Studies on Molecular-Cellular Mechanisms of Protein C AnticoagulantPathway Crucial for Life Maintenance
| Project/Area Number |
19390262
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
SUZUKI Mie University, 大学院・医学系研究科, 教授 (70077808)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Tatsuya 三重県立看護大学, 看護学科, 教授 (00242959)
OKAMOTO Takayuki 三重大学, 大学院・医学系研究科, 助教 (30378286)
GABAZZA Esteban 三重大学, 大学院・医学系研究科, 教授 (00293770)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2008: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 血液凝固制御 / 血管内皮細胞 / プロテインC / プロテインS / C4b結合蛋白質 / プロテインCインヒビター / トロンボモジュリン / コネキシン / 活性化プロテインC(APC) / プロテインS(PS) / C4b-binding protein β(C4BPβ) / EPCR / PAR-1 / Protein C inhibitor (PCI) / Connexin32(Cx32) / 抗炎症作用 / 血管内皮プロテインC受容体(EPCR) / エンドトキシン(LPS) / C4b-binding protein (C4BP) / プロテインCインヒビター(PCI) / HGF activator(HGFA) |
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| Research Abstract |
本研究では、生命維持に重要なプロテインC凝固制御系のうち、(1) 血中Protein S(PS)の抗凝固作用発現機構、(2) Protein C inhibitor(PCI)による臓器細胞の機能制御機構、および(3) 炎症性内皮障害を制御する細胞間接着分子の同定、に関する研究を行い、感染時の血中C4BPβ の増加がPS の抗凝固作用を低下させ、PCI が臓器固有の機能を制御し、さらに、Cx32 が血管内皮の炎症を制御することを明らかにした。
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Regulatorymechanisms of C4b-binding protein (C4BP)α andβ expression in rat hepatocytes by lipopolysaccharide and interleukin-6specific increase of C4BPβ expression influences the plasma level ofprotein S-C4BP complex and anticoagulantactivity of protein2008
Author(s)
Kishiwada M, Hayashi T, Yuasa H, Fujii K,Nishioka J, Akita N, Tanaka H, Ido M, OkamotoT, Gabazza EC, Isaji S, Suzuki K
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Journal Title
S. J Thromb Haemost 6
Pages: 858-1867
Related Report
Peer Reviewed
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[Journal Article] Protein C inhibitor inhibits breast cancer cell growth,metastasis and angiogenesis independently of itsprotease inhibitory activity2007
Author(s)
Asanuma K, Yoshikawa T, Hayashi T, Akita N,Nakagawa N, Hamada Y, Nishioka J, Kamada H,Gabazza EC, Ido M, Uchida A, Suzuki K
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Journal Title
Int J Cancer 121
Pages: 955-965
Related Report
Peer Reviewed
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[Journal Article] Protein C inhibitor directly and potently inhibits activatedhepatocyte growth factor activator2007
Author(s)
Hayashi T, Nishioka J, Kamada H, Hamada K,Fujii K, Naka D, Nagaike K, Uemoto S,Kobayashi T, Hattori A, Suzuki K
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Journal Title
J Thromb Haemost 5
Pages: 1477-1485
Related Report
Peer Reviewed
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