドロームへの作用メカニズム2008

    • Author(s)
      中川嘉
    • Organizer
      日本農芸化学会2008年度会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] 脂肪酸組成とインスリン抵抗性 脂肪の質的側面による制御2008

    • Author(s)
      島野 仁
    • Organizer
      第42回糖尿病学の進歩 レクチャー
    • Place of Presentation
      高松 国際会議場
    • Year and Date
      2008-02-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] エネルギー代謝転写調節ネットワークと動脈硬化リスク2007

    • Author(s)
      島野 仁
    • Organizer
      第22回日本糖尿病合併症学会、イブニングセミナー
    • Place of Presentation
      つくば 国際会議場
    • Year and Date
      2007-10-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] エネルギー代謝調節機構からみたメタボリックシンジロームの病態と治療2007

    • Author(s)
      島野 仁
    • Organizer
      第28回日本肥満学会ランチョンセミナー
    • Place of Presentation
      東京 都市センター
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] エネルギー代謝転写調節因子とメタボリックシンドローム2007

    • Author(s)
      島野 仁
    • Organizer
      第44回日本臨床分子医学会学術総会フォーラム シンポジウム
    • Place of Presentation
      和歌山東急イン
    • Year and Date
      2007-07-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] 加齢とメタボリックシンドローム2007

    • Author(s)
      島野 仁
    • Organizer
      第49回日本老年医学会学術集会、シンポジウム
    • Place of Presentation
      札幌ロイトンホテル
    • Year and Date
      2007-07-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] インスリン抵抗性とトリグリセリド2007

    • Author(s)
      島野 仁
    • Organizer
      第39回日本動脈硬化学会学術集会シンポジウム
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-07-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] TFE3による脂肪細胞の分化への影響2007

    • Author(s)
      中川嘉、島野仁、岩崎仁、松坂賢、高橋昭光、鈴木浩明、山田信博
    • Organizer
      第50回日本糖尿病学会年次学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2007-05-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 転写因子と糖尿病、SREBP-1c2007

    • Author(s)
      島野 仁
    • Organizer
      第50回日本糖尿病学会年次集会シンポジウム
    • Place of Presentation
      仙台ホテルメトロポリタン
    • Year and Date
      2007-05-26
    • Related Report
      2007 Annual Research Report
  • [Presentation] エネルギー代謝の転写調節機構、その生理と病態2007

    • Author(s)
      島野 仁
    • Organizer
      第61回日本栄養食糧学会 シンポジウム
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/endocrinology/research/

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.Md.Tsukuba.Ac.Jp/clinical-med/endocrinology/research/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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