Development of a novel interferon with mild adverse effects
| Project/Area Number |
19390264
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
ORITANI Kenji Osaka University, 医学系研究科, 講師 (70324762)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 医学系・研究科, 教授 (20177489)
MATSUMURA Itaru 大阪大学, 医学系・研究科, 准教授 (00294083)
YOKOTA Takahumi 大阪大学, 医学系・研究科, 助教 (60403200)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2007: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
|---|
| Keywords | インターフェロン / サイトカイン / Limitin / ウイルス感染 / IFN-ζ / アミノ酸置換 / 骨髄抑制 / 骨髓抑制 |
|---|
| Research Abstract |
新規インターフェロン(IFN-zeta/Limitin)はIFN-alphaと同等の免疫調節作用・抗腫瘍作用・抗ウイルス作用を持つものの骨髄抑制作用が軽微である。我々は、受容体結合部位でIFN-alphaやIFN-betaと一致しIFN-zeta/Limitinとは異なるアミノ酸に変異を加え、骨髄抑制作用減弱(m3変異)・抗ウイルス活性増強(m1変異)に関わる責任アミノ酸を決定した。さらに、変異ヒトIFN-alpha1を作製し、それらの生理活性を野生型IFN-alpha1と比較した。ヒトIFN-alphaにおいてもm1、m3各変異部位が生理活性に影響を及ぼすことが判明した。
|
Report
(3 results)
Research Products
(46 results)
-
-
-
[Journal Article] Regulation of human B lymphopoiesis by the transforming growth factor-beta superfamily in a newly established coculture system using human mesenchymal stem cells as a supportive microenvironment2008
Author(s)
Ichii M, Oritani K, Yokota T, Nishida M, Takahashi I, Shirogane T, Ezoe S, Saitoh N, Tanigawa R, Kincade PW, Kanakura Y
-
Journal Title
Exp Hematol 36
Pages: 587-597
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells2008
Author(s)
Murayama Y, Shinomura Y, Oritani K, Miyagawa J, Yoshida H, Nishida M, Katsube F, Shiraga M, Miyazaki T, Nakamoto T, Tsutsui S, Tamura S, Higashiyama S, Shimomura I, Hayashi N
-
Journal Title
J Cell Physiol 36
Pages: 135-143
Related Report
Peer Reviewed
-
[Journal Article] AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cells2008
Author(s)
Satoh Y, Matsumura I, Tanaka H, Ezoe S, Fukushima K, Tokunaga M, Yasumi M, Shibayama H, Mizuki M, Era T, Okuda T, Kanakura Y
-
Journal Title
J Biol Chem 283
Pages: 30045-30056
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Adiponectin binds to chemokines via the globular head and modulates interactions between chemokines and heparan sulfates2007
Author(s)
Masaie H, Oritani K, Yokota T, Takahashi I, Shirogane T, Ujiie H, Ichii M, Saitoh N, Maeda T, Tanigawa R, Oka K, Hoshida Y, Tomiyama Y, Kanakura Y
-
Journal Title
Exp Hematol 35
Pages: 947-956
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] SFRP1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis2007
Author(s)
Yokota T, Oritani K, Garrett KP, Kouro T, Nishida M, Takahashi I, Ichii M, Matsumura I, Kincade PW, Kanakura Y
Organizer
American Society of Hematology 49th Annual meeting
Place of Presentation
Atlanta, USA
Related Report
-
-
-
-
-
-
-
-
-
-
-
